• BMB Reports
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• v.54 no.6
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• pp.305-310
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• 2021

Cereblon (CRBN) is a multi-functional protein that acts as a substrate receptor of the E3 ligase complex and a molecular chaperone. While CRBN is proposed to function in mitochondria, its specific roles are yet to be established. Here, we showed that knockdown of CRBN triggers oxidative stress and calcium overload in mitochondria, leading to disruption of mitochondrial membrane potential. Notably, long-term CRBN depletion using PROteolysis TArgeting Chimera (PROTAC) induced irreversible mitochondrial dysfunction, resulting in cell death. Our collective findings indicate that CRBN is required for mitochondrial homeostasis in cells.

• International Journal of Knowledge Content Development & Technology
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• v.8 no.4
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• pp.75-98
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• 2018

In this study, the network analysis of researchers, institutions, and research principal agent was conducted to understand structure characteristics of international cooperation research project implemented from 1997 to 2018. The network of researchers and institutions were decentralized structure. On the other hands, the network of research principal agent was centralized structure. The Soul National University is the leading organization of international cooperation research project. In terms of research principal agent, corporation is the leading principal agent. In additions, the results of the network centroid analysis of the researchers and institutions were correlated with the research funds. As a result, it was confirmed that the network centroid of research organization was linearly related to research funds.

• Ocean Systems Engineering
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• v.3 no.1
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• pp.35-53
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• 2013

In this study, a hybrid floating structure with cylinder was introduced to reduce the hydrodynamic motions of the pontoon type. The hybrid floating structure is composed of cylinders and semi-opened side sections to penetrate the wave impact energy. In order to exactly investigate the hydrodynamic motions and structural behavior of the hybrid floating structure under the wave loadings, integrated analysis of hydrodynamic and structural behavior were carried out on the hybrid floating structure. Firstly, the hydrodynamic analyses were performed on the hybrid and pontoon models. Then, the wave-induced hydrodynamic pressures resulting from hydrodynamic analysis were directly mapped to the structural analysis model. And, finally, the structural analyses were carried out on the hybrid and pontoon models. As a result of this study, it was learned that the hybrid model of this study was showed to have more favorable hydrodynamic motions than the pontoon model. The surge motion was indicated even smaller motion at all over wave periods from 4.0 to 10.0 sec, and the heave and pitch motions indicated smaller motions beyond its wave period of 6.5 sec. However, the hybrid model was shown more unfavorable structural behavior than the pontoon model. High concentrated stress occurred at the bottom slab of the bow and stern part where the cylinder wall was connected to the bottom slab. Also, the hybrid model behaved with the elastic body motion due to weak stiffness of floating body and caused a large stress variation at the pure slab section between the cylinder walls. Hence, in order to overcome these problems, some alternatives which could be easily obtained from the simple modification of structural details were proposed.

• Earthquakes and Structures
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• v.12 no.6
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• pp.653-663
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• 2017

A seismic margin assessment evaluates how much margin exists for the system under beyond design basis earthquake events. Specifically, the seismic margin for the entire system is evaluated by utilizing a systems analysis based on the sub-system and component seismic fragility data. Each seismic fragility curve is obtained by using empirical, experimental, and/or numerical simulation data. The systems analysis is generally performed by employing a fault tree analysis. However, the current practice has clear limitations in that it cannot deal with the uncertainties of basic components and accommodate the newly observed data. Therefore, in this paper, we present a Bayesian-based seismic margin assessment that is conducted using seismic fragility data and fault tree analysis including Bayesian inference. This proposed approach is first applied to the pooltype nuclear research reactor system for the quantitative evaluation of the seismic margin. The results show that the applied approach can allow updating by considering the newly available data/information at any level of the fault tree, and can identify critical scenarios modified due to new information. Also, given the seismic hazard information, this approach is further extended to the real-time risk evaluation. Thus, the proposed approach can finally be expected to solve the fundamental restrictions of the current method.

• Proceedings of the Korean Geotechical Society Conference
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• 2008.03a
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• pp.511-520
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• 2008

The steel pipe strut for a means of the retaining structure has been used generally in North America, Europe and China so far. However, Korea and Japan, two countries are much familiar with H-shape steel strut having its anisotropic strength on two different axes(named as strong and weak axes), even though they recognize the steel pipe's excellence of structural function associated with its compressive ability. This trend is mainly due to a number of its field application, accumulated know-hows and workmanship etc. This paper introduces particular features of a high-strength steel pipe strut in comparison with the H-shape steel strut and its application for two excavation sites in Seoul. As a result of field verification, the high-strength pipe steel strut is more effective than the H-shape steel strut in terms of construction costs, schedules, constructibility and structural stability.

• World Technopolis Review
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• v.5 no.2
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• pp.108-118
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• 2016

There are very few studies on governance structure for the collaboration between HEIs and science and technology parks until today. Major activities between science parks and HEIs are R&D activities, collaborative researches, technology transfer, space provision for BIs and Technology BIs in the science parks, provision of technical, legal and financial services for start-ups and venture firms. Governance structure for the collaboration of high education institutes with science and technology parks is the handling of complexity and management of dynamic flows of collaboration between two groups. Three models on the governance structure for the collaboration are suggested in this study. The first model is a governance structure that links R&D system such as universities, public research institutes and private research institutes with industrial production cluster such as a group of companies and industrial parks. The second model is a governance structure that has four layers of hierarchy. This hierarchical governance model is composed of four levels of organizations such as central government, three actors, one center for collaboration and many individual research performers. The third model is a governance structure that networks all the stakeholders horizontally. Under this structure, governance is conducted by the network members with no separate and unique governance entity.

• Journal of Ginseng Research
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• v.31 no.2
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• pp.69-73
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• 2007

Since chemical structures of ginsenoside as active ingredient of Panax ginseng are known, accumulating evidence have shown that ginsenoside is one of bio-active ligands through the diverse physiological and pharmacological evaluations. Chemical structures of ginsenoside could be divided into three parts depending on diol or triol ginsenoside: Steroid- or cholesterol-like backbone structure, carbohydrate portions, which are attached at the carbon-3, -6 or -20, and aliphatic side chain coupled to the backbone structure at the carbon-20. Ginsenosides also exist as stereoisomer at the carbon-20. Bioactive ligands usually exhibit the their structure-function relationships. In ginsenosides, there is little known about the relationship of chemical structure and biological activity. Recent reports have shown that ginsenoside $Rg_3$, one of active ginsenosides, exhibits its differential physiological or pharmacological actions depending on its chemical structure. This review will show how ginsenoside $Rg_3$, as a model compound, is functionally coupled to voltage-gated ion channel or ligand-gated ion channel regulations in related with its chemical structure.

• Journal of the Earthquake Engineering Society of Korea
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• v.17 no.4
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• pp.187-195
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• 2013

In this paper, firstly, acceleration-time histories were generated by varying strong motion duration in the frequency domain for application to a seismically isolated nuclear power structure, so as to examine the effects of strong motion duration on the behavior of the structure. Secondly, real recorded earthquakes were modified to match the target response spectrum based on the revised SRP 3.7.1(2007) and the modified time histories were applied to the analysis of a seismically isolated nuclear power structure. The obtained values of acceleration and displacement responses of the structure were, finally, compared with the values obtained in case of applying acceleration-time histories generated in the frequency domain to the structure.

• Journal of Technology Innovation
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• v.23 no.4
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• pp.63-87
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• 2015

As the important factors to improve research performance, the researchers' capacity and the input of resources like research funds have been pointed out. As joint researches are recently vitalized, however, the scientific knowledge is produced by forming continuous mutual relations through the structural characteristics between researchers. Since the support of research funds becomes a foothold to perform researches as multiple institutions cooperate with each other, it can be considered to have influence on research performance. In other words, it can be estimated that the support of research funds has influence on research performance by generating differences in the connecting structure of joint researches. In the results of analyzing the relation between network structure and research performance in accordance with the matter of supporting research funds, targeting the joint research theses in the culture technology(CT) area for five years from 2009 to 2013 in SCIE DB, when multiple research institutes are connected to each other, the number of thesis is increased. When the betweenness centrality is increased, the number of thesis is decreased. Also, the matter of supporting research funds has influence on network structure and research performance.

• Journal of Korean Port Research
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• v.8 no.1
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• pp.31-40
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• 1994

Experimental study is carried out to verify the advantages of an air chamber structure in controlling the wave transformation and its dynamic responses. The open, cross and vertical mooring systems are employed in experiments to investigate the variations of wave transmission ratio, natural period of the structures and tensile force acting on the mooring line according to the change of the initial air depth inside the air chamber structure. Experimental results show that the air chamber floating structure expresses the smaller wave transmission ratio and tensile force acting on the mooring line than general one without air chamber, expecially in the long period region of incident wave. Therefore, it is concluded that the air chamber structure suggested in this study can play good roles as a wave controlling castal structure, and a substitute structure of a general floating structure.