• Imaging Science in Dentistry
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• 제52권2호
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• pp.133-140
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• 2022

Purpose: The aim of this review was to systematically analyze the available literature on the correlation between the gray values (GVs) of cone-beam computed tomography (CBCT) and the Hounsfield units (HUs) of computed tomography (CT) for assessing bone mineral density. Materials and Methods: A literature search was carried out in PubMed, Cochrane Library, Google Scholar, Scopus, and LILACS for studies published through September 2021. In vitro, in vivo, and animal studies that analyzed the correlations GVs of CBCT and HUs of CT were included in this review. The review was prepared according to the PRISMA checklist for systematic reviews, and the risk of bias was assessed using the Quality Assessment of Diagnostic Accuracy Studies tool. A quantitative analysis was performed using a fixed-effects model. Results: The literature search identified a total of 5,955 studies, of which 14 studies were included for the qualitative analysis and 2 studies for the quantitative analysis. A positive correlation was observed between the GVs of CBCT and HUs of CT. Out of the 14 studies, 100% had low risks of bias for the domains of patient selection, index test, and reference standards, while 95% of studies had a low risk of bias for the domain of flow and timing. The fixed-effects meta-analysis performed for Pearson correlation coefficients between CBCT and CT showed a moderate positive correlation (r=0.669; 95% CI, 0.388 to 0.836; P<0.05). Conclusion: The available evidence showed a positive correlation between the GVs of CBCT and HUs of CT.

• 한국임상약학회지
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• 제32권1호
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• pp.37-46
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• 2022

Background: Non-valvular atrial fibrillation (NVAF) is associated with ischemic stroke risk in the aging population. Observational studies have indicated beneficial effects of direct-acting oral anticoagulant (DOAC) against ischemic stroke compared to warfarin. This study aimed to investigate ischemic stroke incidence and bleeding risk in patients on DOAC therapy. Methods: Using the database of Korean Health Insurance Review and Assessment-Aged Patient Sample 2015, we conducted a retrospective cohort study. Study subjects with NVAF diagnosis and prescribed anticoagulants were enrolled. Propensity score (PS) matching by age, sex, comorbidities, and medications were used. The clinical outcomes were major adverse cerebro-cardiovascular events (MACCEs, ischemic stroke/systemic embolism, myocardial infarction, cardiac death) and bleeding events. A cox proportional hazard model analysis was performed to compare the outcomes with hazard ratio (HR) and 95% confidence interval (CI). Results: Total 4,773 elderly patients with NVAF were initially included. Four PS-matched groups including rivaroxaban vs. warfarin-only (n=1,079), dabigatran vs. warfarin-only (n=721), rivaroxaban vs. dabigatran (n=721), and switchers of warfarin to rivaroxaban vs. warfarin-only (n=287) were analyzed. Every group showed statistically similar results of MACCEs and bleeding events, except for the group of rivaroxaban vs. dabigatran. Rivaroxaban users showed higher risks of bleeding events than dabigatran users (HR 2.25, 95% CI 1.01-4.99). Conclusion: In the elderly patients with NVAF, efficacy and safety outcomes among oral anticoagulants including DOACs and warfarin were similar, while rivaroxaban are more likely to have higher bleeding risks than dabigatran. Further research using large size sample is needed.

• 한국지반공학회논문집
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• 제39권6호
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• pp.5-12
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• 2023

산사태 위험 지역을 사전에 조사하여 설정하는 것은 다수의 피해를 줄이기 위해 필요하다. 해당 연구의 목적은 machine learning 기법 중 분류 알고리즘을 활용하여 대상 지반의 안전율 분류를 수행할 수 있는 방법론을 제시하는 것이다. 산사태 위험 지역은 high risk area(HRA) 모델을 적용하였으며, 8개의 지반공학 물성치를 통해 위험 지역을 판단하였다. 분류 알고리즘은 decision tree(DT), K-Nearest Neighbor(KNN), logistic regression(LR) 그리고 random forest(RF)의 4가지가 활용 되었으며, 안전율 1.2~2.0 범위에 8가지 지반공학 물성치의 분류 정확도를 계산하였다. 정확도는 안전율이 1.2~1.7 범위에서 신뢰성 높게 나타났지만, 그 외 범위인 1.8~2.0 사이에서는 상대적으로 낮은 정확도를 보였다. 이를 극복하기 위하여 synthetic minority over-sampling technique(SMOTE) 알고리즘을 적용하여 데이터 개수를 증폭하였으며, 증폭한 데이터를 통해 분류 알고리즘을 적용하면 안전율 1.8~2.0 범위에서 정확도가 평균적으로 약 250% 증가한 것으로 나타났다. 해당 연구 결과는 SMOTE 알고리즘이 데이터 개수를 향상시켜 분류 알고리즘의 정확도가 개선된 것을 보여주며, 타 분야에도 정확도 향상에 적용 가능하다고 판단된다.

• 대한토목학회논문집
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• 제30권6B호
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• pp.561-569
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• 2010

본 연구에서는 현재 및 미래 기후에서의 가뭄심도-영향면적-지속기간 곡선의 비교를 통하여 극한 가뭄 사상에 대한 기후변화의 영향을 살펴보았다. 가뭄심도-영향면적-지속기간 곡선은 극한 호우사상을 특성화하기 위한 일반적으로 적용되는 우량깊이-영향면적-지속기간 곡선에서 우량깊이를 가뭄심도를 대표할 수 있는 적절한 지수로 대체함으로써 가뭄사상을 분석할 수 있는 도구를 제공한다. 미래 월 강수량 시계열은 $27km{\times}27km$의 공간적인 해상도를 가지는 기상청 지역기후모형으로부터 획득되었으며, 가뭄심도는 표준강수지수를 이용하여 산출하였다. 분석 결과, 농업가뭄에 대한 위험성은 특히 단기간의 지속기간의 경우에 현재보다 심화될 수 있는 것으로 분석되었으며, 수문학적 가뭄의 경우는 가뭄지속기간에 상관없이 모두 현재보다는 미래에 가뭄심도가 더 깊어질 가능성이 있는 것으로 예측되었다. 이에 따라 현재의 수자원 공급 시스템에 대한 기후변화 취약성 평가가 시급함을 제시하고 있다.

• 마이크로전자및패키징학회지
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• 제23권2호
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• pp.37-42
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• 2016

전력가격의 상승으로 데이터센터의 운영비 부담이 늘어나는 가운데, 슈퍼컴퓨터에 저전력 프로세서를 사용하여 데이터센터의 전력소모를 감소시키는 연구가 활발하다. 일반적으로 모바일 기기 등의 운용환경을 기준으로 신뢰성 평가가 이루어지는 저전력 프로세서를 슈퍼컴퓨터에 사용하는 경우 상대적으로 가혹한 운용환경으로 인해 물리적, 기계적 신뢰성 문제가 발생할 수 있다. 이 논문은 슈퍼컴퓨터 운용 환경을 바탕으로 저전력 프로세서 패키지의 수명을 평가하였다. 먼저 문헌조사, 고장모드 및 치명도 분석을 통해 저전력 프로세서 패키지의 주요 고장원인으로 온도 사이클을 선정하였다. 부하-온도 관계를 확인하기 위해 단계적인 부하를 가하며 프로세서의 온도를 측정하였다. 가장 보수적인 운용조건을 가정하고 온도 사이클에 관련된 고장물리 모델을 이용한 결과 저전력 프로세서 패키지의 기대수명은 약 3년 이하로 예측되었다. 실험 결과를 바탕으로 저전력 프로세서 패키지의 기대수명을 향상하는 방법을 제시하였다.

• Environmental Analysis Health and Toxicology
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• 제30권
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• pp.7.1-7.7
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• 2015

Objectives The widely promising applications of graphene nanomaterials raise considerable concerns regarding their environmental and human health risk assessment. The aim of the current study was to evaluate the toxicity profiling of graphene family nanano-materials (GFNs) in alternative in vitro and in vivo toxicity testing models. Methods The GFNs used in this study are graphene nanoplatelets ([GNPs]-pristine, carboxylate [COOH] and amide [$NH_2$]) and graphene oxides (single layer [SLGO] and few layers [FLGO]). The human bronchial epithelial cells (Beas2B cells) as in vitro system and the nematode Caenorhabditis elegans as in vivo system were used to profile the toxicity response of GFNs. Cytotoxicity assays, colony formation assay for cellular toxicity and reproduction potentiality in C. elegans were used as end points to evaluate the GFNs' toxicity. Results In general, GNPs exhibited higher toxicity than GOs in Beas2B cells, and among the GNPs the order of toxicity was pristine > $NH_2$ > COOH. Although the order of toxicity of the GNPs was maintained in C. elegans reproductive toxicity, but GOs were found to be more toxic in the worms than GNPs. In both systems, SLGO exhibited profoundly greater dose dependency than FLGO. The possible reason of their differential toxicity lay in their distinctive physicochemical characteristics and agglomeration behavior in the exposure media. Conclusions The present study revealed that the toxicity of GFNs is dependent on the graphene nanomaterial's physical forms, surface functionalizations, number of layers, dose, time of exposure and obviously, on the alternative model systems used for toxicity assessment.

• The Korean Journal of Pain
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• 제28권4호
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• pp.244-253
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• 2015

Background: Although circumcision for phimosis in children is a minor surgical procedure, it is followed by pain and carries the risk of increased postoperative anxiety. This study examined predictive factors of postoperative pain and anxiety in children undergoing circumcision. Methods: We conducted a prospective cohort study of children scheduled for elective circumcision. Circumcision was performed applying one of the following surgical techniques: sutureless prepuceplasty (SP), preputial plasty technique (PP), and conventional circumcision (CC). Demographics and base-line clinical characteristics were collected, and assessment of the level of preoperative anxiety was performed. Subsequently, a statistical model was designed in order to examine predictive factors of postoperative pain and postoperative anxiety. Assessment of postoperative pain was performed using the Faces Pain Scale (FPS). The Post Hospitalization Behavior Questionnaire study was used to assess negative behavioral manifestations. Results: A total of 301 children with a mean age of $7.56{\pm}2.61$ years were included in the study. Predictive factors of postoperative pain measured with the FPS included a) the type of surgical technique, b) the absence of siblings, and c) the presence of postoperative complications. Predictive factors of postoperative anxiety included a) the type of surgical technique, b) the level of education of mothers, c) the presence of preoperative anxiety, and d) a history of previous surgery. Conclusions: Although our study was not without its limitations, it expands current knowledge by adding new predictive factors of postoperative pain and postoperative anxiety. Clearly, further randomized controlled studies are needed to confirm its results.

• 환경영향평가
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• 제20권5호
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• pp.747-755
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• 2011

This study was investigated the relationship between the temperature and the mortality of aged (${\geq}65$ yr) during the winter seasons from 1992 to 2007 in Seoul, Korea by utilizing climate data and death records. The study also estimated the future risks by employing the projections of the population in Seoul, Korea and climate change scenario of Korea from 2011 to 2030. The limitation of this study was the impossibility in the prediction of daily mortality counts. Therefore, daily death numbers could be predicted based on the future population projection for Korea and the death records of 2005. The result indicated that risks increased by 0.27%, 0.52%, 0.32% and 0.41% in association with the $1^{\circ}C$ decrease in daily minimum temperature from the mortality counts of total, respiratory, cardiovascular, and cardiorespiratory in the past date while 0.31%, 0.42%, 0.59% and 0.66% in the future. Based on the results obtained from this study, it is concluded that the risk in the future will be higher than the past date although there is an uncertainty in estimating death counts in the future.

• 환경영향평가
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• 제20권2호
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• pp.227-234
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• 2011

In the study, CE-QUAL-W2 was used and its examination and correction were conducted targeting 2001 and 2003 when the condition of rainfall was contradicted. Using the proved model in 2003, a scenario was implemented with management of locations for dewatering outlets and actual data for dam management in 1987 when inflow and outflow level were almost same. In case of the scenario which the location of dewatering outlets was 5m higher than usual location, exclusion efficiency for turbid water inflow at the beginning of precipitation was good. In case of the scenario which the location of dewatering outlets was 10m lower than usual location, exclusion efficiency for excluding turbid water remained in a reservoir after the end of precipitation. However, the scenario applying dam management data in 1987, exclusion efficiency was relatively low. In the scenario, power-generating water release spot at EL.57m for first four days after the beginning of precipitation, EL.52m for 5th to 8th and EL.42m from 9th days. An analysis of the scenario reveals that both excessive days exceeded 30 NTU and average turbidity levels were decreased comparing before and after the alteration on outlets. The average turbidity levels were decreased by minimum of 55% to maximum of 70% and 30NTU exceeding days were decreased by 45 days at maximum. Also, since it could exclude most of turbid water in a reservoir before the destatifcation, the risk for turbid water evenly distributed in a reservoir along with turn-over could be decreased as well.

• Safety and Health at Work
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• 제9권2호
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• pp.133-139
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• 2018

Background: Selecting priority occupational carcinogens is important for cancer prevention efforts; however, standardized selection methods are not available. The objective of this paper was to describe the methods used by CAREX Canada in 2015 to establish priorities for preventing occupational cancer, with a focus on exposure estimation and descriptive profiles. Methods: Four criteria were used in an expert assessment process to guide carcinogen prioritization: (1) the likelihood of presence and/or use in Canadian workplaces; (2) toxicity of the substance (strength of evidence for carcinogenicity and other health effects); (3) feasibility of producing a carcinogen profile and/or an occupational estimate; and (4) special interest from the public/scientific community. Carcinogens were ranked as high, medium or low priority based on specific conditions regarding these criteria, and stakeholder input was incorporated. Priorities were set separately for the creation of new carcinogen profiles and for new occupational exposure estimates. Results: Overall, 246 agents were reviewed for inclusion in the occupational priorities list. For carcinogen profile generation, 103 were prioritized (11 high, 33 medium, and 59 low priority), and 36 carcinogens were deemed priorities for occupational exposure estimation (13 high, 17 medium, and 6 low priority). Conclusion: Prioritizing and ranking occupational carcinogens is required for a variety of purposes, including research, resource allocation at different jurisdictional levels, calculations of occupational cancer burden, and planning of CAREX-type projects in different countries. This paper outlines how this process was achieved in Canada; this may provide a model for other countries and jurisdictions as a part of occupational cancer prevention efforts.