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REPEATOME: A Database for Repeat Element Comparative Analysis in Human and Chimpanzee

  • Woo, Tae-Ha;Hong, Tae-Hui;Kim, Sang-Soo;Chung, Won-Hyong;Kang, Hyo-Jin;Kim, Chang-Bae;Seo, Jung-Min
    • Genomics & Informatics
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    • v.5 no.4
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    • pp.179-187
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    • 2007
  • An increasing number of primate genomes are being sequenced. A direct comparison of repeat elements in human genes and their corresponding chimpanzee orthologs will not only give information on their evolution, but also shed light on the major evolutionary events that shaped our species. We have developed REPEATOME to enable visualization and subsequent comparisons of human and chimpanzee repeat elements. REPEATOME (http://www.repeatome.org/) provides easy access to a complete repeat element map of the human genome, as well as repeat element-associated information. It provides a convenient and effective way to access the repeat elements within or spanning the functional regions in human and chimpanzee genome sequences. REPEATOME includes information to compare repeat elements and gene structures of human genes and their counterparts in chimpanzee. This database can be accessed using comparative search options such as intersection, union, and difference to find lineage-specific or common repeat elements. REPEATOME allows researchers to perform visualization and comparative analysis of repeat elements in human and chimpanzee.

Modeling study on repeat purchase intention on silk products based on the electronic commercial platform

  • Shi, Rui;Li, Gaihang;Liu, Guolian
    • The Research Journal of the Costume Culture
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    • v.20 no.6
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    • pp.937-941
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    • 2012
  • Based on the literature on customer's repeat purchase intention, customer's repeat purchase intention was explored, customer's repeat purchase intention has been a crucial factor influencing consumer behaviors, In this research, the development of models on repeat purchase intention repurchase was indicated. Based on the electronic commerce platform, we focus on the customer's repeat purchase intention on silk products, This paper mainly explores the e-commerce purchase frequency (EPF), customer perceived value (CPV), perceived risk of e-commerce (EPR), and customer satisfaction (CS). The influence of the four factors on repeat purchase intention (RPI) is investigated. In the results, we found that CPV and CS have positive correlations with repeat purchase intention, The EPR has a negative correlation with RPI and has no significant influence on RPI. The result can provide meaningful suggestions for silk product retailers.

Computed Radiography 환경에서의 REPEAT 유형변화에 대한 고찰

  • An, Mi-Seop;Jang, Gwang-Hyeon;Mun, Hui-Seok;Jeong, Hwan
    • Korean Journal of Digital Imaging in Medicine
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    • v.3 no.1
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    • pp.52-58
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    • 1997
  • Before entering 21st Century, modern medical science is requiring more precise display which is highly estimated in diagnostic value as radial science technology is achieving sharp development. And it is also trying to contribute to improve national health and to offer better service by reducing radial exposure. General projection and Fluoroscopy which are most difficult to be displayed in digital tend to change their way ; from analog to digital with development of Electronic Engineering and Computer Technology, Introducing to CR system in 1994, SMC have displayed General projection and Fluoroscopy 100% in digital using CR system. This study searched differences between repeat rate, repeat type in the exam using Film/Screen and those in the exam using CR system. According to the analysis of repeat types and repeat rate of Film which was reused by using CR system in general projection room and Fluoroscopy room of SMC, we found that total 192,813 films were used and 2,097 films, 1.09% of total were reused. However, actual repeat covers 0.76% to 1,461 sheets with the exception of 636sheets. As above, display process using CR system is 0.76% much lower than general repeat rate 2$\sim$4% of Film/Screen exam. Besides decreased under/over exposure, it is appeared that position failure rate in repeat rate 0.76% covers relatively high 31%. Noticing that repeat caused unskilled devices handing was found many times, sufficient understanding seems to be required to reduce repeat.

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Analysis of cytosine adenine(CA) repeat polymorphism of the IGF-I gene and influence on serum IGF-I levels in healthy children and adolescents (한국인 소아 및 청소년에서 IGF-I 유전자형의 분석과 cytosine-adenine(CA) repeat 유전자 다형성이 혈중 IGF-I 농도에 미치는 영향)

  • Ko, Myung Jin;Hwang, Tae Gyu;Lee, Jeong Nye;Chung, Woo Yeong
    • Clinical and Experimental Pediatrics
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    • v.49 no.12
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    • pp.1340-1347
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    • 2006
  • Purpose : The aim of the present study was to investigate the role of polymorphic cytosine adenine (CA) repeat of the IGF-I gene in the age-related alterations of serum IGF-I levels in healthy children. Methods : Two hundred and forty three normal healthy children (136 boys; 107 girls) aged between 7 and 15 years were enrolled in the present study. The primers were designed to cover the promoter regions containing the polymorphic CA repeat. Data were analyzed using GeneMapper software, version 3.7. All analyses were performed using MEDCALC software packages. Results: Deletion of 2 bp (G, A) following 3' of CA repeat were observed in all Korean children. The CA repeat sequences ranged from 17 to 23, and 19 CA repeat were the most common with an alleles frequency of 39.3 percent. Considering genotypes, 63.8 percent of subjects were homozygote or heterozygote for 19 CA repeat (192 bp allele), suggesting that this is wild type allele from which all other alleles originated in Korean children. Homozygote for 19 CA repeat were 14.7 percent, heterozygote for 19 CA repeat was 49.1 percent and 19 CA noncarriers totalled 36.2 percent. In 19 CA repeat noncarriers, the mean height, weight and serum IGF-I level were lower compared with those of 19 CA homozygous carriers, but statistically not significant. Correlations between serum IGF-I level and age according to the IGF-I genotypes revealed statistically significant relationships in the all groups, in the 19 CA repeat carrier group and, even in the noncarrier group. Conclusions : There were no significant differences of the mean height, weight and serum IGF-I levels among three different genotype groups. Also, there were no significantly different correlations between 19 CA repeat polymorphisms and serum IGF-I levels, according to genotype. Our results suggest that the IGF-I 19 CA repeat gene polymorphism is not associated with circulating IGF-I levels in healthy children.

Risk factors for repeat breeder dairy cows and their impacts on reproductive performance

  • Jeong, Jae-Kwan;Kim, Ill-Hwa
    • Korean Journal of Veterinary Research
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    • v.62 no.2
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    • pp.15.1-15.8
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    • 2022
  • The objective of this study was to identify risk factors for repeat breeder dairy cows and their impact on reproductive performance. The characteristics of 1,504 cows, including their peripartum health, nutrition, production, and reproduction, were collected. Cows with metabolic disorder were significantly more likely (odds ratio [OR], 2.47; p < 0.001) and cows with clinical endometritis tended to be more likely (OR, 1.35; p < 0.1) to become repeat breeders than cows without metabolic disorder and clinical endometritis, respectively. Cows initially inseminated > 80 days after calving were less likely (OR, 0.78; p < 0.05) to become repeat breeders than cows initially inseminated ≤ 80 days after calving. As a result, repeat breeding in dairy cows resulted in a 90 day longer (p < 0.0001) mean interval from calving to pregnancy. In conclusion, postpartum metabolic disorder, clinical endometritis, and a short interval from calving to initial insemination were risk factors for repeat breeder dairy cows, resulting in a severely impaired reproductive performance.

Analysis of Factors Contributing to Repeat Surgery in Multi-Segments Cervical Ossification of Posterior Longitudinal Ligament

  • Jeon, Ikchan;Cho, Yong Eun
    • Journal of Korean Neurosurgical Society
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    • v.61 no.2
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    • pp.224-232
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    • 2018
  • Objective : Cervical ossification of the posterior longitudinal ligament (OPLL) can be treated via anterior or posterior approach, or both. The optimal approach depends on the characteristics of OPLL and cervical curvature. Although most patients can be successfully treated by a single surgery with the proper approach, renewed or newly developed neurological deterioration often requires repeat surgery. Methods : Twenty-seven patients with renewed or newly developed neurological deterioration requiring salvage surgery for multi-segment cervical OPLL were enrolled. Ten patients (group AP) underwent anterior approach, and 17 patients (group PA) underwent posterior approach at the initial surgery. Clinical and radiological data from initial and repeat surgeries were obtained and analyzed retrospectively. Results : The intervals between the initial and repeat surgeries were $102.80{\pm}60.08months$ (group AP) and $61.00{\pm}8.16months$ (group PA) (p<0.05). In group AP, the main OPLL lesions were removed during the initial surgery. There was a tendency that the site of main OPLL lesions causing renewed or newly developed neurological deterioration were different from that of the initial surgery (8/10, p<0.05). Repeat surgery was performed for progressed OPLL lesions at another segment as the main pathology. In group PA, the main OPLL lesions at the initial surgery continued as the main pathology for repeat surgery. Progression of kyphosis in the cervical curvature (Cobb's angle on C2-7 and segmental angle on the main OPLL lesion) was noted between the initial and repeat surgeries. Group PA showed more kyphotic cervical curvature compared to group AP at the time of repeat surgery (p<0.05). Conclusion : The reasons for repeat surgery depend on the type of initial surgery. The main factors leading to repeat surgery are progression of remnant OPLL at a different segment in group AP and kyphotic change of the cervical curvature in group PA.

A Survey of Public Preferences on Repeat Dispensing (장기처방약의 조제방식에 대한 일반인의 선호도 조사: 분할조제 관점에서)

  • Young Mi Lee;Daejin Kim;Eunjoo Lee;Hyun Soon Sohn
    • Korean Journal of Clinical Pharmacy
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    • v.34 no.1
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    • pp.30-38
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    • 2024
  • Background: This study examined the public's perceptions of repeat dispensing as one of the measures to reduce the harmful effects of long-term prescriptions in Korea. Methods: From January 11 to 25, 2021, an online survey was conducted for adults using convenience sampling. A self-developed questionnaire was used. Results: There were 310 respondents, of which 228 (73.5%) preferred repeat dispensing. When considering the additional fee payment, 188 (60.6%) preferred repeat dispensing, and 54 (67.5%) out of a total of 80 chronic disease patients preferred it. It was confirmed that there was a difference in the willingness to repeat dispensing considering the additional cost depending on whether the patient had a chronic disease and the distance from home to the nearest pharmacy. As a result of subgroup analysis for patients with chronic diseases, frequency of outpatient visit, number of prescription days, method of packaging pharmaceuticals, and distance from home to the nearest pharmacy were identified as variables that could well predict the willingness to repeat dispensing considering paying additional fees. The preference for repeat dispensing may vary depending on conditions such as additional cost range, frequency and period of prescription use, disease and patient characteristics, so a careful approach is necessary. Conclusion: It is necessary for the government to consider the introduction of repeat dispensing with interest in the public demand.

Analysis of cytosine adenine repeat polymorphism of the IGF-I promoter gene in children with idiopathic short stature (특발성 저신장증 환자에서 IGF-I 프로모터 cytosine-adenine repeat 유전자 다형성의 분석)

  • Moon, Jae Hoon;Chung, Woo Yeong
    • Clinical and Experimental Pediatrics
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    • v.52 no.3
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    • pp.356-363
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    • 2009
  • Purpose : A polymorphism in the IGF-I gene promoter region is known to be associated with serum IGF-I levels, birth weight, and body length, suggesting that IGF-I gene polymorphism might influence postnatal growth. The present study aimed to investigate the role of this polymorphic cytosine-adenine (CA) repeat of the IGF-I gene in children with idiopathic short stature. Methods : The study involved 131 children (72 boys and 59 girls) diagnosed with idiopathic short stature, aged 715 years. Genomic DNA was extracted from anticoagulated peripheral whole blood. The primers were designed to cover the promoter region containing the polymorphic CA repeat. Data were analyzed using GeneMapper software. The correlations between age and serum IGF-I levels were analyzed using Spearmans correlation coefficient. Results : The CA repeat sequences ranged from 15 to 22, with 19 CA repeats the most common with an allele frequency of 40.6%. Homozygous for 19 CA repeat was 13.0%, heterozygous for 19 CA repeat was 56.5%, and 19 CA non-carrier was 30.5%. The three different genotype groups showed no significant differences in height, body weight and body mass index, and serum IGF-I levels. The serum IGF-I level and age according to the IGF-I genotypes were significantly correlated in the entire group, 19 CA repeat carrier group, and the non-carrier group. The three groups also showed no significant differences in the first year responsiveness to GH treatment. Conclusion : There were no significant different correlations between 19 CA repeat polymorphism and serum IGF-I levels according to genotype. Our results suggest that the IGF-I 19 CA repeat gene polymorphism is not functional in children with idiopathic short stature.

On the Performance of Turbo Codes-Based Hybrid ARQ with Segment Selective Repeat in WCDMA

  • Shi Tao;Cao Lei
    • Journal of Communications and Networks
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    • v.8 no.2
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    • pp.212-219
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    • 2006
  • In this paper, a new turbo codes-based hybrid automatic repeat request (TC-HARQ) scheme with segment selective repeat (SSR) is proposed. The main strategy is, upon retransmission, to repeat the data that are most important for the next round of decoding based on the distribution of residual errors after current decoding. The performance in terms of reliability and throughput is analyzed. To adapt to correlated fading channels where an inter-leaver is always employed before transmission, we further modify the SSR strategy so that data having experienced correlated deep fading are selected for retransmission. Finally, this proposed scheme is applied to the wideband code division multiple access (WCDMA) system under frequency selective fading channels. Simulation results demonstrate that in all single and multiple user cases, SSR-based TC-HARQ leads to significant throughput improvement with similar bit error rate (BER) performance as compared to type-I TC-HARQ.

RepWeb: A Web-Based Search Tool for Repeat-Related Literatures

  • Woo, Tae-Ha;Kim, Young-Uk;Kwon, Je-Keun;Seo, Jung-Min
    • Genomics & Informatics
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    • v.5 no.2
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    • pp.88-91
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    • 2007
  • Repetitive sequences such as SINE, LINE, and LTR elements form a major part of eukaryotic genomes. A literature search tool that summarizes the information contained within repeat elements would provide biologists in the field of genomics with a useful tool for analyzing genomic sequence features. We developed a java program designed to make literature access easier by using two search engines simultaneously. RepWeb is a web-based search system that provides a user friendly interface for searching the reference data and journals for information related to repeat elements by using the search engines, Google Scholar and PubMed, simultaneously. It provides an interface that displays the repeat element- related biological information, and includes useful functions such as the production of a repeat tree, clickable links to PubMed and Google Scholar, exporting, and sorting a field into date, author, journal and title.