• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2002년도 International Meeting on Information Display
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• pp.1009-1011
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• 2002

We developed a Retinal Projection Display for a low vision aid. This device can be applied to a low vision whose visual sense is weak. In the device, a digital image was formed with spatial light modulator(SLM) and projected onto a retina with the Maxwellian View. The image on this display can be seen clearly without our ocular accommodation and a low vision can see it without correction of a refraction error.

• 한국생명과학회:학술대회논문집
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• 한국생명과학회 2007년도 제48회 학술심포지움 및 추계국제학술대회
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• pp.71.1-71.1
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• 2007

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• 전기의세계
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• 제26권4호
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• pp.54-60
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• 1977

The feedback sources of oculomotor control system consist of three types of feedback path originating from retinal image displacement, in the proprioceptive fibers of the extraocular muscles, in the efference copy within the C.N.S. From above feedback loops, the retinal image feedback path is a main subject in this experiment. The electrical output of eye ball motion detecting with a photo-electric matrix method is fed into galvanometer through the external feedback path, and the stability was also examined.

• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2004년도 Asia Display / IMID 04
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• pp.442-445
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• 2004

We report principles and results of design large FOV retinal display systems by software WinDEMOS and software for computer testing display systems TEDiS. We discuss results design head mounted and head up display. As combiner we are used volume interference recorded or synthetic HOE, and as the sours of the image high resolution transmitting or reflective liquid crystal matrixes on silicon (LCOS) or CRT.

• 수산해양기술연구
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• 제31권4호
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• pp.379-384
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• 1995

위협광에 의한 어류의 행동제어개발을 위하여, 스트로보광에 대한 전갱이와 잉어의 명순응과정을 조사하였는데, 스트로브광의 섬광빈도는 전갱이의 경우, 1.7, 5, 10, 25, 430Hz의 5단계, 잉어의 경우는 1.7, 5, 25Hz의 3단계로 하였다. 안구표본의 채취는 조사전과 조사직후부터 1, 5, 10, 30분 경과마다 행하였고, 채취한 각 표본은 종단조직절편을 만들고 현미경 관찰을 행하였다. 망막의 순응율은 원추체지수를 구하여 나타내었다. 조사시간에 따른 평균 순응율은; \circled1 전갱이의 경우, 광조사전의 27%가 1, 5, 10, 30분 경과 시마다 각각 42.6%, 49.8%, 59.8%, 83.1%로 증가하였다. \circled2 잉어의 경우, 광조사전의 28.4%가 1, 5, 30분 경과 시마다 각각 51%, 54.9%, 91.3%로 되었다. 명순응과정은; \circled1 전갱이의 경우 430Hz, 25Hz, 5Hz, 1.7Hz, 10Hz의 순으로, \circled2 잉어의 경우는 25Hz, 5Hz, 1.7Hz의 순으로 대략 빨랐다.

• Journal of Photoscience
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• 제7권3호
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• pp.115-121
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• 2000

Although there are high concentrations of zinc and taurine in ocular tissue, their exact role and correlation in the visual process are not clear. The purpose of present study was to clarity this point using electroretinogram (ERG) recording and spectrophotometer measurements before and after zinc and taurine treatment in bullfrog's eye. The optimal zinc concentration used in this study was 10$^{-2}$ M ZnCl$_2$120 ${mu}ell$/12$m\ell$ ringer solution while the optimal turine concentration was 10$^{-2}$ M taurine 12${mu}ell$/12$m\ell$ ringer solution. For the effects of zinc and taurine on the retinal function, the changes of ERG parameters (especially threshold and b-wave) and absorption spectra were observed before and after treatment. It is noteworthy that high concentrations of zinc and taurine present in the retinal pigment epithelium and the retina. Our results indicate that dark-adapted ERG threshold became elevated and the peak amplitude of b-wave was increased with zinc and taurine treatment. Furthermore there are some synergism effects between zinc and taurine as a result of co-treatment. In spectral scan, absorbance increment due to zinc and taurine treatment was shown over the whole range of spectral range (300-750 nm) with some differences in absorbance increment depending on the case of treatment. As the results of above we believe that zinc and taurine, which are abundant in the retinal pigment epithelium and the retina particularly, may be essential factors for visual process, have some synergism with each other and be required to improve the visual sensitivity during visual adaptation.

• Journal of Ginseng Research
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• 제34권3호
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• pp.237-245
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• 2010

The purpose of this study was to evaluate the effect of Korean red ginseng (KRG) on ocular blood flow in patients with glaucoma. In a prospective, randomized, placebo-controlled, double-masked crossover trial, 36 patients with open-angle glaucoma were consecutively recruited. Subjects were randomly assigned into two groups. Group A received 1.5 g KRG, administered orally three times daily for 12 weeks, followed by a wash-out period of 8 weeks and 12 weeks of placebo treatment (identical capsules filled with 1.5 g corn starch). Group B underwent the same regimen, but took the placebo first and then KRG. Blood pressure, heart rate, and intraocular pressure were measured at baseline and at the end of each phase of the study. Visual field examination and ocular blood flow measurements by the Heidelberg Retina Flowmeter were performed at baseline and at the end of each phase of the study. Changes in blood pressure, heart rate, intraocular pressure, visual field indices, and retinal peripapillary blood flow were evaluated. Blood pressure, heart rate, intraocular pressure, and visual field indices did not change after placebo or KRG treatment. After KRG treatment, retinal peripapillary blood flow in the temporal peripapillary region significantly improved (p=0.005). No significant changes were found in retinal peripapillary blood flow in either the rim region or the nasal peripapillary region (p=0.051 and 0.278, respectively). KRG ingestion appears to improve retinal peripapillary blood flow in patients with open-angle glaucoma. These results imply that KRG ingestion might be helpful for glaucoma management.

• 한국광학회지
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• 제17권2호
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• pp.113-119
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• 2006

망막검사를 위한 검안경용 망막 카메라를 개발하기 위한 광학계 설계를 연구하였다. 이에 앞서 사람의 눈에 대한 광학계 제원은 김상기와 박성찬이 발표한 정밀모형안을 채택하였다. 이를 토대로 하여 광학계를 4개의 렌즈 군으로 구성하였고 제 1군으로 모든 시야각에 대한 광을 중심으로 모았다가 제2, 제3, 제4군에 의해 결상하도록 하였다. 결상된 망막의 상은 CCD 광검출기에 의해 모니터로 전시한다. 제 1군을 단일 렌즈로 하고 나머지 광학계를 triplet로 하여 최적화를 통해 설계하였다. 광선수차, spot diagram, 회절을 고려한 point spread function 및 MTF를 계산하여 분석한 결과, 좋은 성능을 가진 광학계 설계가 가능하였다. 본 연구 결과에서 얻은 광학계로서 양질의 망막 카메라를 개발할 순 있을 것으로 믿는다.

• Journal of Korean Medical Science
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• 제33권43호
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• pp.239.1-239.12
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• 2018

Background: We described a novel multi-step retinal fundus image reading system for providing high-quality large data for machine learning algorithms, and assessed the grader variability in the large-scale dataset generated with this system. Methods: A 5-step retinal fundus image reading tool was developed that rates image quality, presence of abnormality, findings with location information, diagnoses, and clinical significance. Each image was evaluated by 3 different graders. Agreements among graders for each decision were evaluated. Results: The 234,242 readings of 79,458 images were collected from 55 licensed ophthalmologists during 6 months. The 34,364 images were graded as abnormal by at-least one rater. Of these, all three raters agreed in 46.6% in abnormality, while 69.9% of the images were rated as abnormal by two or more raters. Agreement rate of at-least two raters on a certain finding was 26.7%-65.2%, and complete agreement rate of all-three raters was 5.7%-43.3%. As for diagnoses, agreement of at-least two raters was 35.6%-65.6%, and complete agreement rate was 11.0%-40.0%. Agreement of findings and diagnoses were higher when restricted to images with prior complete agreement on abnormality. Retinal/glaucoma specialists showed higher agreements on findings and diagnoses of their corresponding subspecialties. Conclusion: This novel reading tool for retinal fundus images generated a large-scale dataset with high level of information, which can be utilized in future development of machine learning-based algorithms for automated identification of abnormal conditions and clinical decision supporting system. These results emphasize the importance of addressing grader variability in algorithm developments.

• Korean Journal of Ophthalmology
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• 제32권6호
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• pp.459-469
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• 2018

Purpose: To evaluate changes in the peripapillary retinal nerve fiber layer (RNFL) thicknesses using spectral-domain optical coherence tomography (SD-OCT) in hydroxychloroquine (HCQ) users. Methods: The medical records of HCQ users were retrospectively reviewed. In these HCQ users, an automated perimetry, fundus autofluorescence photography, and SD-OCT with peripapillary RNFL thickness measurements were performed. The peripapillary RNFL thicknesses were compared between the HCQ users and the control groups. The relationships between the RNFL thicknesses and the duration or cumulative dosage of HCQ use were analyzed. Results: This study included 77 HCQ users and 20 normal controls. The mean duration of HCQ usage was $63.6{\pm}38.4$ months, and the cumulative dose of HCQ was $528.1{\pm}3.44g$. Six patients developed HCQ retinopathy. Global and six sectoral RNFL thicknesses of the HCQ users did not significantly decrease compared to those of the normal controls. No significant correlation was found between the RNFL thickness and the duration of use or cumulative dose. The eyes of those with HCQ retinopathy had temporal peripapillary RNFL thicknesses significantly greater than that of normal controls. Conclusions: The peripapillary RNFL thicknesses did not change in the HCQ users and did not correlate with the duration of HCQ use or cumulative doses of HCQ. RNFL thickness is not a useful biomarker for the early detection of HCQ retinal toxicity.