• 대한물리의학회지
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• 제13권4호
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• pp.139-148
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• 2018

PURPOSE: This study compared the effects of indoor and outdoor environmental changes on the activity of the major lower limb muscles and walking factors in people 40-50 years and those aged older than 70 years. METHODS: Ten middle-aged people in their forties (age:$44.2{\pm}2.7$, BMI:$21.8{\pm}1.8$) and 10 elderly aged more than 70 years (age:$76.4{\pm}5.9$, BMI:$22.2{\pm}1.9$) with a normal walking ability were included. The participants walked 100 m both indoors and outdoors at their own speed. Using a 3D motion analyzer and EMG, the walking speed, angle of the ankle and activity changes of the lower limb muscles were compared. RESULTS: Significant differences in walking speed and peak-plantar flexion angle were observed between the two groups (p<.05). The muscular activity of the gastrocnemius muscle (GCM) was significantly different outdoors in the swing phase between the two groups (p<.05). In the people aged in their forties, the muscular activity of the rectus femoris (RF) was significantly higher outdoors than indoors (p<.05). In the elderly, however, the muscular activity of the RF was lower outdoors than indoors (p<.05). When compared to those in there forties, the muscular activity of the outdoor RF significantly decreased in the elderly group (P<.05). The muscular activity of the biceps femoris (BF) in the elderly decreased significantly outdoors compared to indoors (p<.05). CONCLUSION: For the elderly, increasing the exposure to the new environments or focusing on the performance of repeated movements for gradual speed control and precise movements is required to maintain normal gaits and movements that are less affected by environmental changes.

• 디지털융복합연구
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• 제16권12호
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• pp.441-447
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• 2018

이 연구의 목적은 증강현실기술을 활용하여 치과 방사선 촬영술의 반복 연습이 가능한 디지털 콘텐츠를 개발하는데 있다. 성인 모델의 외형을 사진 촬영하고, 실습용 마네킹 팬텀을 컴퓨터 단층 촬영한 후, 이를 중첩하여 삼차원 객체를 제작하였다. 또한, 결과로 출력되는 106장의 방사선사진은 촬영법과 관련된 치아 정보를 활용하여 데이터베이스화하였고, 학습자가 성공적인 촬영을 수행하면 각 촬영조건에 맞는 부위별 영상이 호출되도록 시스템을 구축하였다. 이를 통해 임상 전 단계에서의 연습을 반복적으로 시행할 수 있었다. 이 콘텐츠를 이용하여 치과위생사의 방사선 촬영 임상 실무역량을 향상하는데 기여하고자 한다. 다만, 직접 얼굴인식을 통해 촬영하는 것이 실습효용 가치가 클 것으로 예상하기 때문에 이에 관련한 후속 연구가 필요하다.

• Journal of Acupuncture Research
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• 제39권4호
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• pp.310-316
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• 2022

Background: Verbenalin is an iridoid glucoside, which is among the active components of some medicinal herbs such as Verbena officinalis Linn, and Cornus officinalis Siebold and Zucc. Previous studies have confirmed the antioxidant activity and neuroprotective potential of verbenalin. To confirm the safety of verbenalin, an approximate lethal dose was determined based on a single oral dose toxicity study. Methods: Institute of Cancer Research mice were randomly assigned to three verbenalin exposure groups (250, 500, and 1,000 mg/kg) and a control group (5% methylcellulose solution). There were (5 male and 5 female mice per group). Mortality, clinical signs, and body weight were monitored for 14 days, and necropsies were conducted. Results: No mortalities were observed in the control group or the verbenalin 250 mg/kg group, whereas mortalities were observed in the 500 mg/kg and 1,000 mg/kg verbenalin groups. During the observation period, stool abnormalities such as mucous stools were observed. Clinical signs such as loss of locomotor activity were observed in the 500 mg/kg and 1,000 mg/kg verbenalin groups. During the study period, significant changes in body weight were observed in the 500 mg/kg and 1,000 mg/kg verbenalin groups; however, no gross abnormalities were observed at necropsy. Overall, no toxicity was found in the 250 mg/kg group. Conclusion: The approximate lethal dose of verbenalin was estimated to be 500 mg/kg. For a more accurate assessment of the safety of verbenalin, other types of studies such as repeated-dose toxicity studies should also be conducted.

• Journal of Microbiology and Biotechnology
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• 제33권5호
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• pp.634-643
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• 2023

Chronic obstructive pulmonary disease (COPD), one of the leading causes of death worldwide, is caused by repeated exposure to harmful matter, such as cigarette smoke. Although Lilium longiflorum Thunb (LLT) has anti-inflammatory effects, there is no report on the fermented LLT bulb extract regulating lung inflammation in COPD. Thus, we investigated the protective effect of LLT bulb extract fermented with Lactobacillus acidophilus 803 in COPD mouse models induced by cigarette smoke extract (CSE) and porcine pancreas elastase (PPE). Oral administration of the fermented product (LS803) suppressed the production of inflammatory mediators and the infiltration of immune cells involving neutrophils and macrophages, resulting in protective effects against lung damage. In addition, LS803 inhibited CSE- and LPS-induced IL-6 and IL-8 production in airway epithelial H292 cells as well as suppressed PMA-induced formation of neutrophil extracellular traps in HL-60 cells. In particular, LS803 significantly repressed the elevated IL-6 and MIP-2 production after CSE and LPS stimulation by suppressing the activity of the nuclear factor kappa-light-chain-enhancer of activated B (NFκB) in mouse peritoneal macrophages. Therefore, our results suggest that the fermented product LS803 is effective in preventing and alleviating lung inflammation.

• Steel and Composite Structures
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• 제46권3호
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• pp.385-401
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• 2023

Steel is becoming increasingly popular due to its high strength, excellent ductility, great assembly performance, and recyclability. In reality, steel structures serving for a long time in atmospheric, industrial, and marine environments inevitably suffer from corrosion, which significantly decreases the durability and the service life with the exposure time. For the mechanical properties of corroded steel, experimental studies are mainly conducted. The existing numerical analyses only evaluate the mechanical properties based on corroded morphology at the isolated time-in-point, ignoring that this morphology varies continuously with corrosion time. To solve this problem, the relationships between pit depth expectation, standard deviation, and corrosion time are initially constructed based on a large amount of wet-dry cyclic accelerated test data. Successively, based on that, an in-situ pitting evolution method for evaluating the residual tensile strength of corroded steel is proposed. To verify the method, 20 repeated simulations of mass loss rates and mechanical properties are adopted against the test results. Then, numerical analyses are conducted on 135 models of corrosion pits with different aspect ratios and uneven corrosion degree on two corroded surfaces. Results show that the power function with exponents of 1.483 and 1.091 can well describe the increase in pit depth expectation and standard deviation with corrosion time, respectively. The effect of the commonly used pit aspect ratios of 0.10-0.25 on yield strength and ultimate strength is negligible. Besides, pit number ratio α equating to 0.6 is the critical value for the strength degradation. When α is less than 0.6, the pit number increases with α, accelerating the degradation of strength. Otherwise, the strength degradation is weakened. In addition, a power function model is adopted to characterize the degradation of yield strength and ultimate strength with corrosion time, which is revised by initial steel plate thickness.

• 한국방사선학회논문지
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• 제17권6호
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• pp.819-825
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• 2023

흉부 CT 검사 조건 중 관전압을 100, 80 kVp, 재구성 알고리즘을 FBP, ASIR-V, DLIR로 변화 적용하여 검사 선량과 화질 변화를 비교 분석해 보았다. 그 결과 기존 관전압 보다 낮은 관전압인 100 kVp 에서 ASIR-V, DLIR 적용 시 선량을 낮추면서 120 kVp, FBP 적용 시와 가장 유사한 화질로 구현. 특히, DLIR 재구성 영상은 모든 관전압에서 SNR, CNR이 우수하였다. 또한, SSIM 지수가 1에 가장 근사하게 분석되어 원본 영상과 가장 유사도가 높은 것을 알 수 있었다. 따라서 반복적으로 흉부 CT 검사를 시행하는 경우 DLIR 적용은 검사 선량을 약 29.7% 감소시킬 수 있어 CT 검사의 가장 큰 문제점인 검사로 인한 피폭을 일부 해결하는 데 도움을 줄 수 있을 것으로 사료된다.

• 한국환경보건학회지
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• 제49권6호
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• pp.295-304
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• 2023

Background: Adolescents are relatively more sensitive than adults to exposure to indoor pollutants. The indoor air quality in classrooms where students spend time together must therefore be managed at a safe level because it can affect the health of students. Objectives: In this study, three types of green-wall models were applied to classrooms where students spend a long time in a limited space, and the resulting effects on reducing PM were evaluated. Methods: In the middle school classrooms which were selected as the experimental subjects, IoT-based indoor air quality monitoring equipment was installed for real-time monitoring. Three types of plant models (passive, active, and active+light) were installed in each classroom to evaluate the effects on improving indoor air quality. Results: The concentration of PM in the classroom is influenced by outdoor air quality, but repeated increases and decreases in concentration were observed due to the influence of students' activities. There was a PM reduction effect by applying the green-wall model. There was a difference in PM reduction efficiency depending on the type of green-wall model, and the reduction efficiency of the active model was higher than the passive model. Conclusions: The active green-wall model can be used as an efficient method of improving indoor air quality. Additionally, more research is needed to increase the efficiency of improving indoor air quality by setting conditions that can stimulate the growth of each type of plant.

• 대한치과교정학회지
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• 제54권3호
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• pp.153-159
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• 2024

Objective: This study aimed to assess the effects of commonly consumed hot drinks on the force decay of orthodontic elastomeric chains. Methods: This in vitro experimental study evaluated 375 pieces of elastomeric chains with six rings placed on a jig. Four rings were stretched by 23.5 mm corresponding to the approximate distance between the canine and the second premolar. Fifteen pieces served as reference samples at time zero, and 360 pieces were randomized into four groups: control, hot water, hot tea, and hot coffee. Each group was further divided into six subgroups (n = 15) according to the different exposure periods. The specimens in the experimental groups were exposed to the respective solutions at 65.5℃ four times per day for 90 seconds at 5-second intervals. The control group was exposed to artificial saliva at 37℃. The force decay of the samples was measured at 1, 2, 7, 14, 21, and 28 days using a universal testing machine. Data were analyzed using repeated-measures analysis of variance. Results: Maximum force decay occurred on day 1 in all groups. The minimum force was recorded in the control group, followed by the tea, coffee, and hot water groups on day 1. At the other time points, the minimum force was observed in the tea group, followed by the control, coffee, and hot water groups. Conclusions: Patients can consume hot drinks without concern about any adverse effect on force decay of the orthodontic elastomeric chains.

• 한국의학물리학회지:의학물리
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• 제26권1호
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• pp.28-35
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• 2015

본 논문에서는 반복적 구성 기법과 관전류 노출자동조절 기법이 영상의 화질과 방사선량에 미치는 영향을 관상동맥 전산화단층촬영 혈관조영 영상(coronary computed tomography angiography, CCTA)을 대상으로 팬텀 실험에 기반하여 평가하고자 한다. 이를 위하여 미국 의학물리학회(American Association of Physics in Medicine) 표준의 성능 평가 팬텀을 320 다중검출열 CT로써 촬영하였다. 80 kVp, 100 kVp, 120 kVp의 관전압에 있어서, 관전류 노출자동조절 기법은 저선량 목표 표준편차(SD=44)와 고선량(목표 표준편차=33)의 두 가지 설정으로써 촬영하였다. 재구성 변수로서는 필터보정 역투영(FBP)와 반복적 재구성 방법을 설정하여, 전부 12개의 재구성 영상을 획득하였다(12=3 (80, 100, 120 kVp)${\times}2$ (저선량(목표SD=44), 고선량(목표SD=33))${\times}2$ (필터보정역투영, 반복적 재구성). 영상의 화질은 잡음의 세기(표준편차), 변조전달함수, 대조대잡음비(CNR)에 의하여 평가하였으며, 관전압과 관전류 노출자동조절 기법에서의 목표 선량과 대소 및 재구성 기법의 선택이 화질과 방사선량에 미치는 영향을 관찰하였다. 반복적 재구성 기법은 필터보정역투영 기법보다 영상 잡음을 대폭 감소시켰으며 이는 저선량의 경우 더욱 뚜렷하였다. 즉, 잡음의 세기는 관전류 노출자동조절의 설정이 고선량 (목표SD=33)과 저선량(목표SD=44)인 경우, 각각 평균 38%와 평균 46% 감소하였다. 반복적 재구성 기법에 의하여, 변조전달 함수에 의한 공간적 해상도의 평가에 있어서 미약한 감소를 보였으나, 이로써 잡음 저감과 대조대잡음비(CNR)에 있어서의 현저한 개선을 상쇄할 정도의 영향에는 미치지 못 하였다. 결과적으로, 관상동맥 전산화단층촬영 혈관조영 영상의 획득에서 있어서, 반복적 재구성 기법과 관전류 노출자동조정 기법을 동시에 사용하는 것은 영상의 화질을 개선하면서 공간적 해상도의 저하 등 그 부작용은 최소화함으로써, 합리적으로 획득 가능한 한 최소한의 선량 (ALARA)의 원칙에 충실한 실제 임상적 효과를 의미한다고 기대할 수 있다.

• 한국안광학회지
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• 제20권2호
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• pp.237-246
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• 2015

목적: 본 연구는 안구에 존재하는 항산화효소인 superoxide dismutase(SOD)와 catalase(CAT)가 UV-B에 반복적으로 노출되었을 때 유발되는 구조변성 및 활성저하의 상관관계를 밝히며, 자외선 차단 RGP렌즈의 사용으로 효소의 변성과 활성저하가 효율적으로 차단되는가를 알아보기 위하여 수행되었다. 방법: SOD와 CAT의 표준품으로 각각의 효소용액을 제조하고 하루 30분, 1시간 및 2시간씩 312 nm의 UV-B에 1, 2, 3, 4 및 5일 동안 반복적으로 노출시켰다. 이 때 UV-B에 직접 노출시킨 항산화효소의 구조 및 활성변화를 자외선 차단기능이 있는 RGP렌즈로 UV-B를 차단시킨 경우와 비교하였다. UV-B 반복노출에 따른 SOD와 CAT의 구조변성은 전기영동분석으로 확인하였으며, 이들 효소활성은 분석키트를 이용하여 비색분석법으로 측정하였다. 결과: UV-B에 반복노출된 SOD는 일일 30분 조사조건으로 반복노출되었을 때에도 전기영동분석에서 효소다중화(polymerization)가 관찰되었으나 활성의 변화는 10% 이내로 나타났다. 반면 UV-B에 반복노출된 CAT은 전기영동 시 효소밴드크기나 진하기가 감소하여 구조변성이 나타났음을 확인할 수 있었으며, 반복노출시간이 긴 경우 CAT은 전기영동분석에서 효소밴드를 보임에도 불구하고 그 활성은 완전히 소실되었다. 또한 UV-B 조사로 인한 CAT의 변성은 63.7%의 UV-B 차단기능을 가진 RGP렌즈의 사용으로 어느 정도 억제되었으나 완전히 억제되는 것은 아니었다. 결론: 이상의 결과로 UV-B 반복노출에 따른 항산화효소의 구조변성은 그 종류에 따라 효소활성의 감소정도와 반드시 일치하는 것은 아님을 알 수 있었다. 따라서 자외선으로 인한 항산화효소의 손상을 막기 위하여서는 콘택트렌즈를 착용한 상태에서 자외선 노출시간을 최소화하거나, FDA Class I 차단제에 해당하는 UV 차단율을 가지는 콘택트렌즈를 착용 또는 이에 상응하는 UV차단율을 가지는 선글라스를 덧착용할 것을 권장한다.