• Molecules and Cells
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• v.38 no.7
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• pp.610-615
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• 2015

Alveolar epithelial cells have been functionally implicated in Mycobacterium tuberculosis infection. This study investigated the role of ursolic acid (UA)-a triterpenoid carboxylic acid with potent antioxidant, anti-tumor, anti-inflammatory, and anti-tuberculosis properties in mycobacterial infection of alveolar epithelial A549 cells. We observed that M. tuberculosis successfully entered A549 cells. Cytotoxicity was mediated by nitric oxide (NO). A549 toxicity peaked along with NO generation 72 h after infection. The NO generated by mycobacterial infection in A549 cells was insufficient to kill mycobacteria, as made evident by the mycobacteria growth indicator tube time to detect (MGIT TTD) and viable cell count assays. Treatment of mycobacteria-infected cells with UA reduced the expression of inducible nitric oxide synthase, NO generation, and eventually improved cell viability. Moreover, UA was found to quench the translocation of the transcription factor, nuclear factor kappa B (NF-${\kappa}B$), from the cytosol to the nucleus in mycobacteria-infected cells. This study is the first to demonstrate the cytotoxic role of NO in the eradication of mycobacteria and the role of UA in reducing this cytotoxicity in A549 cells.

• The Korean Journal of Pain
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• v.34 no.1
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• pp.94-105
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• 2021

Background: Many patients with complex regional pain syndrome (CRPS) have been known to be at risk of suicide, due to severe pain and its comorbid conditions. The risk of suicide may be associated with affective instability, which is an indicator of emotional dysregulation. Particularly, unstable shifts in negative emotions are difficult to cope with, which may result in individuals feeling uncontrollable, hopeless, and entrapped. This study aimed to examine the role of affective instability in the relationship between pain intensity and suicide risk (suicidal ideation and impulsivity) in patients with CRPS, by employing a daily diary. Methods: Twenty-three patients registered at the CRPS Association in Korea were asked to complete a day-to-day routine for 15 days, followed by a diary composed of pain intensity, suicidal ideation, impulsivity, and positive and negative affects. Results: Results showed that the interactions between negative affective instability and daily pain intensity were statistically significant on daily suicidal ideation (coefficient = 0.41, t (21) = 2.56, P < 0.050) and daily impulsiveness (coefficient = 1.20, t (19) = 3.35, P < 0.010). However, those between positive affective instability and daily pain intensity were not. Conclusions: This study is the first attempt to investigate the role of affective instability on the relationship between daily pain intensity and daily suicide risk in patients with CRPS. Our findings suggest that health professionals pay considerable attention to the instability of negative affects when assessing and managing patients with CRPS at risk of suicide.

• Journal of Satellite, Information and Communications
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• v.10 no.3
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• pp.94-101
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• 2015

The display device is an important video information communication system device to connect between human and device. it transfers the information as characters, shapes, images and pattern to enable recognizing by eyes. Theres absolutely needs some key functions and role to quickly display informations. It can analyse a information through a PPI Scope of a cathode-ray tube(CRT) displays information which can perform a role. this research proposed a radar device to display informations as received signal. The radar display researches can apply to fixed function graphics pipeline algorithms of the large capacity type through a vertical blanking interval and buffer swap of display unit. Also, it can be possible to apply to performed algorithms to FPGA logic without high-performance graphics processing unit GPU through synchronization which can implement a display system. In this paper, we improved the affordability and reliability through proposed research. 이So, we have studied the radar display unit which can change a flat display from radar display of CRT radar display.

• Journal of the Korean Institute of Educational Facilities
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• v.25 no.5
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• pp.3-12
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• 2018

The purpose of this study is to examine the degree of appropriateness of using design quality indicators for the educational building, and complements for design quality indicators. For doing this, each items of the Korean educational building design indicator was validated by teachers, school staff and an education officer. First, School Personnel and Teachers considered indicators for the classroom designed for general subjects as being valid. However, in terms of indicators for the outside space, they thought of them as not being valid. In particular, it seemed that school staff would have a passive attitude toward the open of the school facility for the local society. It is judged that there happens an adverse effect caused by the open of the school facility for the local society in the educational environment of the school. Second, Education Office Supervisors thought that eco-friendly indicators, LED lighting, an outer wall, and widows and doors had a high validity. On the contrary, he viewed the validity of a rainwater retention basin as being low, which was likely because he rarely had expertise on the construction. When it comes to the indicator of technology capability, ultrahigh-speed information network was seen as being valid, and the indicator of economic feasibility had high validity on maintenance and durability. Third, compared to groups of Teachers and School Personnel, the group of education officers presented high validity of indicators. Validity of indicators might be differently showed because different items on indicators were measured. However, it is speculated that Education Office Supervisors mostly acknowledged the validity of indicators. Fourth, a majority of Teachers, School staff, and Education Office Supervisors were favor of the system of the evaluation accreditation for school facilities since it played a guide role in improving the quality of school. In order to settle the system of the evaluation accreditation for school facilities, it is most important that institutions in the local society which are publicly reliable should participate in the phase of designing the system of the evaluation accreditation for school facilities. In sum, overall respondents agreed with the system of the evaluation accreditation for school facilities but were aware that reliable organizations in public would need to take part in planning the system of the evaluation accreditation for school facilities from the beginning.

• International Journal of Computer Science & Network Security
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• v.21 no.9
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• pp.67-78
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• 2021

The research aims to identify the role of administrative leaders working in universities in the success of organizational development and change, and the extent of the relationship and ability of administrative leaders at all levels of leadership within universities to the effectiveness of the process of development and organizational change at Northern Border University. In addition to presenting some recommendations and suggestions that can contribute to identifying the best leadership styles that contribute to the success of the development process and positive organizational change. Where leadership, whether in the private sector or the public sector, is one of the main functions concerned with the processes of direction, development, and modernization in the performance of the facility and an important element to activate the organizations' ability to perform their role and achieve their goals. The behavior and trends of leaders represent an important indicator in knowing the type of efforts made by them to improve performance and develop organizations and human resources. The research reached many results, perhaps the most important of which is that the dominant leadership style in universities is the democratic style, followed by the bureaucratic leadership style. The results also showed that there is a significant role for administrative leaders in bringing about development and positive change at Northern Border University at the level of individuals, groups, and organizations. And it became clear that there is an availability of leadership capabilities to an acceptable degree in the administrative leaders. The results of the statistical analysis showed a positive relationship between administrative leadership ability and democratic style. In addition to the existence of a negative relationship between the administrative leadership ability and the bureaucratic style and the freestyle. It was also clear that there were no differences in dealing between males and females, as well as age, educational qualification, experience, and job grade, but there were differences in dealing with the job title.

• The Journal of Asian Finance, Economics and Business
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• v.7 no.12
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• pp.223-231
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• 2020

This research aims to examine (1) the effect of carbon emission disclosure on firm value, (2) the effect of good corporate governance on firm value, (3) the mediating role of financial performance between carbon emission disclosure and firm value, and (4) the mediating role of financial performance between good corporate governance and firm value. The research sample includes 43 mining, agro, and manufacturing firms listed in the Indonesian Stock Exchange over the 2015-2017 period. Carbon emission disclosure is measured by an indicator of the Global Reporting Initiative Series of Environmental Aspect. Good corporate governance is measured by the corporate governance score of shareholder rights, boards of directors, outside directors, audit committee and internal auditor, and disclosure to investors. Financial performance is measured by return on assets, while firm value is measured by Tobin's Q. Data analysis uses the structural equation modeling. The result shows carbon emission disclosure and good corporate governance have no direct effect on firm value. On the other hand, financial performance mediates the effect of carbon emission disclosure and good corporate governance on firm value. It shows that higher carbon emission disclosure and good corporate governance are meaningless for the investor if they do not give any financial performance improvement.

• Korean Journal of Microbiology
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• v.32 no.4
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• pp.280-284
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• 1994

Lack of lysosomal fusion with symbiosomes in symbiont-bearing Amoeba proteus may be due either to the presence of a component in the symbiosome membrane or to the absence of a component needed in the fusion process. Using monoclonal antibody as a probe, lipopolysaccharides were identified as symbiosome-membrane components contributed by symbionts and were found to be exposed on the cytoplasmic side of the membrane. In order to test whether lipopolysaccharides may play a role in the prevention of lysosome-symbiosome fusion, the antilipopolysaccharides antibody was microinjected and processed for double immunostaining in conjuction with anti-lysosome antibody as a lysosome-fusion indicator. Microinjection of the anti-LPS antibody caused symbiosomes to fuse with lysosomes, suggesting that X-bacterial lipopolysaccharides could be 'fusion-preventing' factors.

• School Mathematics
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• v.18 no.2
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• pp.231-256
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• 2016

In this paper I will look into achievement standards which show gender difference. This work is based on the average of percentage of correct answer about items taken in National Assessment of Educational Achievement (2010~2014) at each male and female student of middle school. Achievement standard becomes the basic unit when teachers make study plans as the smallest unit that composes the curriculum. Study plans are expressed concretely according to lesson time numbers, and then lesson time numbers are determined by achievement standards. Therefore, objective informations about gender difference appearing in achievement standards will play an important role in embodiment of programs to obliterate gender difference when teachers make study plans. Also This research is expected to play a role as an indicator in studying on gender difference in mathematics education.

• Nutrition Research and Practice
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• v.17 no.2
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• pp.356-370
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• 2023

BACKGROUND/OBJECTIVES: School food service has played an important role in promoting the health and physical condition of students by providing students with a balanced and nutritious diet. Therefore, boosting the quality of school food service and improving the students' satisfaction is critical. For this purpose, this study examined the structural causal relationship among the quality of school food service factors, emotional responses, and satisfaction in China. SUBJECTS/METHODS: This study was conducted with 4th-6th-grade students from 6 junior high schools in Henan province of China, with 590 questionnaire responses (87.3%) collected and statistically analyzed. RESULTS: The school food service quality factors (including menu management, dietary education, facilities management, price and food distribution management, and personal hygiene during meals) must be enhanced to boost the students' satisfaction. In addition, the study used questionnaire survey data to validate the full mediation of students' emotional responses between school food service quality factors and student satisfaction. CONCLUSIONS: Students' emotions also play an important role in influencing the quality of school food service, all of which affect the emotional responses of students. Therefore, students' positive emotions are an important indicator for improving the quality of school food service. A national support policy is necessary for the ongoing maintenance and development of various programs that drive students' satisfaction and promote the adoption of education guidelines for school food service in China.

• Architectural research
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• v.18 no.1
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• pp.31-38
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• 2016

The surface design in architecture plays a role as an indicator that symbolizes cultures and styles, in accordance with the course of history and the standards of the time. The surface design that determines the facade of an architectural structure allows us to have a more clear understanding about the functions, programs and structures, as well as the periodical concept of the architects than any other components of the architecture. The purpose of this paper was to examine how architectural surface designs were realized, using commonly-used materials. This study provides meaningful implications, in that it suggests common features in terms of design methodologies (between architecture and non-architecture fields), and presented new possibilities for contemporary architectural surface designs through the classification of building system methods depending on fabric properties, and through the case study analysis of architectural surface designs; in addition, the results of this study could be utilized as basic data for future studies on the possibility of the expression of surface designs across a broader domain.