• Journal of Korean Society of Transportation
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• v.24 no.2 s.88
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• pp.101-112
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• 2006

Currently, highway design speed is determined by considering highway function, area type, and terrain type. Sometime it is pointed out that determining a reasonable design speed which is both efficient and safe is not an easy task and that Practicing engineers often select an unsuitable design speed on purpose, capitalizing on some ambiguous and discretionary expressions in describing the highway design speed. This undesirable Problem is arising mostly due to the fact, that the current geometric design standard fails to include rolling terrain type and can not reflect the whole characteristics of land use patterns adjacent to the design highway route. A recent research was Published considering this problem and it attempted to improve the highway design speed determining process. In this research Project, tn see the effects of this recently developed procedure, a new and reduced design speed was calculated based on the new Procedure and subsequently another highway design route was selected. The travel time. construction cost. and the expected degree of safety associated with the new route were assessed to be compared with the ones with the existing procedure. As a result. it was found that the new procedure was successful in reflecting the localities such as terrain type and area type into better determining highway design speed, eliminating much of highway engineers' discretion when applying engineering judgments. Also the new Procedure is keen to produce a more economical highway project. In other words, despite of producing reduced amount of user benefits accrued, in the new highway route, the construction cost has been cut significantly leading to higher values in B/C. NPV, and IRR. Also EMME-II output, which Provided the link assigned volumes, rendered only a slightly reduced Levels of Service along surrounding links in the study network. This reduction was believed to occur because of lower design speed and it had been expected from the beginning.

• The Journal of Internal Korean Medicine
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• v.28 no.3
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• pp.464-472
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• 2007

Objectives : Nowadays the combined use of oriental herbal medicines and western biomedical medicines has been prevalent but controversial. Warfarin has been much reported to interact with some herbal medicines so that it influences prothrombin time(PT) & international normalized ratio(INR). This study was aimed to examine how much warfarin interacts with herbal medicines during treatment of stroke patients Methods : This was a retrospective case control study of 53 patients whowere treated with concomitant treatment of herbal medicines & warfarin. They were within normal limit in liver function, renal function, hematocrit, hemoglobin, and platelet count at first admission lab. We classified them into 2 classes: study group (taking herbal medicines including Panax ginseng, Angelica sinensis, Zingiber officinale, Salvia miltiorrhiza that were reported to interact with warfarin to impact PT (INR) and control group (taking other herbal medicines). We followed up PT (INR) at 5-10 days interval with AST, ALT, BUN, creatinine, hematocrit, hemoglobin, and platelet count. Results : AST, BUN, creatinine, hemoglobin, hematocrit, and platelet count were not changed significantly between first and final tests during the admission period. Only ALT decreased significantly in the control group. Neither baseline nor peak PT (INR) was significantly different between the groups. However, only warfarin dose was significantly correlated with PT and INR (r=0.810, r=0.798, p<0.01). Conclusions : It was concluded that PT(INR) was not influenced with herbal medicines and warfarin but by far dependent on warfarin dose in stroke patients restricted with normal liver function, renal function, and hematocrit, hemoglobin, and platelet count. Further prospective study is needed on larger samples to conclude that the combined therapy of herbal medicines and warfarin is safe.

• Land and Housing Review
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• v.2 no.2
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• pp.195-204
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• 2011

During mechanical demolition of RC structures, weights of dismantling equipment and demolition waste of building are applied to unexpected load which did not be considered during the design of structural member. Nevertheless, the loading of dismantling equipment and dismantling process are mainly dependent on field managers' field workers' or experiences without considering safety of structural member by a structural engineer. It is urgently required that reflecting actual circumstance of mechanical demolition, safety evaluation method to evaluate the safety and the guideline for appropriate capacity of structural member to support dismantling equipment weight, be provided. Through site investigation and questionnaire on field workers, this paper proposed demolition waste load, load factor, strength reduction factor, and so on. These are essential to safe evaluation of a building, ready to demolition. Considering actual circumstance of mechanical demolition, safety evaluation method of building and design method of slab and beam was suggested to a dilapidated building. An capability to loading of dismantling equipment was proposed, applied to RC slab and RC beam. Therefore, the suggested safety evaluation method and the guideline for an capability to loading of dismantling equipment weight can reasonably evaluate the capacity of structural member in demolition and use effectively as increasing efficiency and improving safety of demolition through proper management of dismantling equipments.

• Korean Journal of Medicinal Crop Science
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• v.24 no.5
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• pp.408-419
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• 2016

Background: In recent years, adjuvants have received increasing attention owing to the development of purified subunit and synthetic vaccines which are poor immunogens and require additional adjuvants to evoke an immune response. Therefore, immunologic adjuvants have been developed and tested. Plant polysaccharides have been recognized as effective biological response modifiers with low toxicity. Methods and Results: In this study, the polysaccharide from the aboveground part of Astragalus membranaceus Bunge containing immunomodulating arabino-3,6-galactan was evaluated for its hemolytic activity and adjuvant potential in the specific cellular and humoral immune responses to ovalbumin. The polysaccharide from the aboveground part of Astragalus membranaceus Bunge was co-immunized with the purified Vi capsular polysaccharide of Salmonella typhi vaccine in mice. The polysaccharide from the aboveground part of Astragalus membranaceus Bunge did not induce any hemolytic activity or side effects at doses up to $500{\mu}g/m{\ell}$. The concanavalin A-, lipopolysaccharide-, and ovalbumin-induced splenocyte proliferation and serum ovalbumin-specific IgG, IgG1 and IgG2b antibody titers in immunized mice were significantly enhanced by AMA. Pharmacological data revealed that the polysaccharide from the aboveground part of Astragalus membranaceus Bunge increased antigen-specific antibody levels in immunized mice. The polysaccharide from the aboveground part of Astragalus membranaceus Bunge-adjuvanted purified Vi capsular polysaccharide of Salmonella typhi vaccine improved the proliferation of splenocytes and macrophages as well as stimulated cytokine production. Conclusions: These results suggest that the polysaccharide from the aboveground part of Astragalus membranaceus Bunge-adjuvanted vaccines enhanced humoral and cellular immunity and that the polysaccharide from the aboveground part of Astragalus membranaceus Bunge is a safe and efficacious adjuvant candidate suitable for use in prophylactic and therapeutic vaccines.

• The Korean Journal of Pain
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• v.1 no.2
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• pp.192-198
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• 1988

Sixty patients, of ASA physical status class I for elective operations in the lower abdomen, perineum, or lower extremities, were studied in a comparative prospective trial to evaluate the efficacy of epidural morphine and ketamine for postoperative analgesia. They were divided into two groups: an epidural morphine sulfate group (EMS group; 30 patients), and an epidural ketamine hydrochloride group (EKH group; 30 patients). Indwelling epidural catheters were placed in the patients' lumber areas (L3-4) and then all patients were anesthetized with thiopental, nitrous oxide, and halothane. After the patients had fully recovered from the anesthesia, the analgesic agents were administered epidurally via the catheter when the patients complained of pain in the postoperative period. The groups were given either 0.1 mg/kg of morphine sulfate or 0.5 mg/kg of ketamine hydrochloride administered in a volume of 10 ml of normal saline. Patients were observed for the onset and duration of postoperative analgesia and for other effects. Total doses were $5.7{\pm}0.6\;mg$ of morphine sulfate in the EMS group and $27.9{\pm}3.3\;mg$ of ketamine hydrochloride in the EKH group. The onset of analgesia was detectable within 35 min.($23.5{\pm}6.3$ min) in 86.7% (26 cases) of the EMS group and within 10 min. ($7.8{\pm}3.7$ min.) in 76.7% (23 cases) of the EKH group. Mean duration of postoperative analgesia was $22.3{\pm}2.1\;hr$. in the EMS group. In the EKH group, the duration of analgesia was shorter and variable, the range of duration was from 2 hr. to 24 hr., Cardiopulmonary changes were statistically insignificant ih both groups. Side effects such as nausea, vomiting, urinary retention, pruritus, dizziness, and headache were observed in EMS group. In the EKH group, there was no discomfort except dizziness (3 cases) and headache (1 case). Epidural ketamine was a safe technique for postoperative analgesia, but because of the variability and relative shortness in the duration of analgesia the use of this technique will require further clinical trials.

• Korean Journal of Environmental Agriculture
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• v.2 no.2
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• pp.83-89
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• 1983

To obtain basic information for the safe use of pesticides, the aquatic environment of 5 major rivers was surveyed in April and August 1982 for organochlorine and organophosphorus pesticide residues. Regardless of sampling times and sites, pesticide residue levels were very low. Of the organophosphorus pesticides surveyed, only IBP and diazinon were detected in water samples while fenthion, fenitrothion, chlorpyriphos, chlorpyriphos-methyl, chlorfenvinphos, phenthoate, and edifenphos were not detected in any water samples. Residue levels and detection frequencies of IBP or diazinon were much higher in water samples collected in August than those collected in April. Detection frequencies of organochlorine pesticides, on the other hand, were high, but their actual residue levels were very low. BHC was detected nearly in all water samples while aldrin was not found in any samples. Detection frequencies of heptachlor, endosulfan, and o.p`-DDT were considerably high but dieldrin and p.p`-DDT were detected in a few water samples and their residue levels were also very low.

• Journal of the Korea institute for structural maintenance and inspection
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• v.22 no.5
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• pp.110-118
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• 2018

Due to recent earthquakes, there is a growing awareness that Korea is not a safe zone for earthquakes any more. Therefore, the review of various aspects of the seismic safety of the infrastructures are being carried out. Because of the characteristics of the underground structure buried in the ground, the electric power utility tunnels must be considered not only for the inertia and load capacity of the structure itself but also the characteristics of the surrounding soils. An extensive and accurate numerical analysis is inevitably required in order to consider the interaction with the ground, but it is difficult to apply the soil-structure interaction analyses, which generally requires high cost and extensive time, to all electric power utility tunnel structures. In this study, the major design variables including soil characteristics are considered as independent variables, and the seismic safety factor, which is the result of the numerical analysis, is considered as a dependent variable. Thus, a method is proposed to select vulnerable electric power utility tunnels with low seismic safety factor while excluding costly and time-consuming numerical analyses through the direct correlation analysis between independent and dependent variables. Equations of boundary limits were derived based on the distribution of the seismic safety factor and the cover depth and rebar amounts with high correlation relationship. Consequently, a very efficient and simple approach is proposed to select vulnerable electric power utility tunnels without intensive numerical analyses. Among the 108 electric power utility tunnels that were investigated in this paper, 30% were screened as fragile structures, and it is confirmed that the screening method is valid by checking the safety factors of the fragile structure. The approach is relatively very simple to use and easy to expand, and can be conveniently applied to additional data to be obtained in the future.

• Journal of Pharmacopuncture
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• v.17 no.3
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• pp.25-30
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• 2014

Objectives: This study was performed to evaluate the single-dose intravenous toxicity of Guseonwangdo-go glucose 20% pharmacopuncture. Methods: Forty Sprague-Dawley rats were divided into four groups of five males and five females per group: an intravenous (IV) injection of 1.0 mL of normal saline solution per animal was administered to group 1 (G1, control group); an IV injections of 0.1, 0.5, and 1.0 mL of Guseonwangdo-go glucose pharmacopuncture per animal were administered to experimental groups 2, 3, and 4 (G2, G3, and G4), respectively. General symptoms, body weights, hematological and biochemical test results, and necropsy histopathological observation were recorded in all groups. In the statistical analyses, significance was determined by using the one-way analysis of variance (ANOVA). The significance level was 0.05 in all comparisons. Results: For 14 days, no deaths or abnormalities were observed in any of the 4 groups. The body weights of all groups continuously increased during the observation period. In the hematological test, the WBC count was significantly increased in female rats of G4 compared to the control group, but this difference was considered not to be statistically meaningful. No significant biochemical changes were observed. On necropsy, crust formation was observed in one rat of the control group, and granulation tissues were observed around the injection site in one rat of G4; these changes were concluded to have been caused by injection of the needle into a vein. Conclusion: The findings suggest that the lethal dose of Guseonwangdo-go glucose pharmacopuncture is more than 1.0 mL per animal in both male and female rats. Thus, we can conclude that Guseonwangdo-go glucose pharmacopuncture injection is relatively safe to use in acute toxicity tests. Further studies are needed to establish more detailed evidences of its toxicity.

• The Journal of Korean Medicine
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• v.33 no.3
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• pp.147-159
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• 2012

Objectives: Systems related to the production, authorization, and listing for insurance of herbal medicine products were compared between South Korea and Taiwan to illuminate herbal medicine products system issues in South Korea. Methods: Papers, and laws and policies related to the production, authorization, and listing for insurance of herbal medicine products in South Korea and Taiwan are analyzed to create the primary documents. The documents from South Korea were screened with the advice of a specialist, while those from Taiwan have been verified through local investigation and with the help of a related specialist. The screened documents were then compared and analyzed in the order of the systems related to the production, authorization, and listing for insurance of herbal medicine products. Results: The systems related to the production of herbal medicine products satisfy GMP requirements in both countries, while Taiwan has more specialized systems related to the production of herbal medicine products and a more strict authorization program as compared to South Korea. While South Korea has most of the herbal medicine products classified as non-prescription drugs, Taiwan has them as prescription drugs. And while South Korea does not allow new herbal medicine products to be listed for insurance, Taiwan allows for once-a-year application toward listing for insurance. Conclusions: In order to ensure the safe and effective use of herbal medicine products, systems related to the production, authorization, and listing for insurance of herbal medicine products are to be established, while the categorization of medicine products principally used by Korean medicine doctors should be prepared. Furthermore, prescription by a Korean medicine doctor for new drugs made with natural products and their listing for insurance need to be encouraged.

• Journal of Life Science
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• v.24 no.7
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• pp.769-776
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• 2014

Anisomycin, also known as flagecidin, is an antibiotic produced by Streptomyces griseolus that inhibits protein synthesis by binding to the ribosomal 28S subunit. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a protein that induces apoptotic cell death. TRAIL primarily causes apoptosis in tumor cells by binding to death receptors. Many human cancer cell lines are refractory to TRAIL-induced cell death. In this study, we investigated whether anisomycin could enhance TRAIL-mediated apoptosis in TRAIL-resistant human hepatocarcinoma Hep3B cells. Treatment with anisomycin and TRAIL alone did not reduce cell viability in Hep3B cells. However, in the presence of TRAIL, the anisomycin concentration dependently reduced the cell viability. Our results indicate that anisomycin sensitizes Hep3B cells to TRAIL-mediated apoptosis and that this occurs, at least partly, via caspase activation. Interestingly, Bid knockdown by small interfering RNA significantly reduced the induction of apoptosis in combination with anisomycin and TRAIL, indicating that anisomycin effectively acts to lower the threshold at which TRAIL-mediated truncated Bid triggers the mitochondrial-mediated apoptosis program in Hep3B cells. Therefore, the use of TRAIL in combination with anisomycin might provide an effective therapeutic strategy for the safe treatment of some TRAIL-resistant cancer cells.