• The Journal of the Korea Contents Association
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• v.22 no.7
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• pp.663-669
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• 2022

The content of fluoride in toothpaste commercially available in Korea has been increased to less than 1500 ppm. The purpose is to provide these results to consumers and to suggest alternatives to the safe use of toothpaste. This study was conducted on 1,300 people for 2 weeks from March 2021. As a research tool, general characteristics and oral health behaviors were surveyed. ConsExpo Web 1.0.2. It was used as an input variable for exposure evaluation. As a result of the study, when a toothpaste containing 1500 ppm of fluoride was used, the external dose on day of exposure was 2.3×10-2 mg/kg/day for males, 2.9×10-2 mg/kg/day for females, and children aged 2-3 years was estimated to be 7.3×10 -2 mg/kg/day. As a result of this study, it is thought that as the fluoride content of toothpaste distributed in the market increases, it will be used as a basic data to present standards for safe use by consumers.

• Safety and Health at Work
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• v.13 no.3
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• pp.336-342
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• 2022

Background: This study aims to identify the safety and health risk perceptions toward the coronavirus disease-2019 (COVID-19) pandemic based on gender in Korean university students who work and study during the pandemic. Methods: A nationwide convenient sampling method was implemented to eliminate any regional characteristics in 757 university students, including those who studied while working. The participants answered the online questionnaire for one week. The collected data were analyzed using the R version 3.4.1 program. Results: The results comparing the safety and health risk perceptions toward COVID-19 based on the gender of the subjects who work while studying, "I often use the Internet to obtain information on COVID-19 infection control" are females appeared to use the internet more often (t = -2.18, p = 0.031) than males. "Compared to pre-COVID-19, I am currently feeling safe after the outbreak" is females felt less safe (t = 3.43, p < 0.001). Although COVID-19 infection control awareness is high among Korean university students and officials, males reported higher scores over females in all the questions, which was statistically significant. Conclusion: There should be prioritized psychological measures for prevention against COVID-19 for vulnerable groups with high mental health risks. A network must be established to protect the mental health of such groups, and candidates who require intervention must be actively identified and supported. Therefore, there must be efforts to deliver accurate information based on scientific evidence of the infectious disease, and the actions should be supported through such active communication.

• Korean journal of applied entomology
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• v.61 no.1
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• pp.51-62
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• 2022

Numerous insect pests threaten the Korean orchard industry through feeding on various tissues of fruit trees. Generally, the control of economically important orchard pests is based on the use of chemical insecticides. Owing to growing concerns regarding the environmental and human health effects of insecticides, environment-friendly pest control strategies are urgently needed. Pheromones of orchard pests could lead to an environmentally safe control system based on mating disruption or mass trapping. This review summarizes the functions and compounds of known pheromones from 51 orchard pests in Korea. The pheromones identified to date from 14 species in the families Miridae, Aphididae, Diaspididae, Pseudococcidae, Rutelidae, Cecidomyiidae, and Eurytomidae and 26 species in the order Lepidoptera are female-produced sex pheromones that attract only males. In contrast, all known examples for 11 species in the families Alydidae, Pentatomidae, Thripidae and Cerambycidae are male-produced aggregation pheromones that attract both sexes. Research on pheromones in new pests, kairomones in key orchard pests, mating disruption dispensers to generate prolonged release of the pheromones, and trap design and trap location for mass trapping will be required for the expanded use of pheromones and other semiochemicals in orchard pest management in the future.

• Korean Journal of Transplantation
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• v.31 no.4
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• pp.157-169
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• 2017

Regulatory T cells (Treg) naturally rein in immune attacks, and they can inhibit rejection of transplanted organs and even reverse the progression of autoimmune diseases in mice. The initial safety trials of Treg against graft-versus-host disease (GVHD) provided evidence that the adoptive transfer of Treg is safe and capable of limiting disease progression. Supported by such evidence, numerous clinical trials have been actively investigating the efficacy of Treg targeting autoimmune diseases, type I diabetes, and organ transplant rejection, including kidney and liver. The limited quantity of Treg cells harvested from peripheral blood and subsequent in vitro culture have posed a great challenge to large-scale clinical application of Treg; nevertheless, the concept of CAR (chimeric antigen receptor)-Treg has emerged as a potential resolution to the problem. Recently, two CAR-T therapies, tisagenlecleucel and axicabtagene ciloleucel, were approved by the US FDA for the treatment of refractory or recurrent acute lymhoblastic leukemia. This approval could serve as a guideline for the production protocols for other genetically engineered T cells for clinical use as well. The phase I and II clinical trials of these agents has demonstrated that genetically engineered and antigen-targeting T cells are safe and efficacious in humans. In conclusion, both the promising results of Treg cell therapy from the clinical studies and the recent FDA approval of CAR-T therapies are paving the way for CAR-Treg therapy in clinical use.

• Journal of Korean Medicine for Obesity Research
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• v.23 no.1
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• pp.28-41
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• 2023

Objectives: This study was aimed to evaluate the hemodynamic feasibility using pulse parameters as a way to establish safe dose guidelines for herbal prescription containing Ephedra herb (Ephedra intermedia Schrenk & C.A.Mey) on weight loss, and to provide a foundation for developing evidence-based guidelines for clinical use. Methods: Forty-two volunteers were recruited to participate in a study examining the changes in pulse wave characteristics following the ingestion of Gambi-hwan, a herbal prescription containing ephedra, over a period of 4 weeks, and pulse wave measurements were taken before and after the administration. Pulse wave parameters were measured in this study using a 3-dimensional radial pulse tonometry device (DMP-Lifeplus). In addition, questionnaire, blood pressure, temperature, and body composition were also measured as secondary measures. Results: Fifteen minutes after administration of Gambi-hwan, the non-adverse event group (non-AE) exhibited a statistically significant increase in several power and pressure-related parameters, including h1, h5, systolic area, pulse area, and pulse width, while the AE group showed a trend of decreasing stroke volume and increasing Radial Augmentation Index (RAI), w, and w/t. After 4 weeks of administration, both groups exhibited significant changes in pulse rate, w/t, RAI, t3/t, stroke volume (SV), and stroke volume Index (SVI). Notably, there are significant differences between AE group and non-AE group in w/t, SV, and SVI. Conclusions: These findings suggest that pulse parameters may be a useful way to establish safe dosing guidelines for weight loss herbal prescription containing ephedra. Further research is needed to confirm these results and to develop evidence-based guidelines for clinical use.

• Journal of Convergence Korean Medicine
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• v.6 no.1
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• pp.5-20
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• 2024

Objectives: This study was aimed to evaluate the hemodynamic feasibility using pulse parameters as a way to establish safe dose guidelines for Chunwangbosim-dan, and to provide a foundation for developing evidence-based guidelines for clinical use. Methods: Forty-one volunteers were recruited to participate in a study examining the changes in pulse wave characteristics following the ingestion of Chunwangbosim-dan, over a period of 2 weeks, and pulse wave measurements were taken before and after the administration. Pulse wave parameters were measured in this study using a 3-dimensional radial pulse tonometry device(DMP-Lifeplus). In addition, questionnaire, blood pressure, temperature, and body composition were also measured as secondary measures. Results: Fifteen minutes after administration of Chunwangbosim-dan, the non-adverse event group(non-AE) exhibited a statistically significant increase in several power and pressure-related parameters, including h1, h3, h4, h5, SA, PA and PW, while the adverse event group(AE) showed a trend of decreasing stroke volume and increasing Systemic Vascular Resistance Index(SVRI) and applied pressure. After 2 weeks of administration, non-adverse event group(non-AE) exhibited significant changes in standard deviation of pulse rate and HRV_LH ratio. Notably, there are significant differences between AE group and non-AE group in h4/h1, w/t, applied pressure, SV and pulse rate. Conclusion: These findings suggest that pulse parameters may be a useful way to establish safe dosing guidelines for Chunwangbosim-dan. Further research is needed to confirm these results and to develop evidence-based guidelines for clinical use.

• Journal of the Ergonomics Society of Korea
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• v.27 no.2
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• pp.15-24
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• 2008

As users increasingly recognize the importance of safety and the Product Liability comes into effect, a company should take responsibility of protecting the users who use its product. In order to produce a safe product and satisfy the needs of users, it is critical for develope opriately and understand the characteristics of the product accurately. Furthermore, a safe product can be realized by considering a safety level of the product in a whole product development process. However, in general, product development projects hardly evaluate the safety of a product in the product planning step. In addition, most of safety evaluation methods which are applied in the product planning step have a tendency to be qualitative because a detailed product design step. Therefore, this research aims at enhancing the performance of the safety evaluation process by applying quantitative methods such as 'AHP' and 'Fuzzy'. AHP can help analysts derive the weight of safety factors. Fuzzy is applied to evaluate the degree of safety of product elements in this paper. The proposed method will be able to improve the safety level of a product by using the quantitative methods in the product planning step.

• Journal of Korean Academy of Nursing
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• v.44 no.6
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• pp.697-707
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• 2014

Purpose: The purposes of this study was to develop a comprehensive community-based fall prevention program and to test the effects of the program on the muscle strength, postural balance and fall efficacy for elderly people. Methods: The design of this study was a nonequivalent control group pretest-posttest design. There were 28 participants in the experimental group and 29 in the control group. The program consisted of balance exercises, elastic resistance exercises and prevention education. The program was provided five times a week for 8 weeks and each session lasted 90 minutes. Data were analyzed using ${\chi}^2$-test, independent t-test and paired t-test using the SPSS program. Results: Muscle strength of the lower extremities, postural balance and fall efficacy scores significantly improved in the experimental group compared to the control group. Conclusion: These results suggest that this program can improve lower extremity muscle strength, postural balance and fall efficacy in elders. Therefore, this program is recommended for use in fall prevention programs for elders living in the community.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.27 no.4
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• pp.721-729
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• 2017

In order to take rapid action against malware, efficiency in malware analysis is essential. For instance, it would be helpful to identify and eliminate open-source function bodies or other safe portions out of the target binary codes. In this paper, we propose an tool to create open source dynamic link library files in Windows environment, extract signature information by opensource and compiler version, and compare open source function information to find suspicious function. In addition, the tool can save the information used in the comparison to the DB and use it later, reducing the analysis time overhead.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.41 no.11
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• pp.1598-1607
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• 2016

Safe transmitting monitoring data is essential for supporting IoT-Cloud services efficiently. In this paper, we find ways to configure data path flexibly in SDN based for IoT-Cloud services utilizing SmartX-mini Playground. To do this, we use ONOS(Open Network Operating System) SDN Controller, ONOS NBI Applications made from us to check flexible and safe data path configuration for IoT-Cloud monitoring data transmitting in real IoT-SDN-Cloud environments.