Browse > Article
http://dx.doi.org/10.7314/APJCP.2013.14.10.5965

Pin1 Promoter rs2233678 and rs2233679 Polymorphisms in Cancer: A Meta-analysis  

Zhu, Yan-Mei (Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, the Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department)
Liu, Jing-Wei (Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, the Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department)
Xu, Qian (Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, the Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department)
Yuan, Yuan (Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Affiliated Hospital of China Medical University, the Key Laboratory of Cancer Etiology and Prevention (China Medical University), Liaoning Provincial Education Department)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.10, 2013 , pp. 5965-5972 More about this Journal
Abstract
PIN1 is one member of the parvulin PPIase family. By controlling Pro-directed phosphorylation, PIN1 plays an important role in cell transformation and oncogenesis. There are many polymorphisms in the PIN1 gene, including rs2233678 and rs2233679 affecting the PIN1 promoter. Recently, a number of case-control studies were conducted to investigate the association between PIN1 gene rs2233678 and rs2233679 polymorphism and cancer risk. However, published data are still conflicting. In this paper, we summarized data for 5,427 cancer cases and 5,469 controls from 9 studies and attempted to assess the susceptibility of PIN1 gene polymorphism to cancers by a synthetic meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated to assess the relationship. All analyses were performed using Stata software. Our results suggested that rs2233678 represented a protective factor in overall analysis (CC vs GG: OR= 0.697, 95%CI: 0.498-0.976; CG vs GG: OR=0.701, 95%CI: 0.572-0.858; Dominant model: OR= 0.707, 95%CI: 0.590-0.847; C allele vs G allele: OR=0.734, 95%CI: 0.623-0.867) and especially for squamous cell carcinoma of the head and neck, lung cancer and breast cancer in Asians and Caucasians. The rs2233679 polymorphism was significantly associated with decreased cancer risk in overall analysis (CT vs CC: OR=0.893, 95%CI=0.812-0.981; Dominant model: OR=0.893, 95%CI=0.816-0.976; T allele vs C allele; OR=0.947, 95%CI=0.896-1.000) and especially in Asians. In conclusion, our meta-analysis suggested that -842G>C (rs2233678) and -667C>T (rs2233679) may contribute to genetic susceptibility for cancer risks. Further prospective research with larger numbers of worldwide participants is warranted to draw comprehensive and firm conclusions.
Keywords
PIN1; single nucleotide polymorphism; cancer; susceptibility; meta-analysis;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Han CH, Lu J, Wei Q, et al (2010). The functional promoter polymorphism (-842G>C) in the PIN1 gene is associated with decreased risk of breast cancer in non-Hispanic white women 55 years and younger. Breast Cancer Res Treat, 122, 243-9.   DOI
2 He J, Zhou F, Shao K, et al (2007). Overexpression of Pin1 in non-small cell lung cancer (NSCLC) and its correlation with lymph node metastases. Lung Cancer, 56, 51-8.   DOI   ScienceOn
3 Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003). Measuring inconsistency in meta-analyses. BMJ, 327, 557-60.   DOI   ScienceOn
4 Lu J, Yang L, Zhao H, et al (2011). The polymorphism and haplotypes of PIN1 gene are associated with the risk of lung cancer in Southern and Eastern Chinese populations. Hum Mutat, 32, 1299-308.   DOI   ScienceOn
5 Lu KP, Zhou XZ (2007). The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease. Nat Rev Mol Cell Biol, 8, 904-16.   DOI   ScienceOn
6 Lu Y, Huang GL, Pu XX, et al (2013). Association between PIN1 promoter polymorphisms and risk of nasopharyngeal carcinoma. Mol Biol Rep, 40, 3777-82.   DOI   ScienceOn
7 Miyashita H, Mori S, Motegi K, et al (2003). Pin1 is overexpressed in oral squamous cell carcinoma and its levels correlate with cyclin D1 overexpression. Oncol Rep, 10, 455-61.
8 Ramsberg J, Asseburg C, Henriksson M (2012). Effectiveness and cost-effectiveness of antidepressants in primary care: a multiple treatment comparison meta-analysis and cost-effectiveness model. PLoS One, 7, e42003.   DOI
9 Molina JD, Lopez-Munoz F, Stein DJ, et al (2009). Borderline personality disorder: a review and reformulation from evolutionary theory. Med Hypotheses, 73, 382-6.   DOI   ScienceOn
10 Naidu R, Har YC, Taib NA (2011). Analysis of peptidyl-propyl-cis/trans isomerase 1 (PIN1) gene -842(G > C) and -667(T> C) polymorphic variants in relation to breast cancer risk and clinico-pathological parameters. Scand J Clin Lab Invest, 71, 500-6.   DOI   ScienceOn
11 Perez-Losada J, Castellanos-Martin A, Mao JH (2011). Cancer evolution and individual susceptibility. Integr Biol (Camb), 3, 316-28.   DOI   ScienceOn
12 Segat L, Milanese M, Crovella S (2007). Pin1 promoter polymorphisms in hepatocellular carcinoma patients. Gastroenterology, 132, 2618-9; author reply 9-20.   DOI   ScienceOn
13 Theuerkorn M, Fischer G, Schiene-Fischer C (2011). Prolyl cis/trans isomerase signalling pathways in cancer. Curr Opin Pharmacol, 11, 281-7.   DOI   ScienceOn
14 Xue H, Lin B, Ni P, et al (2010). Interleukin-1B and interleukin-1 RN polymorphisms and gastric carcinoma risk: a meta-analysis. J Gastroenterol Hepatol, 25, 1604-17.   DOI   ScienceOn
15 You Y, Deng J, Zheng J, et al (2013). Functional polymorphisms in PIN1 promoter and esophageal carcinoma susceptibility in Chinese population. Mol Biol Rep, 40, 829-38.   DOI   ScienceOn
16 Zhao H (2009). Association between polymorphisms in prolyl isomerase Pin1 promoter and risk for lung cancer. . Guangzhou Medical University: [D] Guangzhou.
17 Chung CC, Chanock SJ (2011). Current status of genome-wide association studies in cancer. Hum Genet, 130, 59-78.   DOI
18 Carpenter RW, Tomko RL, Trull TJ, Boomsma DI. (2013). Gene-environment studies and borderline personality disorder: a review. Curr Psychiatry Rep, 15, 336.   DOI
19 Ayala G, Wang D, Wulf G, et al (2003). The prolyl isomerase Pin1 is a novel prognostic marker in human prostate cancer. Cancer Res, 63, 6244-51.
20 Begg CB, Mazumdar M (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics, 50, 1088-101.   DOI   ScienceOn
21 DeYoung CG, Clark R (2012). The gene in its natural habitat: the importance of gene-trait interactions. Dev Psychopathol, 24, 1307-18.   DOI   ScienceOn
22 Dick, DM (2011). Gene-environment interaction in psychological traits and disorders. Annu Rev Clin Psychol, 7, 383-409.   DOI   ScienceOn
23 Egger M, Davey Smith G, Schneider M, Minder C (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-34.   DOI   ScienceOn
24 Euhus DM, Robinson L (2013). Genetic predisposition syndromes and their management. Surg Clin North Am, 93, 341-62.   DOI   ScienceOn
25 Fukuchi M, Fukai Y, Kimura H, et al (2006). Prolyl isomerase Pin1 expression predicts prognosis in patients with esophageal squamous cell carcinoma and correlates with cyclinD1 expression. Int J Oncol, 29, 329-34.
26 Gao LB, Pan XM, Sun H, et al (2010). The association between ATM D1853N polymorphism and breast cancer susceptibility: a meta-analysis. J Exp Clin Cancer Res, 29, 117.   DOI   ScienceOn
27 Liou YC, Zhou XZ, Lu KP (2011). Prolyl isomerase Pin1 as a molecular switch to determine the fate of phosphoproteins. Trends Biochem Sci, 36, 501-14.   DOI   ScienceOn
28 Lu J, Hu Z, Wei S, et al (2009). A novel functional variant (-842G>C) in the PIN1 promoter contributes to decreased risk of squamous cell carcinoma of the head and neck by diminishing the promoter activity. Carcinogenesis, 30, 1717-21.   DOI   ScienceOn
29 Cao WP, Tang HL, Lin P (2012). Association between polymorphisms in prolyl isomerase Pin1 and risk for laryngeal squamous cell carcinoma. Jiangsu Med, 38, 1067-670.