• Journal of Animal Science and Technology
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• v.63 no.3
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• pp.603-613
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• 2021

This research improved the growth potential of Bifidobacterium animalis subsp lactis strain JNU306, a commercial medium that is appropriate for large-scale production, in yeast extract, soy peptone, glucose, L-cysteine, and ferrous sulfate. Response surface methodology (RSM) was used to optimize the components of this medium, using a central composite design and subsequent analyses. A second-order polynomial regression model, which was fitted to the data at first, significantly lacked fitness. Thus, through further analyses, the model with linear and quadratic terms plus two-way, three-way, and four-way interactions was selected as the final model. Through this model, the optimized medium composition was found as 2.8791% yeast extract, 2.8030% peptone soy, 0.6196% glucose, 0.2823% L-cysteine, and 0.0055% ferrous sulfate, w/v. This optimized medium ensured that the maximum biomass was no lower than the biomass from the commonly used blood-liver (BL) medium. The application of RSM improved the biomass production of this strain in a more cost-effective way by creating an optimum medium. This result shows that B. animalis subsp lactis JNU306 may be used as a commercial starter culture in manufacturing probiotics, including dairy products.

• Geomechanics and Engineering
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• v.31 no.5
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• pp.529-543
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• 2022

The lattice-spring-based synthetic rock mass model (LS-SRM) technique has been extensively employed in large open-pit mining and underground projects in the last decade. Since the LS-SRM requires a complex and time-consuming calibration process, a robust approach was developed using the Response Surface Methodology (RSM) to optimize the calibration procedure. For this purpose, numerical models were designed using the Box-Behnken Design technique, and numerical simulations were performed under uniaxial and triaxial stress states. The model input parameters represented the models' micro-mechanical (lattice) properties and the macro-scale properties, including uniaxial compressive strength (UCS), elastic modulus, cohesion, and friction angle constitute the output parameters of the model. The results from RSM models indicate that the lattice UCS and lattice friction angle are the most influential parameters on the macro-scale UCS of the specimen. Moreover, lattice UCS and elastic modulus mainly control macro-scale cohesion. Lattice friction angle (flat joint fiction angle) and lattice elastic modulus affect the macro-scale friction angle. Model validation was performed using physical laboratory experiment results, ranging from weak to hard rock. The results indicated that the RSM model could be employed to calibrate LS-SRM numerical models without a trial-and-error process.

• International Journal of Automotive Technology
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• v.6 no.6
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• pp.635-641
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• 2005

This paper presents an ASF (Aluminum Space Frame) BIW (Body in White) optimal design, which minimizes weight and satisfies multidisciplinary constraints such as static stiffness, vibration characteristics, low-/high-speed crash, and occupant safety. As only one cycle CPU time for all the analyses is 12 hours, the ASF design having 11-design variable is a large scaled problem. In this study, ISCD-II and conservative least square fitting method were used for efficient RSM modeling. Likewise, the ALM method was used to solve the approximate optimization problem. The approximate optimum was sequentially added to remodel the RSM. The proposed optimization method uses only 20 analyses to solve the 11-design variable problem. Moreover, the optimal design can achieve $15.6\%$ weight reduction while satisfying all the multidisciplinary design constraints.

• Proceedings of the KSME Conference
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• 2007.05b
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• pp.2384-2389
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• 2007

The 2nd order response surface method (RSM) has been carried out to get optimum thermal design for enhanced heat transfer on square channel with bleed holes. The RSM was used as an optimization technique with Reynolds-averaged navier-stokes equation. Turbulence model for heat transfer analysis used RNG k-epsilon model. The wall function used enhanced wall function. Numerical local heat transfer coefficients were similar to the experimental tendency. Two design variables such as attack angle of rib (${\alpha}$), rib pitch-to-rib height ratio (p/e) were chosen. Operation condition considered bleeding ratio per bleed hole ($BR_{hole}$). A response surface were constructed by the design variables and operation condition. As a result, adjusted $R^2$ was more than 0.9. Optimization results of various objective function were similar to heat transfer in channel with and without bleed flow. But friction factor was lower than channel without bleed flow.

• Wind and Structures
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• v.21 no.6
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• pp.597-607
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• 2015

With an increasing demand of a renewable energy, new offshore wind turbine farms are being planned in some parts of the world. Foundation installation asks a significant cost of the total budget of offshore wind turbine (OWT) projects. Hence, a cost reduction from foundation parts is a key element when a cost-efficient designing of OWT budget. Mono-piles have been largely used, accounting about 78% of existing OWT foundations, because they are considered as a most economical alternative with a relatively shallow-water, less than 30 m of seawater depth. OWT design standards such as IEC, GL, DNV, API, and Eurocode are being developed in a form of reliability based limit state design method. In this paper, reliability analysis using the response surface method (RSM) and numerical simulation technique for an OWT mono-pile foundation were performed to investigate the sensitivities of mono-pile design parameters, and to find practical implications of RSM reliability analysis.

• Journal of Korean Society of Environmental Engineers
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• v.33 no.3
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• pp.149-156
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• 2011

This experimental design and response surface methodology (RSM) have been applied to the investigation of the electro-UV-ultrasonic complex process for the disinfection of E. coli in the water. The disinfection reactions of electro-UV-ultrasonic process were mathematically described as a function of parameters power of electrolysis ($X_1$), UV ($X_2$), and ultrasonic process ($X_3$) being modeled by use of the Box-Behnken technique, which was used for fitting 2nd order response surface model. The application of RSM yielded the following regression equation, which is empirical relationship between the residual E. coli number (Ln CFU) in water and test variables in coded unit: residual E. coli number (Ln CFU) = 23.69 - 3.75 Electrolysis - 0.67 UV - 0.26 Ultrasonic - 0.16 Electrolysis UV + 0.05 Electrolysis Ultrasonic + 0.27 $Electrolysis^2$ + 0.14 $UV^2$ - 0.01 $Ultrasonic^2$). The model predictions agreed well with the experimentally observed result ($R^2$ = 0.983). Graphical 2D contour and 3D response surface plots were used to locate the optimum range. The estimated ridge of maximum response and optimal conditions for residual E. coli number (Ln CFU) using 'numerical optimization' of Design-Expert software were 1.47 Ln CFU/L and 6.94 W of electrolysis, 6.72 W of UV and 14.23 W of ultrasonic process. This study clearly showed that response surface methodology was one of the suitable methods to optimize the operating conditions and minimize the residual E. coli number of the complex disinfection.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.27 no.2
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• pp.155-162
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• 2003

Design optimization of a transonic compressor rotor (NASA rotor 37) using response surface method and three-dimensional Navier-Stokes analysis has been carried out in this work. Baldwin-Lomax turbulence model was used in the flow analysis. Three design variables were selected to optimize the stacking line of the blade. Data points for response evaluations were selected by D-optimal design, and linear programming method was used for the optimization on the response surface. As a main result of the optimization, adiabatic efficiency was successfully improved. It is also found that the design process provides reliable design of a turbomachinery blade with reasonable computing time.

• International Journal of Automotive Technology
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• v.8 no.1
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• pp.93-102
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• 2007

The frontal crash optimization of an engine room member using the response surface method was studied. The engine room member is composed of the front side member and the sub-frame. The thicknesses of the panels on the front side member and the sub-frame were selected as the design variables. The purpose of the optimization was to reduce the weight of the structure, under the constraint that the objective quantity of crash energy is absorbed. The response surface method was used to approximate the crash behavior in mathematical form for optimization procedure. To research the effect of the regression method, two different methodologies were used in constructing the response surface model, the least square method and the moving least square method. The optimum with the two methods was verified by the simulation result. The precision of the surrogate model affected the optimal design. The moving least square method showed better approximation than the least square method. In addition to the deterministic optimization, the reliability-based design optimization using the response surface method was executed to examine the effect of uncertainties in design variables. The requirement for reliability made the optimal structure be heavier than the result of the deterministic optimization. Compared with the deterministic optimum, the optimal design using the reliability-based design optimization showed higher crash energy absorption and little probability of failure in achieving the objective.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2001.11a
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• pp.99-106
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• 2001

The design for cold extrusion dies is very important, because the die insert is subjected to very high radial and hoop stresses. The design of cold extrusion dies has many constrained conditions. In this paper, the used assumptions are such that the yield strength of each ring is selected according to the allowable tensile or compressive hoop stress in each ring and the maximum allowable inner pressure, when yielding occurs in one ring of the dies, is obtained by the proposed equation. In order to obtain design variables, such as diameter ratios and interferences, using the maximum inner pressure, the flexible tolerance method was used for shrink-fitted thick-walled cylinders. ANSYS APDL was used to perform the repeated analysis of deformation of the dies due to the variation of the design variables. The response surface methodology is utilized to analyze the relationship between the design variables and the maximum radial displacement of the die insert during extrusion. From the results, it is found that outer diameter of the die Insert has the largest effect on the minimization of maximum radial displacement at the inner surface of the dies.

• Structural Engineering and Mechanics
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• v.73 no.5
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• pp.501-513
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• 2020

In the present work, the optimization of machining parameters to achieve the desired technological parameters such as surface roughness, tool radial vibration and material removal rate have been carried out using response surface methodology (RSM). The hard turning of EN19 alloy steel with coated carbide (GC3015) cutting tools was studied. The main problem faced in manufacturer of hard and high precision components is the selection of optimum combination of cutting parameters for achieving required quality of surface finish with maximum production rate. This problem can be solved by development of mathematical model and execution of experiments by RSM. A face centred central composite design (FCCD), which comes under the RSM approach, with cutting parameters (cutting speed, feed rate and depth of cut) was used for statistical analysis. A second-order regression model were developed to correlate the cutting parameters with surface roughness, tool vibration and material removal rate. Consequently, numerical and graphical optimization were performed to obtain the most appropriate cutting parameters to produce the lowest surface roughness with minimal tool vibration and maximum material removal rate using desirability function approach. Finally, confirmation experiments were performed to verify the pertinence of the developed mathematical models.