• 한국정보통신학회논문지
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• 제25권11호
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• pp.1512-1518
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• 2021

단일세포 RNA-Seq 은 개별 세포의 유전자 발현을 제공하므로 세포마다 차등적인 고해상도 정보를 준다. 단일세포 RNA-Seq 자료에 대하여 군집화는 세포의 유형과 고수준의 생물 과정을 이해하기 위하여 수행된다. 매우 고차원이고 대용량인 단일세포 RNA-Seq을 효과적으로 처리하기 위하여, 본 논문은 변이 자동인코더를 사용하여 고차원의 자료공간을 저차원의 잠재공간으로 변환하여, 보다 정확한 군집화를 수행할 수 있는 특징공간을 만든다. 차원이 축소된 잠재공간에 다양한 군집화 방법을 적용하는 접근을 다양한 전통적인 단일세포 RNA-Seq 군집화 방법과 성능을 비교하였다. 군집화 실험을 통하여, 제안한 방법은 기존 방법들보다 다양한 군집화 성능기준에서 성능이 개선되었다.

• 천문학회지
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• 제38권2호
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• pp.237-240
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• 2005

We present images of L1551 IRS5 at angular resolutions as high as ${\~}$30 mas, corresponding to a spatial resolution of ${\~}$5 AU, made at 7 mm with the VLA. Previously known to be a binary protostellar system, we show that L1551 IRS5 is likely a triple protostellar system. The primary and secondary components have a projected separation of ${\~}$46 AU, whereas the tertiary component has a projected separation of ${\~}$11 AU from the primary component. The circumstellar dust disks of the primary and secondary components have dimensions of ${\~}$15 AU, whereas that of the tertiary component has a dimension of ${\~}$10 AU. Their major axes are closely, but not perfectly, aligned with each other, as well as the major axis of the surrounding flattened, rotating, and contracting molecular condensation (pseudodisk). Furthermore, the orbital motion of the primary and secondary components is in the same direction as the rotational motion of this pseudodisk. We suggest that all three protostellar components formed as a result of the fragmentation of the central region of the molecular pseudo disk. The primary and secondary components, but apparently not the tertiary component, each exhibits a bipolar ionized jet that is centered on and which emergers perpendicular to its associated dust disk. Neither jets are resolved along their base, implying that they are driven within a radial distance of ${\~}$2.5 AU from their central protostars. Finally, we show evidence for what may be dusty matter streams feeding the two main protostellar components.

• 한국지리정보학회지
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• 제19권3호
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• pp.127-143
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• 2016

본 연구는 상이한 셀 크기에 따라 밀도구분적 인구추정의 정확성이 어떻게 변화하는지를 탐색하였다. 미국 조지아주 풀턴 카운티를 사례로 한 밀도구분적 인구 지도가 지능적인 밀도구분적 지도제작기법, 인구자료, 원본 및 모의된 토지이용 및 피복 자료를 이용하여 30m에서 420m의 해상도까지 매 30m 간격으로 생성되었다. 밀도구분적 인구 지도의 정확성은 RMSE 및 수정 RMSE 통계치를 이용하여 평가되었다. 프랙털 차원 값은 TPSA 방법을 사용하면서 30m에서 420m의 해상도까지 생성된 밀도구분적 인구 지도에 대해 각각 계산되었다. 연구결과에 따르면, 속성의 정확성 측면에서 인구를 보다 정확하게 추정하기 위해서 210m 이하의 격자 셀 크기가 적절하였나, 사례지역에서 밀도구분적 인구추정의 허용가능한 공간적 정확성을 충족시키기 위해 30m의 격자 셀 크기가 적절하였다. 또한, 프랙털 분석은 120m의 격자 셀 크기가 사례지역에서 밀도구분적 인구추정을 위한 최적의 해상도 이다는 것을 보여준다.

• 한국광학회지
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• 제9권3호
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• pp.146-150
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• 1998

광학적 분해능의 한계에 도달한 크기를 갖는 패턴의 분해능과 초점심도를 향상시키기 위해서 여러 가지 결상 방법들이 시도되고 있다. 일반적으로 선형 편광에서는 패턴 방향에 따라 TM mode 와 TE mode 사이에 contrast gap이 존재한다. 하지만 기존의 연구에서 이러한 conteast gap을 해결해 줄 수 있는 방법으로 타원편광 조명법이 제안하였다. 본 연구에서는 서로 방향이 수직인 패턴이 함께 있는 임의의 마스크에 타원편광을 포함한 여러 편광 조건을 적\ulcorner해 봄으로써, 초점심도를 향상시킬 수 있는 편광 조명 상태를 찾았보았다. 각 편광 조건에 따른 초점심도는, 허용 가능한 노광량(Exposure Dose0과 Critical Dimension(CD)의 오차 범위에 대한 ED-Tree(Exposure-Defocus Tree)를 통해 구하였다. 그 결과, 광학계의 조건에 따라 타원편광 조명이 초점심도를 향상시키는 효과가 있음을 알 수 있었다.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.150-153
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• 2002

High dose rate (HDR) brachytherapy in the treatment of cervix carcinoma has become popular, because it eliminated many of the problems with conventional brachytherapy. In order to improve clinical effectiveness with HDR brachytherapy, dose calculation algorithm, optimization procedures, and image registrations should be verified by comparing the dose distributions from a planning computer and those from a humanoid phantom irradiated. Therefore, the humanoid phantom should be designed such that the dose distributions could be quantitatively evaluated by utilizing the dosimeters with high spatial resolution. Therefore, the small size of thermoluminescent dosimeter (TLD) chips with the dimension of 1/8" and film dosimetry with spatial resolution of <1mm used to measure the radiation dosages in the phantom. The humanoid phantom called a pelvic phantom is made of water and tissue-equivalent acrylic plates. In order to firmly hold the HDR applicators in the water phantom, the applicators are inserted into the grooves of the applicator supporters. The dose distributions around the applicators, such as Point A and B, can be measured by placing a series of TLD chips (TLD-to- TLD distance: 5mm) in three TLD holders, and placing three verification films in orthogonal planes.

• Molecules and Cells
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• 제22권1호
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• pp.119-125
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• 2006

The rat is an accepted model for studying human psychiatric/neurological disorders. We provide a protocol for total soluble protein extraction using trichloroacetic acid/acetone (TCA/A) from rat (female) whole brain, 10 brain regions and the pituitary gland, and show that two-dimensional gel electrophoresis (2-DGE) using precast immobilized pH (4-7) gradient (IPG) strip gels (13 cm) in the first dimension yields clean silver nitrate stained protein profiles. Though TCA/A precipitation may not be "ideal", the important choice here is the selection of an appropriate lysis buffer (LB) for solubilizing precipitated proteins. Our results reveal enrichment of protein spots by use of individual brain regions rather than whole brain, as well as the presence of differentially expressed spots in their proteomes. Thus individual brain regions provide improved protein coverage and are better suited for differential protein detection. Moreover, using a phosphoprotein-specific dye, ingel detection of phosphoproteins was demonstrated. Representative high-resolution silver nitrate stained proteome profiles of rat whole brain total soluble protein are presented. Shortcomings apart (failure to separate membrane proteins), gel-based proteomics remains a viable option, and 2-DGE is the method of choice for generating high-resolution proteome maps of rat brain and brain regions.

• 사상체질의학회지
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• 제18권3호
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• pp.49-56
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• 2006

1. Objectives We are going to develope 3D Face Recognition Apparatus to analyse the facial characteristics of the Sasangin. In the process, we should identify a Hardware Error Analysis of this Apparatus. 2. Methods We verified The resolution, the repetition ability, the Flatness and the Cylindericity of 3D Face Recognition Apparatus by measuring a triangular pyramid, an exact square pillar and a cylinder. 3. Results and Conclusions In this test, The resolution of 3D-FARA was $0.0368mm{\times}0.0594mm{\times}0.2748mm(X{\times}Y{\times}Z)$, the repetition ability was 0.1187mm, the Flatness was 0.17188mm. the Flatness of triangular pyramid was 1.39034mm and the Cylindericity of cylinder was 3.1306mm. In conclusion, If we use 3D-FARA, It is necessary to complement the site of top of the nose and the outline of face, which is likely to occur hardware error, by using software invention or attaching the Land mark to subject.

• 대기
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• 제22권4호
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• pp.387-400
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• 2012

This study aims at examining the sensitivity of numerical simulations to the resolution of initial and boundary data, and to an application of WRF (Weather Research and Forecasting) 3DVAR (Three Dimension Variational data Assimilation). To do this, we ran the WRF model by using GDAS (Global Data Assimilation System) FNL (Final analyses) and the KLAPS (Korea Local Analysis and Prediction System) analyses as the WRF's initial and boundary data, and by using an initial field made by assimilating the radar data to the KLAPS analyses. For the sensitivity experiment, we selected a heavy rainfall case of 21 September 2010, where there was localized torrential rain, which was recorded as 259.5 mm precipitation in a day at Seoul. The result of the simulation using the FNL as initial and boundary data (FNL exp) showed that the localized heavy rainfall area was not accurately simulated and that the simulated amount of precipitation was about 4% of the observed accumulated precipitation. That of the simulation using KLAPS analyses as initial and boundary data (KLAPC exp) showed that the localized heavy rainfall area was simulated on the northern area of Seoul-Gyeonggi area, which renders rather difference in location, and that the simulated amount was underestimated as about 6.4% of the precipitation. Finally, that of the simulation using an initial field made by assimilating the radar data to the KLAPS using 3DVAR system (KLAP3D exp) showed that the localized heavy rainfall area was located properly on Seoul-Gyeonggi area, but still the amount itself was underestimated as about 29% of the precipitation. Even though KLAP3D exp still showed an underestimation in the precipitation, it showed the best result among them. Even if it is difficult to generalize the effect of data assimilation by one case, this study showed that the radar data assimilation can somewhat improve the accuracy of the simulated precipitation.

• 대한원격탐사학회지
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• 제24권3호
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• pp.223-233
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• 2008

In the mid 90's, the U.S. government released images acquired by the first generation of photo reconnaissance satellite missions between 1960 and 1972. The Declassified Intelligent Satellite Photographs (DISP) from the Corona mission are of high quality with an astounding ground resolution of about 2 m. The KH-4A panoramic camera system employed a scan angle of $70^{\circ}$ that produces film strips with a dimension of $55\;mm\;{\times}\;757\;mm$. Since GPS/INS did not exist at the time of data acquisition, the exterior orientation must be established in the traditional way by using control information and the interior orientation of the camera. Detailed information about the camera is not available, however. For reconstructing points in object space from DISP imagery to an accuracy that is comparable to high resolution (a few meters), a precise camera model is essential. This paper is concerned with the derivation of a rigorous mathematical model for the KH-4A/B panoramic camera. The proposed model is compared with generic sensor models, such as affine transformation and rational functions. The paper concludes with experimental results concerning the precision of reconstructed points in object space. The rigorous mathematical panoramic camera model for the KH-4A camera system is based on extended collinearity equations assuming that the satellite trajectory during one scan is smooth and the attitude remains unchanged. As a result, the collinearity equations express the perspective center as a function of the scan time. With the known satellite velocity this will translate into a shift along-track. Therefore, the exterior orientation contains seven parameters to be estimated. The reconstruction of object points can now be performed with the exterior orientation parameters, either by intersecting bundle rays with a known surface or by using the stereoscopic KH-4A arrangement with fore and aft cameras mounted an angle of $30^{\circ}$.

• 한국음향학회지
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• 제42권5호
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• pp.422-428
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• 2023

초고속 초음파 영상은 탄성 영상, 초고속 도플러, 초해상도 영상과 같은 다양한 초음파 기반의 기능성 영상기술에 폭넓게 적용되고 있다. 하지만, 획득하는 데이터의 양이 많아 실시간 영상 재구성이나 3차원 또는 모바일 초음파 영상 응용으로의 확장이 제한된다. 본 논문은 적응 양자화 기법을 통해 초고속 초음파 영상으로 획득되는 대용량 Radio frequency(RF) 데이터의 전송 효율을 높이는 방법을 제안한다. 인체에서 반사된 초음파 신호는 높은 동적 범위를 가져 대부분의 현재 시스템에서 사용되는 고정 양자화 기법은 10 bits ~ 14 bits 이상의 높은 양자화 단계를 가진다. 양자화 단계 저감에 대한 화질 저하의 한계를 극복하기 위해, 본 연구는 영상 깊이에 따라 구간을 설정하고, 각 영역별 RF 데이터를 정규화하고 양자화하는 방안을 제안한다. 정량적인 검증을 위해, Field II 컴퓨터 모사 실험을 활용하여, 고정 양자화 방법과 제안하는 방법의 대조도 대 잡음 비, 공간 해상도 및 원본 대비 유사도를 비교하였다. 또한, 연구용 초음파 장비를 활용한 인체 모사 실험 및 인체 실험을 통해 최종 3-bit로 재구성한 영상에서도 제안하는 방법이 효과적으로 적용되는 것을 입증하였다.