• Journal of The Korean Society of Clinical Toxicology
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• v.13 no.1
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• pp.1-10
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• 2015

Purpose: The purpose of this study was to evaluate the usefulness of intravenous lipid emulsion as well as adverse events in acute poisoning patients. Methods: Literature was accessed through PubMed, EMBASE, Cochrane library, Web of science, and KoreaMed. All forms of literatures relevant to human use of intravenous lipid emulsion for acute poisoning were included. Cases reports or letters without description of clinical outcomes for each case were excluded. The literature search was conducted by two investigators in March, 2015, with publication language restricted to English and Korean. The effect, onset time, and adverse event of lipid emulsion and final outcome of each case were analyzed. Results: Eighty-one published articles were included, excluding articles whose title and abstract were not relevant to this study. No articles were classified as high level of evidence. Sixty-eight case reports were identified, consisting of 25 local anesthetics and 43 other drugs, such as tricyclic antidepressants and calcium channel blockers. Although most cases described significant clinical improvements, some of them showed no beneficial effect or worsening of clinical course. Several adverse events including hyperamylasemia and laboratory interference were reported. Conclusion: Although there were many case reports illustrating successful use of lipid for various drug poisonings, the effect cannot be estimated due to significant possibility of publication bias. Therefore, lipids might be considered in severe hemodynamic instability resulting from lipophilic drug poisoning, however further studies should follow to establish the use of lipid as the standard of care.

• Journal of the Korean Wood Science and Technology
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• v.43 no.1
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• pp.25-35
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• 2015

The goal of this study was to review the visual grading and allowable stress determination methodologies for the domestic softwood. Previous studies used different grading (KFRI 1995-27, KFRI 2000-39, KFRI 2007-3, KFRI 2009-1) and allowable stress determination methodologies (ASTM D 245, KS F 2152, JAS 1990). The results of the visual grading were different by each researcher. Compared to the $1^{st}$ grade proportion from the previous studies using the previous specification on visual grading (KFRI 1995-2007), a higher $1^{st}$ grade proportion was found from the studies using the current specification (KFRI 2009). Compared to the allowable stress values from the small clear sample, the higher allowable stress values from the structural size were found. The results indicated that the strength reduction factor used in small clear sample was too conservative for the different grades. To obtain consistent results for the grade, it is required to have experts in visual grading and authorized organizations. An official standard methodology for the allowable stress value determination needs to be defined for the reliable stress value.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• 2008.11a
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• pp.891-896
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• 2008

Recently our country need to change about hospital building operation and business change. The recent real estate development projects are made in very complex due to the diversity of development method or its legal aspects. Under such a real estate investment, the review of investment yield rate is fundamentally important for the one that invests and the one that finances it. Previously, the focus was in the review of the time to turn the surplus or the plan for making repayment of the borrowings, and without the analysis of sufficient investment yield rate. For a simple issue of finding the most advantageous project method, there is a need for reviewing the taxation issues, fund procurement method, legal aspects, policy analysis aspects and others. Therefore, the real estate investment is now likely to encounter the form of having the time of venture as well. In conclusion, the scientific and reasonable decision making in investing on the real estate does not suggest the absolute evaluation standard but the need and the use are more and more demanded.

• Korean Journal of Clinical Pharmacy
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• v.21 no.4
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• pp.319-331
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• 2011

Purpose: The purpose of this study is to evaluate current criteria for insurance coverage by Health Insurance Review & Assessment Service (HIRA) on the systemic therapy used in the treatment of advanced or metastatic renal cell carcinoma (RCC), by reviewing all available clinical evidences including a variety of clinical practice guidelines. Methods: We searched clinical databases and collected data from published phase 1 through 3 randomized clinical trials on all systemic therapies used in RCC, including novel targeted therapies. Additionally, current clinical practice guidelines on the management of kidney cancer or RCC were reviewed. Based on the collected data we evaluated the appropriateness of the HIRA criteria for insurance coverage on the systemic therapy of RCC whether they are evidence-based and up to date. Results: On the basis of the collected data we concluded that there was a need for a revision in HIRA criteria for systemic therapy of RCC. Despite recent emerging therapeutic advances and changes in therapeutic strategies of management of RCC, some of anticancer regimens were inappropriately listed even though they were not proven to provide efficacy or safety superior to those of other therapies. We thus proposed an updated recommendation based on current clinical evidences. Conclusion: Systemic therapy of RCC is being rapidly changed with the advancement of understanding of the molecular biology of cancer. Consequently newly developed targeted therapies are becoming the standard therapy in the management of medically or surgically unresectable advanced or metastatic RCC. To provide effective and safe therapy to patients with RCC, the criteria for insurance coverage should be made carefully taking into consideration of most up-to-date and high-quality clinical evidences, and should be continuously reviewed so as to reflect evidence-based clinical practice.

• Korean Journal of Construction Engineering and Management
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• v.11 no.1
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• pp.70-78
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• 2010

Recently our country need to change about hospital building operation and business change.The recent real estate development projects are made in very complex due to the diversity of development method or its legal aspects. Under such a real estate investment, the review of investment yield rate is fundamentally important for the one that invests and the one that finances it. Previously, the focus was in the review of the time to turn the surplus or the plan for making repayment of the borrowings, and without the analysis of sufficient investment yield rate. For a simple issue of finding the most advantageous project method, there is a need for reviewing the taxation issues, fund procurement method, legal aspects, policy analysis aspects and others. Therefore, the real estate investment is now likely to encounter the form of having the time of venture as well. In conclusion, the scientific and reasonable decision making in investing on the real estate does not suggest the absolute evaluation standard but the need and the use are more and more demanded.

• Journal of Korean Clinical Nursing Research
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• v.26 no.2
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• pp.240-253
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• 2020

Purpose: This study was conducted to provide basic data for the systematization of 13 areas related to Advanced Practice Nurses (APN). Methods: The three-phase study was conducted as follows. 1) review of APN system and curriculum, 2) Focus Group Interviews (FGI) with 9 APNs, 6 physicians, and 3 nursing professors on the APN system, 3) analysis of clinical practice of the 13 APN areas, and of the accreditation and certification system for APNs, medical board, and medical subspecialty board. Based on the above data, a systematic plan was drawn. Results: The 13 APN areas could be divided into 7 groups based on a review of the APN system and curriculum for the 13 areas. Analysis based on clinical practice showed that the 13 APN areas could be divided into 4 groups. Two themes and seven categories emerged in FGI. The two themes were 1) 13 APN areas that need to be discussed, 2) improving the curriculum for APN. Considering these themes from FGI and the system of the medical subspecialty board, results could be integrated into 2 groups - clinical area and non-clinical area. Conclusion: The 13 APN areas need to be integrated in order to activate the APN system. For that, further discussions on improvements and a standard curriculum according to legislation related to APN should be carried out.

• Journal of Genetic Medicine
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• v.13 no.2
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• pp.59-64
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• 2016

Gaucher disease type 1 (GD1) is an inherited lysosomal storage disorder caused by deficiency of acid ${\beta}$-glucosidase. The diminished enzyme activity leads to the accumulation of substrates and results in multi-systemic manifestations including hepatosplenomegaly, anemia, thrombocytopenia, and bone diseases. Enzyme replacement therapy (ERT) by infusion of recombinant protein has been the standard treatment for over 20 years. Despite the successful long-term treatment with ERT, several unmet needs remain in the treatment of GD1 such as severe pulmonary and skeletal manifestations. Substrate reduction therapy (SRT) reduces the accumulation of substrates by inhibiting their biosynthesis. Eliglustat, a new oral SRT, was approved in United States and Europe as a first-line therapy for treating adult patients with GD1 who have compatible CYP2D6 metabolism phenotypes. Although eliglustat is not yet available in Korea, introduction and summary of this new treatment modality are provided in this paper by review of literatures. Despite the fact that there are only limited studies to draw resolute conclusions, the current data demonstrated that eliglustat is not inferior to ERT in terms of its clinical efficacy. The approval of eligustat enables eligible adult GD1 patients to have the option of oral therapy although it still needs further studies on long-term outcomes. The individual patient should be assessed carefully for the choice of treatment modality when eliglustat becomes available in Korea. Furthermore, the clinical guidelines for Korean patients with GD1 regarding the use of eliglustat needs to be developed in near future.

• Journal of the Korean Institute of Gas
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• v.16 no.4
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• pp.1-7
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• 2012

Systematic safety research by Korea Government has been made to enhance the safety of CNG (compressed natural gas) vehicles since the burst of compressed cylinder of an urban bus in August 9, 2010. This article summarizes some major activities to ensure the safety of CNG vehicles, which covers review of regulation, safety management system including standard of inspection and certification, and training program of inspectors and car mechanics. Specifically, the followings were reviewed; type of CNG cylinder, location of CNG cylinder, material and type of fuel line and vent line, modification of pipeline connection, installation of gas detector, installation of emergency shutdown valve, installation of protecting cover for cylinder, obligations for CNG vehicle filling station. improving periodical inspection, routine test on gas vehicles, training program for engaged in gas vehicles, and designation of safety manager for CNG bus company. This paper suggests how to improve safety of CNG vehicles as a result of review of above mentioned check items.

• Korean Journal of Social Welfare Studies
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• v.49 no.1
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• pp.85-107
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• 2018

The purpose of this research is to review a grandparent visitation case which court decided grandparent visitation rights in 2016 for the first time, to determined how justices interpreted the best interests of the child standard. Based on the critical review of a target case, three categories emerged: parental rights, child's rights, and the developmental environment of child. These categories help to explain how courts influence the social construction of status withing families and child's rights. This research closes the study with implications and suggestions for future social policy.

• Journal of Korea Water Resources Association
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• v.52 no.10
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• pp.657-669
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• 2019

To estimate accurate design quantiles considering statistical characteristics of hydrological data is one of the most important procedures in the design of hydraulic structures. While at-site frequency analysis estimates design quantile using observed data at a site of interest, regional frequency analysis (RFA) utilizes a number of sites included in a hydrologically homogeneous region. Therefore, RFA could provide a more accurate design quantile at ungauged site or sites with short observation period. In this review article, RFA is classified into stationary RFA and nonstationary RFA depending on the characteristic of hydrological data, and the basic concept, procedure, and application of each technique are explained in detail focused on the index flood method. Additionally, a review of the state of the art for RFA procedure is presented. This paper is finalized by describing the stationary regional rainfall frequency analysis over South Korea contained in the amendment of "Standard guidelines for design flood estimation" and various future study topics related to nonstationary RFA.