• Title/Summary/Keyword: resistance management

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Innovation Resistance Model of Sustainable SCM: Mediating Effect on Dynamic Capability

  • Da-Sol Lee
    • Journal of Korea Trade
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    • v.27 no.3
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    • pp.87-102
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    • 2023
  • Purpose - Although the importance and necessity of "sustainable supply chain management (SCM)" is emphasized, it is often not realized due to conflicting results, the long time required, and large-scale changes brought about by sustainability. This study used the innovation resistance model to confirm the influence of sustainable SCM innovation resistance factors and dynamic capabilities on adoption intentions. This approach made it possible to understand the factors that hinder adoption of sustainability practices and to identify the relationships among influencing factors. It should also help to establish effective policies or strategies. Design/methodology - Through a literature review, the characteristics of sustainable SCM were classified into relative advantage, compatibility, perceived risk, and complexity. The effects of these innovation characteristics on innovation resistance in sustainable SCM and the effects of innovation resistance on adoption intentions were confirmed. In addition, the effects of SCM capabilities on innovation resistance and adoption intentions were analyzed, and the mediating effect of innovation resistance was analyzed. Findings - Compatibility, perceived risk, and flexibility had significant effects on innovation resistance. In turn, innovation resistance had a significant effect on adoption intention, and flexibility had a significant effect on intention to adopt. A partial mediating effect of resistance to innovation was confirmed. Originality/value - Although many previous studies have acknowledged trade-offs with sustainability, most sustainable SCM studies dealt with the correlations among positive drivers of adoption, practices, and performance. This study confirmed the process of accepting sustainable SCM innovation in a single model and is expected to serve as a cornerstone for future sustainable SCM adoption studies. In addition, our findings should help establish effective policies or strategies to activate SSCM adoption by identifying the factors that hinder the adoption of sustainable SCM.

Corn Gluten Hydrolysate Affects the Time-Course of Metabolic Changes Through Appetite Control in High-Fat Diet-Induced Obese Rats

  • Lee, Hyojung;Lee, Hyo Jin;Kim, Ji Yeon;Kwon, Oran
    • Molecules and Cells
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    • v.38 no.12
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    • pp.1044-1053
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    • 2015
  • This study first investigated the effects of corn gluten hydrolysate (CGH) (1.5 g/day) administration for 7 days on appetite-responsive genes in lean Sprague-Dawley (SD) rats. In a second set of experiments, the metabolic changes occurring at multiple time points over 8 weeks in response to CGH (35.33% wt/wt) were observed in high-fat (HF, 60% of energy as fat) diet-fed SD rats. In lean rats, the hypothalamus neuropeptide-Y and proopiomelanocortin mRNA levels of the CGH group were significantly changed in response to CGH administration. In the second part of the study, CGH treatment was found to reduce body weight and perirenal and epididymal fat weight. CGH also prevented an increase in food intake at 2 weeks and lowered plasma leptin and insulin levels in comparison with the HF group. This reduction in the plasma and hepatic lipid levels was followed by improved insulin resistance, and the beneficial metabolic effects of CGH were also partly related to increases in plasma adiponectin levels. The Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR), an index of insulin resistance, was markedly improved in the HF-CGH group compared with the HF group at 6 weeks. According to the microarray results, adipose tissue mRNA expression related to G-protein coupled receptor protein signaling pathway and sensory perception was significantly improved after 8 weeks of CGH administration. In conclusion, the present findings suggest that dietary CGH may be effective for improving hyperglycemia, dyslipidemia and insulin resistance in diet-induced obese rats as well as appetite control in lean rats.

Pathogenic Diversity of Ascochyta rabiei Isolates and Identification of Resistance Sources in Core Collection of Chickpea Germplasm

  • Farahani, Somayeh;Talebi, Reza;Maleki, Mojdeh;Mehrabi, Rahim;Kanouni, Homayoun
    • The Plant Pathology Journal
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    • v.35 no.4
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    • pp.321-329
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    • 2019
  • Ascochyta blight caused by Ascochyta rabiei (Pass.) Lab. (Telomorph: Didymella rabiei) (Kov.) is one of the most important fungal diseases in chickpea worldwide. Knowledge about pathogen aggressiveness and identification resistance sources to different pathotypes is very useful for proper decisions in breeding programs. In this study, virulence of 32 A. rabiei isolates from different part of Iran were analyzed on seven chickpea differentials and grouped into six races based on 0-9 rating scale and susceptibility/resistant pattern of chickpea differentials. The least and most frequent races were race V and race I, respectively. Race V and VI showed highly virulence on most of differential, while race I showed least aggressiveness. Resistance pattern of 165 chickpea genotypes also were tested against six different A. rabiei races. ANOVA analysis showed high significant difference for isolate, chickpea genotypes and their interactions. Overall $chickpea{\times}isolate$ (race) interactions, 259 resistance responses (disease severity ${\leq}4$) were identified. Resistance spectra of chickpea genotypes showed more resistance rate to race I (49.70%) and race III (35.15%), while there were no resistance genotypes to race VI. Cluster analysis based on disease severity rate, grouped chickpea genotypes into four distinct clusters. Interactions between isolates or races used in this study, showed the lack of a genotype with complete resistance. Our finding for virulence pattern of A. rabiei and newly identified resistance sources could be considerably important for integration of ascochyta blight resistance genes into chickpea breeding programs and proper decision in future for germplasm conservation and diseases management.

Management of the Development of Insecticide Resistance by Sensible Use of Insecticide, Operational Methods (실행방식 측면에서 살충제의 신중한 사용에 의한 저항성 발달의 관리)

  • Chung, Bu-Keun;Park, Chung-Gyoo
    • Korean journal of applied entomology
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    • v.48 no.2
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    • pp.123-158
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    • 2009
  • An attempt was made to stimulate future research by providing exemplary information, which would integrate published knowledge to solve specific pest problem caused by resistance. This review was directed to find a way for delaying resistance development with consideration of chemical(s) nature, of mixture, rotation, or mosaics, and of insecticide(s) compatible with the biological agents in integrated pest management (IPM). The application frequency, related to the resistance development, was influenced by insecticide activity from potentiation, residual period, and the vulnerability to resistance development of chemical, with secondary pest. Chemical affected feeding, locomotion, flight, mating, and predator avoidance. Insecticides with negative cross-resistance by the difference of target sites and mode of action would be adapted to mixture, rotation and mosaic. Mixtures for delaying resistance depend on each component killing very high percentage of the insects, considering allele dominance, cross-resistance, and immigration and fitness disadvantage. Potential disadvantages associated with mixtures include disruption of biological control, resistance in secondary pests, selecting very resistant population, and extending cross-resistance range. The rotation would use insecticides in high and low doses, or with different metabolic mechanisms. Mosaic apply insecticides to the different sectors of a grid for highly mobile insects, spray unrelated insecticides to sedentary aphids in different areas, or mix plots of insecticide-treated and untreated rows. On the evolution of pest resistance, selectivity and resistance of parasitoids and predator decreased the number of generations in which pesticide treatment is required and they could be complementary to refuges from pesticides To enhance the viability of parasitoids, the terms on the insecticides selectivity and factors affecting to the selectivity in field were examined. For establishment of resistant parasitoid, migration, survivorship, refuge, alternative pesticides were considered. To use parasitoids under the pressure of pesticides, resistant or tolerant parasitoids were tested, collected, and/or selected. A parasitoid parasitized more successfully in the susceptible host than the resistant. Factors affecting to selective toxicity of predator are mixing mineral oil, application method, insecticide contaminated prey, trait of individual insecticide, sub-lethal doses, and the developmental stage of predators. To improve the predator/prey ratio in field, application time, method, and formulation of pesticide, reducing dose rate, using mulches and weeds, multicropping and managing of surroundings are suggested. Plant resistance, predator activity, selective insect growth regulator, and alternative prey positively contributed to the increase of the ratio. Using selective insecticides or insecticide resistant predator controlled its phytophagous prey mites, kept them below an economic level, increased yield, and reduced the spray number and fruits damaged.

Production of transgenic Alstroemeria plants containing virus resistance genes via particle bombardment

  • Kim, Jong Bo
    • Journal of Plant Biotechnology
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    • v.47 no.2
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    • pp.164-171
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    • 2020
  • Transgenic Alstroemeria plants resistant to Alstroemeria mosaic virus (AlMV) were generated through RNA-mediated resistance. To this end, the friable embryogenic callus (FEC) of Alstroemeria was induced from the leaf axil tissue and transformed with a DNA fragment containing the coat protein gene and 3'-nontranslated region of AlMV through an improved particle bombardment system. The bar gene was used as a selection marker. More than 300 independent transgenic FEC lines were obtained. Among these, 155 lines resistant to phosphinothricin (PPT) were selected under low stringent conditions. After increasing the stringency of PPT selection, 44 transgenic lines remained, and 710 somatic embryos from these lines germinated and developed into shoots. These transgenic shoots were then transferred to the greenhouse and challenged with AlMV. In total, 25 of the 44 lines showed some degree of resistance. PCR analysis confirmed the presence of the viral sequence. Virus resistance was observed at various levels. Establishment of an efficient transformation system for Alstroemeria will allow inserting transgenes into this plant to confer resistance to viral and fungal pathogens. Accordingly, this is the first report on the production of a transgenic virus-resistant Alstroemeria and lays the foundation for alternative management of viral diseases in this plant.

Multiple Drug Resistance and Transferable R-plasmid of Streptococci Isolated from Diseased Olive Flounder (연쇄상구균의 약제내성과 전이성 R-plasmid의 특성)

  • Kim, Jong-Hun;Im, Dae-Hwan;Lee, Chang-Hun;Lee, Su-Jeong;Lee, Wol-Ra;Hwang, Mi-Hye;Kim, Eun-Hui
    • Journal of fish pathology
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    • v.16 no.1
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    • pp.61-68
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    • 2003
  • MICs of 8 chemotherapeutic agents against forty streptococcal isolates were determined. These strains were isolated from diseased olive flounder, Paralichthys olivaceus, and showed 2-5 multiple drug resistance against different antibacterial agents including ampicillin, doxycycline (DOXY), erythromycin, florfenicol, flumequine, norfloxacin, oxolinic acid, and oxytetracycline (OTC). In conjugation experiment, we found transferable R plasmids carrying OTC and DOXY resistance determinant in 3 drug resistance strains analyzed. Six out of 40 isolates showed positive signal in colony hybridization with the R plasmid DNA (pST9) as a probe. It suggests that other types R plasmid different from pST9 is also involving in multiple drug resistance of streptococci isolated from olive flounder.

Early menarche and its consequence in Korean female: reducing fructose intake could be one solution

  • Kim, Ji Hyun;Lim, Jung Sub
    • Clinical and Experimental Pediatrics
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    • v.64 no.1
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    • pp.12-20
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    • 2021
  • The mean age at menarche (AAM) of Korean females has been rapidly decreasing over the last 50 years; currently, the prevalence of early menarche (<12 years) is 22.3%. Female adolescents who experience early menarche are known to be at greater risk of psychosocial and behavioral problems along with several physical health problems such as menstrual problems. They also tend to achieve a shorter final height and develop obesity. Population-based Korean studies have shown a strong association between early menarche and the risk of obesity, insulin resistance, metabolic syndrome, nonalcoholic fatty liver disease, diabetes, breast cancer, and cardiovascular disease in adulthood. Although the exact mechanism of how early menarche causes cardiometabolic derangement in later adulthood is unknown, childhood obesity and insulin resistance might be major contributors. Recent studies demonstrated that an excessive consumption of fructose might underlie the development of obesity and insulin resistance along with an earlier AAM. A positive association was observed between sugar-sweetened beverages (a major source of fructose) intake and obesity, metabolic syndrome, insulin resistance, and cardiometabolic risk in Korean females. In pediatrics, establishing risk factors is important in preventing disease in later life. In this regard, early menarche is a simple and good marker for the management of cardiometabolic diseases in adulthood. Decreasing one's fructose intake might prevent early menarche as well as the development of obesity, insulin resistance, and cardiometabolic diseases.

A Study on Innovation Resistance of Digital Trade Based On Cloud Services (클라우드 서비스를 활용한 디지털무역 사용자의 혁신저항에 관한 연구)

  • Lee, In-Seong;Kim, Sok-Tae
    • Asia-Pacific Journal of Business
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    • v.12 no.4
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    • pp.313-329
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    • 2021
  • Purpose - Digital trade, which started in the early 2000s, is showing a sharp increase due to the recent pandemic. However, despite this proliferation, users' acceptance of innovation is very slow. Cloud services are at the center of digital trade activation. This study aims to contribute to the spread of digital trade through empirical analysis of the resistance factors that hinder the use of cloud service-based digital trade using the innovation resistance theory and the status quo bias theory. Design/Methodology/Approach - In order to achieve the research purpose, this study was conducted with 171 entrepreneurs using cloud service-based digital trade. Structural equation model(SEM) was used through empirical analysis. Findings - As a result of the study, it was found that the complexity of technology, perceived risk, compatibility, and trust in service providers had a significant effect on innovation resistance, and policy trust did not affect innovation resistance. Also, security concerns and institutional trust were analyzed to have a significant effect on the trust of service providers. Research Implications - This study is meaningful to help the rapid diffusion of innovative technologies through empirical analysis of factors that lower the intention to accept cloud service-based digital trade.

Analysis of Ground Resistance Reduction Effect by Common use of Ground Poles (접지극의 공용화를 통한 접지저항 저감효과 분석)

  • Hong Sung Taek;Lee Eun Chun;Shin Gang Wook
    • Proceedings of the KIEE Conference
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    • summer
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    • pp.440-442
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    • 2004
  • The ground resistance of middle scale ground pole was measured by using the 'fall of potential method' suggested by IEEE However, the measured resistance value was lower than the minimum value required To solve this problem. ground pole was set to be used commonly. In this research. ground resistance was measured using the newly suggested method and the results were analyzed to see if they satisfied the domestic regulation The results of this research will be applied to the management works as well as the establishment of new plan.

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Experimental Study on the Improvement of Surface Treatment of Mechanical Structures in Field Environment (야전 환경에서 기계구조물 표면처리 개선에 관한 실험적 연구)

  • Kim, Jongwha;Hyun, Jonghun;Kang, Seokjoong
    • Journal of the Korea Institute of Military Science and Technology
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    • v.24 no.2
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    • pp.197-203
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    • 2021
  • Mechanical structures of military equipment have been mainly applied with black oxide coating due to the limitation of surface treatment thickness. However, the mechanical structures applied by the black oxide coating treatment is constantly being corroded by calcium chloride and humidity. Since this can cause serious problems in the operation of equipment, a review to improve surface treatment and corrosion resistance is required. Therefore, in this study, surface treatment methods that can enhance corrosion resistance were selected and corrosion resistance performance was verified through experiments describing harsh field conditions. Thus, applying a proven surface treatment method to future military equipment will prevent corrosion.