• Journal of Veterinary Science
• /
• 제22권5호
• /
• pp.47.1-47.10
• /
• 2021

Background: Due to multiple similarities in the structure and physiology of human and pig skin, the pig model is extremely useful for biological drug testing after subcutaneous administration. Knowledge of the differences between subcutaneous injection sites could have a significant impact on the absorption phase and pharmacokinetic profiles of biological drugs. Objectives: This study aimed to analyze the impact of administration site on pharmacokinetics and selected biochemical and hematological parameters after a single subcutaneous administration of ustekinumab in pigs. Drug concentrations in blood plasma were analyzed by enzyme-linked immunosorbent assay. Pharmacokinetic analyses were performed based on raw data using Phoenix WinNonlin 8.1 software and ThothPro v 4.1. Methods: The study included 12 healthy, female, large white piglets. Each group received a single dose of ustekinumab given as a 1 mg/kg subcutaneous injection into the internal part of the inguinal fold or the external part of the inguinal fold. Results: The differences in absorption rate between the internal and external parts of the inguinal fold were not significant. However, the time of maximal concentration, clearance, area under the curve calculated between zero and mean residence time and mean residence time between groups were substantially different (p > 0.05). The relative bioavailability after administration of ustekinumab into the external part of the inguinal fold was 40.36% lower than after administration of ustekinumab into the internal part of the inguinal fold. Conclusions: Healthy breeding pigs are a relevant model to study the pharmacokinetic profile of subcutaneously administered ustekinumab.

• Journal of Community Nutrition
• /
• 제4권2호
• /
• pp.90-98
• /
• 2002

This study was performed to examine the dietary and BMI change of Koreans after moving to America and to identify the factors influencing changes of BMI. The subjects were 192 Korean-Americans (men : 86, women : 106) residing in the eastern area of the U.S.A. 1) subjects reported significantly increased consumption frequency in American foods like, low fat milk(p<0.001), cold cereals (p<0.001), whole wheat bread(p<0.001), hamburger(only in males p<0.01) and pizza(only in males p<0.01). Whereas significantly decreased consumption frequency in fish (p<0.05), cooked vegetables(p<0.001), kimchi(p< 0.001) and cooked rice (p<0.001) were reported. 2) It was reported that weight, accordingly BMI were significantly increased (p<0.01). The smoking habit score was significantly decreased for males (p<0.05). 3) Multiple linear regression analysis for BMI change showed that education years in Korea was the most prominent negative factor(p<0.001) in predicting BMI change in America. Elevated frequencies of alcohol, chicken and soft drink in America were also associated with greater increase of BMI. When the length of residence (increase of age) was included in regression model, the increase of age was the most significant factor (p<0.001). Changes of chicken and soda scores were other significant factors.

• 한국소음진동공학회:학술대회논문집
• /
• 한국소음진동공학회 2009년도 추계학술대회 논문집
• /
• pp.716-722
• /
• 2009

4000MW급 유연탄발전소는 기존 500MW급 4기의 발전설비 운영조건에서 지역공동체는 긍정적이었으나, 500MW급의 증설 호기가 늘어나면서 지역 공동체는 발전소 증설과 관련하여 기존 동쪽 부지 경계지역의 소음환경에 대하여 부정적인 문제를 제기하였다. 2000MW급 증설이 진행되어온 4000MW급 발전소의 다양한 소음원에 의한 소음파워 증대와 증가방출 과도소음 에 대하여 고저가 다양한 주변지역에 미치는 영향음 평가하고자 3차원 모델링기법을 적용한다. 기존호기를 비롯한 전체의 발전소 전면부 소음원응 비교 시험결과 증가방출 소음 파워가 기존 설계의 변경 제작되어 기존호기에 비해 20~30dBA 높아져 동시 방출사 주변지역에 과도하게 영향을 미치는 상태였으며 500MW급 4기를 추가 증설에 따라 일상소음원에 의한 소음 영향도 증설전 대비 2~3dBA 증가된 것으로 평가되었다. 따라서 증설호기의 과도 소음원 제거 방안으로 대가 방출증가가 회수되도록 증설호기의 증가방출설비를 개선하였고, 증설에 의하여 증가된 소음 영향음 저감하고자 기존 경계지역에 미치는 소음원음 고려하여 방음벽음 설치한 결과 47 ~ 49dBA를 나타내고 인근 주거건물의 전면부 소음은 43dBA이었다.

• 한국주거학회논문집
• /
• 제25권6호
• /
• pp.11-18
• /
• 2014

This study is to explore the housing problems and environment conditions perceived by residents in traditional houses in Suzhou, China. The empirical data is based on a questionnaire survey, which were from 100 residents in traditional area in Gusu area of Suzhou. In order to understand the traditional houses, on-the-spot investigation and literature review methods are adapted in this study. The main findings are as follows. Firstly, most of residents are middle-aged or older people, and their income is not high. Secondly, there are almost no cases of organizing independent workroom and storage room in their housing. Moreover, the main problems are mildew, theft, rats and cockroaches, etc. Finally, the satisfaction with the internal housing environment was appeared reasonable, but the external environment is unsatisfactory. Therefore, the external environment should be more considered in the Chinese traditional housing policy.

• 한국환경과학회지
• /
• 제12권7호
• /
• pp.705-713
• /
• 2003

In mid-August 2002, under clear summer pressure patterns, we carried out an intensive meteorological observation to examine the warming effects due to artificial constructions in a large housing complex. We set an automatic weather system(AWS) at two places in a bare soil surface within a limited development district and an asphalt surface within a large apartment residence area, respectively. As a result of observation, it became clear that the difference of the surface air(ground) temperature between the bare soil surface and its peripheral asphalt area reached about 4$^{\circ}C$(13$^{\circ}C$) at the maximum from diurnal variation of surface temperatures on AWS data. Through the heat balance analysis using measurement data, it became clear that the thermal conditions at two places are dependent on the properties of surface material. The latent heat flux over the bare soil surface reached to about 300 W/㎡, which is more than a half of net radiation during the daytime. On the other hand, it was nearly zero over the asphalt surface. Hence, the sensible heat flux over the asphalt surface was far more than that of the bare soil surface. The sensible heat flux over the asphalt surface showed about 20∼30 W/㎡ during the night. It was released from asphalt surface which have far more heat capacity than that of bare soil surface.

• 한국콘텐츠학회논문지
• /
• 제9권2호
• /
• pp.359-364
• /
• 2009

본 연구는 관광객의 거리지각이 관광지선택행동에 미치는 영향을 분석하고 이를 통해 지역관광지 활성화를 위한 마케팅 전략수립에 기초자료를 제공하는데 그 목적이 있다. 연구결과 거주지에 따라 심리적 거리지각에 차이가 있었으며, 성별, 직업에 따라 관광지선택행동에 차이가 있는 것으로 나타났다. 또한 심리적 거리지각은 관광지선택행동 중 여행능력에 영향을 미치는 것으로 분석되었다. 본 연구는 심리적 거리지각이 관광지선택행동에 영향을 미친다는 것을 분석한 학문적 의의와 함께 지역관광지 마케팅 전략 수립을 위한 새로운 기초정보를 제공했다는 실무적 의의를 갖는다.

• 한국농촌건축학회논문집
• /
• 제20권3호
• /
• pp.37-45
• /
• 2018

There are many advantages to unit-care welfare facilities' care services for the elderly in Japan. The field research was conducted after holding interviews with employees at five elderly welfare facilities in Japan. This research analyzes the space arrangement of unit-care welfare facilities in Japan's Tohoku rural area. The purpose of this study is to provide design data on the space arrangement of a unit-care facility for Korea. The results of research are as follows. 1. Cafes, restaurants, and stores were operated in the elderly welfare facilities, which were open to the general public as well. Therefore, local residents frequently visited. 2. The kitchen, living rooms, private bedrooms and construction of the elderly welfare facilities were similar to that of normal residential houses. 3. The event hall is conveniently located at the center of the facility. 4. It was easy to understand the health status of the elderly by having a health office in the open living room. 5. There were open spaces which are frequently used by the homebound elderly, including room rehabilitation, daycare and short term residence. The above results will be used for space planning data in Korean unit-care facilities.

• 한국주거학회논문집
• /
• 제26권6호
• /
• pp.127-137
• /
• 2015

This investigation is to question as to whether and how much urban residential superblocks have changed the uses of facilities, as compared with original zoning plan. The difference between the original plan for 'land use' in 1960's and current 'building uses' has been examined on six superblocks in Seoul, and the reasons for change were analyzed. Investigation results are as follows: As the original urban planning was intended for use-purification by the subdivision of zones in a superblock through zoning, current buildings uses are different from the land-use. Commercial facilities are located in residential zone along community paths because of the necessity, and business buildings are placed on the appropriate-sized lots in the middle of residential blocks, due to the need of small and low-rent offices. Also, different types of residence have been built on convenient locations in commercial zone to meet various housing needs. In conclusion, the current zoning system plays a role of controling the volume of buildings rather than the use of land. Therefore, mixed use of land, not functional separation, becomes a natural phenomenon taken place in the contemporary cities, and it is high time to adopt a mixed-use zoning system.

• 한국농촌건축학회논문집
• /
• 제19권3호
• /
• pp.17-24
• /
• 2017

The aim of this study is how to understand of structural and elemental landscape image in suburban village. Nowadays, it is well known fact that suburban villages are most likely to be invaded by urbanization. Therefore, the research is focused on how the image of suburb has been changed, what patterns have been created in residential area, what are the different outcomes from different distance, and what are the changes in types of buildings, at particular village called Doojeong in Pyeongtaek city. When collecting supplemental information, elders in village have been participated in comparison of traditional and foreign. The village shows significant characteristics of such phenomenon. According to the research, there are three results. First, ironically, the structural patterns of the village is concentric as seen on urban garden, yet they do not have central function. Second, traditional homes are transformed into functional shape. The most popular roof design that takes 65 percent of whole is modernized flat roof shape. Hanok (Korean traditional house) style is disappearing. Third, due to the massive barn buildings and their monochrome, the beauty of community and architectural harmony are buried.

• 한국통신학회논문지
• /
• 제42권2호
• /
• pp.505-513
• /
• 2017

본 연구는 전 세계에서 발생한 200,578,703건의 지오트윗을 수집하여 트윗 봇을 제거한 후, 인간의 도시 내 이동패턴을 분석하였다. 활동반경(Activity Radius)이라는 개념을 이용하여 트위터 사용자를 구분하였으며, 거주지역을 국내와 국외로 구분하고 국내는 다시 시내와 시외로 구분하였다. 그리고 활동반경과 거주지역에 따라 트위터 사용자의 활동성과 활동지역에 대한 통계적 특성을 기술하였고 지리적 분포를 시각적으로 표현하였다. 라스베이거스를 대상으로 하는 사례 분석을 통해, 거주지역에 따른 활동성과 활동지역의 차이를 확인하였다. 향후 본 연구의 방법에 따라 다양한 도시를 대상으로 분석을 수행하면, 인간의 이동성에 대한 다양한 이론을 도출할 수 있을 것이다.