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Effects of Norepinephrine and Neuropeptide Y on the Contractility of Small Mesenteric Artery from 2K1C and DOCA-Salt Hypertensive Rats

  • Nam, Sang-Chae;Kang, Seong-Su;Kim, Won-Jae;Lee, Jong-Un
    • The Korean Journal of Physiology and Pharmacology
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    • v.4 no.1
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    • pp.55-61
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    • 2000
  • The present study was conducted to investigate the possible role of the sympathetic nervous system in two-kidney, one clip (2K1C) and deoxycorticosterone acetate (DOCA)-salt hypertension. 2K1C and DOCA- salt hypertension were made in Sprague-Dawley rats. Four weeks after induction of hypertension, systolic blood pressure measured in conscious state was significantly higher in 2K1C $(216{\pm}18\;mmHg)$ and DOCA-salt $(205{\pm}29\;mmHg)$ groups than that in control $(128{\pm}4\;mmHg).$ The third branches (<300 ${\mu}m$ in outer diameter) of the mesenteric artery were isolated and cut into ring segments of $2{\sim}3$ mm in length. Each ring segment was mounted in tissue bath and connected to a force displacement transducer for measurement of isometric tension. The arterial rings were contracted by application of norepinephrine (NE) in a dose-dependent manner. The amplitude of the NE-induced contraction of the vessels was significantly larger in hypertension than in control. The NE-induced contraction was significantly enhanced by neuropeptide Y (NPY) in hypertension. Reciprocally, NPY-elicited vasocontraction was increased by NE in hypertension. These results suggest that the sympathetic nervous system contributes to the development of 2K1C and DOCA-salt hypertension.

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Study on elemental analysis of metal and ceramic samples by using laser ablation ion trap mass spectrometry(LAITMS) (레이저 이온화 이온트랩 질량분석법을 이용한 금속 및 세라믹 시료의 원소분석에 관한 연구)

  • Song, Kyuseok;Park, Hyunkook;Cha, Hyungki;Lee, Sang Chun
    • Analytical Science and Technology
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    • v.15 no.1
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    • pp.7-14
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    • 2002
  • Laser ablation ion trap mass spectrometry (LAITMS) was developed for the analysis of metal and ceramic samples. For this study, XeCl excimer laser (308 nm) was used for ablating the samples and ITMS was used as a detector. Samples were introduced from outside of a ring electrode and this way of sample introduction was very effective for solid samples when laser ablation was employed. Helium gas was used as a buffer gas, and its effect on sensitivity and some parameters (buffer gas pressure, ion storage time, and cut-off RF voltage) were studied. The optimized conditions were $1{\times}10^{-4}$ Torr of buffer gas pressure, 100 ms of ion storage time and $1150V_{p-p}$ of cut-off RF voltage. From that results, copper (Cu) and molybdenum (Mo) metals were tested with LAITMS and the mass spectra of these pure metals were compared with the natural abundance of isotope ratio. We also examined ceramic samples ($Al_2O_3$, $ZrO_2$) and represented the result of elemental analysis.

Frequency Doubling in LiIO3 Crystals by the Ring Enhancement Cavity (고리형 증폭 공진기에 의한 LiIO3결정에서 제2조화파 발생)

  • Kim, Sang-Gee
    • Journal of Korean Ophthalmic Optics Society
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    • v.4 no.2
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    • pp.45-49
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    • 1999
  • The second harmonic, wavelength is 397nm, of the continuous wave diode laser, whose maximum power is 35mW, was generated in $LiIO_3$ crystals in a ring enhancement cavity. 5mm- and 10mm-long crystals cut $43.21^{\circ}$ for optic axis were used in this experiment. Both surfaces of those were anti-reflection coated for 794nm. In case the crystal was inserted into the cavity, the condition of separation between two concave mirrors for the optimum mode matching was found. The conversion efficiency of second harmonic generation was increased by the resonant enhancement of pumping power in the ring enhancement cavity, and the frequency of diode laser was locked to that of the counter-propagation mode generated from the surface of crystal. When the pumping power was 28 mW, the infrared buildup factor was about 45 without the crystal, and 14 with the crystal due to the transmission loss of crystal. The maximum second harmonic powers of $1.5{\mu}W$ and $6.6{\mu}W$ were obtained, and corresponding conversion efficiencies were $(6.584{\pm}0.56){\times}10^{-3}$%, $2.6{\pm}0.21){\times}10%{-2}$% in 5mm- and 10mm-long $LiIO_3$, respectively.

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Fabrication of a sterling silver ring with folding process (폴딩 기법을 이용한 스털링실버 링 제조 공정)

  • Kim, Ik gyu;Kim, Kwangbae;Kim, Eun-Seok;Song, Ohsung
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.20 no.9
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    • pp.382-389
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    • 2019
  • A novel folding process is proposed using a repeated cold-die forging and annealing to form a sterling silver ring. Sterling silver plate was cut into a doughnut shape, and lattices with 0.43-mm line-width were imprinted on it. The sample was folded by forging using dies with slopes of $45^{\circ}$, $60^{\circ}$, and $75^{\circ}$ and annealing. For comparison, samples were also fabricated without annealing. Strain was identified by measuring the length of lattices. Vernier calipers, a Vickers hardness tester, an optical microscope, and a UV-VIS colorimeter were used to determine the size, hardness, microstructure, and body color. Without annealing, cracks occurred. However, successful deformation was possible when annealing was used. The results of macro strain measurements show that the outer diameter and width decreased, while the inner diameter and thickness increased after the final process. The maximum strain was increased 0.128 toward the parallel direction. The Vickers hardness decreased after annealing and increased after the folding process. The microstructure results showed that the grain size increased after annealing but decreased after folding. The color difference based on the Lab index was under 10 for all processes. Eventually, a doughnut-shaped silver plate was successfully deformed into a ring shape by the folding process.

Nucleophilic Substitution Reactions of Aryl Thiophene-2-carbodithioates with Pyridines in Acetonitrile

  • Oh, Hyuck-Keun;Lee, Jae-Myon
    • Bulletin of the Korean Chemical Society
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    • v.25 no.2
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    • pp.203-206
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    • 2004
  • The kinetics of reactions between Z-aryl thiophene-2-carbodithioates and X-pyridines in acetonitrile at 60.0 $^{\circ}C$ have been investigated. The Bronsted plots obtained for the pyridinolysis of aryl thiophene-2-carbodithioates are curved, with the center of curvature at $pK_a$ ~ 5.2 ($pK_a^{\circ}$). The Bronsted plots for these nucleophilic reactions show a change in slope from a large ( ${\beta}_X{\cong}$0.78-0.87) to a small ( ${\beta}_X{\cong}$0.33-0.35) value, which can be attributed to a change in the rate-determining step from breakdown to formation of a zwitterionic tetrahedral intermediate in the reaction path as the basicity of the pyridine nucleophile increases. A clear-cut change in the crossinteraction constants, ${\rho}_{XZ}$, from +0.92 to -0.23 supports the proposed mechanistic change. The breakpoint at $pK_a$ = 5.2 for R = thiophene ring in the present work is in agreement with those for the pyridinolysis of R = Me and 2-furyl, and attests to the insignificant effects of acyl group, R, on the breakpoint.

Residual Strain Effect on Circumferential Strain on Arterial Cross-Section (동맥 전단부에 분포된 원주 변형율에 대한 잔유 변형율의 영향)

  • 황민철;신정욱
    • Journal of Biomedical Engineering Research
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    • v.16 no.3
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    • pp.325-330
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    • 1995
  • The distribution of circumferential strain of arterial cross-section Is highest at intima and lowest at adventitia. However, the circumferential strain is theoretically severe at Intima because there is strain concentration. The theoretical degree of the intimal strain can not be explained in physiological condition even though artery is physiologically normal. Physiological adaptation may be undertaken to strain concentration. However, it is not clear, yet. Residual strain of artery is eagerly studied. There is experimental evidence that residual strain exists in artery. When ring of artery is longitudinally cut, it is opened. Assumption is made that intimal strain concentration is reduced with the considel'ation of residual strain. This study experimentally attempts to quantify the effect of residual strain on circumferential strain which is determined under the assumption of zero strain with zero pressure.

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Impacts of Trapezoidal Fin of 20-nm Double-Gate FinFET on the Electrical Characteristics of Circuits

  • Ryu, Myunghwan;Kim, Youngmin
    • JSTS:Journal of Semiconductor Technology and Science
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    • v.15 no.4
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    • pp.462-470
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    • 2015
  • In this study, we analyze the impacts of the trapezoidal fin shape of a double-gate FinFET on the electrical characteristics of circuits. The trapezoidal nature of a fin body is generated by varying the angle of the sidewall of the FinFET. A technology computer-aided-design (TCAD) simulation shows that the on-state current increases, and the capacitance becomes larger, as the bottom fin width increases. Several circuit performance metrics for both digital and analog circuits, such as the fan-out 4 (FO4) delay, ring oscillator (RO) frequency, and cut-off frequency, are evaluated with mixed-mode simulations using the 3D TCAD tool. The trapezoidal nature of the FinFET results in different effects on the driving current and gate capacitance. As a result, the propagation delay of an inverter decreases as the angle increases because of the higher on-current, and the FO4 speed and RO frequency increase as the angle increases but decrease for wider angles because of the higher impact on the capacitance rather than the driving strength. Finally, the simulation reveals that the trapezoidal angle range from $10^{\circ}$ to $20^{\circ}$ is a good tradeoff between larger on-current and higher capacitance for an optimum trapezoidal FinFET shape.

흰쥐 기도의 섬모를 이용한 담배의 품질평가 연구

  • 임흥빈;강영국;문자영;손형옥;이영구;이동욱
    • Journal of the Korean Society of Tobacco Science
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    • v.20 no.2
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    • pp.218-224
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    • 1998
  • Long-term exposure of cigarette smoke or air pollutants to human can induce damages in the airway mucociliary function and can be closely related to the irritation and sputum formation in the respiratory system. This study was undertaken to investigate whether rat trachea can be used as a tool for evaluating the cigarette smoke quality. It was identified that, through the examination with inverted microscope, ciliary beating in 1 mm long cut of nat trachea ring was continued for at least 48 hours in saline solution at $25^{\circ}C$. The ciliostasis time in a KCN solution as a positive control was decreased with increasing the concentration of KCN. There were no significant differences in the ciliostasis time by body weight and individual variation of rats. Ciliotoxicity of whole smoke trapped in saline was not significantly changed by aging for more than 6 hrs. The ciliostasis time was in inverse proportion to the number of sample cigarettes applied. As moisture in the cigarette was increased, ciliostasis time was linearly increased. Therefore, these data indicate that the ciliotoxicity test using rat trachea in vitro can be applied to evaluate the cigarette smoke quality and to search factors for the irritation and sputum formation by cigarette smoke as well as air pollutants.

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Studies on the Acoustical Characteristics of Violin Bridges and SDM Simulation (바이올린 브릿지의 음향적 특성 및 SDM 시뮬레이션에 관한 연구)

  • 정우양
    • Journal of the Korea Furniture Society
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    • v.12 no.1
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    • pp.47-55
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    • 2001
  • Violin bridge blank cut from maple wood with good quality has typical pattern of the radial direction in the side edge with minimal dispersion. This experimental study was designed and carried out to examine the effect of the physical and macroscopical characteristics on the compressive creep of violin bridge blank which had been imported from European manufacturer. This research arose from the idea that the maple solid wood with heterogeneous wood density and ray direction in the side edge would have uneven rheological property of violin bridge blank which is supposed to be pressed by the tension of strings. Experimentally, the compressive creep of bridge blank became smaller with the higher density of imported maple wood and showed clear density-dependence for the duration of load under the string tension of 5 kgf. Every bridge blank showed the behavior of primary creep stage(stress stabilization) having logarithmic regression creep curve with high correlation coefficient under the designed stress level. Even though the relationship between compressive creep and ray direction on the side edge of bridge was not so clear contrary to expectation, we could conclude that wood density and ray direction should be the quality decisive factors affecting the acoustical characteristics and performance of the bridge, the core member of violin-family bow instruments.

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Evaluation of Dark Spots Formated on the High Temperature Metal Filter Elements (고온 금속필터 element 표면에 생성된 반점에 대한 평가)

  • Park, Seung-Chul;Hwang, Tae-Won;Moon, Chan-Kook
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.6 no.3
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    • pp.171-178
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    • 2008
  • Metal filter elements were newly introduced to the high temperature filter(HTF) system in the low- and intermediate-level radioactive waste vitrification plant. In order to evaluate the performance of various metal materials as filter media, elements made of AISI 316L, AISI 904L, and Inconel 600 were included to the test set of filter elements. At the visual inspection to the elements performed after completion of each test, a few dark spots were observed on the surface of some elements. Especially they were found much more at the AISI 316L elements than others. To check the dark spots are the corrosion phenomena or not, two kinds of analyses were performed to the tested filter elements. Firstly, the surfaces or the cross sections of filter specimens cut out from both normal area and dark spot area of elements were analyzed by SEM/EDS. The results showed that the dark spots were not evidences of corrosion but the deposition of sodium, sulfur and silica compounds volatilized from waste or molten glass. Secondly, the ring tensile strength were analyzed for the ring-shape filter specimens cut out from each kind of element. The result obtained from the strength tested showed no evidence of corrosion as well. Conclusionally, depending on the two kinds of analysis, no evidences of corrosion were found at the tested metal filter elements. But the dark spots formed on the surface could reduce the effective filtering area and increase the overall pressure drop of HTF system. Thus, continuous heating inside filter housing up to dew point will be required normally. And a few long-period test should be followed for the exact evaluation of corrosion of the metal filter elements.

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