• Journal of the Korean Applied Science and Technology
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• v.39 no.1
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• pp.132-145
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• 2022

The emission factor and activity data of fugitive dust in the domestic agricultural field have been applied to the US inventory system without reflecting the domestic environmental conditions (wind speed, humidity, etc.) and agricultural characteristics. In this study, the temporal resolution was improved for each region by deriving a monthly distribution factor through the application of wind speed and dry season and the spatial resolution was improved for each region by subdivided into dong and ri from ci·gun·gu. Through this study, it is judged that it can be used as an important data for improving the emission and activity data of fugitive dust in the agricultural field that currently exist.

• Korean Journal of Clinical Laboratory Science
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• v.38 no.2
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• pp.135-140
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• 2006

Magnetocardiography (MCG) is the measurement and analysis of the magnetic component of the electro-magnetic field of the human heart, usually conducted externally, using extremely sensitive devices such as a Superconducting Quantum Interference Device (SQUID). MCG is a totally noninvasive method, it uses neither radiation nor ultrasonics. The magnetic activity of the heart is registered from outside the thorax. MCG has a very high sensitivity and a high spatial resolution for very a small, local myocardial current. In comparison to the electrical signals measured by an ECG, the magnetic signal does not disturb the boundaries of tissues with different electrical properties. MCG measures the myocardial function rather than describing the morphology. MCG is a relatively new technique that promises good spatial resolution and extremely high temporal resolution, thus complementing other heart activity measurement techniques such as Electrocardiography (ECG). The clinical uses of MCG are in detecting various cardiac disorders including myocardial infarction, ventricular hypertrophy, ventricular conduction defects, Wolff-Parkinson-White (WPW) syndrome, sudden cardiac death and fetal magnetocardiography. Magnetocardiography may be used alone or together with electrcardiography for the measurement of spontaneous or overloaded activity and for research or clinical purposes.

• BMB Reports
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• v.51 no.6
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• pp.302-307
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• 2018

Pinosylvin is known to have anti-inflammatory activity in endothelial cells. In this study, we found that pinosylvin had a pro-apoptotic activity in lipopolysaccharide (LPS)-preconditioned leukocytes. This finding suggests that pinosylvin has an effect on the resolution of inflammation. To understand the detailed mechanism, we examined if pinosylvin enhances cyclooxygenase (COX) or lipoxygenase (LOX) activity in THP-1 and U937 cells. LOX activity was found to be markedly increased by pinosylvin, whereas COX activity was not altered. Furthermore, we found that pinosylvin enhanced both levels of ALOX 15 mRNA and protein, implying that LOX activity, elevated by pinosylvin, is attributed to upregulation of ALOX 15 expression. From this cell signaling study, pinosylvin appeared to promote phosphorylations of ERK and JNK. ERK or JNK inhibitors were found to attenuate ALOX 15 expression and LPS-induced apoptosis promoted by pinosylvin. In conclusion, pinosylvin enhances the apoptosis of LPS-preconditioned leukocytes by up-regulating ALOX 15 expression through ERK and JNK. These findings suggest that pinosylvin may induce the resolution of inflammation.

• Mass Spectrometry Letters
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• v.1 no.1
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• pp.13-16
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• 2010

The active components in a plant extract can be represented as mass profiles. We introduce here a new, multi-compound discovery method known as Scaling of Correlations between Activity and Mass Profiles (SCAMP). In this method, a correlation coefficient is used to quantify similarities between the extract activity and mass profiles. The method was evaluated by first measuring the anti-oxidation activity of eleven fractions of an Astragali Radix extract using DPPH assays. Next, 15 T Fouriertransform ion cyclotron resonance (FT-ICR) MS was employed to generate mass profiles of the eleven fractions. A comparison of correlation coefficients indicated two compounds at m/z 285.076 and 286.076 that were strong antioxidants. Principal component analyses of these profiles yielded the same result. FT-ICR MS, which offers a mass resolving power of 500,000, was used to discern isotopic fine structures and indicated that the molecular formula corresponding to the peak at m/z 285.076 was $C_{16}H_{13}O_5$. SCAMP in combination with high-resolution MS can be applied to any type of mixture to study pharmacological activity and is a powerful tool for active compound discovery in plant extract studies.

• Biotechnology and Bioprocess Engineering:BBE
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• v.5 no.1
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• pp.53-56
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• 2000

A thermostable esterase from the hyper thermophilic archaeon Sulfolobus solfataricus was partially purified 590-fold with $16.2\%$ recovery. The partially purified esterase had a specific activity of $29.5\;{\mu}mol\;min^{-1}mg^{-1}$ when the enzyme activity was determined using p-nitrophenyl butyrate as a substrate. The apparent molecular weight was about 100 kDa, while the optimum temperature and pH for esterase were $75^{\circ}C$ and 8.0, respectively. The enzyme showed high thermal stability and solvent tolerance in comparison to its mesophilic counterpart. The enzyme also showed chiral resolution activity for (S)-ibuprofen, indicating that S. solfataricus esterase can be used for the production of commercially important chiral drugs.

• Korean Journal of Clinical Laboratory Science
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• v.37 no.2
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• pp.123-128
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• 2005

Magnetoencephalography (MEG) is the measurement of the magnetic fields produced by electrical activity in the brain, usually conducted externally, using extremely sensitive devices such as Superconducting Quantum Interference Device (SQUID). MEG needs complex and expensive measurement settings. Because the magnetic signals emitted by the brain are on the order of a few femtoteslas (1 fT = 10-15T), shielding from external magnetic signals, including the Earth's magnetic field, is necessary. An appropriate magnetically shielded room is very expensive, and constitutes the bulk of the expense of an MEG system. MEG is a relatively new technique that promises good spatial resolution and extremely high temporal resolution, thus complementing other brain activity measurement techniques such as electroencephalography (EEG), positron emission tomography (PET), single-photon emission computed tomography (SPECT) and functional magnetic resonance imaging (fMRI). MEG combines functional information from magnetic field recordings with structural information from MRI. The clinical uses of MEG are in detecting and localizing epileptic form spiking activity in patients with epilepsy, and in localizing eloquent cortex for surgical planning in patients with brain tumors. Magnetoencephalography may be used alone or together with electroencephalography, for the measurement of spontaneous or evoked activity, and for research or clinical purposes.

• The Korean Journal of Applied Statistics
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• v.35 no.1
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• pp.161-175
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• 2022

Oscillatory magnetic fields produced in the brain due to neuronal activity can be measured by the sensor. Magnetoencephalography (MEG) is a non-invasive technique to record such neuronal activity due to excellent temporal and fair amount of spatial resolution, which gives information about the brain's functional activity. Potential utilization of high spatial resolution in MEG is likely to provide information related to in-depth brain functioning and underlying factors responsible for changes in neuronal waves in some diseases under resting state or task state. This review is a comprehensive report to introduce statistical models from MEG data including graphical network modelling. It is also meaningful to note that statisticians should play an important role in the brain science field.

• The Transactions of the Korean Institute of Electrical Engineers D
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• v.53 no.1
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• pp.55-64
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• 2004

Conventional bipolar surface electromyography(EMG) technique detects only the superimposed electromyographic activity of a large number of motor units due to its low spatial resolution. For the diagnosis of neuromuscular disorder, the information of single MU is required. In this paper, 9 channel array surface electrode system was as designed and MLoG filter was proposed. Also the MCPT(modified convolution processing technique)method was proposed for the improvement of MUAP resolution. For performance evaluation, power spectrum analysis of random data and raw EMG signal comparison of MUAP shape and quantitative estimation of SNR were executed. As a result, the MUAP resolution improvement of 32％ was obtained from the standpoint of the signal-to-noise ratio(SNR).

• Journal of the Korea Society for Simulation
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• v.9 no.4
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• pp.41-50
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• 2000

We have many simulation constraints to meet as a modeled system becomes large and complex. Real-time simulations are the examples in that they are constrained by certain non-function constraints (e.g., timing constraints). In this paper, an enhanced hierarchical modeling methodology is proposed to efficiently deal with constraint-simulations. The proposed modeling method enhances hierarchical modeling methods to provide multi-resolution model. A simulation model is composed by determining the optimal level of abstraction that is guaranteed to meet the given simulation constraints. Four modeling activities are defined in the proposed method: 1) Perform the logical architectural design activity to produce a multi-resolution model, 2) Organize abstraction information of the multi-resolution model with AT (Abstraction Tree) structure, 3) Formulate the given constraints based on U (Integer Programming) approach and embrace the constraints to AT, and 4) Compose a model based on the determined level of abstraction with which the multi-resolution model can satisfy all given simulation constraints. By systematically handling simulation constraints while minimizing the modeler's interventions, we provide an efficient modeling environment for constraint-simulations.

• Journal of Korean Public Health Nursing
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• v.21 no.1
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• pp.46-56
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• 2007

Purpose: This study attempted to identify the sexual function (ALARM: Activity, Libido, Arousal and orgasm, Resolution, Medical history) of patients who have had an ostomy for the development of an ALARM sexual counseling program. Method: Subjects for this descriptive study were recruited from the outpatient clinic of a university affiliated medical center and peer group. Fifty-two subjects who have had an ostomy and lived with their spouse were selected. Instruments were developed by researchers based on the ALARM model by Anderson (1990). Results: In the subject group, 32.7% patients were not sexually active and 76.9% hesitated to have sexual activity because of the stoma. The mean score of resolution was 13.2 (range: 8-32), with a higher score for couple's intimacy indicating a higher level of libido and resolution. Conclusion: This study presents a series of clinical guidelines that nurses can use to accurately assess sexual health issues and select appropriate sexual counseling for patients with an ostomy.