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Influence of substituted phenyl backbone on the fungicidal activity of 2-thienyl and 2-furyl substituents in bis-aromatic ${\alpha},{\beta}$-unsaturated ketone derivatives (비스 방향족 ${\alpha},{\beta}$-불포화 케톤 유도체 중 2-thienyl 및 2-furyl 치환체의 항균성에 관한 치환 phenyl backbone의 영향)

  • Sung, Nack-Do;Yu, Seong-Jae;Kim, Tae-Young;Ok, Whan-Suk
    • The Korean Journal of Pesticide Science
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    • v.2 no.2
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    • pp.22-28
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    • 1998
  • Twenty six derivatives of bis-aromatic ${\alpha},{\beta}$-unsaturated ketones as substrate(S) were synthesized and their fungicidal activities in vivo against rice blast(Pyricularia oryzae), tomato leaf blight(Phytophtora infestans) and barley powdery mildew(Erysiphe graminis) were examined. The quantitative structure-activity relationship(QSAR) between the fungicidal activities($pI_{50}$) and a physicochemical parameters of substitued($R_{2}$) phenyl backbone group in 2-thienyl and 2-furyl substituents were analyzed with regression equations. The activities of substituted($R_{2}$) phenyl backbone in 2-thienyl substituents, $1{\sim}10$ would depend largely on the resonance(R>0), molecular refractivity($M_{R}<0$) and optimal length of substituent(($L_{1})opt.=5.50{\AA}$). Whereas, in case of 2-furyl substituents, $10{\sim}26$ optimal molar attraction constant ($F_{opt}=0.49{\sim}l.11$), optimal steric($Es_{opt}=1.78$) constant and indicator variables(Io & Ip) for position of substituents. The fungicidal activity relationship of 2-thienyl substituents against Pyricularia oryzae and Phytophtora infestans have been a reciprocal proportioned.

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Analysis of the Efficiency of the Traditional Market's CRM Activities (전통시장의 고객관계관리 전략(CRM)에 대한 효율성 분석)

  • Kim, Soon-Hong;Yoo, Byoung-Kook
    • Journal of Distribution Science
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    • v.11 no.5
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    • pp.43-53
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    • 2013
  • Purpose - The purpose of this study is to analyze the effectiveness of customer relationship management (CRM) support policies for facilitating traditional markets, especially with respect to customer acquisition and maintenance, and to investigate the factors affecting CRM. Research design, data, and methodology - We analyzed the CRM efficiency of traditional markets in 16 cities and provinces in Korea on the basis of DEA analysis and Malmquist productivity analysis. The DEA model calculates a ratio of the weighted mean of various inputs to the weighted mean of various outputs and measures the efficiency of a specific decision making unit (DMU), which is compared to the reference group that has a similar input-output structure. The input variables are coupon, event, parcel service, premiums, while is the number of customers per day. Further, through regression analysis, we analyzed CRM-related factors affecting traditional markets' customer appeal and revenue growth. Results - We obtained the results of the efficiency of traditional markets in 16 provinces. The traditional markets in Seoul, Busan, and Jeju were found to be efficient in a model CCR that used the number of customers per day as an output variable, while Chungbuk, Jeonbuk Province, and According to the results of the DEA analysis and Malmquist productivity analysis, large cities such as Seoul, Busan, and Jeju showed efficiency in CRM-related investment businesses in traditional markets for attracting customers. The Malmquist analysis results confirmed that the productivity of traditional markets increased from 2008 to 2010. The results of the regression analysis revealed that the "customer acquisition/maintenance factor" and the "offering of customer convenience facility factor" were significant to the daily average number of customers, which is a dependent variable. The results of the test with the mediating variable, "number of customers," and the final dependent variable, "sales revenue," were rejected. However, the variable "customer acquisition /maintenance" was found to affect sales revenue positively. Conclusions - It is necessary to enhance the business not only for promotional activities to attract customers, but also to strengthen customer relationships among CRM businesses, such as through the management of key customers. The regression analysis results showed that CRM businesses have yet to produce an increase in sales revenues in traditional markets. Therefore, to help customers who visit traditional markets to keep buying products, it is necessary to prepare various investment methods and provide support to improve "customer loyalty." This study has a limitation in terms of CRM-related statistics. Therefore, in the future, it is necessary to conduct a survey of customers who use traditional markets to analyze the markets by type and size as well as the CRM-related factors. Based on the analysis, we will try to perform a variety of statistical analyses, including structural equations.

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Physiological Changes in Related to Molt Cycle of Macrobrachium nipponense(De Haan) (징거미 새우, Macrobrachium nipponense(De Haan) 유생의 탈피주기와 관련한 생리적 변화)

  • SHIN Yun-Kyung;CHIN Pyung
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.27 no.4
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    • pp.380-389
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    • 1994
  • Larvae of the freshwater shrimp, Macrobrachium nipponense(De Haan) were reared in the laboratory under constant conditions ($25^{\circ}C,\;7\%0$ S), and their feeding rate, oxygen consumption, ammonia nitrogen excretion, and growth were measured at regular intervals during development from hatching to post larval stage. Growth was measured as dry weight, carbon, nitrogen, hydrogen, protein and lipid. All these physiological and biochemical traits revealed significant changes from instar to instar. Average feeding rate was high in intermolt stage of the molt cycle and it showed a bell-shaped pattern. Respiration(R) increased from hatching to post larval stage. Excretion(U) increased in intermolt phase of larvae and it showed a bell-shaped variation pattern, in all larval instars with a maximum near the middle of the molt cycle. Regression equations describing rates of feeding, growth, respiration and ammonia excretion as functions of time during individual larval molt cycles were inserted in a simulation model, in order to analyse time-dependent patterns of variation as well as in bioenergetic efficiencies. Carbon was initially increased and nitrogen showed a tendency to increase in premolt phase during individual molt cycles. Protein remained clearly the predominant biochemical constituent in larval biomass.

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Continuous Near-field Mixing with Variable Oceanic Conditions (해양수리특성의 변화를 고려한 연속적 근역혼합거동)

  • Kang See Whan;Kim Young Do;Lee Ho Jin;Kim Sang Ik;Han Sung Dae
    • Journal of the Korean Society for Marine Environment & Energy
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    • v.4 no.4
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    • pp.12-20
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    • 2001
  • The temporal variability in near-field mixing characteristics of discharging plumes in oceanic environment was investigated using the time series data of the buoyant jet parameters. Based on the currents and density profiles observed in Masan outfall site and effluent discharge flowrates for 63days of summer season, the temporal variabilities and those occurrence frequency were obtained by line plume equations. The results show that wide range of variability in Masan outfall's mixing characteristics was found due to the temporal changes of effluent flowrates and ambient oceanic conditions. The near-field dilution was in the range of 30~71 with the averaged dilution of 34, which was a good agreement with field measurements of salinity deficit. The length of mixing zone was in the range of 5.4~36.2 m with the average of 9.5 m, and the plume rise height was in the range of 8.1~10.2 m with the average of 8.9 m. However, only the 30~44% of the whole results are higher than the averages, which indicates the necessity of this frequency analysis with the continuously measured data for designing and managing the ocean outfall system.

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Design Optimization for Kinematic Characteristics of Automotive Suspension considering Constraints (구속조건을 고려한 자동차 현가장치 기구특성의 최적설계)

  • Lee, Chang-Ro;Kim, Hyo-Jun
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.18 no.3
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    • pp.306-311
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    • 2017
  • This paper deals with the design optimization of the kinematic characteristics of an automotive suspension system. The kinematic characteristics of the suspension determine the attitude of the wheels, such as the toe and camber, which not only relates to tire wear during driving, but also greatly affects the control of the vehicle and its stability, which corresponds to the motion performance of the vehicle. Therefore, it is very important to determine the characteristics of the suspension mechanism at the initial stage of the design. In this study, a displacement analysis is performed to determine the kinematic properties of the suspension for the McPherson strut suspension. For this purpose, a set of constraint equations for the joints constituting the suspension mechanism was established and a program was developed to solve them. We also used ADS, a design optimization program, to obtain the desired kinematic characteristics of the suspension. As the design variables for optimization, we used the coordinates of the hard points, which are the points of attachment of the suspension to the vehicle body, and are defined as the summation of the toe-in for the up and down movement of the wheel as the objective function. As the constraint functions, the maximum camber angle and minimum roll center height, which are design requirements, are considered. As a result of this study, it was possible to determine the optimal locations of the hard points that satisfy both constraint functions and minimize the change of the toe-in.

Reliability Analysis of Plane Stress Element According to Limit State Equations (한계상태방정식에 따른 평면응력요소의 신뢰성해석)

  • Park, Seok Jae;Choi, Wae Ho;Kim, Yo Suk;Shin, Yeong-Soo
    • Journal of Korean Society of Steel Construction
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    • v.13 no.5
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    • pp.567-575
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    • 2001
  • In order to consider statistical properties of probability variables used in the structural analysis the conventional approach using the safety factor based on past experience usually estimated the safety of a structure Also the real structures could only be analyzed with the error in estimation of loads material characters and the dimensions of the members. But the errors should be considered systematically in the structural analysis Safety of structure could not precisely be appraised by the traditional structural design concept Recently new aproach based on the probability concept has been applied to the assessment of structural safety using the reliability concept Thus the computer program by the Probabilitstic FEM is developed by incorporating the probabilistic concept into the conventional FEM method. This paper estimated for the reliability of a plane stress structure by Advanced First-Order Second Moment method using von Mises, Tresca and Mohr-Coulomb failure criterions. Verification of the reliability index and failure probability of attained by the Monte Carlo Simulation method with the von Mises criterion were same as PFEM, but the Monte Carlo Simulation were very time-consuming. The variance of member thickness and load could influence the reliability and failure probability most sensitively among the design variables from the results of the parameter analysis. The proper failure criterion according to characteristic of materials must be used for safe design.

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Experimental Studies on Pathogenicities and Developmental Stages of Nosema apis(Zander, 1909) (꿀벌에 기생(寄生)하는 Nosema apis의 병원성(病原性)과 발육단계(發育段階)에 관한 연구(硏究))

  • Kang, Yung Bai;Kim, Dong Sung;Jang, Du Hwan
    • Korean Journal of Veterinary Research
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    • v.16 no.1
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    • pp.11-25
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    • 1976
  • Studies on pathogenicities and developmental stages of Nosema apis (Zander, 1909) were carried out through artificial infection to Nosema free honey bees with various levels of spores isolated from local honey bee colony. The results obtained were summarized as follows: 1. The clinical symptoms were observed as dysentery, enteritis of mid-gut (enlargement and decoloration), crawling posture and shortening of the longevity of worker bees in the rearing honey bee colony inoculated with the spores. 2. Number of spores harvested from laboratory rearing honey bees were progresively increased to 4 weeks after inoculation. The regression equations and coefficients of correlations to various spore levels were as follows in each treatment colony. Colony 1. ($$1,000{\times}10^4spores/ml$$) $$y_{c1}=471{\times}10^{4}x+454{\times}10^4(r=0.65^*$$) Colony 2. ($$500{\times}10^4spores/ml$$) $$y_{c2}=340{\times}10^{4}x+207.8{\times}10^4(r=0.99^{**}$$) Colony 3. ($$100{\times}10^4spores/ml$$) $$y_{c3}=150{\times}10^{4}x+84.2{\times}10^4(r=0.99^{**}$$) Colony 4. ($$10{\times}10^4spores/ml$$) $$y_{c4}=13.8{\times}10^{4}x+13{\times}10^4(r=0.98^{**}$$) 3. Average longevity of worker bees artificially infected with Nosema apis was shortened as 21.7~43.8% compare to the control. (p<.05, p<.01) 4. The spores which were isolated from honey bee colony infected with Nosema disease were ovoid or spherical form, and measured, as a rule, from $4.7{\mu}m$ to $6.1{\mu}m$ (mean $5.3{\mu}m$) in length and from $2.4{\mu}m$ to $3.2{\mu}m$ (mean $2.9{\mu}m$) in width. 5. In the mid-gut of honey bees, the spore was progresively germinated and became trophozoite stage. The trophozoites were grown to meronts and their binary fission were begun. The divided two sporoblasts were developed to the spores which had elastic membrane. The new spores were shed in excreta of honey bees 10~15 day after inoculation at $25{\pm}2$ centigrade. 6. The ultrastructure of spore membrane consisted of three layers, such as, outer, middle and inner layer. The sporoplasm consisting lamellar structure occupied only anterior part of the spore and was often extended to posterior direction where definite vacuoles and a polar filament was able to detect.

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Application Ranges of Finite Difference Models Using Simplified Momentum Equation in Channel Flow simulation (하천흐름 해석에서 단순화된 운동방정식을 사용한 유한차분모델의 신뢰성 있는 적용 범위)

  • Choi, Gye-Woon;Ahn, Kyung-Soo;Ahn, Sang-Jin
    • Water for future
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    • v.27 no.4
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    • pp.123-133
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    • 1994
  • The kinematic and diffusion models using simplified momentum equations of the full dynamic equation have been frequently used for numerical flow simulations, because they have several computational advantages compared to the full dynamic model. In this paper, the more generally acceptable application ranges of the kinematic and diffusion finite difference models were investigated based on three major parameters, which are channel bed slopes So, dimensionless depth increasing numbers Gw at upstream boundary and Froude numbers Fr. The applicable ranges were obtained by comparing the relative magnitudes of the local acceleration, convective acceleration, pressure, gravity and friction terms in the full dynamic equation. In the simulations, a Courant number of 0.5 was used and the channel bed slopes were changed from 0.00001 to 0.05. Also, Froude numbers of 0.1, 0.5 and 0.9 were employed. In this paper, it is indicated that the applicable ranges of kinematic models are increased with increasing of Froude numbers. However, the applicable ranges of diffusion models are decreased with increasing of Froude numbers. Finally, 9 figures were proposed as a guideline in the application of kinematic and diffusion finite difference models based upon the allowable deviation compared to the full dynamic model. With applying the proposed criteria, it is expected that the flow simulations in the channels, streams or rivers are more efficiently achieved.

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(A) Study on Effects of Multi-cultural Acceptability on Awareness of Unification using Structural Equation Model (구조방정식을 이용한 다문화수용성이 통일인식에 미치는 영향 연구)

  • Han, Seung-Jo
    • Journal of Digital Convergence
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    • v.15 no.10
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    • pp.1-7
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    • 2017
  • The purpose of this paper is to examine how multi-cultural acceptability affects the perception of necessity of unification through structural equation model. The multi-cultural acceptability, familiarity with North Korean defectors, and awareness of unification were selected as the latent variables and the full / partial mediator models were built for structural equations. The observed variables for each latent variable were data that were collected through the National Survey on the Integration of North and South Korea conducted by the Korea Institute for National Unification in 2015. As a result, the acceptance of multiculturalism had a significant effect on the intimacy of the defectors, which had a positive effect on the recognition of the need for unification. The intimacy of the defectors was more influential as a parameter for full mediation than for partial mediation. Although the consciousness of unification gets weakened by postwar generations, that the phenomenon that changes into a multicultural society plays a part in recognizing the necessity of unification. In addition, the increase of North Korean defectors may ultimately become a factor in recognizing the need for unification. This study demonstrated that increasing the acceptance of multiculturalism can increase the need for unification, which means that more research fields can be derived.

The Forced Motion Analyses by Using Two Dimensional 6-Node and Three Dimensional 16-Node Isoparametric Elements with Modification of Gauss Sampling Point (6절점 2차원 및 16절점 3차원 등매개변수 요소의 가우스 적분점 수정을 이용한 강제진동 해석)

  • 김정운;권영두
    • Computational Structural Engineering
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    • v.8 no.4
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    • pp.87-97
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    • 1995
  • For the same configuration of two-dimensional finite element models, 6-node element exhibits stiffer bending stiffness than 8-node element. This is true in the relation between 16-node element and 20-node element for three-dimensional model. This stiffening phenomenon comes from the elimination of several mid nodes from full-node elements. Therefore, this may be called 'relative stiffness stiffening phenomenon'. It seems that there are a couple of ways to correct the stiffening effect, however, we could find only one effective method-the method of modification of Gauss sampling points-which passes the patch test and does not alter other kinds of stiffness, such as extensional stiffness. The quantity of modification is a function of Poisson's ratios of the constituent materials. We could obtain two modification equations, one for plane stress case and the other for plane strain case. This method can be extended to 3-dimensional solid elements. Except the exact plane strain cases, most 3-dimensional plates could be modeled successfully with 16-node element modified by the equation for the plane stress case. The effectiveness of the modification method is checked by applying it to several examples with excellent improvements. In numerical examples, beams with various boundary conditions are subjected to static and time-dependent loads. Free and forced motion analyses of beams and plates are also tested. The beam and plate may be composed of isotropic multilayers as well as a single layer.

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