• 한국해안·해양공학회논문집
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• 제31권6호
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• pp.351-355
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• 2019

무공케이슨 방파제의 한계상태설계를 위한 하중저항계수를 제시하였다. 전국 항만의 16개 방파제에 대한 신뢰성해석을 수행하여 부분안전계수를 산출하였으며 이를 하중과 저항계수로 전환하였다. 개별적으로 구한 하중저항계수에 최적화기법을 적용하여 최종 하중저항계수를 보정하였다. 최종적으로 얻은 하중저항계수를 이용하여 방파제를 재설계한 후 목표수준을 만족하는지 검증하였다. 목표신뢰도수준의 변화에 따른 하중저항계수를 제시하여 한계상태설계가 용이하도록 하였다.

• 한국지반환경공학회 논문집
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• 제16권6호
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• pp.5-11
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• 2015

최근 구조물 기초 분야에 대한 한계상태설계법이 국제적인 기술표준으로 요구됨에 따라 연구기반이 미약한 얕은기초에 대한 하중저항계수설계법 개발의 필요성이 대두되었다. 본 연구에서는 얕은기초 설계 시 풍화토 지반에 위치한 얕은기초에 대한 하중저항계수설계법의 적용 방안에 대하여 연구를 수행하고 그에 따른 저항계수를 제안하였다. 얕은기초 국내 설계 및 시공자료를 수집하여 확률통계학적 기법에 의한 분석을 수행함으로써 풍화토지반 얕은기초의 불확실성과 저항편향계수를 정량적으로 분석하고, 신뢰성 해석 LEVEL II를 이용하여 목표신뢰도 지수를 평가하였으며, 산정된 신뢰도지수를 기존 문헌 값과 비교 분석하여 풍화토 지반 얕은기초에 대한 목표신뢰도 지수를 선정하였다. 국내 풍화토지반 얕은기초에 대한 하중계수를 적용하여 저항계수를 보정하였으며, AASHTO의 하중계수를 적용한 저항계수와 비교 분석하였다.

• Tuberculosis and Respiratory Diseases
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• 제75권5호
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• pp.188-198
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• 2013

Over the past decade, several kinase inhibitors have been approved based on their clinical benefit in cancer patients. Unfortunately, in many cases, patients develop resistance to these agents via secondary mutations and alternative mechanisms. To date, several major mechanisms of acquired resistance, such as secondary mutation of the epidermal growth factor receptor (EGFR) gene, amplification of the MET gene and overexpression of hepatocyte growth factor, have been reported. This review describes the recent findings on the mechanisms of primary and acquired resistance to EGFR tyrosine kinase inhibitors and acquired resistance to anaplastic lymphoma kinase inhibitors, primarily focusing on non-small cell lung carcinoma.

• International Journal of Concrete Structures and Materials
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• 제10권sup3호
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• pp.109-121
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• 2016

Recently, as the use of high-performance materials and complex composite methods has increased, the need for advanced design specifications for steel-concrete composite structures has grown. In this study, various design provisions for ultimate flexural strengths of composite beams were reviewed. Design provisions reviewed included the load and resistance factor design method of AISC 360-10 and the partial factor methods of KSSC-KCI, Eurocode 4 and JSCE 2009. The design moment strengths of composite beams were calculated according to each design specification and the variation of the calculated strengths with design variables was investigated. Furthermore, the relationships between the deformation capacity and resistance factor for flexure were examined quantitatively. Results showed that the design strength and resistance factor for flexure of composite beams were substantially affected by the design formats and variables.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2010년도 춘계 학술발표회
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• pp.427-434
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• 2010

Load Resistance Factor Design method is used increasingly in geotechnical design world widely and resistance factors for drilled shafts are suggested by AASHTO. However, these resistance factors are determined for intact rock conditions, by comparison most of bedrocks in Korea are weathered condition, so that applying the AASHTO resistance factors is not reasonable. Thus, this study suggests the proper resistance factors for design of drilled shaft in Korea. The 22 cases of pile load test data from 8 sites were chosen and reliability-based approach is used to analyze the data. Reliability analysis was performed by First Order Second Moment Method (FOSM) applying 4 bearing capacity equations. As a result, when the Factor of Safety(FOS) were selected as 3.0, the target reliability index($\beta_c$) were evaluated about 2.01~2.30. Resistance factors and load factors are determined from optimization based on above results. The resistance factors ranged between 0.48 and 0.56 and load factor for dead load and live load are evaluated approximately 1.25 and 1.75 respectively. However, when the target reliability are considered as 3.0, the resistance factors are evaluated as approximately 50% of results when the target reliability index were 2.0.

• 콘크리트학회논문집
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• 제12권2호
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• pp.21-30
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• 2000

In the Ultimate Strength Design, the design strength of a member is determined by multiplying the strength reduction factor to the nominal strength. This concept may be a reasonable approach, however it can not consider failure modes appropriately. Moreover, column design strength diagram show an abrupt change at a low level of axial load, which does not seem to be reasonable. This research compares the design strength determined by the strength resistance factors. As the material resistance factors for flexure and compression, 0.65 and 0.90 are proposed for concrete and steel, respectively. The design strength calculation process by applying material resistance factors addresses failure modes more effectively than by applying member strength reduction factor, and provides more resnable design strength for reinforced concrete flexural and compression members.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2008년도 춘계학술대회 논문집
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• pp.428-430
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• 2008

Dye-sensitized solar cell has many internal resistant components such as Pt counter electrode, $TiO_2$/dye/electrolyte, charge diffusion, sheet resistance of TCO. Among these, the resistance about the counter electrode can be reduced by increasing the roughness factor of Pt counter electrode. This causes the increase of fill factor and improvement of efficiency. And the amount of light reflection on the counter electrode also increases as the roughness factor goes up. In our experiment, we suggest a new deposition structure of Pt thin film that is a stepped-type structure. The more step lines are in the counter electrode, the more roughness factor is. As a result, we get the improvement of fill factor and efficiency by controlling the roughness factor of counter electrode.

• 한국해안·해양공학회논문집
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• 제32권6호
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• pp.458-464
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• 2020

유공케이슨 방파제의 한계상태설계법 개발을 위해 하중저항계수 보정을 수행하였다. 전국 항만의 12개 유공케이슨식 방파제에 대하여 설계변수의 불확실성을 고려한 신뢰성해석을 수행하였다. 목표신뢰성지수에 따른 부분 안전계수와 하중, 저항계수를 차례로 산정하였다. 최적화기법을 통해 한계상태설계법 개발을 위한 하중계수와 저항계수를 도출하였다. 최종 하중저항계수를 이용하여 방파제를 재설계하였으며 목표수준의 신뢰성지수를 상회하는지 검증하였다. 목표신뢰성지수를 변화시켜 해당 수준에 맞는 하중저항계수를 최종 제시하였다.

• 한국해안·해양공학회논문집
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• 제33권6호
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• pp.293-297
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• 2021

소파블록 피복제 제체의 한계상태설계법 개발을 위해 하중저항계수 보정을 수행하였다. 실제 시공된 소파블록 피복제 제체의 설계자료를 분석하여 신뢰성해석을 수행하였으며 목표신뢰성지수에 따른 부분안전계수와 하중, 저항계수를 차례로 산정하였다. 최적화기법을 통해 한계상태설계법 개발을 위한 하중계수와 저항계수를 도출하였다. 최종 하중저항계수를 이용하여 방파제를 재설계하였으며 목표수준의 신뢰성지수를 상회하는지 검증하였다. 해외기준의 하중저항계수와 본 연구에서 구한 하중저항계수를 비교하였다.

• Tuberculosis and Respiratory Diseases
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• 제79권4호
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• pp.248-256
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• 2016

Somatic mutations that lead to hyperactivation of epidermal growth factor receptor (EGFR) signaling are detected in approximately 50% of lung adenocarcinoma in people from the Far East population and tyrosine kinase inhibitors are now the standard first line treatment for advanced disease. They have led to a doubling of progression-free survival and an increase in overall survival by more than 2 years. However, emergence of resistant clones has become the primary cause for treatment failure, and has created a new challenge in the daily management of patients with EGFR mutations. Identification of mechanisms leading to inhibitor resistance has led to new therapeutic modalities, some of which have now been adapted for patients with unsuccessful tyrosine kinase inhibitor treatment. In this review, we describe mechanisms of tyrosine kinase inhibitor resistance and the available strategies to overcoming resistance.