• 제목/요약/키워드: rheumatoid factors

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Cytokines, Vascular Endothelial Growth Factors, and PlGF in Autoimmunity: Insights From Rheumatoid Arthritis to Multiple Sclerosis

  • Young eun Lee;Seung-Hyo Lee;Wan-Uk Kim
    • IMMUNE NETWORK
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    • 제24권1호
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    • pp.10.1-10.17
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    • 2024
  • In this review, we will explore the intricate roles of cytokines and vascular endothelial growth factors in autoimmune diseases (ADs), with a particular focus on rheumatoid arthritis (RA) and multiple sclerosis (MS). AD is characterized by self-destructive immune responses due to auto-reactive T lymphocytes and Abs. Among various types of ADs, RA and MS possess inflammation as a central role but in different sites of the patients. Other common aspects among these two ADs are their chronicity and relapsing-remitting symptoms requiring continuous management. First factor inducing these ADs are cytokines, such as IL-6, TNF-α, and IL-17, which play significant roles in the pathogenesis by contributing to inflammation, immune cell activation, and tissue damage. Secondly, vascular endothelial growth factors, including VEGF and angiopoietins, are crucial in promoting angiogenesis and inflammation in these two ADs. Finally, placental growth factor (PlGF), an emerging factor with bi-directional roles in angiogenesis and T cell differentiation, as we introduce as an "angio-lymphokine" is another key factor in ADs. Thus, while angiogenesis recruits more inflammatory cells into the peripheral sites, cytokines secreted by effector cells play critical roles in the pathogenesis of ADs. Various therapeutic interventions targeting these soluble molecules have shown promise in managing autoimmune pathogenic conditions. However, delicate interplay between cytokines, angiogenic factors, and PlGF has more to be studied when considering their complementary role in actual pathogenic conditions. Understanding the complex interactions among these factors provides valuable insights for the development of innovative therapies for RA and MS, offering hope for improved patient outcomes.

관절염 환자의 통증 및 운동 장애성 지각과 관련 요인 (Pain, perceived exercise barriers, and related factors in arthritis patients)

  • 안은정;이태용
    • 한국산학기술학회논문지
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    • 제13권10호
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    • pp.4588-4597
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    • 2012
  • 본 연구는 관절염 환자의 통증 및 운동 장애성 지각과 관련 요인을 파악하기 위하여 대전광역시 C대학병원에 관절염으로 내원하는 환자 중 설문에 동의한 류마티스 관절염 환자군 89명과 골관절염 환자군 51명, 총 140명을 대상으로 2011년 2월부터 9월까지 자가기입식 설문조사를 실시하여 다음과 같은 결과를 얻었다. 모든 환자군의 운동 장애성 지각 정도는 교육수준과 가구총소득(월)이 낮을수록 높았다. 류마티스 환자군의 통증 정도는 주관적 건강 상태가 나쁠수록, 운동 장애성 지각 정도는 관절염 외 다른 질환을 가지고 있는 경우와 주관적 건강 상태가 나쁠수록 높았다. 골관절염 환자군의 통증 정도는 관절염 유병기간이 길수록, 주관적 건강 상태가 나쁠수록 높았다. 모든 환자군의 운동 장애성 지각 정도는 운동단계가 계획 전 단계로 갈수록 높게 나타났다. 다중회귀분석을 실시한 결과 모든 환자군의 통증에 가장 영향력이 큰 변수는 주관적 건강 상태에서 '매우 나쁨'이었다. 다변량 회귀분석에서 운동 장애성 지각에 영향을 주는 변수는 류마티스 환자에서 운동단계, 교육수준이 있었고, 골관절염 환자는 운동단계, 가구총소득(월)이 있었다. 결론적으로 관절염 환자의 통증 및 운동 장애성 지각 정도는 교육수준, 가구총소득(월), 주관적 건강상태, 운동단계 등 여러 변수들과 관련성이 있었으며, 앞으로 운동 프로그램을 개발할 때 이런 변수를 고려할 필요가 있다는 것을 시사해 준다.

류마치스성 관절염 환자의 삶의 질에 대한 구조 모형 (A Structural Model for Quality of Life in Individuals with Rheumatoid Arthritis)

  • 오현수;김영란
    • 대한간호학회지
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    • 제27권3호
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    • pp.614-626
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    • 1997
  • The main purposes of the study were to develop and test a model which explains the dynamic relationship among factors reported as affecting to the quality of life of individuals with rheumatoid arthritis and to examine the relationship between self-help response and quaility of life. Data for the study were collected from March 1996 to December 1996 from 153 female patients who regularly visited a clinic for people with rheumatism. The patients were introduced to the investigators by nurses who worked at that clinic, and then the investigator interviewed the patients for 30 to 40 minutes to collect the data. Instruments used in the study were modified self-report questionaires from the ones which were already developed in previous studies or from related literature. Data analysis were performed using LISREL(Lineal Structural Relations) 8 program to test whether the proposed hypothesized model fit the collected data. To test the fitablity of the hypothesized model both a general fit measure and a detailed fit measure were used. Based on the test results from the various fit measures, the hypothesized model was found to be well suited to the real data. As characteristics related to illness becomes severe, the feasibility for these characteristics leading to the perception of uncertainty about the illness tend to increase, but, the direct effects from the illness characteristics(such as level of physical symptoms, sense of social-psychologic change, limitations of action) as they are related to the other intrinsic variables (self-efficacy or self-help behavior and quality of life), were found to be not significant. It was found that uncertainty had a direct effect on self-efficacy but did not have a direct effect on self-help behavior or quality of life. Also, it is noted that self-efficacy had a positive effect on self-help behavior and quality of life and there was a bilateral relationship between self-efficacy and self-help behavior. Lastly, the hypothesis proposed from the theoretical model in this study was supported basis of the results that self-help behavior provides both direct and positive effects to quality of life. Particularity, since a bilateral relationship was also found between self-help behavior and quality of life in the modified model, as self-help behavior increased, so did quality of life. And, reversely, as quality of life increased, so did self-help behavior. In conclusion, the results of this study suggest that focusing on both acquirement and reinforcement of adjustment factors or self-help behavior is more efficient than focusing on the characteristics of illness in establishing the stategies for improving quality of life of individuals with rheumatoid arthritis.

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침 치료가 류머티즘성 관절염 환자의 혈액학적 지표 및 혈장 내 사이토카인에 미치는 영향 (The effect of acupuncture for changing the levels of erythrocyte sedimentation rate, C-reactive protein and cytokines in the sera of rheumatoid arthritis patients)

  • 김승태;김윤주;이향숙;최선미;인창식;이지영;박히준;이혜정
    • Korean Journal of Acupuncture
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    • 제26권2호
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    • pp.27-38
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    • 2009
  • Objectives: Rheumatoid arthritis (RA) is a chronic autoimmune disease, principally characterized by synovial inflammation of the joints. We previously reported the effect of acupuncture for RA, but the mechanism is still unclear. Various factors such as oxidative stress and angiogenesis were involved in the pathogenesis of RA, and recently, it has also been reported that cytokines also play a major role in RA. Thus, we investigated whether acupuncture could induce any changes in the levels of cytokines including vascular endothelial growth factor (VEGF), angiogenin and epidermal growth factor (EGF) as well as erythrocyte sedimentation rate (ESR), c-reactive protein (CRP), and rheumatoid factor (RF) in the sera of RA patients. Methods: The forty three patients who met the American College of Rheumatology (ACR) criteria for RA recruited. The acupuncture group (n=21) underwent 14 sessions of partially individualized acupuncture treatment for 6 weeks, and the control group had no treatment (n=13) over the same periods. We evaluated ESR, CRP and RF. In addition, to find out the mechanism of acupuncture, we assessed the changes of the cytokine activities using protein cytokine array in the sera of the patients. Results: Acupuncture significantly decreased the levels of ESR and CRP, but RF were not changed after 6-week acupuncture treatments. Moreover, acupuncture reduced the levels of VEGF, angiogenin and EGF in the sera of the patients. Interestingly, they were related with angiogenesis, which is an important process in the pathogenesis of RA. The levels of oncostatin, interleukin(IL)-$1{\alpha}$, IL-8, leptin, monocyte chemotactic protein-1, macrophage-derived chemokine, macrophage inflammatory proteins-1, platelet-derived growth factor BB and RANTES were not changed significantly. Conclusions: The effect of acupuncture for reliving RA symptoms can be partially explained by inhibition of angiogenesis factors in the sera of the RA patients.

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류마티스 관절염 환자의 운동행동 변화단계에 관한 연구 (A Study on the Stages of Exercise Behaviors in Patients with Rheumatoid Arthritis)

  • 박지현;손정태
    • 한국산학기술학회논문지
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    • 제21권12호
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    • pp.331-338
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    • 2020
  • 본 연구는 류마티스 관절염 환자 238명을 대상으로 운동행동 변화단계를 확인하고, 운동행동 변화단계에 따른 운동방해요인, 운동 자기효능감, 지각된 건강상태의 차이를 알아봄으로써 운동 실천을 촉진하고 유지할 수 있는 운동 교육프로그램 개발에 필요한 기초자료를 제공하고자 시행되었다. 연구 결과, 연구 참여자의 운동행동 단계는 무관심단계 23.9%, 관심단계 23.0%, 준비단계 33.2%, 실천단계 5.0%, 유지단계 29.0%이었고, 연구 참여자의 운동행동단계에 따라 운동방해요인, 운동 자기효능감, 지각된 건강상태가 통계적으로 유의한 차이가 있는 것으로 나타났다. 또한 운동방해요인 중 신체적 요인과 인지심리적 요인이 운동행동 변화단계에 유의하게 영향을 미치는 것으로 나타났다. 이를 통해 류마티스 관절염 환자의 운동프로그램을 계획할 때 운동행동단계별로 미리 예상되는 운동방해요인을 파악하고 이를 고려한 계획을 함으로써 운동 중도 포기자를 예측하고 관리하여 지속적인 운동 유지에 도움이 될 것이다. 류마티스 관절염 환자가 운동을 실천하고 지속하도록 하기 위해 간호사는 환자의 운동방해요인을 파악하고 줄이기 위한 중재를 계획하고, 운동에 대한 자기효능감을 증진할 수 있도록 도와주어야 한다.

정통탕(定痛湯)이 콜라젠으로 유도한 관절염 동물 병태 모델에 미치는 효과 (Suppressive Effects of JTT on Collagen-Induced Arthritis in Mice)

  • 조종철;구영선;김동희
    • 동의생리병리학회지
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    • 제21권1호
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    • pp.39-49
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    • 2007
  • Rheumatoid arthritis is an autoimmune disease involving multiple joint. In order to access the suppressive effects of JTT on rheumatoid arthritis and it's effects on immune system we investigated whether JTT could suppress the disease progression of collagen-induced arthritis. DBA/1 mice were immunized with bovine type II collagen. After a second collagen immunization, mice were treated with DW, JTT (200 or 400 mg/kg) or methotrexate (MTX, 30 mg/kg) as a positive control. Oral administration of JTT significantly suppressed the progression of CIA, which extend is comparable to that of MTX. Histological examination reveled that JTT inhibited infiltration of inflammatory cells into affected paw joint and bone erosion and cartilage destruction were greatly reduced compared with control. Total cell number of spleen, lymph node and peripheral blood were significantly reduced. The absolute number of CD19$^+$, CD3$^+$/CD69$^+$, CD4$^+$/CD25$^+$ cell in spleen from JTT treated mice were significantly decreased. The absolute number of CD19$^+$, CD3$^+$, CD3$^+$/CD69$^+$, CD4$^+$, CD4$^+$/CD25$^+$ CD8$^+$, CD49b, CD3/CD49b cells in draining lymph node were significantly increased compared with control. In peripheral blood mononuclear cells of JTT treated mice, the absolute number of CD4$^+$, CD4$^+$/CD25$^+$, CD3$^+$/CD69$^+$ cells were significantly decreased compared with control, while that of CD49b$^+$ was slightly increased. Infiltration of CD3$^+$ cells and CD11b$^+$/Gr-1$^+$ cells into paw joint was significantly reduced in JTT treated mice. The levels of pathologic cytokines including TNF-a and IL-6 in serum were significantly decreased by oral treatment with JTT The levels of IFN-g in the culture supernatant of splenocyte stimulated with CD3$^+$/CD28$^+$ or collagen were dramatically decreased, while the levels of IL-4 was increased under CD3$^+$/CD28$^+$ or collagen stimulation. Rheumatoid factors including IgG, IgM and collagen specific antibody were present much lower in the serum of JTT treated mice than control. Taken together, JTT has suppressive effects on rheumatoid arthritis by modulating immune system, and has potential to use anti-rheumatic arthritic agent in human.

류마티스 관절염.루프스.섬유조직염 환자의 피로 양상 비교 (The Comparison of Fatigue of the Patients with Rheumatoid Arthritis, Lupus, and Fibromyalgia)

  • 이경숙;송경자;이은옥
    • 근관절건강학회지
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    • 제7권1호
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    • pp.131-147
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    • 2000
  • Almost all patients with rheumatic disease experience fatigue. The fatigue affects the patient's life extensively at home and at work, therefore it is necessary to investigate the nature of the fatigue which the patients perceive. The purpose of this study is to explore the nature and pattern of fatigue of the patients with rheumatic diseases. Rheumatoid arthritis is typical disease for its joint involvement which leads to deformity. Whereas lupus is a characteristic systemic autoimmune disease and the fibromyalgia is characterized by the general bodyache and multiple local tenderness. The prevalence of these diseases and the fatigue was known to be higher in women than men. Therefore the subjects were woman patient diagnosed as rheumatoid arthritis, lupus or fibromyalgia, and they were recruited from the H-Rheumatic Disease Hospital. The two instruments, the Multidimensional Assessment of Fatigue by Belza(1995) and the Piper Fatigue Scale by Piper, et al(1995) were used to explore the nature and pattern of self-reported fatigue. In total, the data from 157 patients were analysed by the SPSS-PC program for statistical analysis. The results were as follows: 1. Most patients with rheumatic disease experienced fatigue and the degree of fatigue was at the middle range by the scores of the two instruments. 2. The degree of fatigue of the patients with fibromyalgia was the highest and the next was that of the patients with lupus and the fatigue of the patients with rheumatoid arthritis. But there were no statistically significant differences among the patients with three rheumatic diseases, except the subcategory, the meaning of fatigue of the Piper Fatigue Scale. 3. Even when the period of the symptom and pain were covariated, there were no statistically significant differences among patients with three rheumatic diseases. The fatigue of the patients with lupus and fibromyalgia is rarely investigated in Korea and this study can be the base for the further understanding of the patients with rheumatic diseases. Therefore repeated studies are required to identify the factors to affect the fatigue and to understanding the nature of the diseases and to develop the nursing interventions to alleviate the fatigue.

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오디 분말차 제조 및 생리활성 평가 (The Manufacturing and Physiological Evaluation of Mulberry Fruit Tea)

  • 조미자;김애정
    • 한국식품영양학회지
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    • 제20권2호
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    • pp.173-178
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    • 2007
  • In this study we manufactured mulberry fruit tea(MFT) to be used as an anti-inflammatory agent. Here, MFT was consumed by thirty middle-aged women with symptoms of rheumatoid arthritis for 4 weeks. The anthropometric measurements and serum inflammatory factors were measured before and after consumption of the MFT. For the anthropometric measurements, BMI and body fat decreased after 4 weeks of tea consumption although there were no significant differences. The serum inflammatory factors(uric acid and homocysteine) as well as serum amino transferase activity(aspartate trans-aminase and alanine transaminase) showed a decreasing trend. In addition, serum carbon reactive protein(CRP) decreased significantly decreased after MFT consumption 4 weeks. It's concluded that this MFT is helpful to for rheumatyroid arthritis patients in order to decrease serum inflammatory factors such as CRP.

만성 관절염 환자의 사회적 지지가 우울, 자아존중감에 미치는 영향 (Influence of the Social Support on their Mental Health of the Rheumatoid Arthritis Patients)

  • 이선옥
    • 한국간호교육학회지
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    • 제9권2호
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    • pp.253-263
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    • 2003
  • Rheumatoid arthritis patients not only suffer from the physical damage, but they are afflicted severely mental and psychologic after effects. Their depression and low self-esteem eventually yields serious mental damages, which makes difficult for them to recover. The states of mental health of arthritis patients are diversified depending on the characters and surrounding circumstances, although they may have suffered from the similar condition. Therefore this research was conbucted to the factors that can give positive influences to the patients. In recent time, social support for the arthritis patients has become an important factor that can positively influence their mental health. In other words, social support can act as an important environmental system for arthritis patients to recover their damaged mental health. In order to fulfill this purpose, 118 patients were examined to identify the relationship between the variables. The summary of the result obtained from the research is as follow: 1. The structural aspect of social support for arthritis patients showed the most of them had various social support network size and their highest support system were 'family', 'relative' and 'friends'. The functional aspect of social support for arthritis patients showed moderate degree and their highest sub component was 'approval'. 2. High correlation was found between duration of relationship, similarity, frequency of meeting and functional support. There was no relationship between depression, self-esteem and social support. 3. Therefore this research has suggested that nurses who care rheumatoid arthritis patient consider the above condition to develop self-help group.

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The Protective Effect of Chondroitin from Raja kenojei Cartilage on Collagen-induced Arthritis in DBA/1J Mice

  • Jin, Cheng-Hao;Yang, Ung;Kim, Song-Hee;Ryu, Jae-Won;Lee, Jae-Chang;Lee, Dong-Seok;Lee, Tae-Hoon
    • Food Science and Biotechnology
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    • 제16권4호
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    • pp.594-599
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    • 2007
  • In this study, we evaluated whether the oral administration of chondroitin from the cartilage of Raja kenojei is effective on the progression of rheumatoid arthritis (RA), using collagen-induced arthritic (CIA) mice. Arthritis development was delayed dose-dependently in the chondroitin-treated groups. The pre- and late-treated groups receiving 1,000 mg/kg of chondroitin had clinical scores that were reduced significantly by 56.9 (p<0.05) and 43.3% (p<0.05), respectively, compared to the vehicle-treated groups. Hematoxylin eosin staining and X-ray radiography showed that the chondroitins reduced the infiltration of inflammatory cells and prevented joint destruction of the knee and paw. Reverse transcription-polyerase chain reaction analysis revealed that chondroitin administration inhibited the expressions of tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$), $interlukin-1{\beta}$ ($IL-1{\beta}$), and $interferon-{\gamma}$ ($IFN-{\gamma}$) in joints more than the administration of vehicle. Chondroitin treatment also decreased the production of rheumatoid factors (RF), IgG and IgM, in the serum of CIA mice. These results indicate that chrondroitin administration has a protective effect involving the inhibition of pro-inflammatory cytokine production in CIA mice.