• Clinical and Experimental Pediatrics
• /
• v.57 no.4
• /
• pp.157-163
• /
• 2014

Respiratory distress syndrome (RDS) among preterm infants is typically due to a quantitative deficiency of pulmonary surfactant. Aside from the degree of prematurity, diverse environmental and genetic factors can affect the development of RDS. The variance of the risk of RDS in various races/ethnicities or monozygotic/dizygotic twins has suggested genetic influences on this disorder. So far, several specific mutations in genes encoding surfactant-associated molecules have confirmed this. Specific genetic variants contributing to the regulation of pulmonary development, its structure and function, or the inflammatory response could be candidate risk factors for the development of RDS. This review summarizes the background that suggests the genetic predisposition of RDS, the identified mutations, and candidate genetic polymorphisms of pulmonary surfactant proteins associated with RDS.

• Journal of Navigation and Port Research
• /
• v.37 no.6
• /
• pp.709-718
• /
• 2013

In this study, AHP analysis was conducted through a survey that was organized by 9 job categories. The results show that sustainable operation risks have the highest priority level among all criteria with management interest having the highest priority level within sustainable operation risks related attributes. The most important risk attributes among stakeholder risks appeared to be asset security and cargo and conveyance security, with education and training being the most important among regulatory risks. Effective management and response to the risks from export controls on strategic trade require an understanding of supply chain security and compliance programs, effective training programs, investments for development of security systems that meet international standards. In addition, the government needs to focus on developing professionals and providing support for companies with compliance programs, working closely with businesses.

• Journal of the Architectural Institute of Korea Planning & Design
• /
• v.34 no.3
• /
• pp.73-84
• /
• 2018

The purpose of this study is to analyze the contents of the cultural heritage conservation standards those have been developed throughout the century to reveal the evolution of the conservation. The analysis targets are prepared principles in response to the risks posed by armed conflicts, improper modifications, risks caused by urban planning and development, and the risk posed by environmental impacts. The study analyzed how conservation targets, issues, and conservation methods have changed. The analysis showed that the results of changed trend of conservation, first, the segmentation and diversification of the conservation targets, second, the integrated approaches, third, risk perception changes due to indirect effects from direct risk factors, forth, changes of conservation from safeguard to sustainable development.

• Journal of Korean Society of Transportation
• /
• v.22 no.6
• /
• pp.133-144
• /
• 2004

A model and a measure which can evaluate the risk of rear end collision are developed. Most traffic accidents involve multiple causes such as the human factor, the vehicle factor, and the highway element at any given time. Thus, these factors should be considered in analyzing the risk of an accident and in developing safety models. Although most risky situations and accidents on the roads result from the poor response of a driver to various stimuli, many researchers have modeled the risk or accident by analyzing only the stimuli without considering the response of a driver. Hence, the reliabilities of those models turned out to be low. Thus in developing the model behaviors of a driver, such as reaction time and deceleration rate, are considered. In the past, most studies tried to analyze the relationships between a risk and an accident directly but they, due to the difficulty of finding out the directional relationships between these factors, developed a model by considering these factors, developed a model by considering indirect factors such as volume, speed, etc. However, if the relationships between risk and accidents are looked into in detail, it can be seen that they are linked by the behaviors of a driver, and depending on drivers the risk as it is on the road-vehicle system may be ignored or call drivers' attention. Therefore, an accident depends on how a driver handles risk, so that the more related risk to and accident occurrence is not the risk itself but the risk responded by a driver. Thus, in this study, the behaviors of a driver are considered in the model and to reflect these behaviors three concepts related to accidents are introduced. And safe stopping distance and accident occurrence probability were used for better understanding and for more reliable modeling of the risk. The index which can represent the risk is also developed based on measures used in evaluating noise level, and for the risk comparison between various situations, the equivalent risk level, considering the intensity and duration time, is developed by means of the weighted average. Validation is performed with field surveys on the expressway of Seoul, and the test vehicle was made to collect the traffic flow data, such as deceleration rate, speed and spacing. Based on this data, the risk by section, lane and traffic flow conditions are evaluated and compared with the accident data and traffic conditions. The evaluated risk level corresponds closely to the patterns of actual traffic conditions and counts of accident. The model and the method developed in this study can be applied to various fields, such as safety test of traffic flow, establishment of operation & management strategy for reliable traffic flow, and the safety test for the control algorithm in the advanced safety vehicles and many others.

• STI Policy Review
• /
• v.4 no.2
• /
• pp.41-54
• /
• 2013

R&D is inherently an uncertain endeavor, yet now more than ever those performing R&D with public funding are called upon to clarify the utility of their research. Calls for public accountability are mounting with the increase in constraints on government budgets due to the recent worldwide economic recession, in response to which both policymakers and researchers pay much more attention to rigorously assessing publicly funded R&D. A key issue complicating R&D evaluation in these circumstances is how to adequately account for the nature and degree of risk involved in a given R&D program or project. This study deliberates on certain issues involving the measurement of ex-ante risk in public R&D evaluation: (i) information asymmetry between R&D sponsors and performers, (ii) ambiguity in the measurement of returns in both prospective and retrospective evaluation, and (iii) the dilemma between measurement error and omitted variable bias for empirical estimation of R&D performance. The study then presents an analysis of hypothetical evaluation results that apply risk-relevant weights to the annual evaluation outcomes of South Korea's national R&D programs funded during 2006~2012. In this counterfactual re-evaluation of public R&D program performance, high-risk R&D programs turn out to receive higher evaluation than non-high-risk programs. The current study suggests that R&D evaluation ignoring ex-ante risk is not only conceptually invalid since R&D activities are intrinsically uncertain endeavors, but unfair as R&D performers are asked to be accountable for the results that were in fact out of their reach.

• Journal of Environmental Health Sciences
• /
• v.36 no.4
• /
• pp.294-305
• /
• 2010

This study estimated the health risk of heavy metals in particulate matter $(PM)_{2.5}$ in a Gwangyang industrial complex. The $PM_{2.5}$ containing heavy metal was collected from January to November, 2008 using a denuder air sampler and by IC (Ion Chromatograph). The risk assessment was performed in a four-step process; hazard identification, exposure assessment, dose-response assessment and risk characterization. In the hazard identification process, $Cr^{6+}$, Ni, As, and Pb were categorized as human carcinogens and probable human carcinogens, while Ti, Mn, Se, P, $Cr^{3+}$, Cu, and Zn were not classified as human carcinogens. It was found that the excess cancer risk by Central Tendency Exposure (CTE) of $Cr^{6+}$ and As in $PM_{2.5}$ was > $10^{-6}$, and the total excess cancer risk posed by carcinogen heavy metals in $PM_{2.5}$ was > $10^{-6}$. It was also determined that the total hazard index by CTE of non-carcinogen heavy metals in $PM_{2.5}$ was <1. Taken together, these results indicate a high cancer risk associated whit inhalation of heavy metal-containing$PM_{2.5}$ in industrial areas.

• Food Science of Animal Resources
• /
• v.32 no.1
• /
• pp.118-124
• /
• 2012

This study was conducted for quantitative microbial risk assessment (QMRA) of Clostridium perfringens with consumption on ham and sausage products in Korea, according to Codex guidelines. Frame-work model as product-retail-consumption pathway composed with initial contamination level, the time and temperature in distributions, and consumption data sets for ham and sausage products and also used the published predictive growth and dose-response models for Cl. perfringens. The simulation model and formulas with Microsoft@ Excel spreadsheet program using these data sets was developed and simulated with @RISK. The probability of foodborne disease by Cl. perfringens with consumption of the ham and sausage products per person per day was estimated as $3.97{\times}10^{-11}{\pm}1.80{\times}10^{-9}$. There were also noted that limitations in this study and suggestion for development of QMRA in the future in Korea.

• Journal of Convergence for Information Technology
• /
• v.10 no.8
• /
• pp.187-193
• /
• 2020

This study analyzed how risk factors in management affect the management of working capital in general hospitals in Korea. The data used accounting information for three years (2016~2017 and 2018) of 271 general hospitals using the medical institution accounting information disclosure system. The independent variables were the working capital level and the cash conversion cycle, The dependent variables were operational risk and market risk, Control variables were selected as components of working capital(cash, accounts receivable, inventory assets, accounts payable). According to the study, the lower the operational risk, the higher the level of working capital hospitals in Korea. Working capital decisions were confirmed to be attributable to operating risks, cash, inventory assets and accounts payable. And the lower the market risk (Operating Margin), the higher the cash conversion cycle. Therefore, it is necessary to review appropriate management measures of operational risks, cash, inventory assets and accounts payable identified as operating capital determinants so that medical institutions can also have economic response capabilities in consideration of the specificity of their operations.

• Journal of Korean Tunnelling and Underground Space Association
• /
• v.22 no.4
• /
• pp.401-417
• /
• 2020

As an increasing demand for rapid railway transportation, the construction of sidetrack is inevitable to operate local and express trains simultaneously. However, the current technologies for the sidetrack construction method require a long construction period by interrupting the operation of the existing subway line, as well as cause a huge economic loss. Thus, it is necessary to study the sidetrack construction method under the special situation that the subway is in operation and to analyze the risk of the existing tunnel enlargement process for the sidetrack construction. Therefore, in this paper, the Government Complex Gwacheon station on Subway Line 4 was considered as a target station for the virtual sidetrack construction and the optimal sidetrack construction plan was derived. Subsequently, the application of risk management process was carried out in the order of identifying risk, risk response planning, performing a risk analysis, risk monitoring and control for potential risk events during the construction of sidetrack under the subway operation. A total of eight potential risk events and risk mitigation methods were selected, and a risk assessment matrix was established using the five-step risk probability and impact level criteria to perform the risk assessment including residual risks. Based on the results of the risk assessment, the risk grade and the reduction effect of each risk mitigation method were confirmed.

• Journal of the Korean Society of Marine Environment & Safety
• /
• v.25 no.2
• /
• pp.159-168
• /
• 2019

This study was designed to investigate the physiological response of humans to alcohol during underwater activity and to complete related risk analysis. After comparing human responses to alcohol during underwater activity, we analyzed physiological changes and risk level using a new risk analysis method developed in this study, 'Risk Assessment and Analysis (RAA)'. RAA is a modified method based on an internal control frame work. It has 3 steps, the first of which is to analyze risk correlation. The second step is to quantify risk and build a risk database. The last step is to analyze the diagramed risk map. Using RAA, the risk levels of alcohol use underwater were calculated and diagramed. The diagramed risk map was then used to analyze the difference between risk levels underwater before and after alcohol use. As a result, it was found that risk level underwater increased after alcohol use. This study shows alcohol use increases the ratio of high risk groups during underwater activity. It also indicates that risk levels can be quantified according to the likelihood and impairment scale, which can potentially help in identifying high risk groups for intensive management underwater.