• Journal of Pharmaceutical Investigation
• /
• v.11 no.3
• /
• pp.14-20
• /
• 1981

One of the major objectives in the developments of a progesterone I.U.D. is to prepare devices which release drug at a constant rate for extended periods. A constant release rate is achived by maintaining drug concentration at a constant valve via the introduction of rate limiting membrane to solute diffusion at the surface of the devices. In this study, progesterone dispersed at monolithic device were prepared from polyhydroxy ethyl methacrylate. Constant release rate were obtained with device which were soaked in on ethanol-hexan solution. The release rate was dependant upon the concentration of the ethanolic solution in the soaking solution. This devices offer significant potential for futher development of hydrogel in the intrauterine contraception device for controlled release of progesterone.

• YAKHAK HOEJI
• /
• v.28 no.3
• /
• pp.169-177
• /
• 1984

Release characteristics of salicylic acid from ethylcellulose(EC) films containing varying ratio of dieththylphthalate (DEP) were studied. Mathematical analysis of the release data showed that the release behavior actually conforms with the Higuchi's diffusion-controlled model. The release rate constants(k) were independent from the film thickness and the pH of release medium, but were proportional to the concentration of salicylic acid itself. The logarithm of the release rate constant (log k) increased as the concentration of DEP was increased. In conclusion, hydrophobic plastisizer DEP seemed to be very useful in controlling release rate constant of slightly soluble drugs as like salicylic acid without changing it's release characteristics.

• Journal of Pharmaceutical Investigation
• /
• v.20 no.2
• /
• pp.89-95
• /
• 1990

Ethylcellulose-PEG 4000 film coated on core tablets was investigated as a potential drug delivery system for the controlled release of chlorpheniramine maleate (CPM). The kinetic analysis of the release data indicated that CPM release followed a diffusion-controlled model, where the quantity released per unit area is proportional to the square root of time. The effect of the film composition, CPM concentration, plasticizer concentration and CPM solubility on the release characteristics were examined. The release rate constant increased as CPM concentration increased. It also increased as the PEG 4000 content in the film increased above 10%(w/w), however, it decreased as the PEG 4000 content increased in the concentration range below 10%(w/w). The release rate constant was not affected by the coated weight on the core tablet. The film-coated tablets which contain CPM only in the coated film layer seemed to be a potential oral drug delivery system for the controlled release of CPM.

• Magazine of the Korean Society of Agricultural Engineers
• /
• v.36 no.2
• /
• pp.44-55
• /
• 1994

This paper describes the development of real-time irrigation reservoir operation models that adequately allocate available water resources for paddy rice irrigation. Water requirement deficiency index(WRDI) was proposed as a guide to evaluate the operational performance of release schemes by comparing accumulated differences between daily release requirements for irrigated areas and actual release amounts. Seven reservoir release rules were developed, which are constant release rate method (CRR), mean storage curve method(MSC), frequency analysis method of reservoir storage rate(FAS), storage requirement curve method(SRC), constant optimal storage rate method (COS), ten-day optimal storage rate method(TOS), and release optimization method(ROM). Long-term forecasting reservoir operation model(LFROM) was formulated to find an optimal release scheme which minimizes WRDIs with long-term weather generation. Rainfall sequences, rainfall amount, and evaporation amount throughout the growing season were to be forecasted and the results used as an input for the model. And short-term forecasting reservoir operation model(SFROM) was developed to find an optimal release scheme which minimizes WRDIs with short-term weather forecasts. The model uses rainfall sequences forecasted by the weather service, and uses rainfall and evaporation amounts generated according to rainfall sequences.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.4 no.4
• /
• pp.171-178
• /
• 1996

DCB(pure mode I) and CLS(mixed mode) tests were performed to investigate the effect of fracture mode on the interlaminar fracture of composite laminate. Mode I critical strain energy release rate was found to be $133J/m^2$ from the DCB test and total strain energy release rate decreased from $1, 270J/m^2$ as thickness ratio(tl/t) varied from 0.333 to 0.667 from the crease from the CLS test. Crack length had no effect on the total strain energy release rate and load was almost constant during the crack growth of the specimen which had the specific thickness ratio. Crack initiated when the stress of the strap ply reached constant stress $42kgf/mm^2$ which was found to be independent of the thickness ratio.

• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.24 no.11
• /
• pp.1486-1496
• /
• 2000

The initial flame kernel development and flame propagation in a constant volume combustion chamber is analyzed by the heat release rate and the mass fraction burnt. The combustion pressure is measured with a piezoelectric type pressure sensor. In order to evaluate the effects of ignition system and ignition energy on the flame propagation, four different ignition systems are designed and tested, and the ignition energy is varied by the dwell time. Several different spark plugs are also tested and examined to analysis the effects of electrodes on flame kernel development. The results show that the when the dwell time is increased, and when the spark plug gap is extended, heat release rate and the mass burnt fraction are increased. The materials and shapes of electrodes affect the flame development, because they change the energy transfer efficiency from electrical energy to chemical energy. The diameter of electrodes influences not only the heat release rate but also the mass burnt fraction as well.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.24 no.7 s.178
• /
• pp.1863-1870
• /
• 2000

When an impact stress is applied on the external boundary of double cantilever beam of orthotropic material which crack length is greater than specimen hight and anistropic ratio is very high, dyna mic energy release rate is derived, and the relationship between dynamic energy release rate and crack propagating velocity is studied. Dynamic energy release rate to static energy release rate is decreased with increasment of crack propagating velocity. The relationships between dynamic energy release rate and vertical strain have a similar pattern with those between static energy release rate and vertical strain. When normalized time(Cstla) is greater than or equal to 2, dynamic energy release rate approaches to a constant value.

• Journal of Advanced Marine Engineering and Technology
• /
• v.23 no.2
• /
• pp.184-191
• /
• 1999

Th effects of exhaust gas recirculation(EGR) on the characteristics of combustion exhaust emissions and specific fuel consumption(SFC) are experimentally investigated by four-cylin-der four-cycle and direct injection marine diesel engine. In order to reduce soot contents in the recirculated exhaust gas to intake system of the engines a novel diesel soot removal system with a cylinder-type scrubber which has water injector(4 nozzles in 1.0mm diameter)is specially designed and manufactured for the experi-mental system. The obtained results are as follows; The combustion pressure in cylinder is decreased and ignition is delayed with increasing EGR rate. The accumulated quantity of heat release is slightly decreased and the tendency of heat release rate is not constant. NOx and Soot emissions are decreased by maximum 7% and 540% with scrubber tan without scrubber in the range of experimental conditions. Those are increased at the lean burn area with increasing equivalence ration in the constant value of engine speed and EGR rate. Also those are decreased with increasing EGR rate in the constant value of engine speed and equivalence ratio.

• Journal of Pharmaceutical Investigation
• /
• v.20 no.2
• /
• pp.79-88
• /
• 1990

A numerical model for diffusion and dissolution controlled transport from dispersed matrix is presented. The rate controlling process for transport is considered to be diffusion of drug through a concentration gradient coupled with time-dependent surface change and/or disappearance of the dispersed drug in response to the dissolution. The transport behavior of drug was explained in terms of ${\nu}$ parameter: ${\nu}$ value means a ratio of diffusion time constant and dissolution time constant. This general model has wide range of application from where release is controlled by the diffusion rate to where release is governed by the dissolution rate. Based on this model, theoretical drug concentration, particle size distributions in the polymer matrix system and the resulting release rate were also investigated.

• Transactions of the Korean Society of Automotive Engineers
• /
• v.4 no.4
• /
• pp.201-209
• /
• 1996

This study describes the combustion characteristics of methance-air mixture with various equivalence retio and initial conditions of mixture in constant volume combustion chamber. Combustion characteristics of methane-air mixture such as combustion pressure, combustion temperature, and heat release were investigated by the measurement of combustion pressure and temperature in the combustion chamber. The results show that maximum combustion pressure, gas temperature and rate of heat release have peaks at equivalence ratio of 1.1. Combustion duration is also the shortest at the equivalence ratio of 1.1 and it is shortened as initial mixture temperature increases.