• Korean Journal of Clinical Laboratory Science
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• v.41 no.3
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• pp.140-144
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• 2009

Clinical laboratory testing plays a crucial role in the detection, diagnosis, and treatment of disease. Clinical laboratory scientists evaluate test results, develop and modify procedures, and establish and monitor programs, to ensure the accuracy of tests. It is clear that over the past decade the role of the clinical laboratory scientists has expanded and this process will be continued into the future. The purpose of this study is to clarify the factors influencing the job performance of clinical laboratory scientists and aim to provide the role and duties of clinical laboratory scientists. To examine the frequency of work context and the importance of task, the surveys were conducted on 168 clinical laboratory scientists. The questionnaire items were used 10 score by Likert scale. According to the results of this study, the important factor affecting the job performance was "Analyze laboratory findings to check the accuracy of the results", and the next factors were "Establish and monitor quality assurance programs", "Enter data from analyzer into computer", "Calibrate and maintain equipment". And the factors of "repeating same tasks" and "spend time making repetitive motions" were answered the highest. This study will provide strategies for improving work environment, developing education curriculum and method, and role of clinical laboratory scientists. We must continually upgrade our knowledge, and identify the new trends in technology and science and accept changes.

• Journal of Korean Elementary Science Education
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• v.38 no.2
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• pp.203-215
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• 2019

The purpose of this study is to clarify the roles of laboratory work in school. Twenty-one literatures were identified about roles of laboratory work in school by applying criteria such as published in CI level journals or used as a reference over 100 times during 1960-2017. Twenty-one literatures were reviewed according to periods such as 1960-1989, 1990-2003, and 2004-2017, and identified the roles of laboratory work in school that commonly presented in more than two literature. Seven roles of laboratory work in school identified were as follows (a) learning scientific knowledge, (b) enhancing attitude toward science, (c) learning scientific inquiry methods, (d) acquiring skills to use specific laboratory instruments, (e) enhancing scientific attitude, (f) understanding the nature of science(NOS), and (g) providing opportunity to experience natural or scientific phenomena. The results of this study can be used to provide school teachers and students a clear meaning of the roles of laboratory work in school.

• Safety and Health at Work
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• v.7 no.2
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• pp.111-119
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• 2016

Background: Shift work and/or sleep quality may affect health. We investigated whether shift work and sleep quality, separately and jointly, were associated with abnormal levels of triglycerides, total cholesterol (TC), and low-and high-density lipoprotein cholesterol in 360 police officers (27.5% women). Methods: Triglycerides, TC, and high-density lipoprotein were analyzed on the Abbott Architect; low-density lipoprotein was calculated. Shift work was assessed using City of Buffalo payroll work history records. Sleep quality (good, ${\leq}5$; intermediate, 6-8; poor, ${\geq}9$) was assessed using the Pittsburgh Sleep Quality Index questionnaire. A shift work + sleep quality variable was created: day plus good sleep; day plus poor sleep; afternoon/night plus good; and poor sleep quality. Mean values of lipid biomarkers were compared across categories of the exposures using analysis of variance/analysis of covariance. Results: Shift work was not significantly associated with lipids. However, as sleep quality worsened, mean levels of triglycerides and TC gradually increased but only among female officers (age- and race-adjusted p = 0.013 and 0.030, respectively). Age significantly modified the association between sleep quality and TC. Among officers ${\geq}40$ years old, those reporting poor sleep quality had a significantly higher mean level of TC ($202.9{\pm}3.7mg/dL$) compared with those reporting good sleep quality ($190.6{\pm}4.0mg/dL$) (gender- and race-adjusted p = 0.010). Female officers who worked the day shift and also reported good sleep quality had the lowest mean level of TC compared with women in the other three categories (p = 0.014). Conclusion: Sleep quality and its combined influence with shift work may play a role in the alteration of some lipid measures.

• Parasites, Hosts and Diseases
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• v.60 no.5
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• pp.317-325
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• 2022

Hypoxia-inducible factor-1 alpha (HIF-1α) is one of the master regulators of immune and metabolic cellular functions. HIF-1α, a transcriptional factor whose activity is closely related to oxygen levels, is a target for understanding infectious disease control. Several studies have demonstrated that HIF-1α plays an important role during the infectious process, while its role in relation to parasite virulence has not been addressed. In this work, we studied the expression levels of HIF-1α and related angiogenic vascular endothelial growth factor A (VEGF-A) in human macrophages infected with promastigotes of hypo- or hyper-virulent Leishmania major human isolates. L. major parasites readily subverted host macrophage functions for their survival and induced local oxygen consumption at the site of infection. In contrast to hypo-virulent parasites that induce high HIF-1α expression levels, hyper-virulent L. major reduced HIF-1α expression in macrophages under normoxic or hypoxic conditions, and consequently impeded the expression of VEGF-A mRNA. HIF-1α may play a key role during control of disease chronicity, severity, or outcome.

• Proceedings of the IEEK Conference
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• 2000.06b
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• pp.306-309
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• 2000

In this work, we investigated A1 cluster deposition on Al (100) surface using molecular dynamics simulation. A result of simulations showed that large cluster with low energy was proper for good surfaced-films without craters at the low temperatures. We investigated the maximum substrate temperature and the time taken for substrate temperature to reach its maximum as a function of cluster size in the case of the same total energy and in the case of the same energy Per atom. The correlated collisions play an important role in interaction between energetic cluster and surface, and as cluster size and cluster energy increases, the correlated collisions effect affects interaction between energetic cluster and surface.

• Earthquakes and Structures
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• v.11 no.5
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• pp.823-840
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• 2016

The plastic hinge lengths of beams and columns are a critical demand parameter in the nonlinear analysis of structures using the finite element method. The numerical model of a plastic hinge plays an important role in evaluating the response and damage of a structure to earthquakes or other loads causing the formation of plastic hinges. Previous research demonstrates that the plastic hinge length of reinforced concrete (RC) columns is closely related to section size, reinforcement ratio, reinforcement strength, concrete strength, axial compression ratio, and so on. However, because of the limitations of testing facilities, there is a lack of experimental data on columns with large section sizes and high axial compression ratios. In this work, we conducted a series of quasi-static tests for columns with large section sizes (up to 700 mm) and high axial compression ratios (up to 0.6) to explore the propagation of plastic hinge length during the whole loading process. The experimental results show that besides these parameters mentioned in previous work, the plastic hinge of RC columns is also affected by loading amplitude and size effect. Therefore, an approach toward considering the effect of these two parameters is discussed in this work.

• Biomedical Science Letters
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• v.14 no.4
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• pp.263-267
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• 2008

Photodynamic therapy (PDT) is a treatment utilizing the generation of singlet oxygen and other reactive oxygen species (ROS), which selectively accumulate in target cells. Peroxiredoxin (prx) plays an important role in eliminating peroxides generated during metabolism. Prx exert protective antioxidant role in cells though peroxidase activity. The aim of present work is to investigate the cytotoxicity of photofrin-mediated PDT in prx IV-transfectant AMC-HN3 cell lines. We confirmed that PDT has an effect on ROS generation in prx IV-induced cell lines. Treatment of PDT in prx IV-HN3 cell lines inhibits cytotoxic effects. Prx IV-induced HN3 cell lines resists in cell death during PDT. Also, prx IV-HN3 cell lines treated PDT inhibited ROS generation in contrast with vector control. We indicated that prx IV-induced AMC-HN3 cell lines have a function as inhibitors during PDT.

• Ocean Systems Engineering
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• v.5 no.4
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• pp.279-299
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• 2015

Suction anchors are widely adopted and play an important role in mooring systems. However, how to reliably predict the failure mode and ultimate pullout capacity of the anchor in sand, especially by an easy-to-use theoretical method, is still a great challenge. Existing methods for predicting the inclined pullout capacity of suction anchors in sand are mainly based on experiments or finite element analysis. In the present work, based on a rational mechanical model for suction anchors and the failure mechanism of the anchor in the seabed, an analytical model is developed which can predict the failure mode and ultimate pullout capacity of suction anchors in sand under inclined loading. Detailed parametric analysis is performed to explore the effects of different parameters on the failure mode and ultimate pullout capacity of the anchor. To examine the present model, the results from experiments and finite element analysis are employed to compare with the theoretical predictions, and a general agreement is obtained. An analytical method that can evaluate the optimal position of the attachment point is also proposed in the present study. The present work demonstrates that the failure mode and pullout capacity of suction anchors in sand can be easily and reasonably predicted by the theoretical model, which might be a useful supplement to the experimental and numerical methods in analyzing the behavior of suction anchors.

• Journal of Science and Technology Studies
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• v.5 no.2 s.10
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• pp.49-67
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• 2005

With increasing interest on scientists and the influence of science technology, their role in the modem society has been expanding. Scientists work in the laboratory as researchers, work in their expertise area as professionals, and work socially as social agents. Scientists are responsible to keep up the regulations during the research, and also are responsible for the results of the research. Therefore, there is a need of contemplation in terms of what their identity is and what their responsibilities are. Despite of this need, there hasn't been much discussion or education on the scientists social role or responsibilities as of now. This study purported to contemplate on the scientists role and responsibility, its qualification, and what it means to be a scientist as a social agent. Also the study further explored the efficient educational strategies and methods relevant to the contemplated issues.

• Structural Engineering and Mechanics
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• v.78 no.2
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• pp.117-124
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• 2021

This work focused on the novel numerical tool for the bending responses of carbon nanotube reinforced composites (CNTRC) beams. The higher order shear deformation beam theory (HSDT) is used to determine strain-displacement relationships. A new exponential function was introduced into the carbon nanotube (CNT) volume fraction equation to show the effect of the CNT distribution on the CNTRC beams through displacements and stresses. To determine the mechanical properties of CNTRCs, the rule of the mixture was employed by assuming that the single-walled carbon nanotubes (SWCNTs)are aligned and distributed in the matrix. The governing equations were derived by Hamilton's principle, and the mathematical models presented in this work are numerically provided to verify the accuracy of the present theory. The effects of aspect ratio (l/d), CNT volume fraction (Vcnt), and the order of exponent (n) on the displacement and stresses are presented and discussed in detail. Based on the analytical results. It turns out that the increase of the exponent degree (n) makes the X-beam stiffer and the exponential CNTs distribution plays an indispensable role to improve the mechanical properties of the CNTRC beams.