• Toxicological Research
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• 제33권1호
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• pp.1-5
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• 2017

Nuclear factor E2-related factor 2 (Nrf2), a transcription factor, controls the expression of genes encoding cytoprotective proteins, including antioxidant enzymes that combat oxidative and electrophilic stress to maintain redox homeostasis. However, recent studies demonstrated that, in cancer, aberrant activation of Nrf2 by epigenetic alterations promotes high expression of cytoprotective proteins, which can decrease the efficacy of anticancer drugs used for chemotherapy. In this review, we summarize recent findings regarding the relationship between oxidative stress, Nrf2, epigenetic modification, and anticancer drug resistance, which should aid in development of new strategies to improve chemotherapeutic efficacy.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2001년도 봄 학술발표회 논문집
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• pp.859-864
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• 2001

For earthquake resistance design, a response modification factor is used to reduce the design strength and it reflects ductility, reserve strength, redundancy and damping effect. But this factor has not theoretical basis. In this study, two response modification factors are compared and analyzed for shear wall apartment building.; the one is introduced by ATC-19 Procedures, the other is suggested FEMA-273 and ATC-40 through nonlinear static analysis. For the results, ATC-19 procedure gives a reasonable estimation to R factor. But $R_{u}$ by using FEAM-273 and ATC-40 methods is estimated so small in case of a minor or moderate earthquake region. Due to this fact, response modification factor is smaller than suggested load criterion 3.0. So, it needs to decrease wall volume and reduce the global strength and system stiffness for proper ductile behavior matching to domestic load criterion.

• 한국전산구조공학회논문집
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• 제27권6호
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• pp.643-651
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• 2014

이 논문에서는 케이블교량 설계기준의 설계하중조합에 대한 신뢰도분석을 수행하였다. 설계기준에서 정의한 하중계수와 저항계수를 적용하여 설계된 실제 케이블교량을 대상으로 주 부재별 통계특성과 설계지배 하중조합을 분석하였다. 신뢰도분석을 통하여 하중조합별로 설정된 목표신뢰도지수를 확보됨을 확인하였고, 교량의 중요도를 상향할 수 있는 저항수정계수의 적용성을 검토하였다. 설계변수들이 신뢰도지수에 미치는 민감도 분석을 통하여 케이블의 신뢰도에 중요한 영향을 주는 요소를 분석하였다. 이를 통하여 설계기준의 안전계수들을 적용한 설계를 통하여 케이블교량의 목표신뢰도지수를 확보할 수 있음을 확인하였다.

• Structural Engineering and Mechanics
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• 제67권1호
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• pp.1-8
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• 2018

Shake table tests performed on five 1:3 reduced scale two story RC moment resisting frames having construction defects, have shown severe joint damageability in deficient RC frames, resulting in joint panels' cover spalling and core concrete crushing. Haunch retrofitting technique was adopted herein to upgrade the seismic resistance of the deficient RC frames. Additional four deficient RC frames were built and retrofitted with steel haunch; both axially stiffer and deformable with energy dissipation, fixed to the beam-column connections to reduce shear demand on joint panels. The as-built and retrofitted frames' seismic response parameters are calculated and compared to evaluate the viability of haunch retrofitting technique. The haunch retrofitting technique increased the lateral stiffness and strength of the structure, resulting in the increase of structure's overstrength. The retrofitting increased response modification factor R by 60% to 100%. Further, the input excitation PGA was correlated with the lateral roof displacement to derive structure response curve that have shown significant resistance of retrofitted models against input excitations. The technique can significantly enhance the seismic performance of deficient RC frames, particularly against the frequent and rare earthquake events, hence, promising for seismic risk mitigation.

• 멤브레인
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• 제33권1호
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• pp.1-12
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• 2023

본 총설은 소수성 불소수지계 분리막의 표면 개질에 대한 개론으로 다양한 표면 개질 방법 및 그 연구 결과를 중점적으로 서술하였다. PTFE로 대표되는 불소수지계 고분자 분리막은 막 증류, 유수 분리, 기체 분리를 포함한 다양한 막 분리 공정에서 사용되어왔다. PTFE 막은 내화학성, 내열성, 높은 기계적 강도와 같은 뛰어난 물성에도 불구하고 소수성 표면 특성으로 인해 기술 적용의 확장에 제한적이다. 친수성 향상을 위해 습식 화학법, 친수성 고분자 코팅, 플라즈마 처리, 조사, 원자층 증착과 같은 다양한 PTFE 표면 개질 방법을 이용하며 이를 통해 불소수지계 분리막의 응용분야가 확장될 수 있다.

• 대한조선학회지
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• 제25권4호
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• pp.28-38
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• 1988

본 논문은 선박저항 추정을 위한 통계해석 방법을 기술하고 있다. 조파저항계수 추정식은 조파저항이론을 이용하여 선체주요치수와 횡단면적계수들로부터 유도하였으며, 그 회귀계수들은 저항시험 결과들을 회귀 분석하여 얻었다. 형상영향계수 추정식은 선체주요지수, 횡단면적와 저항시험결과들로부터 순수하게 회귀분석하여 얻었다. 또한 선체주요지수는 바꾸지 않고 횡단면적곡선만을 변화시켜 조파저항을 최소로 해주는 방법을 제시하였다. 이 방법들은 산적화물선의 저항성능 추정에 적용하였다. 그리고 조파저항이 최소가 되는 수정선형을 도출해 냈으며, 이로인한 유효동력의 절감효과를 저항시험을 통해 확인하였다.

• 한국표면공학회:학술대회논문집
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• 한국표면공학회 2000년도 춘계학술발표회 초록집
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• pp.1-1
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• 2000

The results of the modification of metal materials treated by high temperature pulst:d plasma fluxes (HTlPPF) with a specific power of incident flux changing in the $(3...100)10^5{]\;}W/cm^2$ range and a pulse duration lying from 15 to $50{\;}\mu\textrm{s}$ have been presented. The results of HTPPF action were studied on the stainless steels of 18Cr-l0Ni, 16Cr- 15Ni, 13Cr-2Mo types; on the structural carbon steels of (13...35)Cr, St. 3, St. 20, St. 45 types; on the tool steels of U8, 65G, ShHI5 types, and others; on nickel and high nickel alloy of 20Cr-45Ni type; on zirconium- and vanadium-base alloys and other materials. The microstructure and properties (mechanical, tribological, erosion, and other properties) of modified materials and surface alloying of metals exposed to HTPPF action have been investigated. It was found that the modification of materials by HTPPF resulted in a simultaneous increase of several properties of the treated articles: microhardness of the surface and layers of 40...60 $\mu\textrm{m}$ in depth, tribological characteristics (friction coefficient, wear resistance), mechanical properties ({\sigma_y}, {\;}{\sigma_{0.2}}.{\;}{\sigma_r}) on retention of the initial plasticity ($\delta$), corrosion resistance, radistanation erosion under ion irradiation, and others. The determining factor of the changes observed is the structural-phase modification of the near-surface layers, in particular, the formation of the fine cellular structure in the near-surface layers at a depth of $20{\;}{\mu\textrm{m}}$ with dimension of cells changing in the range from 0.1 to $1., 5{\;}\mu\textrm{m}$, depending on the kind of material, its preliminary treatment, and the parameters of plasma fluxes. The remits obtained have shown the possibility of purposeful surface alloying of metals exposed to HTPPF action over a depth up to 20...45 $\mu\textrm{m}$ and the concentration of alloying element (Ni, Cr, V) up to 20 wt.%. Possible industrial brunches for using the treatment have been also considered, as well as some results on modifying the serial industrial articles by HTPPF.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2011년도 정기총회 및 추계학술대회 논문집
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• pp.1320-1326
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• 2011

The maximum speed of high-speed rail is restricted to various factors such as track condition including slope and radius, tunnel and dynamic stability of vehicle. Among the various factors, traction effort and resistance to motion is principal and basic factor. In addition, at high speed over 300km/h, aerodynamic drag amounts up to 80% of resistance to motion, that it can be said that aerodynamic drag is the most important factor to decide the maximum speed of high-speed rail system. This paper deals with a measure to increase the maximum speed of high-speed train by reducing aerodynamic drag. The traction effort curve and resistance to motion curve of existing high-speed train under development has been employed to set up the target of aerodynamic drag reduction to reach up to 500km/h without modification traction system. In addition, the contribution of various sources of aerodynamic drag to total value has been analyzed and the strategy for implementation of aerodynamic drag reduction has been discussed based on the aerodynamic simulation results around the train using computational fluid dynamics.

• Steel and Composite Structures
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• 제19권5호
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• pp.1167-1184
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• 2015

Despite considerable life casualty and financial loss resulting from past earthquakes, many existing steel buildings are still seismically vulnerable as they have no lateral resistance or at least need some sort of retrofitting. Passive control methods with decreasing seismic demand and increasing ductility reduce rate of vulnerability of structures against earthquakes. One of the most effective and practical passive control methods is to use a shear panel system working as a ductile fuse in the structure. The shear Panel System, SPS, is located vertically between apex of two chevron braces and the flange of the floor beam. Seismic energy is highly dissipated through shear yielding of shear panel web while other elements of the structure remain almost elastic. In this paper, lateral behavior and related benefits of this system with narrow-flange link beams is experimentally investigated in chevron braced simple steel frames. For this purpose, five specimens with IPE (narrow-flange I section) shear panels were examined. All of the specimens showed high ductility and dissipated almost all input energy imposed to the structure. For example, maximum SPS shear distortion of 0.128-0.156 rad, overall ductility of 5.3-7.2, response modification factor of 7.1-11.2, and finally maximum equivalent viscous damping ratio of 35.5-40.2% in the last loading cycle corresponding to an average damping ratio of 26.7-30.6% were obtained. It was also shown that the beam, columns and braces remained elastic as expected. Considering this fact, by just changing the probably damaged shear panel pieces after earthquake, the structure can still be continuously used as another benefit of this proposed retrofitting system without the need to change the floor beam.

• BMB Reports
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• 제56권11호
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• pp.584-593
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• 2023

Hypoxia, a widespread occurrence observed in various malignant tumors, results from rapid tumor growth that outpaces the oxygen supply. Tumor hypoxia precipitates several effects on tumor biology; these include activating angiogenesis, intensifying invasiveness, enhancing the survival of tumor cells, suppressing anti-tumor immunity, and fostering resistance to therapy. Aligned with the findings that correlate CMGC kinases with the regulation of Hypoxia-Inducible Factor (HIF), a pivotal modulator, reports also indicate that hypoxia governs the activity of CMGC kinases, including DYRK1 kinases. Prolyl hydroxylation of DYRK1 kinases by PHD1 constitutes a novel mechanism of kinase maturation and activation. This modification "primes" DYRK1 kinases for subsequent tyrosine autophosphorylation, a vital step in their activation cascade. This mechanism adds a layer of intricacy to comprehending the regulation of CMGC kinases, and underscores the complex interplay between distinct post-translational modifications in harmonizing precise kinase activity. Overall, hypoxia assumes a substantial role in cancer progression, influencing diverse aspects of tumor biology that include angiogenesis, invasiveness, cell survival, and resistance to treatment. CMGC kinases are deeply entwined in its regulation. To fathom the molecular mechanisms underpinning hypoxia's impact on cancer cells, comprehending how hypoxia and prolyl hydroxylation govern the activity of CMGC kinases, including DYRK1 kinases, becomes imperative. This insight may pave the way for pioneering therapeutic approaches that target the hypoxic tumor microenvironment and its associated challenges.