• Title/Summary/Keyword: resist development

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SYNTHETIC DEVELOPMENT OF NEW 1$\beta$-SUBSTITUTED CARBAPENEMS

  • Nagao, Yoshimitsu
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1993.04a
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    • pp.34-35
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    • 1993
  • The Development of new asymmetric induction methods useful for syntheses of biologically active natural products and drugs, using C4-chiral 1,3-th-iazolidine-2-thiones, has been a recent focus of interest. 1-8) The present account describes the significance of particular heterocycles in the synthetic development of new 1${\beta}$-substituted carbapenems. A fungal metabolite, (+)-thienamycin (1) has attracted one's attention as a hopeful candidate for new-generation antibiotic drugs because of its strong antimicrobial activities and wide antimicrobial spectra due to the extensive inhibition against various ${\beta}$-lactamases. However, it has been serious problems toward a practically useful drug that (+)-thienamycin is fairly labile in the solution and can be metabolized by renal dehydropept- idase-I (DHP-I). Recently, a Merck Sharp & Dohme research group exploited a non-natural ${\beta}$-lactam, imipenem (2) which has been appeared in the drug market as the first carbapenem-type antibiotic drug. 9) However 2 must be used with a DHP-I inhibitor, cilastatin sodium (3).9) Thus, a 1,${\beta}$-methyl- carbapenem derivative 4 has been disclosed by the same group. 10) It seems to be more hopeful candidate as a new-generation antibiotic because it can directly resist against metabolism by the renal DHP-1 without an enzyme inhibitor 3. 10)

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A Study on Conquest Plans of the Barrier and Resistance in Innovation Management (혁신관리에 있어서 장애와 저항의 극복방안)

  • Lee, Seung-Hui;No, Gyu-Seong
    • 한국디지털정책학회:학술대회논문집
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    • 2005.06a
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    • pp.13-28
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    • 2005
  • The purpose of this study is to explore conquest plans of the barrier and resistance in innovation management. This paper focuses to understand the model of innovation that reflects adoption process stages and identify the factors that drive the resistance of consumers. Whenever organizations try to plan and implement some kind of innovation in organizations, they confront resistance in many ways. By understanding innovation resistance, organizations can not only design better innovations but can develop strategies to reduce resistance. Thus they accelerate innovation. Understanding the factors that drive the innovation resistance has important implications for both theoretical development and managerial action. These results indicate that people resist innovation strongly when it betrays their value, needs and beliefs or when they felt the pressure on self-conviction and mental risk, loss, and lack of knowledge.

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A Simulator for High Energy E-beam Lithography for Nano-Patterning (나노패터닝을 위한 고에너지 전자빔 리소그래피 시뮬레이터 개발 및 검증)

  • Kim Jinkwang;Kim Hak;Han Chanho;Chun Kukjin
    • Proceedings of the IEEK Conference
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    • 2004.06b
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    • pp.359-362
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    • 2004
  • Electron beam on high energy acceleration, which travels deeply and sharply through photoresist, became to be used in e-beam lithography apparatus for nano-patterning in due to its high resolution. An advanced electron beam lithography simulation tool is currently undergoing development for nano-patterning. This paper will demonstrate such simulation efforts with experiments at 200 keV e-beam lithography processes on PMMA, ZEP520 of which photoresist parameters and characteristics will be explained with simulation results. Neureuther parameters was extracted from the contrast curve of the resist

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The Internalization of the Gender Identity for Korean Female College Students (한국 여대생의 성 정체감 내면화 과정)

  • Cheon, Hye-Jung
    • Journal of the Korean Home Economics Association
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    • v.41 no.9
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    • pp.149-161
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    • 2003
  • The purpose of this study is to investigate the subjective experiences of female college students about how they accept, resist, and interpret their gender identities and roles. The research data were autobiographic essays reflecting research participants' gender identities internalization process. Thirty essays were chosen, and carried by qualitative content analysis. It turned out that most of these female students were not blessed their birth among their family members only because of their sexes. On the one hand, these female students were restricted their behaviors by their sexes in their daily lives such as responsibility on household work, not permitting drinking, late returning home, and sexual behavior before marriage. On the other hand, they sometimes took advantage of their sexes for self-rationalization. But they were proud of the fact that they will be mothers someday. It seemed that motherhood was center for their female identity.

Comparison of Some Properties of Naked Barley Starches (쌀 보리 전분의 성질비교)

  • Kim, Oh-Mok;Kim, Kwan;Kim, Sung-Kon
    • Korean Journal of Food Science and Technology
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    • v.17 no.1
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    • pp.33-36
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    • 1985
  • Some properties of starches from three naked barley cultivars(Songhak, Youngsan and Jinan 56) were compared. No significant differences in water-binding capacity, amylose content, relative crystallinity, swelling power and gelatinization degree at various pasting temperatures among cultivars were observed. However, starches showed characteristic viscograph indices and viscosity development patterns in aqueous sodium hydroxide solution. Songhak starch exhibited the lowest pasting temperature and was the most resist to alkali gelatinization.

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Development of High Pressure & Temperature Constant Volume Chamber for Visualization Study of Fuel Spray and Combustion (연료 분무 및 연소 가시화 연구를 위한 고온 고압 정적 연소실 개발)

  • Kim, Kihyun
    • Journal of Power System Engineering
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    • v.21 no.3
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    • pp.12-18
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    • 2017
  • Diesel and gasoline engines will be used as main power system of automobiles. Recently, engine downsizing is widely applied to both gasoline and diesel engines in order to improve fuel economy and exhaust emissions. Engine downsizing means small engine combustion chamber with higher combustion pressure. Therefore, spray and combustion process should be investigated under these high pressure and temperature conditions. In this study, constant volume combustion chamber which enables easy optical access from six directions was developed. Combustion chamber was designed to resist maximum pressure of 15 MPa and maximum temperature of 2,000 K. Combustible pre-mixed mixture was introduced into combustion chamber and ignited by spark plugs. High pressure and temperature were implemented by combustion of pre-mixed mixture. Three initial conditions of different pressure and density were tested. High repeatability of combustion process was implemented which was proven by low standard deviation of combustion pressure.

A Development of Tooth Profile Modification for Spur Gear (스퍼기어의 치형수정 프로그램의 개발)

  • Hwang, Jin-Young;Hwang, Sung-Wook;Kim, Tae-Wan;Cho, Yong-Joo
    • Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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    • 2002.05a
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    • pp.259-266
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    • 2002
  • The basic concept of 'tooth profile modification' is to change a part of the involute profile to reduce the load in that area and appropriate profile modifications can help gears to run quietly and resist scoring, pitting and tooth breakage. In this study, the modification of tooth profile to make a smooth transmission of the normal loads in spur gears has been developed. The modified tooth profile has been determined by the total deflection at contact points. We use the AGMA Standard to design basic gear profile, We also developed a gear design Program using tooth profile modification

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Enhanced Password-based Remote User Authentication Scheme Using Smart Cards

  • Jeon, II-Soo;Kim, Hyun-Sung
    • Journal of Korea Society of Industrial Information Systems
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    • v.16 no.1
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    • pp.9-19
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    • 2011
  • Secure and efficient authentication schemes over insecure networks have been a very important issue with the rapid development of networking technologies. Wang et al. proposed a remote user authentication scheme using smart cards. However, recently, Chen et al. pointed out that their scheme is vulnerable to the impersonation attack and the parallel session attack, and they proposed an enhanced authentication scheme. Chen et al. claimed that their scheme is secure against the various attacks. However, we have found that their scheme cannot resist the parallel attack and the stolen smart card attack. Therefore, in this paper, we show the security flaws in Chen et al.'s scheme and propose an improved remote user authentication scheme using tamper-resistant smart cards to solve the problem of Chen et al.'s scheme. We also analyze our scheme in terms of security and performance.

Development of Acceleration Duability test condition for Fireproof Spray-Application. (옥내용 뿜칠내화피복재의 촉진내구성 조건 설정 연구)

  • Kim, Dae-Hoi;Lee, Gun-Chol
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2014.05a
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    • pp.170-171
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    • 2014
  • The buildings constructed with steel structure is coated with certified fire resistive material to resist from fire. Coating materials lose their initial performances as time passes, so they need some maintenance. This study is covers standardization of the methods for assessing the durability of SFRM. In Korea, more than 90 percent of SFRM are used indoors. So This study is to decide proper test method through investigation and examination of effect factor to performance of fire-resistant structure and applicable test method.

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The Traits of International Marriage in Rural Korea (한국농촌의 국제결혼의 특징)

  • Lim, Hyung-Baek
    • Journal of Agricultural Extension & Community Development
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    • v.14 no.2
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    • pp.471-491
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    • 2007
  • The purpose of this study were (1) to thumbnail sketch of present general condition of foreigners and international marriage in Korea, (2) to study special trend of international marriage in rural Korea, particularly immigration connected with poverty, and (3) to focus on prospect of the problem of mixed-bloods, especially half blood children in rural Korea. Many of foreigners were treated discriminatingly, for example racial discrimination and wage discrimination. And discrimination to mixed-blood children will be happen in future. They are in a disadvantageous position because of economic status and appearances. Half blood children have korean nationality because one of his parent is korean. When they grow up and reach their the age of puberty and the age of working, they will resist to discrimination in working and marriage. I had examined precedent studies, and class theory in general, and to suggest it is time to looking for way of reduce social cost and way of coexistence.

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