• 대한의생명과학회지
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• 제11권3호
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• pp.355-363
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• 2005

This study aimed to investigate the cerebroprotective effect of vascular endothelial growth factor (VEGF) on permanent focal cerebral ischemia in Sprague-Dawley rats. Right middle cerebral artery (MCA) was occluded for 6 and 24 hours by an intraluminal monofilament technique. An open cranial window was made on the right parietal bone for determination of continuous changes in regional cerebral blood flow (rCBF) by laser-Doppler flowmetry. The infarct size was morphometrically determined using the 2,3,5-triphenyltetrazolium chloride technique. Brain edema was determined by measuring brain water content. In normal rats, rCBF was significantly increased by intravenous infusion of VEGF for 10 minutes. The VEGF-induced increase in rCBF was significantly inhibited by pretreatment with suramin, a heparin-binding growth factor inhibitor as well as $N^{\omega}-nitro-L-arginine$, a nitric oxide synthase inhibitor. In focal cerebral ischemic rats, the amplitude of decrease in rCBF during ischemic period was significantly less in VEGF-treated group, compared with that in vehicle-treated group. The cerebral infarct size was reduced by VEGF in a dose-dependent manner. The brain edema formation was dose-dependently reduced by VEGF in 24-hour MCA occlusion group but not in 6-hour MCA occlusion group. It is suggested that VEGF not only improves the rCBF during cerebral ischemic period but also reduces the brain edema formation, and thereby exert a protective effect on focal cerebral ischemia in rats.

• 한국주거학회논문집
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• 제12권4호
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• pp.105-113
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• 2001

This research indicates to controversial point that store equipments were not applying correct development factor in the each apartment house by that change rate by scale and uniformity of form and inefficiency, effect of discount store is increasing in apartment house and progressed research. The result are as follows; First, interior main point of store of that influence greatly to change rate number of store be. Second, being lot area in jar in outside factor of store. Third, discount store separation appeared by leading person who influence greatly to change rate in middle who is contiguity market singleness residential quarter and contiguity existence of commercial district and nonexistence and discount store separation of only outside right near at hand. Construction of commerce equipment may have to consist in practical apartment house after examine various kinds factor such as store indoor, store outside and only outside while plan practical use of systematic and efficient commerce equipment focusing more in efficient utilization of commerce institution that consist after plan that is not planed commerce equipment focusing in development in plan of commerce equipment in apartment house hereafter accordingly.

• 기본간호학회지
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• 제8권1호
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• pp.95-104
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• 2001

This study was done to develop an euthanasia attitude scale. Subjects who participated in the study were a convenience sample of 234 Korean nurses. Data were collected through a survey over a period of three months. The analysis of the data was done using SPSS PC for descriptive statistics, factor analysis and Cronbach's Coefficient Alpha. Initially 63 items were generated from interview data from eighteen nurses and from a literature review. This preliminary scale was analyzed for a reliability and validity. The results are as follow: 1, Crombach's Coefficient alpha for the 19 items was .8804. 2. Factor analysis was done in order to confirm construct validity and four factor were extracted from the results. These contributed 56.6% of the variance in the total score. 3. Each factor was labled 'qualify of life', 'respect of life, 'client's right', 'medical ethics'. The author suggests that this scale could be used in assessing the attitude of Korean nurses toward euthanasia.

• Molecules and Cells
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• 제43권4호
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• pp.408-418
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• 2020

The sinus node (SN) is located at the apex of the cardiac conduction system, and SN dysfunction (SND)-characterized by electrical remodeling-is generally attributed to idiopathic fibrosis or ischemic injuries in the SN. SND is associated with increased risk of cardiovascular disorders, including syncope, heart failure, and atrial arrhythmias, particularly atrial fibrillation. One of the histological SND hallmarks is degenerative atrial remodeling that is associated with conduction abnormalities and increased right atrial refractoriness. Although SND is frequently accompanied by increased fibrosis in the right atrium (RA), its molecular basis still remains elusive. Therefore, we investigated whether SND can induce significant molecular changes that account for the structural remodeling of RA. Towards this, we employed a rabbit model of experimental SND, and then compared the genome-wide RNA expression profiles in RA between SND-induced rabbits and sham-operated controls to identify the differentially expressed transcripts. The accompanying gene enrichment analysis revealed extensive pro-fibrotic changes within 7 days after the SN ablation, including activation of transforming growth factor-β (TGF-β) signaling and alterations in the levels of extracellular matrix components and their regulators. Importantly, our findings suggest that periostin, a matricellular factor that regulates the development of cardiac tissue, might play a key role in mediating TGF-β-signaling-induced aberrant atrial remodeling. In conclusion, the present study provides valuable information regarding the molecular signatures underlying SND-induced atrial remodeling, and indicates that periostin can be potentially used in the diagnosis of fibroproliferative cardiac dysfunctions.

• Journal of Chest Surgery
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• 제30권6호
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• pp.607-612
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• 1997

저자들은 1964년부터 1994년까지 발살바동 동맥류파열로 진단받고 수술받은 53례를 분석하고 추적조사 하였다. 파열된 발살바동은 우관상 발살바동이 43례(81%)로 가장 많았고 무관상 발살바동이 7례(13%), 다발성이 2례있었다. 우관상동에서 발생한 파열은 대부분 우심실로 유출되었고(81.4%), 무관상 발살바동에서 발생한 것은 대부분 우심방으로 유출되었다(71.4%). 수술방법으로는 대동맥과 유출된 심장챔버 양측을 절 개하는 방법을 주로 사용하였고 41례(77%)에서는 직접봉합을 12례(23%)에서는 청포를 이용하여 봉합하였다. 대동맥판막부전은 26례(49%)에서 동반되었는데 14례에서는 대동맥판 성형술을 10례에서는 대동맥판 치환수술을 하였다. 대동맥판 성형술을 한 14례에서 9년동안 대동맥판쇄부전이 발생하지 않을 빈도는 55%였다. 수술사망은 없었으며 2례에서 만기사망이 발생하여 10년 생존률은 95%였다. 15례에서 만기합병증이 발생하였다. 대동맥판 부전이 5례, 조직판막의 구조적실패가 3례, 발살바동의 재파열이 2례였다. 10년동안 만기합병증이 발생하지 않을 확률은 53%로 비교적 높았고 심내막염 동반이 위험인자로 작용하였다. 결론적 으로 발 移姆옰커\ulcorner\ulcorner외과적 치료는 만족할 만한 단기 및 장기생존율을 보였으나 대동맥판부전 또는 심내 막염과 관련된 경우 만기 합병증 발생률이 높은 것으로 나타나 대동맥판부전이나 심내막염이 동반되었을 때에는 좀 더 세심한 관찰이 요망된다고 생각된다.

• Journal of Korean Neurosurgical Society
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• 제55권2호
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• pp.89-91
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• 2014

Chronic encapsulated intracerebral hematoma (CEIH) is a rare cerebrovascular disease that behaves as a slowly expanding lesion with a gradual onset. It is well established that CEIH is associated with arteriovenous malformations; however, CEIH associated with cavernous malformation (CM) is extremely rare. We herein report a case of CEIH associated with CM, and discuss its pathogenesis. A 12-year-old female was admitted to our hospital because of a one week history of progressive headache and nausea. Brain computed tomography scan and magnetic resonance imaging showed an intracerebral hematoma surrounded by edema in the right frontal lobe. One week later, her headache and nausea worsened, and a brain computed tomography scan revealed the enlargement of hematoma. A right frontal craniotomy was performed. The capsule, mass, and hematoma were totally removed. Histological examination confirmed the diagnosis of CEIH associated with CM. Immunohistochemical analysis revealed increased expression of vascular endothelial growth factor (VEGF) and the VEGF receptor-1 in the endothelium and fibroblasts. Our findings suggest that the activated VEGF pathway might have positively contributed to development of CEIH in the present patient.

• 전기학회논문지
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• 제58권6호
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• pp.1078-1086
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• 2009

This paper presents a Fourier based algorithm for estimating the parameters of the low frequency oscillating modes. The proposed methods estimates various parameters(frequency, damping factor, mode magnitude, phase) by fitting Fourier spectrum and phase with a damped exponential cosine function. Dominant frequency is selected by taking frequency corresponding to the peak spectrum, and damping factor is estimated using the left/right spectra of Fourier spectrum. In addition, mode magnitude is calculated by the normalized peak spectrum, and phase is estimated from spectrum phase. Also, we introduce an accuracy index in order to determine the accuracy of the estimated parameters, and the index is calculated using the deviations of the peak spectrum and the left/right spectra. The parameter estimation methods proposed in this paper include very simple arithmetical processes, so the algorithms are simple and the calculation speed is very fast. The proposed methods are applied to test functions with two dominant modes. The results show that the proposed methods are highly applicable to low frequency parameter estimation.

• Journal of Acupuncture Research
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• 제21권5호
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• pp.101-111
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• 2004

Objective : Assuming that the characteristic of meridian system has been similar to this of electric potentials in human body and that measurements of electric potential at well(井穴) and sea (合穴) points in branches of the twelve meridians(WSBTM) will be representative of measurements of the twelve meridians, to measure the electric potentials of 13 patients with Lumbago due to strain and contusion(좌섬요통<挫閃腰痛>, LSC), to find out the characteristic of meridian system in patients with LSC. Methods : Electric potentials of well and sea points in the meridians in twenty one patients with the pain in the lion diagnosed as LSC were repeatedly measured by physiograph(PowerLab). Measurements of those electrical potentials were analyzed by factor analysis. Results : The electric potentials of WSBTM at the left side were divided into four factors. On the other hand those at the right side Were divided into four factors. Conclusion : In conclusion, their electrical potentials at the left and right side were factors which are different from each side. Thus electrical potentials of well and sea points might be the representative meridian to show their characteristics.

• 대한기계학회논문집
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• 제16권5호
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• pp.983-991
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• 1992

본 연구에서는 정사각형 밀폐공간에서 밑면과 윗면이 각각 고온과 저온부이고 좌측, 우측면일부가 단열이며 우측면 일부는 저온부인 온돌공간으로 가정하였다. 일 사에너지가 우측면 저온부(창)으로 통과된 경우와 통과되지 않는 경우의 표면복사와 자연대류에 관하여 연구하였다.그리고 창에서 일사 에너지가 존재하는 표면복사의 경우는 표면복사와 구별하기 위하여 일사복사로 취급하였다. 표면복사 열전달을 해 석하기 위해서는 Hottel에 의해 고안된후 보안 발전된 정미복사방법(net radiation method)을 이용하여 벽면에서의 정미 복사량을 구하였으며 형상계수(shape factor)를 구하기 위하여 교차선방법(crossed string method)을 이용하였다.

• 무역상무연구
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• 제12권
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• pp.39-64
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• 1999

Under the CISG, there is a unequitable factor in comparing buyer's remedy with seller's remedy. In my opinion, CISG is more unequitable remedy clause than UCC or UNIDROIT principle of International Commercial Contract(1994) between seller and buyer. First, buyer who accepted defect goods must give seller notice the facts that seller delivered defect goods in two years after accepting defect goods. The cap of two year is unreasonable in a position of aggrieved buyer. This is being provided as 'within reasonable time' in UCC and there is no such provision in UNIDROIT Principle. Second, Buyer can avoid contract when seller breached fundamentally contract or seller didn't set a additional performance period about breaching of contract. Accordingly if buyer would not set a additional performance period, although seller's breachment of contract, he could not avoid the contract. Therefore, From a viewpoint of aggrieved buyer avoidable right of contract is restrainted. Third, to compare seller's remedy with buyer's, seller have more opportunity to cure breachment of contract than buyer. Under the CISG buyer is relatively placed at disadvantage in remedy of aggrieved party. In connection with remedy of aggrieved party, 'UNIDROIT principle of international commercial contracts' instead seller and buyer of aggrieved party, so there is not unequitable factor in remedy of aggrieved parties.