• Toxicological Research
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• v.31 no.2
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• pp.137-149
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• 2015

Human hepatocytes, with complete hepatic metabolizing enzymes, transporters and cofactors, represent the gold standard for in vitro evaluation of drug metabolism, drug-drug interactions, and hepatotoxicity. Successful cryopreservation of human hepatocytes enables this experimental system to be used routinely. The use of human hepatocytes to evaluate two major adverse drug properties: drug-drug interactions and hepatotoxicity, are summarized in this review. The application of human hepatocytes in metabolism-based drug-drug interaction includes metabolite profiling, pathway identification, P450 inhibition, P450 induction, and uptake and efflux transporter inhibition. The application of human hepatocytes in toxicity evaluation includes in vitro hepatotoxicity and metabolism-based drug toxicity determination. A novel system, the Integrated Discrete Multiple Organ Co-culture (IdMOC) which allows the evaluation of nonhepatic toxicity in the presence of hepatic metabolism, is described.

• Journal of Korean Physical Therapy Science
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• v.10 no.1
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• pp.212-221
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• 2003

To observe the anatomical structures which cause a cervicogenic headache it reports, from viewpoint of physical therapist in treatment multiple to observe method which approaches, the reporter it does. With the manipulation the vertebral manipulation effected an affirmative effect to cervicogenic headache(Niels Nilsson et al,1997). The manipulation, soft the tissue massage, postural education/advice, muscular elongation, the traction, and postural exercises initially came to be used with that technique which the upper cervical vertebra(0-C3) passive accessory intervertebral movement comes to be used with a cervicogenic headache treatment technique(Grant T & Niere K., 2000). Also, it relates with the diagnosis standard about a cervicogenic headache when the body function over of the cervical vertebra is discovered, the Muscle energy technique was proposed in the treatment which is safety and effect(Bogduk N,2001). The TENS and the Mange gave a reduction effect of pain often.

• Environmental and Resource Economics Review
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• v.16 no.3
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• pp.629-641
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• 2007

Chinese government has implemented the West Development Strategy since 1999 to boost the region's growth and prevent the environmental degradation. Until now, the regional economy and living standard in Western China have been greatly improved, while it also indicated by the State Council that the ecological environment still deteriorated with part improvement, and pressure of water shortage increased. The paper focus on the relationship of GDP per capita and the volume of industrial waste water discharge of all the 12 provinces in Western China from 1989 to 2004, by the expanded EKC model in the cubic form. Results show that they mainly have down trend in the whole sample space but small up trend in the recent years. That means controlling of industrial wastewater discharge is still an important task to be insisted in the Western China.

• Journal of the Society of Disaster Information
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• v.6 no.2
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• pp.45-65
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• 2010

There has been tighten up the need of seismic retrofit about 31 public facilites since published "Korean Earthquake Damage Prevention Law". Therefore, seismic studies have been developed and enforced the studies. Measuring dynamic stiffness of subsurface materials influence on seismic performance evaluation to build up seismic retrofit. The soil dynamic properties for seismic performance evaluation are N-value from using SPT(standard penetration test), dynamic shear elastic modulus and dynamic deformation modulus using laboratory tests. The most unscientific element in ground dynamic properties involved uncertainties is obviously N-value using SPT. This study shows that effect of N-value included natural and artificial uncertainties to seismic performance evaluation of ground structures is not only approached probabilistic analysis using FOSM method and tornado diagram, but also review how to spread effect of seismic performance evaluation of ground structures.

• Reproductive and Developmental Biology
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• v.36 no.1
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• pp.79-85
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• 2012

Minipigs are regarded as one of the most important laboratory animal in that anatomical and physiological properties are similar to human and their reproduction efficiency is relatively higher compared to other large animal species. Particularly, several diseases that cannot be mimicked in rodent models are successfully occurred or induced in pig models therefore it has been interested in a valuable model for human diseases. Pigs are also 'standard' species in xenotransplantation research. To maximize experimental outcome using minipigs, establishment and management of proper animal facility, right animal husbandry and control of pathogens are very important. In this review, we summarized several international guidelines related with minipigs published by several companies or governments and discuss optimal conditions for providing informative ideas to the researchers who want to use minipigs in their future studies.

• Clinics in Shoulder and Elbow
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• v.23 no.3
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• pp.159-165
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• 2020

Acromioclavicular (AC) joint dislocations account for about 9% of shoulder injuries. Among them, acute high-grade injury following high-energy trauma accounts for a large proportion of patients requiring surgical treatment. However, there is no gold standard procedure for operative treatment of acute high-grade AC joint injury, and several different procedures have been used for this purpose in clinical practice. This review article summarizes the most recent and relevant surgical options for acute high-grade AC joint dislocation patients and the outcomes of each treatment type.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2018.05a
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• pp.56-57
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• 2018

This study is a fundamental consideration for using CGS from the IGCC as a fine aggregate for concrete. For the review, the physical properties and hazardous materials content of KS F 2527 were considered. The results showed that KS F 2527 standard was generally satisfied, making it possible to confirm the possibility that it is a fine metal considering its physical properties and hazardous materials content characteristics.

• Asian review of World Histories
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• v.1 no.1
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• pp.117-149
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• 2013

The purpose of this essay is threefold. First, to highlight research of Seonmin KIM, whose 2006 Ph.D. dissertation elucidates complex relationships among Ming China, Choson Korea, Tokugawa Japan, and mountainous ginseng-producing "borderlands" between Korea and China; her story concludes with the remarkable rise of a borderlands power that overthrew Ming China, there-by establishing dominance that lasted into the $20^{th}$ century - the Qing Dynasty. A second purpose is to showcase application of a non-standard-model - the Hydraulic Metaphor - that elucidates economic components of Professor KIM's history via visual and intuitive mechanisms designed to be understandable for non-specialists. Last, an outline of East Asian history is placed within context of centuries of monetary evolution that eventually yielded the late-$16^{th}$-century birth of globalization.

• 유체기계공업학회:학술대회논문집
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• 2004.12a
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• pp.189-192
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• 2004

Utilizing pump selection softwares is becoming a new general trend in pump industries, substituting the old fashioned pump catalogs. One of the most powerful pump selection softwares is developed, which features pump performance viscosity correction function as well as pump selection based on the exact pump performance curves, NPSH warning, automatic determination of impeller diameter cutting to meet the customer's performance specification, performance simulation for the rpm and diameter variation, standard motor recommendation according to the motor standards and enclosure types and automatic pump datasheet generation for sales submission, automatic pump drawings and dimension generation for installation check and part preparation. This software provides pump distributors and customers with a quick, easy and exact pump selection, various performance curves review (system curves, performance curve of series or parallel operation) of the selected pumps.

• Korean Journal of Bronchoesophagology
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• v.9 no.2
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• pp.69-73
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• 2003

Various flaps are using for reconstruction of esophageal defect. The choice of reconstruction is depended to the oncologic needs of the situation. If the entire esophagus or significant part of the thoracic esophagus is involved by tumor, then total esophagectomy and gastric pull-up or colon transposition is indicated. But for most hypopharyngeal tumors, laryngopharyngeal tumors, and cervical esophageal tumors, segmental resection of these area and replacement with a jejunal fee or forearm free flap has become the standard technique. The authors have experienced a case of total pharyngo-laryngo-esophago-gastrectomy and colon transposition in a patient of esophageal cancer following partial esophagectomy and gastic pull-up due to corrosive esophageal stricture. We report this case with brief review of the literatures.