• Journal of the Korean Society of Safety
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• v.18 no.2
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• pp.132-138
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• 2003

The use of long rails in high-speed railway bridges causes additional stresses due to nonlinear behaviours between the rail and bridge decks in the neighbourhood of the deck joints. In the seismic response analysis of high-speed railway bridges, since structural response is highly sensitive to properties of the ground motion, spatial variation of the ground excitation affects responses of the bridges, which in turn affect stresses in the rails. In addition, it is shown that high-speed trains need very long distances to stop when braking under seismic occurrence corresponding to operational earthquake performance level so that verification of the safe stoppage of the train is also required. In view of such additional stresses due to long rails, sensibility of structural response to the properties of the ground motion and braking distance needed by the train to stop safely, this paper proposes and establishes a time domain nonlinear dynamic analysis method that accounts for braking loads, spatial variation of the ground motion and material nonlinearities of rails to analyze long rail stresses in high-speed railway bridges subjected to seismic event. The accuracy of the proposed method is demonstrated through an application on a typical site of the Korean high-speed railway.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.15 no.5
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• pp.1087-1096
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• 2011

Vehicular Ad Hoc Network(VANET) using wireless network is offering the communications between vehicle and vehicle(V2V) or vehicle and infrastructure(V2I). VANET is being actively researched from industry field and university because of the rapid developments of the industry and vehicular automation. Information, collected from VANET, of velocity, acceleration, condition of road and environments provides various services related with safe drive to the drivers, so security over network is the inevitable factor. For the secure message authentication, a number of authentication proposals have been proposed. Among of them, a scheme, proposed by Jung, applying database search algorithm, Bloom filter, to RAISE scheme, is efficient authentication algorithm in a dense space. However, k-anonymity used for obtaining the accurate vehicular identification in the paper has a weak point. Whenever requesting the righteous identification, all hash value of messages are calculated. For this reason, as the number of car increases, a amount of hash operation increases exponentially. Moreover the paper does not provide a complete key exchange algorithm while the hand-over operation. In this paper, we use a Received Signal Strength Indicator(RSSI) based velocity and distance estimation algorithm to localize the identification and provide the secure and efficient algorithm in which the problem of hand-over algorithm is corrected.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• v.1
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• pp.495-500
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• 2006

Satellite systems for objects positioning appeared indispensable for performing basic tasks of maritime navigation. Navigation, understood as safe and effective conducting a vehicle from one point to another, within a specific physical-geographical environment. [Kopacz, $Urba{\acute{n}}ski$, 1998]. However, the systems have not solved the problem of accessibility to reliable and highly accurate information about a position of an object, especially if surveyed toward on-shore navigational signs or in sea depth. And it's of considerable significance for many navigational tasks, carried out within the frameworks of special works performance and submarine navigation. In addition, positioning precisely the objects other than vessels, while executing hydrographical works, is not always possible with a use of any satellite system. Difficulties with GPS application show up also while positioning such off-lying dangers as wrecks, underwater and aquatic rocks also other naturaland artificial obstacles. It is caused by impossibility of surveyors approaching directly any such object while its positioning. Moreover, determination of vessels positions mutually (mutual geometrical relations) by teams carrying out one common tasks at sea, demands applying the navigational techniques other than the satellite ones. Vessels'staying precisely on specified positions is of special importance in, among the others, the cases as follows: - surveying vessels while carrying out bathymetric works, wire dragging; - special tasks watercraft in course of carrying out scientific research, sea bottom exploration etc. The problems are essential for maritime economy and the Country defence readiness. Resolving them requires applying not only the satellite navigation methods, but also the terrestrial ones. The condition for implementation of the geo-navigation methods is at present the methods development both: in aspects of their techniques and technologies as well as survey data evaluation. Now, the classical geo-navigation comprises procedures, which meet out-of-date accuracy standards. To enable meeting the present-day requirements, the methods should refer to well-recognised and still developed methods of contemporary geodesy. Moreover, in a time of computerization and automation of calculating, it is feasible to create also such software, which could be applied in the integrated navigational systems, allowing carrying out navigation, provided with combinatory systems as well as with the new positioning methods. Whereas, as regards data evaluation, there should be applied the most advanced achievements in that subject; first of all the newest, although theoretically well-recognised estimation methods, including estimation [Hampel et al. 1986; $Wi{\acute{s}}niewski$ 2005; Yang 1997; Yang et al. 1999]. Such approach to the problem consisting in positioning a vehicle in motion and solid objects under observation enables an opportunity of creating dynamic and interactive navigational structures. The main subject of the theoretical suggested in this paper is the Interactive Navigational Structure. In this paper, the Structure will stand for the existing navigational signs systems, any observed solid objects and also vehicles, carrying out navigation (submarines inclusive), which, owing to mutual dependencies, (geometrical and physical) allow to determine coordinates of this new Structure's elements and to correct the already known coordinates of other elements.

• The KIPS Transactions:PartD
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• v.11D no.6
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• pp.1247-1258
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• 2004

The LBS(Location-Based Service), which is based on individual's mobility, is required increasingly as mobile telecommunication and various infrastructures have developed rapidly. The technologies for LBS are location determination technology, service platform technology, contents provider technology and moving object database technology generally. Among these, service platform must be interoperable with location gate-way server and provide common function of billing, authentification, protect location information, privacy control, location trigger and intelligent acquisition and so on. The TTA(Telecommunications Technology Association) published specification that defines a standard protocol for safe and simple interface between LBS client and LBS platform and the OpenLS(Open Location Service) in OGC (Open GIS Consortium) released implementation specifications for providing Location based core services. In this paper, we implemented service platform for LBS which is able to interoperable with location gateway server and contents provider and is caracterized as follows. First, it could require and response location information from different types of location gateway server with same interface. Second, it complies with the standard interfaces with OpenLS 4 contents providers for core LBS. Third, it could provide location of wired phone as well as wireless mobile terminal compling with the standard protocol. Last, it could provide trajectorH information based past location as well as current location, because it is able to interoperable with moving object DBMS. This paper contributes to the construction and practical use of LBS by providing the method of implementation of service platform for LBS.

• Journal of Pharmacopuncture
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• v.18 no.1
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• pp.63-71
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• 2015

Objectives: This study was carried out to analyze the single-dose toxicity of Eun-Bi San pharmacopuncture injected into the muscle of Sprague-Dawley (SD) rats. Methods: All experiments were performed at Biotoxtech, an institution certified to conduct non-clinical studies under the Good Laboratory Practice (GLP) regulations. Six week old SD rats reared by ORIENTBIO were chosen for this pilot study. The reason SD rats were chosen is that they have been widely used in safety tests in the field of medicine, so the results can be easily compared with many other databases. The Eun-Bi San pharmacopuncture was made in a clean room at the Korean Pharmacopuncture Institute (KPI, K-GMP). The constituents of the Eun-Bi San pharmacopuncture are Angelicae gigantis radix, Strychni semen and Glycyrrhizae radix. These were extracted at low temperature and low pressure in an aseptic room at the KPI. Doses of Eun-Bi San pharmacopuncture, 0.25, 0.5 and 1.0 mL, were administered to the experimental groups, and a dose of normal saline solution, 1.0 mL, was administered to the control group. This study was performed under the approval of the Institutional Animal Ethics Committee of Biotoxtech Co., Ltd. Results: No deaths or abnormalities occurred in any of the four groups. No significant changes in weight, hematological parameters or clinical chemistry between the control group and the experimental groups were observed. To determine if abnormalities existed in any organs and tissues, we used microscopy to examine representative histological sections of each specified organ; the results showed no significant differences in any of the organs or tissues. Conclusion: The results of this study suggest that treatment with Eun-Bi San pharmacopuncture is relatively safe and that its clinical use may be beneficial. Further evaluations and studies on this subject will be needed to provide more concrete evidence in support of these conclusions.

• Journal of Pharmacopuncture
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• v.18 no.1
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• pp.56-62
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• 2015

Objectives: The purpose of the study is to assess both the approximate lethal dose and the single dose intramuscular injection toxicity of Danggui (Angelica gigantis radix) pharmacopuncture (DGP) in Sprague-Dawley (SD) rats. Methods: The experiments were conducted at the good laboratory practice (GLP) laboratory, Biotoxtech Co., which is a laboratory approved by the ministry of food and drug safety (MFDS). The study was performed according to the GLP regulation and the toxicity test guidelines of the MFDS (2009) after approval of the institutional animal care and use committee of Biotoxtech. Single doses of DGP were injected intramuscularly into the rats in three test groups of 6 week old SD rats (5 male and 5 female rats per groups) in the amounts of 0.1, 0.5, and 1.0 mL/animal for groups 2, 3, and 4, respectively, and normal saline solution in the amount of 1.0 mL/animal was injected intramuscularly into the rats (5 male and 5 female rats) in the control group. Observations of the general symptoms and weight measurements were performed during the 14 day observation period after the injection. Hematologic and serum biochemical examination, necropsy, and a local tolerance test at the injection site were done after the observation period. Results: No death was observed in three test groups (0.1, 0.5 and 1.0 mL/animal group). In addition, the injection of DGP had no effect on general symptoms, weights, hematologic and serum biochemical examination, and necropsy. The results from the local tolerance tests at injection site showed no treatment related effects in the SD rats. Conclusion: The results of single dose intramuscular injection of DGP suggest that the approximate lethal dose is above 1.0 mL/animal for both male and female SD rats and that intramuscular injection of DGP may be safe.

• Microbiology and Biotechnology Letters
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• v.42 no.2
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• pp.194-201
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• 2014

Clitocybin A is a novel anti-wrinkle cosmetic agent produced by the strain from a Korean native mushroom Clitocybe aurantiaca. In this study, fermentation, extraction, and purification conditions for a large scale production of clitocybin A were optimized, and its cytotoxicity and inhibition activity on the expression of matrix metalloproteinase-1 (MMP-1) were characterized. The mass production of anti-wrinkle agent was achieved according to the 300 L fermentation process with a fed-batch cultivation using the modified yeast-maltose (YM) broth, and a total of 12.5 kg of cell mass was obtained in a 120 L culture broth for 14 days. After extraction and purification, clitocybin A was identified by HPLC. The cytotoxicity of clitocybin A was examined by the MTT assay. When assayed at 100 and 200 ${\mu}g/ml$ concentrations, clitocybin A showed no cytotoxicity, demonstrating safety. The inhibition activity of clitocybin A on the expression of MMP-1 was examined against UV irradiation. Oleanolic acid (control group) showed a relatively low MMP-1 inhibiting activity (ca. 16.7%) at 10 ${\mu}g/ml$ and showed increased cytotoxicity at higher concentrations. In contrast, clitocybin A showed no cytotoxicity at 100 ${\mu}g/ml$, and exhibited a relatively high MMP-1-inhibiting activity (33.1%). These findings indicate that clitocybin A may be a safe and effective anti-wrinkle agent for use in functional cosmetics.

• Economic and Environmental Geology
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• v.41 no.4
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• pp.383-392
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• 2008

This study aims to evaluate the mechanical-chemical stability of used coal ash blocks, for improving fishing grounds. The surface of weathered ash blocks in seawater showed a decrease in the Ca and an increase in the Mg contents, compared to that of fresh blocks. This result reflects the substitution of Ca by Mg in seawater. The compressive strengths of ash blocks submerged into seawater during 12 months ranged from 235.23 to $447.43\;kgf/cm^2$; this is higher than the standard strength of wave-absorbing blocks($180\;kgf/cm^2)$ that are used for harbor construction. In addition, the compressive strength of ash blocks tends to increase with increasing installation time in seawater. The result of leaching experiments on coal ash blocks by Korean Standard Leaching Test(KSLT) method showed that leached concentrations of most metals except Cr(that leached up to 50 ppb, approaching standard concentration) do not exceed the seawater quality standards. A long-term(112 days) heavy metal leaching test to analyze seawater without mixing-dilution also showed that the concentrations of leached heavy metals, except for Cu, under anaerobic conditions do not exceed the seawater quality standards. Accordingly, the use of coal ash blocks in marine environments appears to be safe from chemical and mechanical factors that decrease the efficiency of concrete. Also, leaching concentration of Cu seems to be stable by decrease of leaching concentration due to dilution of seawater.

• The Korean Journal of Pesticide Science
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• v.15 no.1
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• pp.8-14
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• 2011

Methoxyfenozide and novaluron was sprayed on Aster scaber during cultivation period. Samples were collected 7 times in 0-10 days after spraying. Both methoxyfenozide and novaluron were extracted with methanol, partitioned with dichloromethane and analyzed by HPLC. At the fortified level of 0.4 and $2\;mg{\cdot}kg^{-1}$, average recovery of methoxyfenozide were $102.5{\pm}3.03$ and $84.4{\pm}2.82%$, and novaluron were $88.7{\pm}2.32$ and $90.6{\pm}4.50%$, respectively. Biological half-life of methoxyfenozide was 3.99 days and novaluron which was 3.16 days at recommended spray level on cultivation period of the plant. The major reducing factor of novaluron was the increased weight of the plant. In case of application of methoxyfenozide and novaluron following pesticide guide line for safe use, the final residue level was calculated to lower than maximum residue level (MRL).

• Journal of Navigation and Port Research
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• v.42 no.1
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• pp.25-30
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• 2018

This study was carried out to analyze the risk attitude based on situation awareness of the Vessel Traffic Service Operator (VTSO) on the risk of collision between vessels during the monitoring of vessel traffic through the use of the VTS system. In general, when two vessels are in the close quarters situation, we analyzed the degree of risk of collision from the subjective viewpoint of the VTSOs through an administered survey. Chiefly, we analyzed the risk attitudes of each VTSO in the close quarters situation, by comparing it with the calculated value by the CoRi, which is the ship collision risk model from the VTSO's viewpoint. As a result, it was confirmed that more than 40% of the total VTSO was noted as being in a weak risk aversion type of category. Through a review of the results of analyzing the risk attitude of VTSO according to gender, age, VTS career, VTS center position, accident experience, and boarded career, it was found that there was a significant difference in the VTS career, VTS center position and accident experience. In addition, a regression model that is able to further explain the risk attitude of VTSO was derived as a factor that confirmed the significant difference and applied to CoRi to predict the collision risk according to the individual VTSO to be used as a fundamental information gathering tool for providing more accurate and safe VTS service at sea.