• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2007년도 학술대회
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• pp.38-38
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• 2007

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 1997년도 제2차 추계학술대회 초록집
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• pp.12-12
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• 1997

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회.한국자기공명학회 2005년도 공동학술대회
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• pp.31-31
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• 2005

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회.한국자기공명학회 2005년도 공동학술대회
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• pp.34-34
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• 2005

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2006년도 제11차 학술대회
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• pp.60-60
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• 2006

• Toxicological Research
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• 제35권1호
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• pp.37-44
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• 2019

A major predictor of the efficacy of natural or synthetic cannabinoids is their binding affinity to the cannabinoid type I receptor ($CB_1$) in the central nervous system, as the main psychological effects of cannabinoids are achieved via binding to this receptor. Conventionally, receptor binding assays have been performed using isotopes, which are inconvenient owing to the effects of radioactivity. In the present study, the binding affinities of five cannabinoids for purified $CB_1$ were measured using a surface plasmon resonance (SPR) technique as a putative non-isotopic receptor binding assay. Results were compared with those of a radio-isotope-labeled receptor binding assay. The representative natural cannabinoid ${\Delta}^9$-tetrahydrocannabinol and four synthetic cannabinoids, JWH-015, JWH-210, RCS-4, and JWH-250, were assessed using both the SPR biosensor assay and the conventional isotopic receptor binding assay. The binding affinities of the test substances to $CB_1$ were determined to be (from highest to lowest) $9.52{\times}10^{-3}M$ (JWH-210), $6.54{\times}10^{-12}M$ (JWH-250), $1.56{\times}10^{-11}M$ (${\Delta}^9$-tetrahydrocannabinol), $2.75{\times}10^{-11}M$ (RCS-4), and $6.80{\times}10^{-11}M$ (JWH-015) using the non-isotopic method. Using the conventional isotopic receptor binding assay, the same order of affinities was observed. In conclusion, our results support the use of kinetic analysis via SPR in place of the isotopic receptor binding assay. To replace the receptor binding affinity assay with SPR techniques in routine assays, further studies for method validation will be needed in the future.

• 한국도로학회논문집
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• 제9권2호
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• pp.89-99
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• 2007

복소수계수 $E^*$로 표현되는 아스팔트 콘크리트의 탄성계수는 아스팔트 포장설계에서 매우 중요한 입력변수다. 일반적으로 아스팔트 콘크리트의 탄성계수는 동탄성 계수시험 (Dynamic Modulus Test)을 사용하여 평가한다. 그러나 동탄성계수시험은 일상적인 시험법으로 적용하기에는 고가의 시험장비, 복잡한 시험장비, 많은 시험시간 등의 문제가 있다. 이에 반하여 충격공진시험(IR: Impact Resonance test)은 비파괴시험으로서 간편한 시험장치, 단순한 시험방법이며 반복성이 뛰어나다. 본 연구의 주요 목적은 충격하중의 타격위치 시편거치 방법 충격하중원의 특성, 신호획득 속도, 신호처리방법 등을 포함한 IR시험의 시험조건의 영향을 평가하는 것이다. 본 연구에서 적용한 모든 시험조건 범위에서 충격공진시험에서 측정된 결과의 변동은 ${\pm}2.7%$ 이내에 들었다.

• Journal of Magnetics
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• 제19권4호
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• pp.365-371
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• 2014

The aim of this study was to evaluate the utility of 3-D images by comparing and analyzing reconstructed 3-D images from fast spin echo images of MRI cholangiopancreatography (MRCP) images using maximum intensity projection (MIP) with the subtraction images derived from dynamic tests of magnetic resonance mammography. The study targeted 20 patients histologically diagnosed with pancreaticobiliary duct disease and 20 patients showing pancreaticobiliary duct diseases, where dynamic breast MR (magnetic resonance) images, fast spin echo imaged of pancreaticobiliary duct, and 3-D reconstitution images using a 1.5T MR scanner and 3.0T MR scanner were taken. As a result of the study, the signal-to-noise ratio in the subtracted breast image before and after administering the contrast agent and in the reconstructed 3-D breast image showed a high ratio in the reconstructed image of lesional tissue, relevant tissue, and fat tissue. However, no statistically meaningful differences were found in the contrast-to-noise ratio of the two images. In the case of the MRCP image, no differences were found in the ratios of the fast spin echo image and reconstructed 3-D image.

• Investigative Magnetic Resonance Imaging
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• 제21권4호
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• pp.242-251
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• 2017

Purpose: To investigate the association of carotid intraplaque hemorrhage (IPH) with acute cerebral ischemic events and progression of stenosis using magnetic resonance (MR) imaging. Materials and Methods: From April 2014 to December 2016, 53 patients underwent carotid plaque MR imaging, including magnetization-prepared rapid acquisition with gradient-echo (MPRAGE) sequence. A total of 66 carotid arteries in 53 patients had carotid stenosis, and they were included in this study. Carotid arteries were classified according to the presence of IPH, the age of hemorrhage, and degree of stenosis. We assessed ipsilateral cerebrovascular event rates and progression of stenosis between the IPH and no-IPH groups. Results: Of the 61 carotid arteries assessed, 34 (56%) had IPH, and 27 (44%) had no IPH. Acute cerebral ischemic events were more frequent in the IPH group (47% vs. 22%, P = 0.045), especially in the < 30%-stenosis group (100% vs. 0%, P = 0.028). However, there was no significant difference in the incidence of ischemic events according to the age of hemorrhage (50% vs. 44%, P = 0.492). Among the 61 carotid arteries, 20 carotid arteries had previously undergone carotid artery imaging and were evaluated for plaque progression. The trend for progression of stenosis favored the IPH group versus the no-IPH group, with a marginal P-value ($20%{\pm}12.7$ vs. $9.6%{\pm}5.7$, P = 0.063). Conclusion: IPH was associated with an increased incidence of acute ischemic events, especially in the mild-stenosis group and it was also associated with progression of stenosis. Evaluation of the carotid IPH by carotid plaque MR could improve discrimination of carotid plaques that cause ischemic events and progression of stenosis.

• 비파괴검사학회지
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• 제32권4호
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• pp.369-375
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• 2012

기존 비파괴평가 기술의 결함 탐지 한계를 극복하기 위하여 비선형 초음파공명 특성을 이용한 미세 균열 진단 기술을 개발하였다. 가진 전압에 따른 초음파공명 주파수의 천이현상과 정규화 공명 진폭 감소 현상을 비선형 초음파공명 특성 파라미터로 제안하였으며 이를 실험적으로 확인하였다. CT 시편에 피로시험을 통하여 미세한 자연 균열을 생성하였으며 피로 사이클 단계마다 초음파공명주파수와 정규화 공명진폭의 변화를 측정하였다. 무결함 또는 10 ${\mu}m$ 정도의 매우 미세한 균열이 존재하는 시편에서는 초음파공명 주파수 천이현상이나 정규화 공명 진폭의 변화가 나타나지 않는 반면에 30 ${\mu}m$급 이상의 미세 균열 시편에서는 균열 크기가 증가함에 따라 초음파공명주파수의 천이 현상이나 정규화 공명 진폭의 감소량이 증가함을 확인하였다.