• Asian Pacific Journal of Cancer Prevention
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• 제13권10호
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• pp.4901-4903
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• 2012

To assess the awareness of cervical cancer among couples, data were collected from two urban slums community in Mumbai. A total of 1958 married women aged from 18 to 49 and their husbands were selected using simple random sampling. Women (37.7%) were significantly more aware of cervical cancer than husbands (8.7%). A slight agreement (kappa statistics=0.16) was observed between husbands and wives on awareness of cervical cancer. Significantly higher percentages of wives were aware of pap smear test than husbands. Overall, awareness of cervical cancer and pap smear test among couples is low. There is need to educate and motivate both of them to participate in cervical cancer screening program.

• Clinical and Experimental Reproductive Medicine
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• 제44권2호
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• pp.85-89
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• 2017

Objective: The aim of this study was to explore the effects of the insemination method on the outcomes of elective blastocyst culture. Methods: We retrospectively analyzed the outcomes of elective blastocyst culture performed between January 2011 and December 2014. Results: There were 2,003 cycles of conventional in vitro fertilization (IVF) and 336 cycles of intracytoplasmic sperm injection (ICSI), including 25,652 and 4,164 embryos that underwent sequential blastocyst culture, respectively. No significant differences were found in the female patients' age, basal follicle-stimulating hormone level, basal luteinizing hormone level, body mass index, number of oocytes, maturity rate, fertilization rate, or good-quality embryo rate. However, the blastocyst formation rate and embryo utilization rate were significantly higher in the conventional IVF group than in the ICSI group (54.70% vs. 50.94% and 51.09% vs. 47.65%, respectively, p<0.05). The implantation/pregnancy rate (IVF, 50.93%; ICSI, 55.10%), miscarriage rate (IVF, 12.57%; ICSI, 16.29%), and live birth rate (IVF, 42.12%; ICSI, 44.08%) were similar (p>0.05). No cycles were canceled due to the formation of no usable blastocysts. Conclusion: Although the fertilization method had no effect on clinical outcomes, the blastocyst formation rate and embryo utilization rate in the ICSI group were significantly lower than those observed in the conventional IVF group. Therefore, more care should be taken when choosing to perform blastocyst culture in ICSI patients.

• 월간산업보건
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• 통권349호
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• pp.51-70
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• 2017

• 보건교육건강증진학회지
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• 제31권5호
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• pp.29-43
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• 2014

Objectives: This study was to develop a reliable and valid instrument measuring the reproductive health promoting behavior of undergraduates. Methods: The initial questionnaires were made of 106 items from four domains through literature review. All questionnaire items were revised by an expert group and a pilot test. Data were collected using the revised initial questionnaire of men's 58 items and female's 64 items from 634 male and 685 female undergraduate students. The collected questionnaires were analyzed by factor analysis using varimax rotation to evaluate the construct validity. Results: According to the gender, two measurement were invented and analysed separately. Four common factors consisting of 'safe sex', 'sexual responsibility', 'genital health management' and 'STD prevention' were discovered in both groups. The 'genital hygiene' factor was added as a female factor. Male students' scale was made up 4 factors 16 items and female students' scale was made up 5 factors 18 items. Cronbach's alpha for male scale was estimated to be .892 and female scale to be .882. Conclusions: This scale will make it possible to measure the level of reproductive health among Korean university students. This scale may be useful for developing effective methods of education as well as policy programs for improving the reproductive health of Korean university students.

• Clinical and Experimental Reproductive Medicine
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• 제47권4호
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• pp.245-262
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• 2020

In recent years, nanotechnology has revolutionized global healthcare and has been predicted to exert a remarkable effect on clinical medicine. In this context, the clinical use of nanomaterials for cancer diagnosis, fertility preservation, and the management of infertility and other pathologies linked to pubertal development, menopause, sexually transmitted infections, and HIV (human immunodeficiency virus) has substantial promise to fill the existing lacunae in reproductive healthcare. Of late, a number of clinical trials involving the use of nanoparticles for the early detection of reproductive tract infections and cancers, targeted drug delivery, and cellular therapeutics have been conducted. However, most of these trials of nanoengineering are still at a nascent stage, and better synergy between pharmaceutics, chemistry, and cutting-edge molecular sciences is needed for effective translation of these interventions from bench to bedside. To bridge the gap between translational outcome and product development, strategic partnerships with the insight and ability to anticipate challenges, as well as an indepth understanding of the molecular pathways involved, are highly essential. Such amalgamations would overcome the regulatory gauntlet and technical hurdles, thereby facilitating the effective clinical translation of these nano-based tools and technologies. The present review comprehensively focuses on emerging applications of nanotechnology, which holds enormous promise for improved therapeutics and early diagnosis of various human reproductive tract diseases and conditions.

• Clinical and Experimental Reproductive Medicine
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• 제46권1호
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• pp.36-40
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• 2019

A viable spermatozoon is a prerequisite for fertilization in intracytoplasmic sperm injection (ICSI). Thus, it is crucial to select viable but immotile spermatozoa on the day of ICSI. We report conflicting results in the identification of viable but immotile spermatozoa between the eosin-nigrosin staining and the laser test, which resulted in confusion for embryologists during assisted reproductive technology (ART). Three patients' semen samples that showed no motile spermatozoa are described in this report. To identify viable spermatozoa, we used both the eosin-nigrosin test and the laser test for each sample, and repeated the semen analysis twice in each patient. Viable but immotile spermatozoa selected by the laser test were used for ICSI. Viable spermatozoa were detected by both the eosin-nigrosin and laser tests in two patients (case 1, 95.00% vs. 24.21% and 92.68% vs. 22.22%; case 2, 41.18% vs. 23.48% and 39.81% vs. 22.52%), indicating consistent results between the two methods. In the third patient, the eosin-nigrosin test yielded viability rates of 20.75% and 19.14%, while the result of the laser test was 0%. Thus, testicular aspiration was performed to collect viable sperm from this patient. Normal fertilization was achieved after the injection of viable but immotile spermatozoa selected from these patients by the laser test, resulting in the birth of two healthy babies. Our study documents a case where the eosin-nigrosin test showed a limitation in identifying viable but immotile spermatozoa for ART, while the laser test may overcome this limitation. Larger samples may be required to corroborate the clinical value of the laser test.

• 대한한의학원전학회지
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• 제36권4호
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• pp.55-67
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• 2023

Objectives : Contents on causes of male infertility, reproductive health improvement, sexual tips were studied in classical texts of Korean Medicine, followed by representative formulas for male infertility treatment. Methods : Related texts from the Qiusimen chapters of the Yixuerumen, Yixuexinwu, Donguibogam, Nukejinglun, Jiaozhufurenliangfang, Jiyingandmu were collected, and their medical meaning discussed. Results : As immoderate libido and excessive mental consumption leads to sexual dysfunction causing male infertility, 'moderating sexual desire and accumulating Jing' should be the principle for improving reproductive health. Also, sufficient foreplay is recommended. In terms of formula, the Wuziyanzongwan with sufficient therapeutic evidence in both classical texts and contemporary Korean Medicine can be applied in cases of male infertility. Conclusions : Excessive sensual stimulation and immoderate sexual desire consumes the mind and results in decline in male reproductive health. While moderating sexual desire and accumulating Jing through controlling desire, not overworking, moderating anger, drinking in moderation, balanced eating should be the principle for improving reproductive health, having sexual intercourse 2~3 times per week rather than long-term abstinence is recommended. To improve the success rate in pregnancy, sufficient foreplay and time should be done and taken for intercourse. Wuziyanzongwan should be taken for at least three months or longer.

• 한국융합학회논문지
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• 제9권3호
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• pp.145-152
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• 2018

본 연구의 목적은 생식건강증진 프로그램이 대학생의 성 지식, 성 태도, 생식건강증진행위에 미치는 영향을 융복합적으로 알아보기 위해 실시하였다. 108명의 대학생이(평균연령 20.84세) 생식건강증진 교육 프로그램에 참여하였다. 생식건강증진 프로그램은 2016년 11월 9일부터 12월 7일까지 4주간 주 2회, 110분 동안 진행되었고 설문지를 통해 성 지식, 성 태도, 생식건강증진행위를 조사하였다. 결과적으로, 성 태도는 생식건강증진 프로그램을 진행한 뒤 유의하게 더 향상되었고 성 지식과 생식건강증진행위 사이에 유의한 상관관계가 있었으나(p<0.05) 성 지식과 생식건강증진행위는 유의한 변화가 없었다. 본 연구를 통해 생식건강증진 프로그램은 대학생의 성 태도를 유의하게 향상시키고 성 지식과 생식건강증진행위 사이에 상관관계가 있음을 알 수 있었다. 본 연구는 추후 대학생들의 생식건강증진을 위한 교육 프로그램 개발에 활용하고자 한다.

• Safety and Health at Work
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• 제2권3호
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• pp.290-300
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• 2011

Objectives: There is limited data regarding the toxicity of methylcyclohexane, despite its wide use in rubber adhesives, paint diluents, and cleansing agents. This study aimed to verify the toxicity and influence on the reproductive system of methylcyclohexane after its repeated injection in Sprague Dawley (SD) rats. Methods: Methylcyclohexane was injected subcutaneously into male and female SD rats once a day, five times a week, for 13 weeks at different doses (0, 10, 100, and 1,000 mg/kg/day) for each group. The toxicity of testing material was verified by observing the change in body and organ weight, hematological change, pathological findings, and effect on the reproductive system at each different concentration. Results: In the 1,000 mg/kg/day group, there were cases of animal deaths. In animals that survived, hematological changes, including a decrease in the red blood cell count, were observed. A considerable weight gain or loss and pathological abnormalities in the liver, kidney, and other organs were found. However, the 10 and 100 mg/kg/day groups did not cause deaths or other specific abnormalities. In terms of reproductive toxicity, there were changes in hormone levels, including a significant decrease in hormones such as estradiol and progesterone (p < 0.001) in male animals. Menstrual cycle change for female animals did not show concentration dependency. Conclusion: When injected repeatedly for 13 weeks, methylcyclohexane proved to be toxic for the liver, heart, and kidney at a high dose. The absolute toxic dose was 1,000 mg/kg/day, while the no observed adverse effect level was less than 100 mg/kg/day. The substance exerted little influence on the reproductive system.

• Safety and Health at Work
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• 제8권2호
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• pp.143-150
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• 2017

A huge number of chemicals are produced and used in the world, and some of them can have negative effects on the reproductive health of workers. To date, most chemicals and work environments have not been studied for their potential to have damaging effects on the workers' reproductive system. Because of the lack of information, many workers may not be aware that such problems can be related to occupational exposures. Newly industrialized countries such as Republic of Korea have rapidly amassed chemicals and other toxicants that pose health hazards, especially to the reproductive systems of workers. This literature review provides an overview of peer-reviewed literature regarding the teratogenic impact and need for safe handling of chemicals. Literature searches were performed using PubMed, Google Scholar, and ScienceDirect. Search strategies were narrowed based on author expertise and 100 articles were chosen for detailed analysis. A total of 47 articles met prespecified inclusion criteria. The majority of papers contained studies that were descriptive in nature with respect to the Medical Subject Headings (MeSH) terms and keywords: "reproductive and heath or hazard and/or workplace or workers or occupations." In the absence of complete information about the safe occupational handling of chemicals in Republic of Korea (other than a material safety data sheet), this review serves as a valuable reference for identifying and remedying potential gaps in relevant regulations. The review also proposes other public health actions including hazard surveillance and primary prevention activities such as reduction, substitution, ventilation, as well as protective equipment.