• Title/Summary/Keyword: reproductive medicine

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Molecular Cloning, Identification and Characteristics of a Novel Isoform of Carbamyl Phosphate Synthetase I in Human Testis

  • Huo, Ran;Zhu, Hui;Lu, Li;Ying, Lanlan;Xu, Min;Xu, Zhiyang;Li, Jianmin;Zhou, Zuomin;Sha, Jiahao
    • BMB Reports
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    • v.38 no.1
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    • pp.28-33
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    • 2005

  • A gene coding a novel isoform of carbamyl phosphate synthetase I (CPS1) was cloned from a human testicular library. As shown by cDNA microarray hybridization, this gene was expressed at a higher level in human adult testes than in fetal testes. The full length of its cDNA was 3831 bp, with a 3149 bp open reading frame, encoding a 1050-amino-acid protein. The cDNA sequence was deposited in the GenBank (AY317138). Sequence analysis showed that it was homologous to the human CPS1 gene. The putative protein contained functional domains composing the intact large subunit of carbamoyl phosphate synthetase, thus indicated it has the capability of arginine biosynthesis. A multiple tissue expression profile showed high expression of this gene in human testis, suggesting the novel alternative splicing form of CPS1 may be correlated with human spermatogenesis.

  • https://doi.org/10.5483/BMBRep.2005.38.1.028 인용 PDF

Developing a deeper insight into reproductive biomarkers

  • Wahid, Braira;Bashir, Hamid;Bilal, Muhammad;Wahid, Khansa;Sumrin, Aleena
    • Clinical and Experimental Reproductive Medicine
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    • v.44 no.4
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    • pp.159-170
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    • 2017

  • The development of biomarkers of reproductive medicine is still in its infancy because many black boxes are still present in reproductive medicine. Novel approaches to human infertility diagnostics and treatment must be developed because reproductive medicine has lagged behind in the implementation of biomarkers in clinical medicine. Despite the dearth of the available literature, the current rapid pace of publications suggests that this gap will soon be filled therefore; this review is a $pr\acute{e}cis$ of the research that has been done so far and will provide a basis for the development of biomarkers in reproductive medicine.

  • https://doi.org/10.5653/cerm.2017.44.4.159 인용 PDF KSCI