• 약학회지
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• 제45권5호
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• pp.437-441
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• 2001

The quasi-drugs including nonwoven fabric and gauze were sterilized using ethylene oxide (EO) gas. Residual EO in the quasi-drugs was extracted with water (20 mL of water for 1 g of sample) for 24h at 37$^{\circ}C$. Residual EO was determined using GC. The optimal analytical conditions were as follows : column, Carbowax 20M (1.D. 0.2 mm); mobile phase, helium with 30 mL/min; oven temperature 57$^{\circ}C$, injector temperature 18$0^{\circ}C$, detector temperature 20$0^{\circ}C$. The detection limit for EO was 0.10$\mu$g/mL. When the residual EO extracted from nonwoven fabric and gauze was determined, it took more than 9h to get the lower level than 25 ppm which is the limit value of FDA guideline. When the EO residues, ethylene chlorohydrine (ECH) and ethylene glycol (EG) in the 7 commercially available quasi-drugs were determined, no residual EO, ECH, EG were found from the seven commercially available quasi-drugs analyzed by this method.

• 대한한의학회지
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• 제20권1호
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• pp.44-51
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• 1999

Analysis of residual pesticides in herbal drugs was performed by GC-ECD and GC-MS. Especially, selected ion monitoring(SIM) technique was applied to increase the GC/MS sensitivity. Analysis of residual pesticides was determined sensitivity and selectively without any internal standard by setting the SIM technique to their characteristic fragments for quantitation ion and confirmation ion. The combination of two detector, GC-ECD and MS-SIM technique, is abailable for determining a multiclass residual pesticides in herbal drugs. The average recoveries through the method were $65.9%{\sim}99.7%$ in herbal drugs. The data of gas chromatographic analysis was compared with the limits of residual pesticides in herbal drugs and agricultural foods. 4. 4-DDT was detected above the limits to the residual pesticides in herbal drugs. Diazinon and EPN were detected, but the limits of residual pesticides were less than that of agricultural foods.

• Toxicological Research
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• 제8권1호
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• pp.144-156
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• 1992

The residue of drug in foods of animal origin has increasingly become of interest to the entire livestock industry as growing consumer health concerns. The current overvie of feed additives and veterinary drugs used in Japan and their residual analysis has been reviewed. High performance liquid chromatographic technique(HPLC) with various detectors can be expected to be successfully applied for the routine analysis of residual feed additives and veterinary drugs including anabolic agents in livestock products.

• KNOM Review
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• 제23권2호
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• pp.11-17
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• 2020

현재 잔류물질정보를 제공하는 웹 페이지에서는 농약 및 동물용의약품의 식품 내 잔류허용기준 정보를 제공하고 있다. 잔류물질이란 농약 혹은 동물용의약품을 수천 배 희석하여 사용 후 농산물 또는 축, 수산물에 남아 있게 되는 극미량의 농약 혹은 동물용의약품을 뜻한다. 하지만 농약과 동물용의약품에 대한 정보의 누락, 웹 페이지 오류 등 정보 제공이 원활하게 이루어지지 않고 있기 때문에 사용자들이 불편을 겪고 있다. 또한 관리자는 잔류허용 기준 및 분석법 등 정보들을 수동으로 입력해야하는 불편함이 있다. 이에 본 논문에서는 농약 및 동물용의약품에 대한 잔류물질기준과 약품의 특성 등 정보들의 변화이력을 효율적으로 관리하고 업데이트 할 수 있는 시스템을 제안한다.

• 약학회지
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• 제40권2호
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• pp.141-148
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• 1996

GC/MS analysis of 27 controlled pesticides in herbal drugs was studied. Selected ion monitoring(sim) technique was applied to increase the GC/MS sensitivity. Typical peaks in th e mass spectrum of each pesticides were selected as quantitation, comfirmation or alternate ion. Twenty seven pesticides were divided into five groups according to their retention time and the peaks for SIM were programmed accordingly. The combination of two ionization methods, electron impact(EI)-SIM-MS and negative ion chemical ionization(NCI)-SIM-MS, were well-fitted for the detection, confirmation and quantitation of multiclass residual pesticides in herbal drugs.

• 생약학회지
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• 제32권3호통권126호
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• pp.200-211
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• 2001

This study was carried out to determine the 11 organochlorine, 7 organophosphorus residual pesticides in 251 crude drugs. These residual pesticides in herbal drugs were extracted with acetonitrile and the extracts were cleaned up via LC-florisil solid phase extraction column. The prepared samples were assayed for pesticide residues using GC-ECD, NPD with capillary column and identified by GC-MSD. Recoveries were $63.9{\sim}111.5%$ in the organochlorine pesticides and $69.8{\sim}92.4%$ in the organophosphorus pesticides, and detection limits were $0.001{\sim}0.65\;ppm$ in the organochlorine pesticides and $0.0009{\sim}0.0074\;ppm$ in the organophosphorus pesticides. Pesticide residues were detected in 9 cases.

• 한국동물위생학회지
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• 제27권3호
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• pp.265-272
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• 2004

It was carried out to compare the residual materials by EEC 4-plate, Charm II and HPLC method in the muscles of cattle and pigs from slaughter-houses in Seoul from 2000 to 2003. Residual materials were detected from $1.10\%$(73/6,623) samples by EEC 4-plate method, and $10.93\%$(55/503) samples by Charm II method. The highest residual concentration(ppm) of oxytetracycline, tetracycline, chloramphenicol, chlortetracycline, sulfamethazine, sulfamerazine, sulfadimethoxine, penicillin and sulfamonomethoxine were 25.5, 3.46, 3.26, 1.5, 0.3, 0.2, 0.2, 0.14, and 0.07, respectively. Eighty nine samples were classified as 58($65.17\%$) only tetracyclines, 20($22.47\%$) only sulfonamides, 3($3.37\%$) only ${\beta}$-lactams, 2($2.25\%$) only chloramphenicol, 4($4.49\%$) tetracyclines and sulfonamides simultaneously, 1($1.12\%$) chloramphenicol and sulfonamides simultaneously, and 1($1.12\%$) chloramphenicol, sulfonamides and tetracyclines simultaneously.

• 한국환경보건학회지
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• 제44권5호
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• pp.444-451
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• 2018

Objectives: This study was carried out to provide safe seafood to the public through simultaneous analysis rapid inspections for residual veterinary drugs in 150 fishery products in 2016. Methods: Quinolones (9), Sulfonamides (14), Penicillins (2), Cephalosporins (3), Tetracyclines (4), Macrolides (4), Lincosamides (2), Pleuromutilin (1), Phenicols (4), benzylpyrimidines (2), Others (1) Malachite green (2), and Melamine (1) were analyzed for 49 species using by HPLC and HPLC-MSMS. Results: There were six unsuitable samples, five among fish and one for crustaceans. Within the standard detection were five fish. The antibiotics found were Quinolones (50%), Tetracyclines (33%) and Penicillins (17%). Conclusions: As a result of the experiment, there were six unsuitable samples, five for fish and one for crustaceans. The most prevalent antibiotics were Quinolones. The quinolone antibiotics are highly persistent in fish tissues, so they require more time than the withdrawal period for other common veterinary drugs. Careful attention is required when they are used in fish farms.

• 한국식품위생안전성학회지
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• 제35권5호
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• pp.447-451
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• 2020

본 연구에서는 2018년 충남지역에서 생산, 출하되는 수산물에 대해 잔류동물용의약품 실태를 조사하였다. 수산물 115건을 대상으로 식품공전 수산물 중 동물용의약품 동시 다성분 시험법으로 분석이 가능한 29종의 잔류동물용의약품을 분석하였다. 115건의 수산물 중 9건에서 6종의 잔류동물용의약품이 검출되었으며, 검출률은 7.8%이었다. 검출된 잔류동물용의약품은 옥소린산, 엔로플록사신이 가장 많이 검출되었으며 시프로플록사신, 설파디아진, 플루메퀸, 옥시테트라사이클린이 각각 검출되었다. 미꾸라지 검체 1건에서 엔로플록사신이 잔류기준을 초과하였으나 전체적으로 안전한 수준으로 평가되었다. 그렇지만 잔류동물용의약품 검출률이 높아지는 추세이고 종류 또한 다양해지고 있어 지속적인 모니터링이 필요하다.

• 대한치과마취과학회지
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• 제1권1호
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• pp.5-9
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• 2001

Day stay anesthesia should include: rapid smooth onset; rapid recovery without residual side effects; absence of adverse effects (N/V); and providing postoperative analgesia. General anesthesia with multi-modalities (inhalation, intravenous and local anesthesia) may be preferable in day stay surgery. Future studies on new drugs and techniques for day stay anesthesia need comparing the increased coat of newer treatments with the potential financial savings resulting from earlier hospital discharge, reduced supplemental drugs, and earlier return to work.