• Journal of Korean Academy of Nursing
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• v.35 no.7
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• pp.1420-1425
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• 2005

Purpose: We try to disclose how much the keywords of the papers from the Journal of the Korean Academy of Nursing coincide with MeSH terminologies and to understand the major subjects of the recent nursing research in Korea from keywords. Methods: Keywords of journals were extracted and compared with MeSH terms. The frequency of the appearance of each keyword was sorted by a descending order. Results: Coincidence rate of 1,235 keywords with MeSH terms was $51.6\%$. Out of them, depression, elderly, stress, self efficacy, quality of life, exercise, middle-aged women, and women appeared most frequently in descending order. Conclusion: Coincidence rate of the keywords with MeSH terms was at an acceptable level, however to improve it, the education of submitters and editorial board members are required, as well as the copy editor, to take a role in checking keywords. To infer the subjects of the research from keywords might well represent the recent topics of research work.

• International Journal of Oral Biology
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• v.42 no.2
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• pp.71-78
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• 2017

BMP-2 is a well-known TGF-beta related growth factor, having a significant role in bone and cartilage formation. It has been employed to promote bone formation in some clinical trials, and to differentiate mesenchymal stem cells into osteoblasts. However, it is difficult to obtain this protein in its soluble and active form. hBMP-2 is expressed as an inclusion body in the bacterial system. To continuously supply hBMP-2 for research, we optimized the refolding of recombinant hBMP-2 expressed in E. coli, and established an efficient method by using detergent and alkali. Using a heparin column, the recombinant hBMP-2 was purified with the correct refolding. Although combinatorial refolding remarkably enhanced the solubility of the inclusion body, a higher yield of active dimer form of hBMP-2 was obtained from one-step refolding with detergent. The refolded recombinant hBMP-2 induced alkaline phosphatase activity in mouse myoblasts, at $ED_{50}$ of 300-480ng/ml. Furthermore, the expressions of osteogenic markers were upregulated in hPDLSCs and hDPSCs. Therefore, using the process described in this study, the refolded hBMP-2 might be cost-effectively useful for various differentiation experiments in a laboratory.

• Journal of Ginseng Research
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• v.44 no.2
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• pp.194-204
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• 2020

The detrimental impact of air pollution as a result of frequent exposure to fine particles posed a global public health risk mainly to the pulmonary disorders in pediatric and geriatric population. Here, we reviewed the current literature regarding the role of ginseng and/or its components as antimicrobials, especially against pathogens that cause respiratory infections in animal and in vitro models. Some of the possible mechanisms for ginseng-mediated viral inhibition suggested are improvements in systemic and mucosa-specific antibody responses, serum hemagglutinin inhibition, lymphocyte proliferation, cell survival rate, and viral clearance in the lungs. In addition, ginseng reduces the expression levels of proinflammatory cytokines (IFN-γ, TNF-α, IL-2, IL-4, IL-5, IL-6, IL-8) and chemokines produced by airway epithelial cells and macrophages, thus preventing weight loss. In case of bacterial infections, ginseng acts by alleviating inflammatory cytokine production, increasing survival rates, and activating phagocytes and natural killer cells. In addition, ginseng inhibits biofilm formation and induces the dispersion and dissolution of mature biofilms. Most clinical trials revealed that ginseng, at various dosages, is a safe and effective method of seasonal prophylaxis, relieving the symptoms and reducing the risk and duration of colds and flu. Taken together, these findings support the efficacy of ginseng as a therapeutic and prophylactic agent for respiratory infections.

• Korean Journal of Environmental Agriculture
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• v.27 no.1
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• pp.80-85
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• 2008

This study was carried out to assess the antidermatophytic potential of the ethyl acetate(EtOAc) extract of the marine isolate of Aspergillus sp.. The fungus was isolated by serial dilution, and was identified Aspergillus sp.. The EtOAc extract of the fungus was examined to evaluate the antidermatophytic efficacy against the fungal pathogens infecting human skin using the disc diffusion and MIC(minimum inhibitory concentration) determination methods. The EtOAc extract($5{\mu}l\;disc^{-1}$) was considered to have the antidermatophytic activity based on the inhibition percentage of the mycelial growth of the fungi tested such as Trichophyton mentagrophytes KCTC 6085, Microsporum canis KCTC 6591, Microsporum canis KCTC 6348, Trichophyton rubrum KCTC 6352, Microsporum canis KCTC 6349 and Trichophyton mentagrophytes KCTC 6316. The percentage of the inhibition ranged from 54% to 81, and the MIC obtained was 62.5, 62.5, 250, 125, 125, and $125{\mu}g\;ml^{-1}$, respectively. The extract had a strong detrimental effect on the spore germination of the tested skin infectious pathogens. These findings strongly support the role of the ethyl acetate extract as a potential antidermatophytic agent.

• Journal of the Korean Society for Precision Engineering
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• v.11 no.4
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• pp.138-147
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• 1994

Performance management of computer networks is intended to improve a given network performance in order for more efficient information exchange between subsystems of an integrated large-scale system. Improtance of performance management is growing as many function of the large- scale system depend on the quality of communication services provided by the network. The role of performance management is to manipulate the adjustable protocol parameters on line so that the network can adapt itself to a dynamic environment. This can be divided into two subtasks : performance evaluation to find how changes in protocol parameters affect the network performance and decision making to detemine the magnitude and direction of parameter adjustment. This paper is the second part of the two papers focusing on conceptual design, development, and evaluation of performance management for token bus networks. This paper specifically deals with the task of decision making which utilizes the principles of stochastic optimization and learning automata. The developed algorithm can adjuxt four timer settings of a token bus protocol based on the result of performance evaluation. The overall performance management has been evaluated for its efficacy on a network testbed.

• Korean Medical Education Review
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• v.18 no.2
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• pp.106-113
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• 2016

The purpose of this study is to identify factors associated with effective peer-assisted learning (PAL) for nursing students. This review examined studies on PAL in nursing education. The literature was searched using terms including 'nursing & peer assisted learning,' 'nursing & peer learning,' and 'nursing & peer teaching.' Potentially relevant research on PAL was identified, and 12 studies were determined to meet the inclusion criteria. This review includes five qualitative, three mixed-methods, and three experimental studies published on the topic. In the studies reviewed, practicum classes were found to use PAL the most. Students of the same age were most commonly the subjects of PAL, as indicated in six papers. PAL has been suggested to affect participants' knowledge, self-efficacy, confidence, and anxiety. The findings indicate that interactions between peers promote learning and lead to mutually positive responses, which provide opportunities for self-development. Finally, students' learning outcomes improve and their confidence in their knowledge and skills increases as they experience the role of student nurse. These findings indicate that PAL can be utilized as an efficient learning method in nursing education programs. However, effective strategies for using PAL to achieve learning objectives and maximize learning outcomes are needed.

• Journal of the Korea Convergence Society
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• v.10 no.7
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• pp.267-279
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• 2019

The study studied dermal protection and crease improvement from the sunlight of the lipid extract and narinjin. Sunlight was investigated in HR-1 (motherless mice) to identify changes in epithelial thickness and changes in collagen fibers, which account for around 90% of dermis, as the inhibitory efficacy of collagenase dissolving collagen also plays an important role in wrinkles. The experiment was validated using narinjin and jisil extract. First: The components of jisil and narinjin were analyzed. Second, antioxidant capabilities were confirmed with DPPH. Third: The inhibitory activity of collagen was measured. Studies have shown that the skin's upper skin thickness suppression of dermal extracts and narinzine has increased and that collagen thicknesses and wrinkles have decreased significantly compared to controls.

• The Korean Journal of Food And Nutrition
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• v.32 no.4
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• pp.275-283
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• 2019

This study was carried out to investigate the various roles and effects of Morinda citrifolia L.(noni) on the human body and to utilize the findings obtained for future disease related research on food and nutrition. Morinda citrifolia L. has been used in folk medicine by Polynesians for over 2,000 years and is reported to have a broad range of therapeutic effects. Noni is an alkaloid system such as proxeronine, scopoletin, octanoic acid, terpenoids, alkaloids, anthraquinones, nordamnacanthal, morindone, rubiadin, b-sitosterol, flavone glycosides, linoleic acid, acubin, L-asperuloside, caproic acid, caprylic acid, ursolic acid, rutin. Noni's side effects have been reported to affect anti-inflammatory, analgesics, LDL antioxidant, anti-tumor, antifungal, antibiotic, antiviral, antiparasitic and immunosuppressive effects. In particular, noni's efficacy is considered to be important for the prevention of diseases by inhibiting active oxygen, which is a direct cause of oxidative stress, through various metabolites through 'xeronine system'. Noni's functions and effects that have been examined in this study include anti-inflammation, pain relief, antioxidant, anticancer, hepatocyte protection among others. Therefore, noni's extracts are considered highly useful for diverse scientific and nutritional health functional foods.

• Journal of Pharmacopuncture
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• v.22 no.3
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• pp.184-191
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• 2019

Objectives: Recently several Korean medical doctors have begun practicing applied kinesiology (AK). Although the efficacy of combining traditional acupuncture (TA) and pharmacopuncture (PP) on lumbar diseases such as lumbar spinal stenosis (LSS) and lumbar herniation of intervertebral disk (LHID) has been examined, the possible benefits of combining TA, PP and AK approaches have not been examined. Therefore the aim of this study was to develop effective treatment for lumbar disorders by combining TA, PP, and AK treatments. Methods: Twenty-four patients hospitalized at Samse Korean Traditional Medicine Hospital between March and September 2018 with L5 or S1 root radiculopathy associated with LSS and LHID were included in this study. They were treated for 10 days with TA, PP and AK approaches that included category block, manipulation and strain/counterstrain treatments. The primary outcomes were mainly assessed using Japanese Orthopedic Association lumbar scores (JOALS). JOALS were determined before the start of treatment as well as five and 10 days after treatment started. Results: The treatments improved the lumbar condition of the patients based on JOA pain score. Conclusion: The combined TA, PP and AK treatments were effective in treating spinal diseases of resident patients. Prospective, controlled, and relevant protocols using multimodal strategies to define the role of TA, PP and AK are needed.

• Advances in environmental research
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• v.7 no.3
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• pp.225-237
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• 2018

The sorption of metal ions with low-cost adsorbents plays an important role in sustainable development. In the present study, the efficacy of sugarcane bagasse, rain tree fruits (samaneasaman), banana stem and their mixtures, used as bio-sorbents, in the removal of Cu(II) and Pb(II) ions from aqueous solution is evaluated. Batch studies are conducted, and residual ions were measured using Inductively Coupled Plasma (ICP)-atomic spectrometer. Effect of pH, initial metal ion concentration, reaction time and adsorbent dosage are studied. The Pb(II) removal efficiency was observed to be 97.88%, 98.60% and 91.74% for rain tree fruits, banana stem and a mixture of adsorbents respectively. The highest Cu(II) ion removal was observed for sugarcane bagasse sorbent with an efficiency of 82.10% with a pH of 4.5 and a reaction time of 90 min. Finally, desorption studies were carried out to study the leaching potential of adsorbent, and it was found that the adsorbent is stable in water than the other leaching agents such as HCl, ammonium acetate, Sodium EDTA. Hence, these adsorbents can be effectively used for the removal of these heavy metals.