• Radiation Oncology Journal
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• 제32권2호
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• pp.77-83
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• 2014

Purpose: To determine the prognostic and predictive value of liver volume in colorectal cancer patients with unresectable liver metastases. Materials and Methods: Sixteen patients received whole liver radiotherapy (WLRT) between January 1997 and June 2013. A total dose of 21 Gy was delivered in 7 fractions. Results: The median survival time after WLRT was 9 weeks. In univariate analysis, performance status, serum albumin and total bilirubin level, liver volume and extrahepatic metastases were associated with survival. The mean liver volume was significantly different between subgroups with and without pain relief (3,097 and 4,739 mL, respectively; p = 0.002). Conclusion: A larger liver volume is a poor prognostic factor for survival and also a negative predictive factor for response to WLRT. If patients who are referred for WLRT have large liver volume, they should be informed of the poor prognosis and should be closely observed during and after WLRT.

• IMMUNE NETWORK
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• 제15권2호
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• pp.83-90
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• 2015

Evaluation and screening of vaccines against tuberculosis depends on development of proper cost effective disease models along with identification of different immune markers that can be used as surrogate endpoints of protection in preclinical and clinical studies. The objective of the present study was therefore evaluation of subcutaneous model of M.tuberculosis infection along with investigation of different immune biomarkers of tuberculosis infection in BALB/c mice. Groups of mice were infected subcutaneously with two different doses : high ($2{\times}10^6CFU$) and low doses ($2{\times}10^2CFU$) of M.tuberculosis and immune markers including humoral and cellular markers were evaluated 30 days post M.tuberculosis infections. Based on results, we found that high dose of subcutaneous infection produced chronic disease with significant (p<0.001) production of immune markers of infection like $IFN{\gamma}$, heat shock antigens (65, 71) and antibody titres against panel of M.tuberculosis antigens (ESAT-6, CFP-10, Ag85B, 45kDa, GroES, Hsp-16) all of which correlated with high bacterial burden in lungs and spleen. To conclude high dose of subcutaneous infection produces chronic TB infection in mice and can be used as convenient alternative to aerosol models in resource limited settings. Moreover assessment of immune markers namely mycobacterial antigens and antibodies can provide us valuable insights on modulation of immune response post infection. However further investigations along with optimization of study protocols are needed to justify the outcome of present study and establish such markers as surrogate endpoints of vaccine protection in preclinical and clinical studies in future.

• 대한전자공학회논문지SP
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• 제42권1호
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• pp.71-77
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• 2005

본 논문에서는 5.1채널 입체음향 오디오 신호를 2채널의 헤드폰으로 재생하기 위한 HRTF (Head Related Transfer Function) 기반의 입체음향 생성 시스템에 대하여 다룬다. 각 채널의 모노 입력신호는 HRTF를 이용한 바이노럴(binaural) 필터링을 통해 가상적으로 음상정위되며, 입체감과 공간감을 증가시키기 위해 잔향효과가 추가된다. 연산량 감소를 위해 음상정위 성능을 저하시키지 않는 범위에서 HRTF의 임펄스 응답 탭 수를 줄였으며, 잔향효과를 위한 음장제어부에서는 초기반사열중 주요한 성분만을 지연기로 모델링하였다. 또한 비개인화된 HRTF DB에 의란 앞/뒤 혼돈 문제를 줄이기 위하여 앞/뒤 스펙트럼의 차를 가중치로 하여 HRTF 스펙트럼을 강조하는 방법을 적용하였다. 구현한 시스템의 성능 평가 결과, 단순한 스테레오 방법이나 2채널 Down Mixing 방식에 비해 현실감 있고 방향성 있는 입체음향을 느낄 수가 있었다.

• Safety and Health at Work
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• 제8권3호
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• pp.231-236
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• 2017

Vital to the prevention of work-related ill-health (WRIH) is the availability of good quality data regarding WRIH burden and risks. Physician-based surveillance systems such as The Health and Occupation Research (THOR) network in the UK are often established in response to limitations of statutory, compensation-based systems for addressing certain epidemiological aspects of disease surveillance. However, to fulfil their purpose, THOR and others need to have methodologic rigor in capturing and ascertaining cases. This article describes how data collected by THOR and analogous systems can inform WRIH incidence, trends, and other determinants. An overview of the different strands of THOR research is provided, including methodologic advancements facilitated by increased data quantity/quality over time and the value of the research outputs for informing Government and other policy makers. In doing so, the utility of data collected by systems such as THOR to address a wide range of research questions, both in relation to WRIH and to wider issues of public and social health, is demonstrated.

• 지역사회간호학회지
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• 제15권3호
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• pp.385-396
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• 2004

Purpose: Hypertension has been a major cause of death in Korea since the 1970s, and has resulted in being a significant economic burden to the finances of national health care. The Ministry of Health and Welfare made several efforts. but hypertension control programs in Korea are still non standardized and ineffective. We wanted to investigate the current hypertension control program in public health centers systematically and suggest the direction for future programs. Method: The design of this study is a cross sectional investigation. From September to October in 2002, we sent a set of questionnaires to all PHCs, and 179 centers responded (response rate = 74.0%). The instrument was developed based on components of National health systems. Results: 1) Resources: The department responsible for hypertension control programs is the Department of Health Promotion. Health Education Center, Community Health Center, Citizen's Health Center, etc. The chief personnel of those departments are nurses. but 27.4% of PHCs have no full time nurse for hypertension management programs. PHCs had a lot of teaching materials (nine types per a PHC) and most of the recommended contents were included. But, periodical evaluation and revision were not being made, 2) Management: Nurses' (13.03 9.46 in 23 score) actions for hypertension control were not qualitative, but regular training and evaluation were seldom carried out. Need assessment (25.9%) and evaluation (about 10-20%) for the hypertension control program were indicated as low. 3) Programs: Programs focused on individuals rather than community or public, and 2nd prevention rather than 1st, 3rd prevention. Conclusion: The Ministry of Health and Welfare has to construct the infrastructure for hypertension control programs. Related scholars and committees should develop and declare standardized manuals for hypertension control and the management system, as well.

• 대한전자공학회논문지SD
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• 제45권4호
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• pp.105-116
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• 2008

오늘날의 시스템-온-칩(SoC)은 짧은 제품 생산 주기를 맞추기 위하여 재사용 가능한 IP 코아들을 이용하여 설계한다. 그러나 고집적 칩을 생산하는데 있어 증가한 칩의 테스트 비용은 큰 문제가 된다. 본 논문에서는 Advanced High-performance Bus(AHB)와 Peripheral Component Interconnect(PCI) 버스를 위한 온/오프-칩 버스 브리지를 이용한 효율적인 테스트 접근 메커니즘을 제시한다. 본 기술은 독립적인 테스트 입력 경로와 출력 경로를 제공하고 버스 방향 전환을 위한 턴어라운드 지연시간을 없앰으로써 테스트 시간을 매우 줄였다. 실험 결과는 면적 오버헤드와 기능적 구조적 테스트 모두 에서의 시간이 줄어들었음을 보여준다 제안하는 기술은 다른 종류의 온/오프-칩 버스 브리지에도 적용 가능하다.

• Ecology and Resilient Infrastructure
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• 제2권4호
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• pp.296-304
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• 2015

급속한 기후변화에 따른 자연재해의 증가와 재해 규모의 대형화 및 다양화는 근본적인 해결 방안을 요구하고 있다. 특히 도시 공간은 도시 인구의 증가 현상과 불투수층의 기반시설에 기초하여 재해의 피해와 대응에 대한 복합적 대책을 수립해야 하는 실정이다. 이에 공공 공간인 도시의 녹색공간을 활용하여 방재공간을 확보하고, 재해저감형 공원시스템을 도입함으로써 토지 매입의 경제적 문제와 방재시스템의 문제를 동시에 해결할 수 있다. 각 지자체는 최근 발표된 국토교통부의 가이드라인을 통해 재해저감 유형별 시스템과 선도 사업을 선정하여 진행 중에 있다. 본 연구의 목적은 도시민의 생활 건강과 행복의 녹색 공간인 도보권 근린공원을 대상으로 도시의 물 관리와 소생태계 보전을 함께 갖추는 도시 녹지 공간을 방재형 근린공원의 조성 모델로 제시하는데 있다. 이를 통해 추후 기존 도시 구조 내 생활권 근린공원의 기후변화 적응 모델로 활용하는데 기여하고자 한다.

• Ocean Systems Engineering
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• 제3권3호
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• pp.219-236
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• 2013

The accurate prediction of motion in waves of a marine vehicle is essential to assess the maximum sea state vs. operational requirements. This is particularly true for small crafts, such as Autonomous Surface Vessels (ASV). Two different numerical methods to predict motions of a SWATH-ASV are considered: an inviscid strip theory initially developed at MIT for catamarans and then adapted for SWATHs and new a hybrid strip theory, based on the numerical solution of the radiation forces by an unsteady viscous, non-linear free surface flow solver. Motion predictions obtained by the viscous flow method are critically discussed against those obtained by potential flow strip theory. Effects of viscosity are analyzed by comparison of sectional added mass and damping calculated at different frequencies and for different sections, RAOs and motions response in irregular waves at zero speed. Some relevant conclusions can be drawn from this study: influence of viscosity is definitely non negligible for SWATH vessels like the one presented: amplitude of the pitch and heave motions predicted at the resonance frequency differ of 20% respectively and 50%; in this respect, the hybrid method with fully non-linear, viscous free surface calculation of the radiation forces turns out to be a very valuable tool to improve the accuracy of traditional strip theories, without the burden of long computational times requested by fully viscous time domain three dimensional simulations.

• Asian Pacific Journal of Cancer Prevention
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• 제15권16호
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• pp.6721-6726
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• 2014

Background: The aim of this preliminary study was to address variations of responses observed with different starting tumor sizes of 10 and 15 mm, and the effects of different doses of tamoxifen (TAM) on experimental rat mammary tumors. Materials and Methods: Thirty-five inbred female Sprague Dawley rats aged 43 days were administered with three weekly doses of N-methyl-N-nitrosourea (NMU) intraperitoneally (ip) at 50 mg/kg body weight. Animals were randomized (beginning from 10 mm tumor size) into four TAM-treated (50, 100, 200 and $500{\mu}g/day$) groups of six animals each, and another group (n=6) treated with TAM $100{\mu}g/day$ at starting tumour size of 15 mm. The animals were treated by oral gavage daily for 8 weeks before sacrifice. Results: Serum urea and creatinine, and overall physical tumor burden were significantly modulated in animals treated with variable doses of TAM compared to the untreated controls (n=5). Final body weight and tumor number were significantly different in the 10 mm-treated animals compared to those treated at 15 mm. There were no significant differences in histopathological features among all the groups. Conclusions: Our findings suggest the importance of standardizing tumour size and drug doses before initiation of treatment, particularly in the direct comparison of basic end-tumour physical parameters.

• Radiation Oncology Journal
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• 제35권2호
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• pp.172-179
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• 2017

Purpose: To evaluate the outcomes of stereotactic body radiation therapy (SBRT) for patients with liver oligo-recurrence and oligo-progression from various primary tumors. Materials and Methods: Between 2002 and 2013, 72 patients with liver oligo-recurrence (oligo-metastasis with a controlled primary tumor) and oligo-progression (contradictory progression of a few sites of disease despite an overall tumor burden response to therapy) underwent SBRT. Of these, 9 and 8 patients with uncontrollable distant metastases and patients immediate loss to follow-up, respectively, were excluded. The total planning target volume was used to select the SBRT dose (median, 48 Gy; range, 30 to 60 Gy, 3-4 fractions). Toxicity was evaluated using the Common Toxicity Criteria for Adverse Events v4.0. Results: We evaluated 55 patients (77 lesions) treated with SBRT for liver metastases. All patients had controlled primary lesions, and 28 patients had stable lesions at another site (oligo-progression). The most common primary site was the colon (36 patients), followed by the stomach (6 patients) and other sites (13 patients). The 2-year local control and progression-free survival rates were 68% and 22%, respectively. The 2- and 5-year overall survival rates were 56% and 20%, respectively. The most common adverse events were grade 1-2 fatigue, nausea, and vomiting; no grade ${\geq}3$ toxicities were observed. Univariate analysis revealed that oligo-progression associated with poor survival. Conclusion: SBRT for liver oligo-recurrence and oligo-progression appears safe, with similar local control rates. For liver oligo-progression, criteria are needed to select patients in whom improved overall survival can be expected through SBRT.