• Nuclear Engineering and Technology
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• v.53 no.7
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• pp.2268-2276
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• 2021

Spent nuclear fuel, which can degrade during long-term storage, must be transported intact in normal transport conditions. In this regard, many studies, including those involving Multi-Modal Transportation Test (MMTT) campaigns, have been conducted. In order to transport the spent fuel safely, a tie-down structure for supporting and transporting a cask containing the spent fuel is essential. To ensure its structural integrity, a method for finding an optimum conceptual design for the tie-down structure is presented. An optimized transportation test model of a tie-down structure for the KORAD-21 metal cask is derived based on the proposed optimization approach, and the transportation test model is manufactured by redesigning the optimized model to enable its producibility. The topology optimization approach presented in this paper can be used to obtain optimum conceptual designs of tie-down structures developed in the future.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2006.11a
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• pp.237-240
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• 2006

This paper investigates the applicability of modularized floating structure. A floating parking place is considered as an example of moularized structure. It is assumed that the example structure is composed of reinforced concrete box modules and steel connectors. By analyzing stresses of the structure under static and wave loads, the optimal stiffness of the module is determined In the numerical calculation, the direct method is used Economical effectiveness of the modularized structure is also evaluated by analyzing cost for materials, manufacture and installation.

• Journal of Korean Port Research
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• v.13 no.2
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• pp.365-380
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• 1999

In this thesis the legal systems related to real estate and sea area utilization are studied in order to improve them for construction of Very Large Floating Structure. Main research subjects are as follows: 1) Whether can Very Large Floating Structure be accepted or not as real estate like house and land\ulcorner 2) How can the sea area which is occupied by Very Large Floating Structure be utilized\ulcorner As the conclusion, the Very Large Floating Structure can be registered as real estate even though it is not specified by Korean law for the present. The design concept of Very Large Floating Structure can be interpreted as satisfying enough necessary conditions and factors for Very Large Floating Structure to become real estate. In the near future, we have to make improvement on the laws related with the construction of Very Large Floating Structures so that private sectors can joint the construction. In additions, a new law for various floating structures should be made as soon as possible.

• Proceedings of the Korea Technology Innovation Society Conference
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• 2000.05a
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• pp.141-153
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• 2000

Interdisciplinary research is one of the well-known key words represent the 21st century As in the developed countries, interdisciplinary research is a pervasive phenomenon in Korea. This paper intends to clear up the interdependent structure among disciplines of university researches. First, 39.9% of individual and 59.8% of collaborative research projects of university researches are interdisciplinary. Second, the interdependency among disciplines of collaborative research is more severe than that of individual research. Third, The interdependency among disciplines indicates tile importance of the balanced development in all science and engineering fields.

• BMB Reports
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• v.37 no.1
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• pp.28-34
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• 2004

The discovery of biochemical and cellular functions of unannotated gene products begins with a database search of proteins with structure/sequence homologues based on known genes. Very recently, a number of frontier groups in structural biology proposed a new paradigm to predict biological functions of an unknown protein on the basis of its three-dimensional structure on a genomic scale. Structural proteomics (genomics), a research area for structure-based functional discovery, aims to complete the protein-folding universe of all gene products in a cell. It would lead us to a complete understanding of a living organism from protein structure. Two major complementary experimental techniques, X-ray crystallography and NMR spectroscopy, combined with recently developed high throughput methods have played a central role in structural proteomics research; however, an integration of these methodologies together with comparative modeling and electron microscopy would speed up the goal for completing a full dictionary of protein folding space in the near future.

• ETRI Journal
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• v.31 no.6
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• pp.642-646
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• 2009

Highly efficient white phosphorescent organic light-emitting diodes with a mixed-host structure are developed and the device characteristics are studied. The introduction of a hole-transport-type host (N, N'-dicarbazolyl-3-3-benzen (mCP)) into an electron-transport-type host (m-bis-(triphenylsilyl)benzene (UGH3)) as a mixed-host emissive layer effectively achieves higher current density and lower driving voltage. The peak external quantum and power efficiency with the mixed-host structure improve up to 18.9% and 40.9 lm/W, respectively. Moreover, this mixed-host structure device shows over 30% enhanced performance compared with a single-host structure device at a luminance of 10,000 $cd/m^2$ without any change in the electroluminescence spectra.

• BMB Reports
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• v.33 no.1
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• pp.49-53
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• 2000

PMAP-23 is a 23-residue antimicrobial peptide derived from porcine myloid cells. In order to investigate the effects of two Pro residues at positions 12 and 15 of PMAP-23 on antibiotic activity, two analogues in which Ala was substituted for Pro residue at position 12 or 15 were synthesized. $Pro^{12}{\rightarrow}Ala$ (PMAPl) or $Pro^{15}{\rightarrow}Ala$(PMAP2) substitution in PMAP-23 caused a significant reduction on antitumor and phospholipid vesicle-disrupting activities, but did not cause a significant effect on antibacterial activity. PMAP-23 displayed the type I ${\beta}-turn$ structure with a negative ellipticity at near 205 om in SDS micelle, whereas PMAP1 and PMAP2 had a somewhat ${\alpha}-helical$ propensity in TFE solution, as compared to PMAP-23. These results suggest that two Pro residues of positions 12 and 15 in PMAP-23 play important roles in the formation of ${\beta}-turn$ structure on lipid membrane and its ${\beta}-turn$ structure may be essential for antibiotic activity including phospholipid vesicle-disrupting property.

• BMB Reports
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• v.53 no.7
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• pp.373-378
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• 2020

Phosphorylation of the signaling component by protein kinase often leads to a kinase cascade or feedback loop. 3-Phosphoinositide-dependent kinase 1 (PDK1) signaling pathway diverges into various kinases including Akt and p70 S6 kinase (p70S6k). However, the PDK1 feedback mechanism remains elusive. Here, we demonstrated that UNC-51-like kinase (ULK1), an autophagy initiator kinase downstream of mechanistic target of rapamycin (mTOR), directly phosphorylated PDK1 on serine 389 at the linker region. Furthermore, our data showed that this phosphorylation affected the kinase activity of PDK1 toward downstream substrates. These results suggest a possible negative feedback loop between PDK1 and ULK1.

• Journal of the Earthquake Engineering Society of Korea
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• v.18 no.6
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• pp.279-289
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• 2014

Considering a rigorously fluid-structure interaction, a method for an earthquake response analysis of a floating offshore structure subjected to vertical ground motion from a seaquake is developed. Mass, damping, stiffness, and hydrostatic stiffness matrices of the floating offshore structure are obtained from a finite-element model. The sea water is assumed to be a compressible, nonviscous, ideal fluid. Hydrodynamic pressure, which is applied to the structure, from the sea water is assessed using its finite elements and transmitting boundary. Considering the fluid-structure interaction, added mass and force from the hydrodynamic pressure is obtained, which will be combined with the numerical model for the structure. Hydrodynamic pressure in a free field subjected to vertical ground motion and due to harmonic vibration of a floating massless rigid circular plate are calculated and compared with analytical solutions for verification. Using the developed method, the earthquake responses of a floating offshore structure subjected to a vertical ground motion from the seaquake is obtained. It is concluded that the earthquake responses of a floating offshore structure to vertical ground motion is severely influenced by the compressibility of sea water.

• Structural Engineering and Mechanics
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• v.41 no.1
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• pp.1-24
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• 2012

A reinforced concrete (RC) framed structure detailed according to non-seismic detailing provisions as per Indian Standard was tested on shake table under dynamic loads. The structure had 3 main storeys and an additional storey to simulate the footing to plinth level. In plan the structure was symmetric with 2 bays in each direction. In order to optimize the information obtained from the tests, tests were planned in three different stages. In the first stage, tests were done with masonry infill panels in one direction to obtain information on the stiffness increase due to addition of infill panels. In second stage, the infills were removed and tests were conducted on the structure without and with tuned liquid dampers (TLD) on the roof of the structure to investigate the effect of TLD on seismic response of the structure. In the third stage, tests were conducted on bare frame structure under biaxial time histories with gradually increasing peak ground acceleration (PGA) till failure. The simulated earthquakes represented low, moderate and severe seismic ground motions. The effects of masonry infill panels on dynamic characteristics of the structure, effectiveness of TLD in reducing the seismic response of structure and the failure patterns of non-seismically detailed structures, are clearly brought out. Details of design and similitude are also discussed.