• The Journal of Korean Medicine
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• v.25 no.2
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• pp.207-219
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• 2004

Objectives : We investigated to find the relationship between single-nucleotide polymorphism (SNP) of IL4R, IL-10 and bee venom therapy efficacy in patients with RA treated with bee venom for 8 weeks. Methods : Korean RA patients (n=114) and healthy subjects (n=109) were included in this prospective study. Korean bee venom was dissolved in saline (diluted 1:3000) and administrated into acupuncture points. Bee venom therapy was applied twice a week and continued for 8 weeks. The clinical response was evaluated using various assessments before and after treatment. Disease severity was measured by determining the number of tender joints and swollen joints. Laboratory studies included ESR, CRP, and rheumatoid factor. Genotyping for IL-4R and IL-10 polymorphism was done by pyrosequencing analysis. Results : 1. In IL4R genotypes, there was significant difference between RA ptitients tind controls group. 2. In IL4R genotypes, there was significant difference among Good, Mild and Bad responders to in RA patients, but in the frequency of alleles and carriers, there were no significant difference. 3. There was no significant difference between RA patients and controls group in IL-10 gene genotypes. 4. In IL-10 genotypes, there was no significant difference among Good, Mild and Bad responders to in RA patients. 5. There was no significant difference in the improvement of ESR, CRP and KHAQ scores after bee venom therapy in RA patients among the IL4R or IL-10 genotypes. Conclusions : In IL-4R genotypes, there was significant difference between RA patients and control group, and among Good, Mild and Bad responders in RA patients. However, in IL-10 genotypes, there was no significant difference between RA patients and controls group and among Good, Mild and Bad responders in RA patients.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2004.04a
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• pp.55-60
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• 2004

The paper describes measurement techniques for an acoustic transfer characteristic of ship's bridge stimulated by a whistle sound. The response sounds, according to the opening-shutting conditions of bridge doors for T／S ‘SAENURI’, are measured by B＆K 2260D equipment, and then extracted the frequency responses by B＆K 7830 software. To evaluate the measured transfer characteristic, the 128th order FIR (Finite Impulse Response) filters, containing the frequency characteristic, are constructed based on the frequency sampling-based design method. Using evaluation indexes with six scales, psychological assessments by five subjects are carried out with test sounds which are convolved source sound and FIR filters. As results of tests, the test sounds gives A／sub s／=3.3∼4.7 which means the psychological sense of 'it is almost similar sound as original ones in a real world', and thus it is cleary seen tint the proposed method can be suit for the measurement of an acoustic transfer characteristic of ship's bridg.

• The Korea Journal of Herbology
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• v.23 no.1
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• pp.103-108
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• 2008

Objective: Atopic dermatitis is the most common chronic inflammatory skin disease in childhood. Phellinus linteus, an orange color mushroom, has been used as a traditional herb medicine for years. Recent preliminary animal experiments suggest that Phellinus linteus grown on germinated brown rice is effective in chronic inflammatory disease. The aim of this study was to evaluate the efficacy of Phellinus linteus grown on germinated brown rice in the treatment of atopic dermatitis(AD). Methods: 35 patients, 2 to 14 years of age, with mild to moderate AD were treated with Phellinus linteus grown on germinated brown rice powder per oral, $6{\sim}12g$/day adjusted by the body weight, divided three for up to 12 weeks without other treatment. The mean age of patients was 7.3 years. The disease activity has been monitored by objective SCORAD index. The symptom score of the pruritus was measured by using a traditional visual analogue scale (VAS). In addition, the global assessments of clinical response were also monitored by patients or their parents. Results: After 12 weeks of the study, significant reductions in mean severity scores and mean symptom scores were observed. The mean objective SCORAD indices of 35 patients decreased from 25.31${\pm}$8.96 to 18.73${\pm}$13.89(p<0.05). And the mean symptom score of pruritus assessment decreased from 7.37${\pm}$1.33 to 4.6${\pm}$2.3(p<0.05). The patient's global assessment of clinical response were also improved through the period of treatment(p<0.05). Conclusions: Phellinus linteusgrown on germinated brown rice may play a role in the treatment of mild and moderate AD in Children.

• Korean Journal of Comparative Education
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• v.28 no.5
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• pp.1-19
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• 2018

The purpose of educational assessments such as the Trends in International Mathematics and Science Study (TIMSS) is to compare groups such as countries. When the unit of measurement is above the student level, group-level diagnostic assessment based on multilevel item response theory (ML-IRT) can be considered just as cognitive diagnosis models are developed from item response theory. This study suggests an ML-IRT-based group-level diagnostic assessment model by modifying an item feature model by Park and bolt (2008). The model is illustrated on the recently released TIMSS 2015 Grade 8 mathematics assessment. The results provide skill profiles for the studied countries and the nine cognitive attributes; that is, the attribute effects can be compared across the countries and also across the attributes. By controlling unexplained variance, the suggested model may provide more reliable and more informative group-level comparisons. The results are interpreted using an example. Limitations and directions for future research are also discussed.

• Journal of the Korean Geotechnical Society
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• v.23 no.8
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• pp.117-127
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• 2007

Slope stability analysis is a geotechnical engineering problem characterized by many sources of uncertainty. Some of them are connected to the uncertainties of soil properties involved in the analysis. In this paper, a numerical procedure for integrating commercial finite difference method into probabilistic analysis of slope stability is presented. Since the limit-state function cannot be expressed in an explicit form, the ANN-based response surface method is adopted to approximate the limit-state function and the first-, second-order reliability method and the Monte Carlo simulation technique are used to calculate the probability of failure. Probabilistic stability assessments for a hypothetical two-layer slope and the Sugar Creek embankment were performed to verify the application potential to the slope stability problems. The examples show the successful implementation and the possibility of the extension of the proposed procedure to the variety of geotechnical engineering problems.

• The Journal of the Acoustical Society of Korea
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• v.42 no.6
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• pp.584-593
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• 2023

This study attempted to develop repetitive impact sources similar to real-life floor impact noise and to find an assessment approach corresponding to this new impact source. The necessity for the development of the new impact source arises from the fact that issues related to floor impact noise in actual residential buildings mainly stem from children running. However, the standard impact sources which have been used for measuring and evaluating floor impact noise are of single-impulse type, which differs from the actual problematic impact sources. The study encompassed 18 evaluation items, and the results suggest that items applicable for assessing floor impact noise include psychological effects (annoying, becoming angry), disturbances to daily life (interference with sleep, disruption of relaxation), and physiological effects (elevated blood pressure). These items can be employed individually and, depending on the type of evaluation for floor impact noise, can be selectively utilized. By doing so, more comprehensive evaluations of auditory experiments in laboratories or assessments of residential noise in living environments related to floor impact noise could be conducted.

• Transactions of the Korean hydrogen and new energy society
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• v.35 no.1
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• pp.66-74
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• 2024

This study addresses the escalating issue of worldwide hydrogen gas accidents, which has seen a significant increase in occurrences. To comprehensively evaluate the risks associated with hydrogen, a two approach was employed in this study. Firstly, a qualitative risk assessment was conducted using the bow-tie method. Secondly, a quantitative consequence analysis was carried out utilizing the areal locations of hazardous atmospheres (ALOHA) model. The study applied this method to two incidents, the hydrogen explosion accident occurred at the Muskingum River power plant in Ohio, USA, 2007 and the hydrogen storage tank explosion accident occurred at the K Technopark water electrolysis system in Korea, 2019. The results of the risk assessments revealed critical issues such as deterioration of gas pipe, human errors in incident response and the omission of important gas cleaning facility. By analyzing the cause of accidents and assessing risks quantitatively, the effective accident response plans are proposed and the effectiveness is evaluated by comparing the effective distance obtained by ALOHA simulation. Notably, the implementation of these measures led to a significant 54.5% reduction in the risk degree of potential explosions compared to the existing risk levels.

• Journal of the Earthquake Engineering Society of Korea
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• v.24 no.6
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• pp.293-303
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• 2020

Seismic fragility was assessed for non-seismic reinforced concrete shear walls in Korean high-rise apartment buildings in order to implement an earthquake damage prediction system. Seismic hazard was defined with an earthquake scenario, in which ground motion intensity was varied with respect to prescribed seismic center distances given an earthquake magnitude. Ground motion response spectra were computed using Korean ground motion attenuation equations to match accelerograms. Seismic fragility functions were developed using nonlinear static and dynamic analysis for comparison. Differences in seismic fragility between damage state criteria including inter-story drifts and the performance of individual structural members were investigated. The analyzed building had an exceptionally long period for the fundamental mode in the longitudinal direction and corresponding contribution of higher modes because of a prominently insufficient wall quantity in such direction. The results showed that nonlinear static analyses based on a single mode tend to underestimate structural damage. Moreover, detailed assessments of structural members are recommended for seismic fragility assessment of a relatively low performance level such as collapse prevention. On the other hand, inter-story drift is a more appropriate criterion for a relatively high performance level such as immediate occupancy.

• Journal of Environmental Impact Assessment
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• v.19 no.3
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• pp.223-230
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• 2010

Trajectory dispersion models are used for the dispersion calculations in air quality assessments, Yellow-sand modeling, environmental planning and the emergency response. Meso-scale forcing and coastal circulations are calculated by trajectory model in the East Asia region. In this study the meteorological fields (GDAS and MM5) coupled to the trajectory model (HY-SPLIT) are applied to simulate the transport and the dispersion. Seoul is selected as a starting point of the HY-SPLIT. The sensitivity studies are performed by conducting an ensemble of simulations using the GDAS and the MM5 model for the same dispersion cases. The results in this study show a significant difference depending on the resolution of meteorological models. Additionally, in most cases of the compared tionally,results from MM5 and GDAS, the absolute and relative distance, shows significant difference and the difference increased with the increasing distance of HY-SPLIT. Therefore, for the case of small domai for twi d field distefbution over complex terrai, should be used only high model temporal or spatial resolution to improve the HY-SPLIT model results.

• The Journal of the Acoustical Society of Korea
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• v.21 no.1
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• pp.37-41
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• 2002

In this paper, we made shorter EDT(early decay time) of room reverberation curve using multiple-channel. The speech signal was processed inverse filtering with full-band and sub-band in the basis MINT, and then the multiple-channel adaptive filters were used LMS (Least Mean Square) and NLMS (Normalized Least Mean Square) algorithm. Experimental results, we could get 1/3 of time reduction at 20dB level in the reverberation curve using full-band NLMS when two microphones were used. Also, it is shown that the speech articulation was improved 80% from the test listeners with the speech, which was to shorten EDT by MINT in the subjective assessments using real room impulse response.