• Journal of Korean Society of Steel Construction
• /
• v.27 no.3
• /
• pp.289-298
• /
• 2015

The steel tube of Concrete-Filled Tube(CFT) confines the concrete and the concrete restrains the buckling of the tube, The objective of this study is to investigate the influences of the opening shape of the through diaphragm in case of the rectangular CFT column-to-beam connection through the structural experiment. The experiment results are compared with analysis results obtained by using the FEM program. These results are shown that strength of the rectangular CFT column-to-beam connection have similar structural performance regardless of the opening shape if opening areas of the through diaphragm are same. Also in case the connection area/shape of the through diaphragm and the flange of H-beam are similar, it was ascertained that the bending stress occurred at the beam can be transferred to the column through the diaphragm.

• BMB Reports
• /
• v.50 no.1
• /
• pp.1-2
• /
• 2017

Acquiring a selective growth advantage by breaking the proliferation barrier established by gatekeeper genes is a centrally important event in tumor formation. Removal of the mammalian Hippo kinase Mst1 and Mst2 in hepatocytes leads to rapid hepatocellular carcinoma (HCC) formation, indicating that the Hippo signaling pathway is a critical gatekeeper that restrains abnormal growth in hepatocytes. By rigorous genetic approaches, we identified an interacting network of the Hippo, Wnt/${\beta}$-catenin and Notch signaling pathways that control organ size and HCC development. We found that in hepatocytes, the loss of Mst1/2 leads to the activation of Notch signaling, which forms a positive feedback loop with Yap/Taz (transcription factors controlled by Mst1/2). This positive feedback loop results in severe liver enlargement and rapid HCC formation. Blocking the Yap/Taz-Notch positive feedback loop by Notch inhibition in vivo significantly reduced the Yap/Taz activities, hepatocyte proliferation and tumor formation. Furthermore, we uncovered a surprising inhibitory role of Wnt/${\beta}$-catenin signaling to Yap/Taz activities, which are important in tumor initiation. Genetic removal of ${\beta}$-catenin in the liver of the Mst1/2 mutants significantly accelerates tumoriogenesis. Therefore, Wnt/${\beta}$-catenin signaling, known for its oncogenic property, exerts an unexpected function in restricting Yap/Taz and Notch activities in HCC initiation. The molecular interplay between the three signaling pathways identified in our study provides new insights in developing novel therapeutic strategies to treat liver tumors.

• Journal of Korean Society of Steel Construction
• /
• v.13 no.6
• /
• pp.693-702
• /
• 2001

Ductility pipes, like corrugated steel structures, are expected to reduce its deformation when they are arranged in a row. Verifying this assumption can help make economic designs possible. Though checking the deformation of ductility pipe structures, like corrugated steel structure, decreasing deformation was found when the pipes are arranged in a row. In this way, arranging a corrugated steel structures in a row shows decreased deformation compared to corrugated steel pipes arranged in a single structure because the bedding effect restrains deformation. The deformation rates of reduction are proportionate to the diameter of the corrugated steel structure.

• The Journal of Internal Korean Medicine
• /
• v.24 no.1
• /
• pp.104-112
• /
• 2003

Objectives : The purpose of this study is to evaluate the effects of Sohaphyang-won and is to study the mechanism for neuronal death protection in hypoxia with Embryonic day 20(E20) cortical cells of a guinea pig(Sprague Dawley). Methods : E20 cortical cells, used in this investigation were dissociated in Neurobasal media and grown for 14 days in vitro (DIV). On 14 DIV, Sohaphyang-won was added to the culture media for 72 hours. On 17 DIV, cells were given a hypoxic shock and further incubated in normoxia for another three days. On 20 DIV, Sohaphyang-won's effects for neuronal death protection were evaluated by LDH assay and the mechanism was studied by Bcl-2, Bak, Bax, caspase family. Results : This study indicates that Sohaphyang-won's effects for neuronal death protection in hypoxia is confirmed by LDH assay by the method of Embryonic day 20(E20) cortical neuroblast. Conclusions : Sohaphyang-won's mechanism for neuronal death protection in hypoxia restrains inflow of cytochrome C into cellularity caused by Bcl-2 increase and reduces the caspase cascade initiator caspase-10 and the effector caspase-3.

• Health Policy and Management
• /
• v.8 no.2
• /
• pp.191-215
• /
• 1998

This descriptive correlational study was done to identify ICU nurses' intention to use restraints and related factors using Ajzen and Madden(1986)'s Theory of Planned Behavior. Self-reported questionnaires were used to measure intention and related factors. The subjects of this study were 287 ICU nurses in 21 general hospitals with at least 200 beds at Taegu, Pusan and Kyungbuk area in Korea. The results of this study were : 1. There were significant differences in intention according to age and marnital status, attitude according to educastion(with indirect measure), subjective norm according to career in ICU(with both measures), perceived behavioral control according to age and career in ICU(with direct measure), and knowledge according to education and position. 2. There were significant correlations among intention and all factors. Intention was correlated with attitude(r=.2119), subjective norm(r=.1112), and perceived behavioral control(r=.3448) with direct measure. Attitude was correlated with subjective norm(r=.2530), perceived behavioral control(r=.3005), and knowledge(r=.1388) with direct measure. Subjective norm was correlated with perceived behavioral control(r=.1321) with direct measure. Intention was correlated with attitude(r=.1496) and perceived behavioral control(r=.2922) with indirect measure. Attitude was correlated with subjectivenorm(r=.2829) and knowledge(r=-.1390) with indirect measure. Also, subjective norm was correlated with perceived behavioral control(r=.2363) with indirect measure. 3. ICU nurses' intention to use restraints was explained 16.7% by perceived behavioral control, attitude with direct measure, control belief, and age. By this study, it was foundr that ICU nurses reported high level of intention to use restraints. The most important predictor of intention to use restraints was perceived behavioral control toward using restrains, which reflected the easiness and difficulty in the use of restraints.

• Journal of Korean Society of Coastal and Ocean Engineers
• /
• v.12 no.4
• /
• pp.203-209
• /
• 2000

Mokpo coastal zone suffers from increase of tidal amplitude by the reclamation projects of Youngsan River Scadike, Youngam and Keumho Seawalls, resulting inundation oflower lands. Tidal records at Mokpo harbor show jumps just after each construction not only in the mcan high water level but also in extreme one. Thus the design water levels must be newly estimated by a frequency analysis with the data of period after the last construction. But this period is at most 6 years yet, which restrains the normal frequency analysis. In this paper, new approach of converting the past data to the present one by a numerical model is proposed. Converted 32 years and observed 6 years data enables normal frequency analysis.

• Nutrition Research and Practice
• /
• v.11 no.2
• /
• pp.90-96
• /
• 2017

BACKGROUND/OBJECTIVES: Although the antioxidative effects of lycopene are generally known, the molecular mechanisms underlying the anti-inflammatory properties of lycopene are not fully elucidated. This study aimed to examine the role and mechanism of lycopene as an inhibitor of inflammation. METHODS/MATERIALS: Lipopolysaccharide (LPS)-stimulated SW 480 human colorectal cancer cells were treated with 0, 10, 20, and $30{\mu}M$ lycopene. The MTT assay was performed to determine the effects of lycopene on cell proliferation. Western blotting was performed to observe the expression of inflammation-related proteins, including nuclear factor-kappa B ($NF-{\kappa}B$), inhibitor kappa B ($I{\kappa}B$), mitogen-activated protein kinase (MAPK), extracellular signal-related kinase (ERK), c-jun NH2-terminal kinase (JNK), and p38 (p38 MAP kinase). Real-time polymerase chain reaction was performed to investigate the mRNA expression of tumor necrosis factor ${\alpha}$ ($TNF-{\alpha}$), interleukin-1 beta ($IL-1{\beta}$), interleukin-6 (IL-6), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). Concentrations of nitric oxide (NO) and prostaglandin $E_2$ ($PGE_2$) were determined via enzyme-linked immunosorbent assays. RESULTS: In cells treated with lycopene and LPS, the mRNA expression of $TNF-{\alpha}$, $IL-1{\beta}$, IL-6, iNOS, and COX-2 were decreased significantly in a dose-dependent manner (P < 0.05). The concentrations of $PGE_2$ and NO decreased according to the lycopene concentration (P < 0.05). The protein expressions of $NF-{\kappa}B$ and JNK were decreased significantly according to lycopene concertation (P < 0.05). CONCLUSIONS: Lycopene restrains $NF-{\kappa}B$ and JNK activation, which causes inflammation, and suppresses the expression of $TNF-{\alpha}$, $IL-1{\beta}$, IL-6, COX-2, and iNOS in SW480 human colorectal cancer cells.

• KSII Transactions on Internet and Information Systems (TIIS)
• /
• v.8 no.11
• /
• pp.3916-3936
• /
• 2014

Smartphone applications like games, image processing, e-commerce and social networking are gaining exponential growth, with the ubiquity of cellular services. This demands increased computational power and storage from mobile devices with a sufficiently high bandwidth for mobile internet service. But mobile nodes are highly constrained in the processing and storage, along with the battery power, which further restrains their dependability. Adopting the unlimited storage and computing power offered by cloud servers, it is possible to overcome and turn these issues into a favorable opportunity for the growth of mobile cloud computing. As the mobile internet data traffic is predicted to grow at the rate of around 65 percent yearly, even advanced services like 3G and 4G for mobile communication will fail to accommodate such exponential growth of data. On the other hand, developers extend popular applications with high end graphics leading to smart phones, manufactured with multicore processors and graphics processing units making them unaffordable. Therefore, to address the need of resource constrained mobile nodes and bandwidth constrained cellular networks, the computations can be migrated to resourceful servers connected to cloud. The server now acts as a bridge that should enable the participating mobile nodes to offload their computations through Wi-Fi directly to the virtualized server. Our proposed model enables an on-demand service offloading with a decision support system that identifies the capabilities of the client's hardware and software resources in judging the requirements for offloading. Further, the node's location, context and security capabilities are estimated to facilitate adaptive migration.

• Journal of the Korean Ceramic Society
• /
• v.41 no.7
• /
• pp.541-547
• /
• 2004

Addition of large particles restrains densification by small particles in mixed particle systems. In the present study, large SiC whiskers or particles were introduced into small particles for restraining densification and the mixtures were sintered using yttrium aluminum garnet (Y$_3$A1$\sub$5/O$\sub$12/, YAG) as a sintering additive. By controlling the content of large SiC whiskers or particles and the applied pressure during sintering, porous SiC ceramics, with a porosity ranging from 0.3% to 39%, were fabricated. Porosity increased with increasing the content of restraining materials. SiC whiskers were more effective than large SiC partcles for restraining densification. Permeability of the porous SiC ceramics increased with increasing the porosity. Flexural strength decreased with increasing porosity. A noticeable increase in strain to failure was observed in the porous ceramics with a porosity ranging from 18% to 39%.

• Steel and Composite Structures
• /
• v.37 no.2
• /
• pp.211-227
• /
• 2020

To explore the feasibility of eliminating the longitudinal rebars and stirrups by using ultra-high-performance fiber reinforcement concrete (UHPFRC) in concrete encased steel composite stub column, compressive behavior of UHPFRC encased steel stub column has been experimentally investigated. Effect of concrete types (normal strength concrete, high strength concrete and UHPFRC), fiber fractions, and transverse reinforcement ratio on failure mode, ductility behavior and axial compressive resistance of composite columns have been quantified through axial compression tests. The experimental results show that concrete encased composite columns with NSC and HSC exhibit concrete crushing and spalling failure, respectively, while composite columns using UHPFRC exhibit concrete spitting and no concrete spalling is observed after failure. The incorporation of steel fiber as micro reinforcement significantly improves the concrete toughness, restrains the crack propagation and thus avoids the concrete spalling. No evidence of local buckling of rebars or yielding of stirrups has been detected in composite columns using UHPFRC. Steel fibers improve the bond strength between the concrete and, rebars and core shaped steel which contribute to the improvement of confining pressure on concrete. Three prediction models in Eurocode 4, AISC 360 and JGJ 138 and a proposed toughness index (T.I.) are employed to evaluate the compressive resistance and post peak ductility of the composite columns. It is found that all these three models predict close the compressive resistance of UHPFRC encased composite columns with/without the transverse reinforcement. UHPFRC encased composite columns can achieve a comparable level of ductility with the reinforced concrete (RC) columns using normal strength concrete. In terms of compressive resistance behavior, the feasibility of UHPFRC encased steel composite stub columns with lesser longitudinal reinforcement and stirrups has been verified in this study.