• 설비공학논문집
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• 제20권3호
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• pp.167-174
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• 2008

Cost related to building equipment accounts for about 85% of the life cycle cost of buildings. Therefore proper selection of air-conditioning system is important for reducing the overall cost of buildings. In this study, medium capacity EHP and GHP for air-conditioning a building with a floor area of 1,200 $m^2$ are compared economically. To consider all the factors of initial and operation costs effectively, an annual equal payment method is proposed. For the initial cost, cost of equipment, construction, installation, electric facility, financial subsidy and tax cut is considered. Cost of basic electricity, energy(electricity and gas), space charge, labor, insurance and repair is considered for the operation cost. Under the assumptions made in this study, overall cost of EHP is less than that of GHP, but this is not absolute and different outcome may result if different assumptions are made. This study is useful for those who are interested in choosing an air-conditioning system that costs less for mid-size buildings with simple calculations.

• 전기학회논문지
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• 제64권7호
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• pp.984-991
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• 2015

This paper presents the methodology for optimal design of power grid for offshore wind power plant (OWPP) and optimum location of offshore substation. The proposed optimization process is based on a genetic algorithm, where the objective cost model is composed of investment, power loss, repair, and reliability cost using the net present value during the whole OWPP life cycle. A probability wind power output is modeled to reflect the characteristics of a wind power plant that produces electricity through wind and to calculate the reliability cost called expected energy not supplied. The main objective is to find the minimum cost for grid connection topology by submarine cables which cannot cross each other. Cable crossing was set as a constraint in the optimization algorithm of grid topology of the wind power plant. On the basis of this method, a case study is conducted to validate the model by simulating a 100-MW OWF.

• BMB Reports
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• 제46권2호
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• pp.113-118
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• 2013

TTRAP is a multi-functional protein that is involved in multiple aspects of cellular functions including cell proliferation, apoptosis and the repair of DNA damage. Here, we demonstrated that the lentivirus-mediated overexpression of TTRAP significantly inhibited cell growth and induced apoptosis in osteosarcoma cells. The ectopic TTRAP suppressed the growth and colony formation capacity of two osteosarcoma cell lines, U2OS and Saos-2. Cell apoptosis was induced in U2OS cells and the cell cycle was arrested at G2/M phase in Saos-2 cells. Exogenous expression of TTRAP in serum-starved U2OS and Saos-2 cells induced an increase in caspase-3/-7 activity and a decrease in cyclin B1 expression. In comparison with wild-type TTRAP, mutations in the 5'-tyrosyl-DNA phosphodiesterase activity of TTRAP, in particular $TTRAP^{E152A}$, showed decreased inhibitory activity on cell growth. These results may aid in clarifying the physiological functions of TTRAP, especially its roles in the regulation of cell growth and tumorigenesis.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.1725-1727
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• 2016

Breast cancer contributes to approximately 23% of the cancer cases identified and 14% of cancer related deaths worldwide. Including a strong association between genetic and environmental factors, breast cancer is a complex and multi factorial disorder. Two high penetration breast cancer susceptibility genes (BRCA1 and BRCA2) have been identified, and germ line mutations in these are thought to account for between 5% and 10% of all breast cancer cases. The human BRCA1 gene, located on 17q, is involved in the regulation of cell proliferation by aiding in DNA repair, transcriptional responses to DNA damage and cell cycle check points. Mutations in this gene enhance cell proliferation and facilitate formation of tumors. Two mutations, the 185 deletion of AG and the 4627 substitution from C to A, are founder mutations in the BRCA1 gene for breast cancer in Asian populations. Allele specific PCR was performed to detect these selected mutations in 120 samples. No mutation of 4627 C to A was detected in the samples and only one of the patients had the 185 del AG mutation in the heterozygous condition. Our collected samples had lower consanguinity and family history indicating the greater involvement of environmental as compared to genetic factors.

• Environmental Analysis Health and Toxicology
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• 제19권3호
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• pp.321-326
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• 2004

The study of p53 tumor suppressor protein is one of most important subjects in an environmental toxicology as well as in cancer biology. Generally, p53 has been known to involve the cell cycle regulation and apoptosis by the activation of its target genes such as p21 and bax in a number of cellular stress responses. In addition, associations of p53 with cellular proteins presumably reflect the involvement of p53 in critical cellular processes such as DNA repair. The complex formation of p53 and exogenous proteins such as viral or cellular proteins has been shown in many cases to play important roles in carcinogenic processes against environmental mutagen. Recently, the disruption of p53 protein by oxidative stress has been also reported to have relevance to carcinogenesis. These findings suggested that the maintaining of stability and functional activity of p53 protein was also important aspect to play as a tumor suppressor protein. Therefore, the detection of functional status of p53 proteins might be an effective biomarker for the cancer and human diseases under the environmental toxicologic carcinogen.

• Natural Product Sciences
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• 제19권1호
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• pp.49-53
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• 2013

Paeonia lactiflora Pall (PL) has been used as a traditional herbal medicine in China, Korea, and Japan for more 1,200 years. PL has reported to have antioxidant activity and protective effect of cells from oxidative stress, although the mechanism has not been verified. FOXO3a is a transcription factor that binds to its target gene's consensus FOXO binding site. FOXO3a protein modulates the various biological functions including cell cycle control, apoptosis, DNA repair, and ROS detoxification. Therefore, FOXO3a activity is associated with cancer, aging, diabetes, infertility, neurodegeneration, and immune system dysfunction. Here we found that FOXO3a was activated by PL extract. Transcriptional target genes such as MnSOD, p27, and GADD45 were activated by PL extract. Protein levels of MnSOD and catalase were increased, consequently, ROS level was reduced in HEF cells by PL extract. These findings suggest that PL extract has an antioxidant activity through FOXO activation and thereby activation of FOXO target genes, MnSOD and catalase.

• 한국항공운항학회지
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• 제23권4호
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• pp.117-124
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• 2015

RAM (Reliability, Availability and Maintenance) has been applied to design and analysis tools which affects system's operational sustainability and its life cycle cost as RAM-c(2009 DoD). RAM-c plays also an important role to guarantee the system engineering for mission assurance. Reliability is highly related to the probability of system failure. Availability means mission capability or the condition of ready to mission. Maintenance includes both the repair to recover the system in the event of failure/unexpected breakdown and proactive maintenance to prolong the design service life of the system or machinery. It is the purpose that this paper is to analyze and conclude the objective service life of UAV. The more UAV is operated, the less the level of its reliability becomes. Repairing failures and supplying spare parts on time, system reliability could be improved up until the time over target. Applying statistical Weibull distributions, this paper suggests the analysis of the design service life and economic life of UAV based on RAM-c with operational data.

• 한국구조물진단유지관리공학회 논문집
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• 제13권4호통권56호
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• pp.101-106
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• 2009

현재 시설물의 안전 및 유지관리 선진화를 위한 국가 기본시책과 비전을 제시하고 시설물을 효율적으로 관리할 수 있는 체계를 마련하기 위하여 안전 및 유지관리 기본계획이 수립되어 추진하고 있는 실정이다. 이와 같이 선진국에서 수행하고 있는 시설물에 대하여 예방적이고 적극적인 보수 보강을 수행하는 예방적 유지관리전략을 우리나라에서도 적극적으로 도입하여 안전 및 유지관리체계를 마련하고 이를 수행하는 것이 필요할 것으로 판단된다. 또한 시설물의 안전 및 유지관리기술에 생애주기분석기법을 적극적으로 도입하여 경제성을 높일 수 있는 기반을 마련해야 하겠다. 따라서 본 논문에서는 시설물의 안전 및 유지 관리의 체계, 제도적 문제, 예산 등에 대한 현재 국내의 실태와 문제점에 대한 분석과 함께 개선방안을 제시하였다.

• Genomics & Informatics
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• 제17권3호
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• pp.27.1-27.9
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• 2019

Supernumerary B chromosomes were found in Lilium amabile (2n = 2x = 24), an endemic Korean lily that grows in the wild throughout the Korean Peninsula. The extra B chromosomes do not affect the host-plant morphology; therefore, whole transcriptome analysis was performed in 0B and 1B plants to identify differentially expressed genes. A total of 154,810 transcripts were obtained from over 10 Gbp data by de novo assembly. By mapping the raw reads to the de novo transcripts, we identified 7,852 differentially expressed genes (log₂FC > |10|), in which 4,059 and 3,794 were up-and down-regulated, respectively, in 1B plants compared to 0B plants. Functional enrichment analysis revealed that various differentially expressed genes were involved in cellular processes including the cell cycle, chromosome breakage and repair, and microtubule formation; all of which may be related to the occurrence and maintenance of B chromosomes. Our data provide insight into transcriptomic changes and evolution of plant B chromosomes and deliver an informative database for future study of B chromosome transcriptomes in the Korean lily.

• Corrosion Science and Technology
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• 제3권4호
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• pp.166-171
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• 2004

Recent developments in Bridge Management Systems (BMS) and in Life-Cycle Cost (LCC) of bridges, have raised the need for evaluation procedure of future condition (Deterioration) of a bridge. Predicting future deterioration is not an easy task due to limited past data to extrapolate from and also due to difficulty in measuring actual deterioration such as section loss of steel on an actual steel bridge. Also, increase in live load and reduction of resistance are random variables, thus a probabilistic approach should be adopted for determining the future deterioration. Due to difficulties in evaluation of future deterioration on steel bridges, accepting uncertainties within a reasonable error, a deterministic procedure using bridge condition rating can be a useful tool for projection of future condition of bridges to identify repair and maintenance needs. The object of this paper is to determine applicability of evaluating deterioration of steel bridge components based on Bridge condition ratings. Bridge condition ratings of bridge components show wide variation for bridges of same age and does not directly correlate well with the age of the bridge and/or deterioration of the bridge. High uncertainty can be reduced by breaking down the rating and by sensitivity analysis. From refined condition rating data, generalized deterioration profile of structures based on age can be derived. Examples are shown for sample bridges in USA. Approximately, 3,000 short to medium span steel bridges were listed in the inventory database. Results show wide variation of rating factors but by subdividing the Bridge condition ratings for various categories general deterioration profiles of steel bridges can be determined.