• 생명과학회지
• /
• 제26권10호
• /
• pp.1214-1217
• /
• 2016

Rebamipoide는 위궤양과 위염치료에 쓰이는 위보호제로 임상에서 사용되고 있지만 위암에서의 역할에 대해서는 알려지바가 거의 없다. 헬리코박토 파일로리(Helicobacter pylori)의 주요독성인자인 CagA는 위암의 발생과 관련이 있다. CagA는 위암세포에서 NFκB의 활성을 증가시켜 PLD1 단백질의 발현을 증가시킴으로써 위암세포의 증식과 침윤을 유도한다. Rebamipide는 NFκB의 활성을 억제함으로써 H. pylori의 CagA에 의해 유도되는 PLD1의 발현을 저해하는것으로 규명되었다. 게다가, rebamipide는 H. pylori의 CagA에 의해 유도되는 β-catenin과 그 표적 유전자로서 인 암줄기세포 마커 단백질의 발현을 증가시킴으로써 위암줄기세포의 자가재생능력을 감소시킨다. 또한 rebamipide는 항암제 내성을 극복하는 화학감수성을 증가시켜서 위암생성을 감소시키는 것으로 나타났다. 그래서 rebamipide는 위암치료제로서의 잠재적 효능을 가지고 있는 약물로서의 가능성이 제시되고 있다.

• 인터넷정보학회논문지
• /
• 제22권1호
• /
• pp.89-98
• /
• 2021

지역사회획득폐렴은 만성폐쇄성페질환 환자 사망의 중요 원인 질환이며 폐렴구균은 폐렴의 중요 원인균이다. 폐렴구균에 의한 폐렴을 예방하는 대표적인 방법으로는 폐렴구균백신과 독감백신의 접종을 들 수 있다. 국내 주요 7개 대학병원에서는 전향적, 다기관, 코호트 연구를 통하여 폐렴으로 입원한 만성폐쇄성폐질환 환자를 대상으로 폐렴구균예방접종과 독감예방접종여부에 따라 폐렴의 중증도에 차이가 있는지에 대해 연구하였다. 본 연구의 목적은 다기관 연구자들이 만성폐쇄성폐질환 환자의 데이터를 효과적으로 수집하고 관리하도록 도움을 주는 온라인 등록 시스템을 구축하는 것이다. 본 연구에서는 기존의 오프라인 임상 연구의 단점을 보완하기 위해 정확한 데이터의 입력과 편리한 데이터 완성, 그리고 실시간 데이터 관리 등의 세 가지 기본 전략을 제시하였다. 개발된 온라인 등록 시스템은 다기관 임상 연구에 활용되어 그 성능을 평가받았다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권1호
• /
• pp.495-499
• /
• 2014

Estrogens are considered the major breast cancer risk factor, and the carcinogenic potential of estrogens might be attributed to DNA modification caused by derivatives formed during metabolism. $17{\beta}$-estradiol ($E_2$), the main steroidal estrogen present in women, is metabolized via two major pathways: formation of 2-hydroxyestradiol (2-OH $E_2$) and 4-hydroxyestradiol ($4-OH\;E_2$) through the action of cytochrome P450 (CYP) 1A1 and 1B1, respectively. Previous reports suggested that $2-OH\;E_2$ has putative protective effects, while $4-OH\;E_2$ is genotoxic and has potent carcinogenic activity. Thus, the ratio of $2-OH\;E_2/4-OH\;E_2$ is a critical determinant of the toxicity of $E_2$ in mammary cells. In the present study, we investigated the effects of berberine on the expression profile of the estrogen metabolizing enzymes CYP1A1 and CYP1B1 in breast cancer MCF-7 cells. Berberine treatment produced significant induction of both forms at the level of mRNA expression, but with increased doses produced 16~ to 52~fold greater induction of CYP1A1 mRNA over CYP1B1 mRNA. Furthermore, berberine dramatically increased CYP1A1 protein levels but did not influence CYP1B1 protein levels in MCF-7 cells. In conclusion, we present the first report to show that berberine may provide protection against breast cancer by altering the ratio of CYP1A1/CYP1B1, could redirect $E_2$ metabolism in a more protective pathway in breast cancer MCF-7 cells.

• 한국사회복지학
• /
• 제66권2호
• /
• pp.179-202
• /
• 2014

본 연구는 결혼이주여성의 아동학대 발생위험에 영향을 미치는 요인으로 양육스트레스, 문화적응스트레스, 사회적지지의 구조적관계를 검증하는데 목적이 있다. 선행연구들을 바탕으로 가설모형을 설정한 후, 전국을 표본으로 결혼이주여성 195명에 대한 설문결과를 분석하였다. 분석결과 아동학대에 직접효과를 갖는 변수는 양육스트레스였고, 문화적응스트레스는 양육스트레스를 매개로 간접효과를 갖는 것으로 나타났다. 이와 함께 사회적지지는 아동학대에 영향을 미치는 양육스트레스에 대해 문화적응스트레스를 매개로 간접효과를 갖는 것으로 나타났다. 사회적지지는 아동학대에 직접적인 영향을 미치지 않았으나, 아동학대에 영향을 미치는 위험요인들을 상쇄시키는 보호요인으로 기능하였다. 이와 같은 연구결과에 근거하여 사회복지에 대한 실천적, 정책적 함의를 제안하였다.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권10호
• /
• pp.5965-5972
• /
• 2013

PIN1 is one member of the parvulin PPIase family. By controlling Pro-directed phosphorylation, PIN1 plays an important role in cell transformation and oncogenesis. There are many polymorphisms in the PIN1 gene, including rs2233678 and rs2233679 affecting the PIN1 promoter. Recently, a number of case-control studies were conducted to investigate the association between PIN1 gene rs2233678 and rs2233679 polymorphism and cancer risk. However, published data are still conflicting. In this paper, we summarized data for 5,427 cancer cases and 5,469 controls from 9 studies and attempted to assess the susceptibility of PIN1 gene polymorphism to cancers by a synthetic meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the relationship. All analyses were performed using Stata software. Our results suggested that rs2233678 represented a protective factor in overall analysis (CC vs GG: OR= 0.697, 95%CI: 0.498-0.976; CG vs GG: OR=0.701, 95%CI: 0.572-0.858; Dominant model: OR= 0.707, 95%CI: 0.590-0.847; C allele vs G allele: OR=0.734, 95%CI: 0.623-0.867) and especially for squamous cell carcinoma of the head and neck, lung cancer and breast cancer in Asians and Caucasians. The rs2233679 polymorphism was significantly associated with decreased cancer risk in overall analysis (CT vs CC: OR=0.893, 95%CI=0.812-0.981; Dominant model: OR=0.893, 95%CI=0.816-0.976; T allele vs C allele; OR=0.947, 95%CI=0.896-1.000) and especially in Asians. In conclusion, our meta-analysis suggested that -842G>C (rs2233678) and -667C>T (rs2233679) may contribute to genetic susceptibility for cancer risks. Further prospective research with larger numbers of worldwide participants is warranted to draw comprehensive and firm conclusions.

• Journal of Nutrition and Health
• /
• 제35권3호
• /
• pp.380-393
• /
• 2002

The purpose of this study was to investigate the lift-style and eating behavior of stomach cancer patients in the Daegu and Kyungpook area, and to collect basic data for nutrition education designed to prevent stomach cancer in this community. The subjects of the study were 102 patients who were recently diagnosed as having stomach cancer at the Kyungpook National University Hospital. The control subjects were 105 persons who did not have any gastrointestinal disease, and included patients from the Department of Orthopedic Surgery and healthy volunteers. The survey, which covered the personal characteristics and eating behavior of the subjects, was conducted by individual interviews using questionnaires. It was found that the stomach cancer patients (case group) had experienced a significantly higher level of stress in their daily lives than the control group. A significantly higher proportion of the case group subjects recognized their personality as pessimistic, and had family histories of cancer, compared with the control group subjects. The cancer patients had higher preferences for salty and hot tasting foods, and tended to ingest meals faster without enough chewing, compared with the control subjects. The level of nutritional knowledge of the case group was lower than the control group, and there was a positive correlation between subjects' nutritional knowledge scores and nutritional attitude scores. Subjects' estimates of their food intake frequencies during the decade before the cancer was diagnosed revealed that the case group consumed significantly higher amounts of pickled fish, soybean paste soup and stew, cooked vegetables, beef and pork, charcoal broiled meat and alcohol, while consuming significantly lower amounts of green tea than the control group. In summary, the results of the study suggest that the stress of daily life, a family history of cancer, and a pessimistic personality might be the risk factors for the development of stomach cancer. Dietary factors which were suspected as risk factors for stomach cancer in the present study included strong preferences to salty and hot lasting foods, poor eating habits, and frequent consumption of pickled fish, soybean paste soup, cooked vegetables, beef and pork, charcoal broiled meat and alcohol. A high consumption of green tea seemed to be a protective factor against stomach cancer. The results of the study appear to provide useful data for nutritional education focussed on the prevention on stomach rancor in local residents.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권12호
• /
• pp.6121-6128
• /
• 2012

Radiation-induced side effects on normal tissue are determined largely by the capacity of cells to repair radiation-induced DNA damage. X-ray repair cross-complementing group 1 (XRCC1) plays an important role in the repair of DNA single-strand breaks. Studies have shown conflicting results regarding the association between XRCC1 gene polymorphisms (Arg399Gln, Arg194Trp, -77T>C and Arg280His) and radiation-induced side effects in patients undergoing whole breast radiotherapy. Therefore, we conducted a meta-analysis to determine the predictive value of XRCC1 gene polymorphisms in this regard. Analysis of the 11 eligible studies comprising 2,199 cases showed that carriers of the XRCC1 399 Gln allele had a higher risk of radiation-induced toxicity than those with the 399 ArgArg genotype in studies based on high-quality genotyping methods [Gln vs. ArgArg: OR, 1.85; 95% CI, 1.20-2.86] or in studies with mixed treatment regimens of radiotherapy alone and in combination with chemotherapy [Gln vs. ArgArg: OR, 1.60; 95% CI, 1.09-2.23]. The XRCC1 Arg399Gln variant allele was associated with mixed acute and late adverse reactions when studies on late toxicity only were excluded [Gln allele vs. Arg allele: OR, 1.22; 95% CI, 1.00-1.49]. In contrast, the XRCC1 Arg280His variant allele was protective against radiation-induced toxicity in studies including patients treated by radiotherapy alone [His allele vs. Arg allele: OR, 0.58; 95% CI, 0.35-0.96]. Our results suggest that XRCC1 399Gln and XRCC1 280Arg may be independent predictors of radiation-induced toxicity in post-surgical breast cancer patients, and the selection of genotyping method is an important factor in determining risk factors. No evidence for any predictive value of XRCC1 Arg194Trp and XRCC1 -77T>C was found. So, larger and well-designed studies might be required to further evaluate the predictive value of XRCC1 gene variation on radiation-induced side effects in patients undergoing whole breast radiotherapy.

• 생물치료정신의학
• /
• 제24권3호
• /
• pp.184-193
• /
• 2018

Objectives : This study investigated the effects of social support and chronic medical conditions on depressive symptoms in elderly people living alone in a rural community. Methods : Sociodemographic information on 173 subjects aged 65 years or older who lived alone in a rural community and were recipients of National Basic Livelihood Security was collected and analyzed. All participants completed the Korean Form of the Geriatric Depression Scale and the Lubben Social Network Scale. Additionally, the current prevalence of chronic medical conditions that interfere with the activities of daily living was examined. Multiple logistic regression analysis was conducted to analyze the associations of social support and chronic medical conditions with depressive symptoms. Results : Social support(odds ratio: OR, 0.96; 95% confidence interval: 95% CI, 0.92-0.99) and chronic medical conditions(OR, 1.59; 95% CI, 1.23-2.05) were significantly associated with depressive symptoms in all subjects. When analyzed by gender, social support served as a protective factor against depressive symptoms in elderly men only(OR, 0.91; 95% CI, 0.83-0.99), and chronic medical conditions increased the risk of depressive symptoms in elderly women only(OR, 1.74; 95% CI, 1.26-2.40). Furthermore, osteoarthritis and lumbar pain were risk factors for depressive symptoms in all subjects(OR, 2.24; 95% CI, 1.10-4.56 and OR, 2.10; 95% CI, 1.08-4.12) and in elderly women(OR, 4.07; 95% CI, 1.68-9.84 and OR, 3.34; 95% CI, 1.47-7.57), respectively. Conclusion : This study indicates that improving the social support and managing the chronic medical conditions of elderly people living alone are important for the prevention of depression in this population. Additionally, the present results suggest that it is necessary to establish different depression-prevention strategies for elderly men and women living alone.

• 한국화재소방학회논문지
• /
• 제32권1호
• /
• pp.33-39
• /
• 2018

초고층 건물에서 발생한 화재가 초기 진화에 실패하여 지속적으로 확산되는 경우, 희생자 수를 최소화하기 위한 가장 중요한 일은 건물 내의 인원을 안전하게 건물 밖으로 피난시키는 일이 될 것이다. 최근 초고층 화재로 인한 대규모 인명피해를 경험하면서 이러한 취약점들을 보강하기 위한 조치가 취해졌으나, 개선 사항들이 모두 적용되지 않았고, 적용되었더라도 작동되지 않는 경우를 가정한다면, 최후의 보호막은 효율적인 피난유도가 될 것이 분명하다. 본 연구에서는 기존 화재피난 방법을 조사하고 거주자들이 안전하고 신속하게 피난할 수 있는 방법을 연구하였다. 연구결과에 의하면 화재발생층과 화재위험층에 있는 거주인 들에게 피난 우선권을 주는 순차 피난방법이 적용되어야 하며, 이 들의 피난이 완료되는 시점에서 나머지 층의 인원들에 대한 전체피난이 이루어져야 한다. 화재위험층의 범위는 화재실물시험, 화재 시뮬레이션 등을 통하여 예측하고 결정되며 실제상황이 예측과 달라지는 경우에는 실제 상황에 우선권을 주어야 한다. 이러한 피난방법에 소요되는 피난시간은 피난시뮬레이션을 통해 예측, 비교하였다. 피난시뮬레이션 결과 화재위험층의 순차피난이 건물전체의 동시피난과는 적은 시간차이를 보이면서 피난로의 내화시간 이내에 가능하였으며, 피난용승강기를 사용하는 경우 많은 시간을 단축할 수 있는 것으로 나타났다.

• Journal of Nutrition and Health
• /
• 제56권4호
• /
• pp.361-376
• /
• 2023

본 연구에서는 햄프씨드 오일이 고콜레스테롤혈증을 개선시키는 지 확인하기 위하여 Sprague-Dawley rat에 1.25% 콜레스테롤식이를 8주 동안 급여하였으며, 햄프씨드 오일을 두 농도 (저농도, 고농도)로 경구 투여한 후 혈액, 조직 분석을 통하여 지질개선 및 염증 완화 효과를 발휘하는지 분석하였다. 햄프씨드 오일 식이는AMPK/SREBP-2 경로를 경유하여 혈중 콜레스테롤의 합성을 효과적으로 억제하였으며, PI3IK/Akt/NF-κB의 경로를 유의하게 억제하여 항염증 효과를 발휘함을 알 수 있었다. 이러한 신호전달의 경로는 간 조직에서 지질축적의 감소와도 관련이 있는 것으로 보인다. 이상의 결과를 종합해보면 햄프씨드 오일은 고콜레스테롤혈증의 예방 및 치료를 위한 잠재적 후보소재로서 가능성이 있음을 시사한다.