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Evaluation for Cytopreservability of Manual Liquid-Based Cytology $Liqui-PREP^{TM}$ and its Application to Cerebrospinal Fluid Cytology: Comparative Study with Cytospin (수기 액상세포검사 $Liqui-PREP^{TM}$의 세포보존력 평가 및 뇌척수액 세포검사에의 적용: 세포원심분리법과의 비교)

  • Park, Gyeong-Sin;Lee, Kyung-Ji;Jung, Chan-Kwon;Lee, Dae-Hyoung;Cho, Bin;Lee, Youn-Soo;Shim, Sang-In;Lee, Kyo-Young;Kang, Chang-Suk
    • The Korean Journal of Cytopathology
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    • v.18 no.1
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    • pp.46-54
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    • 2007
  • Cerebrospinal fluid (CSF) cytology is an effective tool for evaluating diseases involving the central nervous system, but this technique is usually limited by its low cellularity and poor cellular preservation. Here we compared the manual liquid-base $Liqui-PREP^{TM}$ (LP) to the cytospin (CS) with using a mononuclear cell suspension and we applied both methods to the CSFs of pediatric leukemia patients. The cytopresevability, in terms of cell yield and cell size, and the clinical efficacy were evaluated. When 2000 and 4000 mononuclear cells were applied, LP was superior to CS for the cell yield, 16.8% vs 1.7% (P=0.001) and 26.2% vs 3.5% (P=0.002), respectively. The mean size of the smeared cells was 10.60 ${\mu}m$ in the CS, 5.01 ${\mu}m$ in the LP and 6.50 ${\mu}m$ in the direct smear (DS), and the size ratio was 1.7 (CS to DS), 0.8(LP to DS) and 2.1 (CS to LP), respectively. As compared to the cells in the DS, the cells in the CS were significantly enlarged, but those in the LP were slightly shrunken. Upon application to 109 CSF samples, 4 were diagnosed as positive for leukemia (positive), 4 had atypical cells and 101 were negative by CS; 6 were positive, one had atypical cells and 102 were negative by LP. For six cases, in which 4 were positive for leukemia and 2 of 4 had atypical cells by CS, they were positive by LP and they were also confirmed as positive according to the follow-up study. Three cases diagnosed as atypical cells (two by CS and one by LP), were confirmed as negative. In conclusion, these results suggest that LP is superior to CS for the cytopresevability and for rendering a definite diagnosis of cerebrospinal fluid.

Analysis of Relationship between Objective Performance Measurement and 3D Visual Discomfort in Depth Map Upsampling (깊이맵 업샘플링 방법의 객관적 성능 측정과 3D 시각적 피로도의 관계 분석)

  • Gil, Jong In;Mahmoudpour, Saeed;Kim, Manbae
    • Journal of Broadcast Engineering
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    • v.19 no.1
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    • pp.31-43
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    • 2014
  • A depth map is an important component for stereoscopic image generation. Since the depth map acquired from a depth camera has a low resolution, upsamling a low-resolution depth map to a high-resolution one has been studied past decades. Upsampling methods are evaluated by objective evaluation tools such as PSNR, Sharpness Degree, Blur Metric. As well, the subjective quality is compared using virtual views generated by DIBR (depth image based rendering). However, works on the analysis of the relation between depth map upsampling and stereoscopic images are relatively few. In this paper, we investigate the relationship between subjective evaluation of stereoscopic images and objective performance of upsampling methods using cross correlation and linear regression. Experimental results demonstrate that the correlation of edge PSNR and visual fatigue is the highest and the blur metric has lowest correlation. Further, from the linear regression, we found relative weights of objective measurements. Further we introduce a formulae that can estimate 3D performance of conventional or new upsampling methods.

Attention Bias Toward Drug Cues in Female Methamphetamine Addicts (여성 메스암페타민 중독자의 약물 단서에 대한 주의편향)

  • Kim, Na-Yeon;Eum, Young-Ji;Kim, Kyo-Heon
    • Science of Emotion and Sensibility
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    • v.22 no.4
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    • pp.75-84
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    • 2019
  • Addicts pay more attention to addiction-related cues, such as substance or behavior. And increased attention to these cues is associated with craving. Methamphetamine is the most abused drug among domestic drug offenders, with continually increasing rates of recidivism. Of the total number of reported drug offenders in the last three years, 21.1 percent have been women. Even so, research on female drug offenders is inadequate, rendering policies and fundamental data for the development of psychotherapy programs insufficient. The present study intended to investigate whether female methamphetamine addicts displayed an attention bias towards drug cues. A dot probe task was conducted on 22 female methamphetamine addicts (addiction group) and 22 non-addicts (control group). The task allowed the correct response rates and correct reaction times of the participants to be calculated according to the positioning of the drug and neutral cues. The analysis results revealed that the control group displayed no difference in correct reaction rates and correct reaction times between the drug or neutral cues. While, the addiction group showed lower correct response rate and slower response time for drug cues in comparison to neutral cues. The results of this study are significant in that it identified the attention bias characteristics toward drug cues of female methamphetamine addicts who were disconnected from drugs.

Evaluation of Information Representation Goodness-of-fit According to Protein Visualization Pattern (단백질 가시화 형태에 따른 정보표현적합도 평가)

  • Byeon, Jaehee;Choi, Yoo-Joo;Suh, Jung-Keun
    • Journal of Internet Computing and Services
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    • v.16 no.2
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    • pp.117-125
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    • 2015
  • The information about protein structure gives the clues for the function of protein. It is needed for the improvement for the efficacy and fast development of protein drugs. So, the studies visualizing the structure of protein effectively increase. Most studies of visualization focus on the structural prediction for protein or the improvement on the rendering speed. However, studies of information delivery depending on the form of protein visualization are very limited. The major objective of this study is to analyze the information representation goodness-of-fit for the patterns of the hybrid visualization with primary and secondary structures of protein. Those hybrid visualizations included the patterns which updated current representative visualization services, Chimera, PDB and Cn3D. Information factor to analyze information representation goodness-of-fit is assorted by protein primary structure, secondary protein structure, the location of amino acid and ratio information about protein secondary structure, based on the result of subject-analysis. Subject is the group of experts who are involved in protein drug development over 5 years. The result of this study shows the meaningful difference in the information representation goodness-of-fit by the patterns of hybrid visualization and proves the difference in the information by the pattern of visualization.

Characteristic of Coils According to Volume in Case of Embolization of Cerebral Aneurysm (뇌동맥류에 대한 색전술 시 체적에 따른 코일 특성)

  • Chae, Soo-In;Baek, Chang-Moo;Kim, Jeong-Koo
    • The Journal of the Korea Contents Association
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    • v.12 no.7
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    • pp.247-254
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    • 2012
  • This study presents the assessment results of coil length characteristics according to the volume of cerebral artery among the inpatients that received angiography and coil embolization following intracranial aneurysm from March, 2010 to September 2011. The volume rendering method was applied to the patients that received embolization to their cerebral arteries to obtain volume measurements. After coil embolization, the volume ratios were calculated with the volumes and lengths of coils. The embolic volume ratios were $43.11{\pm}3.11%$, $36.07{\pm}2.03%$, 40.91%, and 38.25% when the aneurysm sizes were 6mm or less, 6~10mm, 10~15mm and 20mm or more, respectively, being similar to the recommended volume ratios. Regardless of the types of aneurysm, the coil length according to volume was 0.65cm per $1mm^3$ of 20~$100mm^3$ when one type of 0.25mm diameter coil was used. They were 0.62cm per $1mm^3$ of 20~$150mm^3$ when one type of coil was used in the aneurysm volume of the saccular type and 0.60cm per $1mm^3$ of 20~$90mm^3$ when one type of coil was used in the aneurysm volume of the multi-lobulated type.

Motion Map Generation for Maintaining the Temporal Coherence of Brush Strokes in the Painterly Animation (회화적 애니메이션에서 브러시 스트로크의 시간적 일관성을 유지하기 위한 모션 맵 생성)

  • Park Youngs-Up;Yoon Kyung-Hyun
    • Journal of KIISE:Computer Systems and Theory
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    • v.33 no.8
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    • pp.536-546
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    • 2006
  • Painterly animation is a method that expresses painterly images with a hand-painted appearance from a video, and the most crucial element for it is the temporal coherence of brush strokes between frames. A motion map is proposed in this paper as a solution to the issue of maintaining the temporal coherence in the brush strokes between the frames. A motion map is the region that frame-to-frame motions have occurred. Namely, this map refers to the region frame-to-frame edges move by the motion information with the motion occurred edges as a starting point. In this paper, we employ the optical flow method and block-based method to estimate the motion information. The method that yielded the biggest PSNR using the motion information (the directions and magnitudes) acquired by various methods of motion estimation has been chosen as the final motion information to form a motion map. The created motion map determine the part of the frame that should be re-painted. In order to express painterly images with a hand- painted appearance and maintain the temporal coherence of brush strokes, the motion information was applied to only the strong edges that determine the directions of the brush strokes. Also, this paper seek to reduce the flickering phenomenon between the frames by using the multiple exposure method and the difference map created by the difference between images of the source and the canvas. Maintenance of the coherence in the direction of the brush strokes was also attempted by a local gradient interpolation to maintain the structural coherence.

A Systematic Approach Of Construction Management Based On Last Planner System And Its Implementation In The Construction Industry

  • Hussain, SM Abdul Mannan;Sekhar, Dr.T.Seshadri;Fatima, Asra
    • Journal of Construction Engineering and Project Management
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    • v.5 no.2
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    • pp.11-15
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    • 2015
  • The Last PlannerSystem (LPS) has been implemented on construction projects to increase work flow reliability, a precondition for project performance againstproductivity and progress targets. The LPS encompasses four tiers of planning processes:master scheduling, phase scheduling, lookahead planning, and commitment / weeklywork planning. This research highlights deficiencies in the current implementation of LPS including poor lookahead planning which results in poor linkage between weeklywork plans and the master schedule. This poor linkage undetermines the ability of theweekly work planning process to select for execution tasks that are critical to projectsuccess. As a result, percent plan complete (PPC) becomes a weak indicator of project progress. The purpose of this research is to improve lookahead planning (the bridgebetween weekly work planning and master scheduling), improve PPC, and improve theselection of tasks that are critical to project success by increasing the link betweenShould, Can, Will, and Did (components of the LPS), thereby rendering PPC a betterindicator of project progress. The research employs the case study research method to describe deficiencies inthe current implementation of the LPS and suggest guidelines for a better application ofLPS in general and lookahead planning in particular. It then introduces an analyticalsimulation model to analyze the lookahead planning process. This is done by examining the impact on PPC of increasing two lookahead planning performance metrics: tasksanticipated (TA) and tasks made ready (TMR). Finally, the research investigates theimportance of the lookahead planning functions: identification and removal ofconstraints, task breakdown, and operations design.The research findings confirm the positive impact of improving lookaheadplanning (i.e., TA and TMR) on PPC. It also recognizes the need to perform lookaheadplanning differently for three types of work involving different levels of uncertainty:stable work, medium uncertainty work, and highly emergent work.The research confirms the LPS rules for practice and specifically the need to planin greater detail as time gets closer to performing the work. It highlights the role of LPSas a production system that incorporates deliberate planning (predetermined andoptimized) and situated planning (flexible and adaptive). Finally, the research presents recommendations for production planningimprovements in three areas: process related, (suggesting guidelines for practice),technical, (highlighting issues with current software programs and advocating theinclusion of collaborative planning capability), and organizational improvements(suggesting transitional steps when applying the LPS).

Message Quality, Structural Positions in Discussion Network, and Opinion Leadership: A Case Analysis of 'Free-Lunch Debate' in Online Political Discussion (메시지 품질과 토론 연결망의 구조적 위치, 그리고 여론지도력: 서울시 '무상급식 논란'의 온라인 정치토론 사례 분석)

  • Kim, Kyung-Mo;Song, Hyun-Jin
    • Korean journal of communication and information
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    • v.56
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    • pp.194-218
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    • 2011
  • Focusing on the individuals' structural positions and roles in the internet discussion network, this research explores whether and how the opinion leaders' network characteristics are associated with the message quality and interpersonal influence in terms of attention-drawing and response-generation, which prior studies often failed to fully explicate. Findings suggest that discussion participants with high message quality occupy more central positions in the discussion network, thus enjoy more attention and responses of other following participants. However, opinion leader's network centralities, which tap the structural positions and unique roles in the online discussion network, systematically mediate the effect of the message quality on interpersonal influence. Moreover, significant interaction between opinion perception and network centrality was found only on the majority opinion group, rendering the entire discussion structure toward more enclaved deliberation and group polarization. Taken together, the results imply that the influence of the online opinion leader can only be substantiated with participant's central positions in the discussion network, which has been ignored by the prior opinion leadership research.

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Temperature Effect on the Optical Properties of YAG and Silicate Phosphor-based White Light Emitting Diodes (온도 변화에 따른 YAG 및 Silicate형광체 기반 백색 LED의 광특성 변화에 대한 연구)

  • Choi, Hyun-Woo;Ko, Jae-Hyeon
    • Korean Journal of Optics and Photonics
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    • v.24 no.3
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    • pp.135-142
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    • 2013
  • Two white light emitting diodes(LEDs) were fabricated by using two kinds of yellow phosphor, YAG:Ce and $(Sr,Ba)_2SiO4:Eu$, and their spectroscopic properties were analyzed as a function of temperature from room temperature to $80^{\circ}C$. The asymmetric double sigmoidal function was applied to both blue and yellow peaks of the emitting spectrum to obtain the center wavelength, the amplitude, the half width, and the skewness parameters. According to this analysis, the center wavelength of the blue peak shifted to longer wavelength while that of the yellow peak shifted to shorter wavelength. In addition, some of the skewness parameters were found to increase upon heating, which indicates that spectrum asymmetry becomes enhanced at higher temperatures. The changes in the color coordinates and the luminous efficacy were larger for the case of silicate-based white LED. These results suggest that the silicate-based white LED is inferior to the YAG-based white LED from the viewpoint of color stability, efficacy and color rendering index.

Effects of Singular Manner or Mixed Type Treatment of Proteases Isolated from Pear, Pineapple and Kiwifruit on Actomyosin Degradation (배, 파인애플 및 키위로부터 추출 분리한 단백질 분해효소의 단일 또는 혼합처리가 Actomyosin 분해에 미치는 영향)

  • 김은미;최일신;황성구
    • Food Science of Animal Resources
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    • v.23 no.3
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    • pp.193-199
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    • 2003
  • In order to investigate the meat tenderizing effects of pear, pineapple and kiwifruit, crude protease was prepared from each fruit and treated with actomyosin in a single manner or mixed type in several combination. Actomyosin was incubated with various proteases for 24 hrs under three different pH condition, and its degrading performance was evaluated by the SDS-PAGE. Pear extract showed an active degrading activity for actomyosin at pH 5.3 and 7.0. But, little actomyosin degradation was observed at pH 8.0. Actomyosin was strongly degraded by the treatment of protease from pineapple at all different pHs(5.3, 7.0 and 8.0). Kiwifruit protease extract has shown actomyosin degradation activity 1hr after treatment at pH 5.3 and pH 7.0. Meanwhile, the mixture of pear and pineapple extracts(l:l, w/w) showed much more degradation than the results of singular manner treatment at pH 5.3 and 7.0. When the pear protease was mixed with kiwifruit protease(l:l, w/w), the performance of actomyosin degradation was similar to the results of each single protease treatment. When the mixture was made of pineapple and kiwifruit extracts, actomyosin degradation was almost the same as the result of treatment of pineapple protease only. When those three proteases were mixed together(l:l:l, w/w/w), actomyosin degrading activities was in time dependent manner at pH 5.3. In summary, pear protease can be used potentially as a meat tenderizer when it was mixed with pineapple or kiwifruit rendering proper tenderization of the meat.