• Journal of Integrative Natural Science
• /
• v.6 no.3
• /
• pp.163-169
• /
• 2013

The chemokine receptor CCR1 a GPCR super family protein contains seven transmembrane domains. It plays an important role in rheumatoid arthritis, organ transplant rejection, Alzheimer's disease and also causes inflammation. Because of its role in disease processes, antagonism of CCR1 became an attractive therapeutic target. In the current study, we have taken a novel series of recently reported CCR1 antagonist of 1-(4-Phenylpiperazin-1-yl_-2-(1H-Pyrazol-1-yl) ethanone derivatives and performed a HQSAR analysis. The model was developed with Atom (A) and bond (B) parameters and with different set of atom counts to improve the model. The results of HQSAR showed good predictive ability in terms of $r^2$ (0.904) and $q^2$ (0.590) with 0.710 as standard error of prediction and 0.344 as standard error of estimate. The contribution map depicted the atom contribution in inhibitory effect. Compound-14 which was reported to be a highly active compound showed positive atom contribution in three R groups ($R^3$. $R^{5a}$ and $R^{2b}$) in inhibitory effect, which could be the reason why this compound is highly active compound whereas, the lowest active compound-6 showed negative contribution to inhibitory effect.

• Journal of the Korean Society of Clothing and Textiles
• /
• v.35 no.7
• /
• pp.841-855
• /
• 2011

This study examines the structured model of building fashion customer loyalty by service recovery and scrutinizes the effect of explanations on perceived justice and the proposed model. The data of a total of 300 women were collected through an online survey. Employing structural equation modeling, this study demonstrated that both distributive and interactional justice had a positive impact on customers' satisfaction with service encounter that subsequently led to overall satisfaction with the brand. Overall satisfaction influenced the attitudinal loyalty of customers that induced their behavioral loyalty. To examine the effect of explanations on perceived justice and the process of building fashion customer loyalty by service recovery, t-test and multi-group SEM were employed. The result displayed that the group who received explanations after service failure perceived higher level of justice than the one who did not. There was a significant difference between two groups on the direct path from interactional justice to overall satisfaction with the brand. This study clarifies how perceived justice influences fashion customer loyalty mediating by satisfaction in and confirms the critical role of explanations in service recovery context. By implying the understanding of the important role of explanations in service recovery context, this study provides fashion marketers with insight for delivering more successful service recovery strategies that enhance customer loyalty.

• Journal of Korean Society for Quality Management
• /
• v.52 no.2
• /
• pp.241-254
• /
• 2024

Purpose: This paper investigated the effects of issue leadership on employees' work performance. It also explored the mediating role of job challenge in the above relationship. We also tested the moderating effect of psychological ownership in the relationship between issue leadership and job challenge. Finally, this paper examined the moderated mediation effect of psychological ownership in the course of affecting issue leadership on work performance via job challenge. Methods: This paper used a cross-sectional design with questionnaires administered to 390 employees working in Korean firms. It applied an hierarchical and multi-regression analysis by using SPSS 22.0 and Hayes' Macro Process to test the proposed hypotheses including a moderated mediation model. Results: As a result of the analysis, first, it was found that the issue leadership had a positive effect on the work performance. Second, it was also found that issue leadership had a positive effect on the job challenge. In addition, job challenge was found to positive mediating effect in the relationship between issue leadership and work performance. Third, we found that the psychological ownership positively moderated the relationship between issue leadership and job challenge. Finally, the moderated mediating effect was found by confirming that the higher the degree of psychological ownership, the stronger the effect of issue leadership on the work performance via job challenge. Conclusion: This paper contributes to the leadership and work performance studies by identifying the role of issue leadership enhancing employee work performance while confirming connection mechanism and boundary conditions strengthening the positive effect of issue leadership on employee work performance.

• Journal of Digital Convergence
• /
• v.16 no.6
• /
• pp.371-383
• /
• 2018

The purpose of this study was to examine the effects of sex and gender role identity on college life adaptation. The participants were 142 male and 146 female students. The university life adaptation scale and gender role identity scale were carried out, and we conducted a parallel multiple mediator model using Process macro. As a result, while the effect of sex on adaptation level and resources was significant, the explanatory power increased to a meaningful level when effect of gender role identity was considered. In the adaptation level, the effects of masculinity and femininity are similar in magnitude, but in the resources, masculinity has a more positive effect. Finally, male students were mediated through masculinity and female students were mediated through femininity, which has a positive effect on adaptation. These results suggest a differentiated guidance direction according to sex and identity, and suggest that enterprising and challenging spirit is important.

• Atmosphere
• /
• v.27 no.3
• /
• pp.331-344
• /
• 2017

Solar energy is calculated using high-resolution digital elevation model (DEM). In focus on Seoul metropolitan area, correction coefficients of direct and diffuse solar energy with the topographic effect are calculated from DEM with 1720, 900, 450, 90 and 30 spatial resolutions ($m{\times}m$), respectively. The solar energy on the real surface with high-resolution is corrected using by the correction coefficients with topographic effect from the solar energy on horizontal surface with lower resolution. Consequently, the solar energy on the real surface is more detailed distribution than those of horizontal surface. In particular, the topographic effect in the winter is larger than summer because of larger solar zenith angle in winter. In Seoul metropolitan area, the monthly mean topographic effects are more than 200% in winter and within 40% in summer. And annual topographic effects are negative role with more than -60% and positive role with below 40%, respectively. As a result, topographic effect on real surface is not a negligible factor when calculating and analyzing solar energy using regional and global models.

• Journal of the Korean Society of Clothing and Textiles
• /
• v.35 no.10
• /
• pp.1150-1160
• /
• 2011

This study investigates i) the effect of salesperson's self efficacy and work overload on emotional labor and ii) the mediating role of emotion. A survey questionnaire is developed and implemented on salespersons working in the fashion retail stores of department stores. The measurement scales are composed of emotional labor, self efficacy, work overload and emotion. A total of 112 responses are analyzed by confirmatory factor analysis and a structural equation model with AMOS18.0. The results are as follows. Firstly, self efficacy has direct effect on both deep acting and surface acting of emotional labor without the mediating effect of emotion. Self efficacy has a positive effect on deep acting. Secondly, work overload has a negative effect on emotion. Job emotion has positive effect on deep acting and it has a negative effect on surface acting. Thirdly, emotion has a significant mediating effect between work overload and emotional labor. Finally, implications for personal management and job design in the fashion retail organizations are suggested.

• Journal of applied mathematics & informatics
• /
• v.17 no.1_2_3
• /
• pp.361-377
• /
• 2005

A mathematical model dealing with a prey-predator system with disease in the prey is considered. The functional response of the predator is governed by a Hoilling type-2 function. Mathematical analysis of the model regarding stability and persistence has been performed. The effect of delay and diffusion on the above system is studied. The role of diffusivity on stability and persistence criteria of the system has also been discussed.

• 한국전산유체공학회:학술대회논문집
• /
• 1998.11a
• /
• pp.114-120
• /
• 1998

The present numerical study investigates flow characters and heat transfer enhancement by the viscoelastic-driven secondary flow and buoyancy effect in a 2:1 rectangular duct. Three versions of thermal boundary conditions involving difference combination of heated walls and adiabatic walls are analyzed in this study. The Reiner-Rivlin model is adopted as a viscoelastic fluid model to simulate the secondary flow and temperature-dependent viscosity model is used. Calculated Nusselt numbers are very good agreement with experimental results for reported viscoelastic fluids. It is found that the heat transfer enhancement is mainly caused by the viscoelastic-driven secondary flow and buoyancy-induced secondary flow play a role of promoting this effect.

• Structural Engineering and Mechanics
• /
• v.78 no.5
• /
• pp.573-583
• /
• 2021

This paper presents a theoretical approach of the structures reinforced with bonded FRP composites, taking into account loading model, shear lag effect and the thermal effect. These composites are used, in particular, for rehabilitation of structures by stopping the propagation of the cracks. They improve rigidity and resistance, and prolong their lifespan. In this paper, an original model is presented to predict and to determine the stresses concentration at the FRP end, with the new theory analysis approach. The model is based on equilibrium and deformations compatibility requirements in and all parts of the strengthened beam, i.e., the concrete beam, the FRP plate and the adhesive layer. The theoretical predictions are compared with other existing solutions. The numerical resolution was finalized by taking into account the physical and geometric properties of materials that may play an important role in reducing the stress values. This solution is general in nature and may be applicable to all kinds of materials.

• Journal of the Korean Society of Safety
• /
• v.17 no.2
• /
• pp.100-105
• /
• 2002

This study proposed and examined a model in which perceived organizational support and leader-member exchange are linked to safety communication safety commitment, and accidents. In addition, a moderating effect of role overload in the relationship between safety communication and safety commitment and that of performance monitoring in the relationship between safety commitment to accidents. Data were collected from 193 workers in a railroad company. The results indicated that the goodness of fitness of the proposed model was acceptable. More specifically, both perceived organizational support and leader-member exchange were significantly related to safety communication and safety communication was, in turn, significantly related to safety commitment which was ultimately related to accidents. Also, the moderating effects of both role overload and performance monitoring were found. Implications of these findings for safety and the possible roles of variables in the organizational level are discussed.