• 한국농림기상학회지
• /
• 제1권1호
• /
• pp.1-11
• /
• 1999

작물의 수량은 재배하는 식물의 특성과 토양 그리고 기후 등 환경에 의하여 지배된다. 주곡인 쌀 수확량의 지역성과 변이성을 알아내기 위하여 기상청의 기상 자료와 농림부의 쌀생산량 통계 자료를 수집 분석하였다. 기상 자료로부터 순복사량, 증발산량 및 순1차 생산력지수 NPP를 산출하고, Jung의 모형을 이용하여 우리 나라 각 지역의 쌀 생각량을 산출하고, 이를 실생산량과 비교하였다. 7, 8월 기온의 장기 변이를 검토한 결과, 수원의 경우 장주기는 15.1년, 단주기는 7.4년으로 나타났고, 대구의 장주기는 32.9년, 단주기는 4.1년으로 나타났다. 장주기는 대구가 수원 보다 약 2배이상으로 주기성이 강했고, 단주기는 반대로 수원이 대구보다는 주기성이 강하게 나타났다. 한국의 67개 지점에서 순1차생산력지수인 NPP와 총생산력지수 GPP를 추정 결과, 순 복사량이, 16개 지점에서 기온, 1개 지점에서 강수량이 NPP의 제한 요소로 작용하는 것으로 나타났다. 순 복사량은 한국에서의 자연 생산력에 1차적으로 주된 제한 요인으로서 작용하였고, 2차적인 제한 요인는 주로 기온이 작용하였다. 남한 지역의 NPP는 10.87~17.52 Mg ha$^{-1}$, GPP가 18.63~36.31 Mg ha$^{-1}$의 범위이었고, 평균은 NPP와 GPP가 각각 14.69 Mg ha$^{-1}$, 27.94 Mg ha$^{-1}$의 값을 나타냈다. 북한 지역의 경우에는 NPP가 6.47~15.50Mg ha$^{-1}$, GPP가 10.08~24.64 Mg ha$^{-1}$의 범위이었고, 평균은 NPP와 GPP가 각각 12.59 Mg ha$^{-1}$, 13.62 Mg ha$^{-1}$의 값이 나타났다. Jung의 모델에 의하여 97년과 98년의 쌀 생산량을 추정한 결과 실제 쌀 생산량과 근접하였다. 경상도 지역은 타 지역에 비해 실측치보다 예측치가 높게 평가되었고, 추정 생산량과 실제 생산량간 사이에 상관이 없었다. 이 지역에 대한 모델의 수정이 필요하며, 순복사량과 강수량 요인이 고려되면 좀 더 정확한 분포도가 작성될 수 있을 것이다.

• 한국심리학회지ㆍ건강
• /
• 제14권2호
• /
• pp.277-292
• /
• 2009

급성 스트레스 상황에 따른 Type D 성격의 자율신경계 반응을 심박률 변동성을 중심으로 조사하였다. Type DS-14의 점수에 근거하여 Type D 집단(n=23명)과 non-Type D 집단(n=23명)을 구성하였다. 심박률 변동성(heart rate variability, HRV)을 이용하여 기저선, 스트레스 단계 및 회복 단계 동안의 심박활동을 측정하였으며 스트레스 과제로는 Stroop 색채단어 검사가 사용되었다. 반복측정 변랑분석을 통해 두 집단의 심박활동을 비교하였으며, 회귀분석을 통해 Type D 척도와 스트레스 취약성 척도가 기저선 상태에서의 심박활동의 변화를 예측할 수 있는지를 알아보았다. 연구 결과, Type D 집단은 non-Type D 집단보다 고주파수(high frequency, HF) 활성화가 더 낮았고 저주파수(low frequency, LF) 활성화는 더 높았다. 스트레스 과제 수행 시, non-Type D 집단에서는 교감신경계 활성화 지표(LF component, LF/HF)가 증가하고 부교감신경계 활성화 지표(HF component)가 감소하는 것이 관찰된 반면, Type D 집단에서는 심박활동 비율상의 유의한 변화가 나타나지 않았다. 또한, Type D 척도의 총점수, 부정적 정서 소척도와 사회적 억제 소척도는 기저선 상태에서의 심박활동 반응에 대한 유의한 예측인자로 나타났다. 이러한 결과는 Type D 성격이 non-Type D 성격에 비해 교감신경계 활성화 비율이 높거나 또는 부교감신경계 활성화비율이 낮음을 시사한다. 즉, Type D가 스트레스에 취약한 성격임을 시사하며, Type D에서 관찰된 심박 활동 양상, 즉 높은 교감신경계 혹은 낮은 부교감신경계 활성화는 Type D 성격이 심장혈관 장애 등을 포함한 정신신체 질환과 관련될 수 있음을 시사한다.

• 감성과학
• /
• 제14권4호
• /
• pp.653-662
• /
• 2011

최근 3D TV 보급과 확산에 따른 시각 피로문제가 대두되면서 시각 기능과 인지적 관점에서의 연구가 활발하다. 그러나 3D 시각피로가 자율신경계 기능에 미치는 영향에 대한 연구는 미비하다. 따라서 본 연구에서는 3D TV 시청으로 유발되는 3D 시각피로가 자율신경계 기능에 미치는 영향과 이 영향이 교감 및 부교감 신경계와 심혈관계 반응에 미치는 영향을 확인하고자 한다. 피험자는 20 대 남녀 대학생 15 명(남 6 명, 여 9 명, 평균나이 22.53 세 ${\pm}$ 2.55 세)을 대상으로 하였다. 피험자는 편안한 의자에 앉아 3D TV를 1시간 시청하였다. 3D TV 시청 전과 후의 1분간 맥파(PPG, Photo-PlethysmoGram)를 측정하였고 주관설문을 실시하였다. 측정된 신호에서 SDNN (standard deviation of RR intervals), RMS-SD(root mean square successive difference), HF/LF ratio, Ln(LF), Ln(HF)를 추출하여 교감 및 부교감 신경계, 그리고 심혈관계 반응을 확인 하였다. 연구 결과 HF/LF ratio, Ln(LF), Ln(HF)는 시청 후에 유의하게 감소하였고, SDNN, RMS-SD는 통계적 유의차를 확인할 수 없었다. 이 결과는 3D 시각피로가 자율신경계 기능에 영향을 미치고 이로 인해 교감신경계가 항진되는 반응이 나타나며, 심박 변화율이 감소하는 결과를 초래할 가능성을 확인 하였다.

• 대한의료기공학회지
• /
• 제10권1호
• /
• pp.130-157
• /
• 2007

The purpose of this research is to seek for efficient health maintenance device and to suggest desirable daily habit, based on the inquiry on interrelationship between workers' daily lives and their heartbeat change level. The paper survey about general features, case history and daily habits was conducted on workers during medical examination in Jeollabukdo, and examined their change of heartbeat as well. The results of research deducted from data analysis are as follows; 1. There found very positive interrelations between time-domain analysis and frequency-domain analysis, and MHR and LF/HF ratio had negative connection with other analyses. 2. The recipient showed high time-domain analysis when they are younger, have worked shorter or have spouse, and it contributes to stable sympathetic nerve and parasympathetic nerve as it stimulates autonomic nervous system. 3. According to the result of frequency-domain analysis, recipients showed higher TP and LF when they are younger, and the highest HF when they are under 34.The level of VLF was higher for university graduates than the ones who finished high school. The recipients showed higher TP and HF when they don't have spouse, and lower TP, LF and HF when they have worked longer. 4. The level of RMSSD and TSRD was high for the people who don't have case history, and HF was high when they don't have any disease in progress. 5. According to the result concerning correlation of daily habits with time-domain analysis and frequency-domain analysis, cigarette, alcohol and sleeping hours don't affect heartbeat change, but the ones who regularly workout showed higher result in every analysis. It shows that the autonomic nervous system of recipients who regularly exercise response more actively. The result mentioned above suggests that the change of heartbeat is a direct index which shows the change of autonomic nervous system, and it depends on the exercise the most. Thus, workout is proved to be the best method in order for workers to take care of their health.

• Asian Pacific Journal of Cancer Prevention
• /
• 제16권14호
• /
• pp.5721-5726
• /
• 2015

Lung cancer is the leading contributor to cancer deaths in the developing world. Within countries, significant variability exists in the prevalence of lung cancer risk, yet limited information is available whether some of the observed variability is associated with differences in the consumption pattern of local tobacco products with differing potency. We recruited 606 lung cancer cases and 606 controls from the B.P. Koirala Memorial Cancer Hospital in Nepal from 2009-2012. We estimated odds ratios (ORs) and 95% confidence intervals (CI) for lung cancer risk associated with different tobacco products, using unconditional logistic regression. Unfiltered cigarettes tended to be the most frequently used products across ethnic subgroup with about 53.7% of Brahmins, 60.1% of Chettris, and 52.3% of Rai/Limbu/Magar/others. In contrast, about 39.9% of Madishe/Tharu smokers reported using bidi compared with only 27.7% who smoked unfiltered cigarettes. Among those who only smoked one type of product, choor/kankat smokers had the highest lung cancer risk (OR 10.2; 95% CI 6.2-16.6), followed by bidi smokers (OR 5.6; 95% CI 3.6-8.7), unfiltered cigarettes (OR 4.9; 95% CI 3.4-7.2), and filtered cigarettes (OR 3.4; 95% CI 2.2-5.3). A clear dose-response relationship was observed between increased frequency of smoking and lung cancer risk across all ethnic subgroups. These results highlight the important role of traditional tobacco products on lung cancer risk in the low income countries.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권5호
• /
• pp.2937-2943
• /
• 2013

Backgrounds: Polymorphisms of OPRM1 A118G and ABCB1 C3435T have been suggested to contribute to inter-individual variability regarding pain sensitivity, opioid usage, tolerance and dependence and incidence of adverse effects in patients with chronic pain. This study aimed to investigate the association of both two polymorphisms with opioid requirements in Chinese patients with cancer pain. Methods: The genotypes of rs1799971 (OPRM1) and rs1045642 (ABCB1) were determined by PCR-RFLP and direct sequencing methods respectively in 112 patients with cancer-related pain. Comparisons between the different genotype or allele groups were performed with t-tests or one-way ANOVA tests, as appropriate. The potential relationship of allele number with opioid response was performed with a trend Jonckheere-Terpstra test. Results: In the 112 subjects, the frequencies of variant 118 G and 3435T allele were 38.4% and 37.9%, respectively. Significant higher 24h-opioid doses were observed in patients with GG (P=0.0004) and AG + GG (P=0.005) genotypes than the AA carriers. The dominant mutant 118G allele tended to be associated with progressively increasing 24h-opioiddoses (P=0.001). Compared with CC/CT, patients with ABCB1 TT genotype received higher 24h- and weight-surface area-adjusted-24h- opioids doses (P=0.057 and 0.028, respectively). Conclusions: The OPRM1 A118G single nucleotide polymorphism (SNP) is a key contributor for the inter-individual variability in opioidrequirements in Chinese cancer pain patients. This may possibly extend to the ABCB1 C3435T SNP.

• 대기
• /
• 제19권2호
• /
• pp.183-198
• /
• 2009

The purpose of this study is to summarize the tropical cyclone (TC) activity of 2008 over the western North Pacific including the verification of the official track and intensity forecast errors of these TCs. The TC activity - frequency, Normalized Typhoon Activity (NTA), and life span - was lower than 58-year (1951-2008) average. 22 tropical cyclones of tropical storm (TS) intensity or higher formed in the western North Pacific and the South China Sea in 2008. The total number is less than 58-year average frequency of 26.4. Out of 22 tropical cyclones, 11 TCs reached typhoon (TY) intensity, while the rest 11 TCs only reached severe tropical storm (STS) and tropical storm (TS) intensity - six STS and five TS storms. One typhoon KALMAEGI (0807) among them affected the Korea peninsula. However, no significant impact - casualty or property damage - was reported. On average of 22 TCs in 2008, the Korea Meteorological Administration (KMA) official track forecast error for 48 hours was 229 km. There was a big challenge for individual cyclones such as 0806 FENGSHEN and 0817 HIGOS presenting significant forecast error, with both intricate tracks and irregular moving speed. The tropical cyclone season in 2008 began in April with the formation of NEOGURI (0801). In May, four TCs formed in the western North Pacific in response to enhanced convective activity. On the other hand, the TC activity was very weak from June to August. It is found that the unusual anti-cyclonic circulation in the lower level and weak convection near the Philippines are dominant during summertime. The convection and atmospheric circulation in the western North Pacific contributed unfavorable condition for TC activity in the 2008 summertime. The 2008 TC activity has continued the below normal state since mid 1990s which is apparent the decadal variability in TC activity.

• 한국작물학회지
• /
• 제50권2호
• /
• pp.91-96
• /
• 2005

Proper choice of source populations contributes to the ultimate success of selection for genetic improvement. The source population should possess the most desirable alleles at as many loci as possible for intra population improvement. Such desirable alleles can be intensified by introgression of exotic germ plasm into locally adapted ones through hybridization followed by selection. The objectives of this study were to determine the mean performance, genetic variability $({\sigma}^2G)$ and heritability of fresh ear yield and other important traits within two sweet corn source populations, $BC1-10{\times}Syn-II$ and BC2-10. One hundred selfed progenies from each of the two source populations were evaluated in a $10\times10$ lattice design, at the Institute of Bioscience (IBS) Farm, University of Putra Malaysia (UPM) following the recommended cultural practices. Significant differences among selfed progenies within $BC1-10{\times}Syn-II$ were observed for all traits, while differences among selfed progenies within BC2-10 were noted for fresh ear yield, ear length, ear diameter, number of kernels per row, ear height, days to tasseling and days to silking. Progenies developed from $BC1-10{\times}Syn-II$ population had higher estimates of ${\sigma}^2G$ than did progenies from BC2-10 population for number of kernel rows per ear, total soluble solids, plant height, days to tasseling and days to silking, showing that selection to improve these traits would be more effective in selfed progenies of $BC1-10{\times}Syn-II$ than that in BC2-10. On the other hand, progenies developed from BC2-10 population had higher estimates of ${\sigma}^2G$ for ear length, ear diameter and ear height, indicating that progenies from this population would have better genetic gain than $BC1-10{\times}Syn-II$. Comparable estimates of genetic variance were found for fresh ear yield, and number of kernels per row, indicating that genetic improvement of the two source populations is expected to produce similar genetic gains for these two traits. Therefore, selfed progenies developed from both source populations could be used to improve the two populations for various traits and thereby develop superior genotypes for immediate use in the production system.

• Genomics & Informatics
• /
• 제16권3호
• /
• pp.52-58
• /
• 2018

In this report, we present a case study of how pharmacogenomics and pharmacometabolomics can be useful to characterize safety and pharmacokinetic profiles in early phase new drug development clinical trials. During conducting a first-in-human trial for a new molecular entity, we were able to determine the mechanism of dichotomized variability in plasma drug concentrations, which appeared closely related to adverse drug reactions (ADRs) through integrated omics analysis. The pharmacogenomics screening was performed from whole blood samples using the Affymetrix DMET (Drug-Metabolizing Enzymes and Transporters) Plus microarray, and confirmation of genetic variants was performed using real-time polymerase chain reaction. Metabolomics profiling was performed from plasma samples using liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. A GSTM1 null polymorphism was identified in pharmacogenomics test and the drug concentrations was higher in GSTM1 null subjects than GSTM1 functional subjects. The apparent drug clearance was 13-fold lower in GSTM1 null subjects than GSTM1 functional subjects (p < 0.001). By metabolomics analysis, we identified that the study drug was metabolized by cysteinylglycine conjugation in GSTM functional subjects but those not in GSTM1 null subjects. The incidence rate and the severity of ADRs were higher in the GSTM1 null subjects than the GSTM1 functional subjects. Through the integrated omics analysis, we could understand the mechanism of inter-individual variability in drug exposure and in adverse response. In conclusion, integrated multi-omics analysis can be useful for elucidating the various characteristics of new drug candidates in early phase clinical trials.

• 감성과학
• /
• 제22권1호
• /
• pp.55-64
• /
• 2019

스트레스는 자율신경계 반응의 변화를 수반하며, 특히 심박변이도 지표는 스트레스에 의한 자율신경계의 활동을 반영하는 양적 지표로 사용된다. 본 연구에서는 스트레스 완화를 위한 산소와 색채 조명의 복합 자극이 제시되는 동안 자율신경계 반응의 변화를 확인하였다. 42명의 실험참가자는 지난 2주 동안 경험한 스트레스에 대한 증상들을 스트레스 반응 척도에 평가하였다. 스트레스 평가 후, 실험참가자는 복합 자극을 제시받았고, 자극 제시 전과 후, 그리고 자극이 제시되는 동안 심전도 신호가 기록되었다. 자극 조건은 30% 농도의 산소와 백색 조명, 산소와 주황색 조명과 산소와 파란색 조명의 조합의 세 가지로 구성되었다. 심박률(HR), R-R간격의 표준편차(SDNN), 연속한 R-R 간격 차이 값의 평균제곱근(RMSSD)과 심박변이도의 저주파 성분(LF), 고주파 성분(HF), 그리고 LF와 HF의 비율을 심박변이도 지표로 추출하였다. 이들 지표는 자극 제시 전과 후의 평균을 비교하는데 활용되었다. 결과는 자극 조건이 제시되고 난 후, HR과 LF/HF ratio의 유의한 감소를 보여주었다. 특히, 산소와 파란색 조명이 제시된 조건에서 다른 두 조건보다 유의하게 큰 RMSSD와 HF의 증가 및 LF/HF ratio의 감소가 나타났다. 이는 30% 농도의 산소와 파란색 조명의 조건이 부교감신경의 활성화에 의한 자율신경의 균형을 유발하여 스트레스 이완에 가장 효과적임을 보여주었다.