• YAKHAK HOEJI
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• v.29 no.2
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• pp.70-75
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• 1985

The influence of polyethylene glycol derivatives on heparin release from cylindrical monolithic type silicone segment devices was examined in physical saline solution. This water-soluble carrier caused the devices to absorb the water in aqueous media. The release rate of heparin from the devices was increased as molecular weight of polyethylene glycol was increased. Water soluble carrier incorporated into silitone segment devices permits controlled release of heparin that otherwise would be released extremly slowly from the polymer. Heparin released from the silicone segment containing polyethylene glycol showed the first-order kinetics. Without changing the release-pattern, the release rate of heparin could be controlled by varing molecular weight of polyethylene glycol, the water-soluble carrier and depleting polyethylene glycol on the outlayer of devices. The mechanism of release probably showed the creation of pore or microdomine through the devices secondary to the swelling.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.24 no.11
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• pp.1486-1496
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• 2000

The initial flame kernel development and flame propagation in a constant volume combustion chamber is analyzed by the heat release rate and the mass fraction burnt. The combustion pressure is measured with a piezoelectric type pressure sensor. In order to evaluate the effects of ignition system and ignition energy on the flame propagation, four different ignition systems are designed and tested, and the ignition energy is varied by the dwell time. Several different spark plugs are also tested and examined to analysis the effects of electrodes on flame kernel development. The results show that the when the dwell time is increased, and when the spark plug gap is extended, heat release rate and the mass burnt fraction are increased. The materials and shapes of electrodes affect the flame development, because they change the energy transfer efficiency from electrical energy to chemical energy. The diameter of electrodes influences not only the heat release rate but also the mass burnt fraction as well.

• Advances in materials Research
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• v.12 no.1
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• pp.15-29
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• 2023

In this paper, fracture analysis of a continuously inhomogeneous arch structure with two longitudinal cracks is developed in terms of the time-dependent strain energy release rate. The arch under consideration exhibits non-linear creep behavior. The cross-section of the arch is a rectangle. The material is continuously inhomogeneous along the thickness of the cross-section. The arch is loaded by two bending moments applied at its end sections. The mechanical behavior of the material is described by using a non-linear stress-strain-time relationship. The two longitudinal cracks are located symmetrically with respect to the mid-span of the arch. Due to the symmetry, only half of the arch is considered. Time-dependent solutions to strain energy release rate are obtained by analyzing the balance of the energy. For verification, time-dependent solutions to the strain energy release rate are derived also by considering the time-dependent complementary strain energy. The evolution of the strain energy release rate with the time is analyzed. The effects of material inhomogeneity, locations of the two cracks along the thickness of the arch and the magnitude of the external loading on the time-dependent strain energy release rate are evaluated.

• Journal of Pharmaceutical Investigation
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• v.37 no.2
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• pp.95-99
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• 2007

To develop topical nitroglycerin (NTG) preparation far chronic anal fissure treatment, the release rate of NTG should be controlled carefully. For this, microemulsion was prepared from the phase diagram construction with Cremophor ELP, ethanol and Labrafil $M1944CS^{(R)}$ and the topical gel was prepared by dispersing NTG containing microemulsion into hydrophilic polymers. in viかo release characteristics were evaluated with Franz diffusion cell using cellulose membrane and compared with control hydrogels. The release rate of NTG was followed $1^{st}$ order kinetics and, when comparing the NTG release from control hydrogel with that from the microemulsion-based hydrogel, the NTG release rate was controlled by the content of polymers within continuous phase and the concentration of dispersed phase.

• Journal of Pharmaceutical Investigation
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• v.35 no.3
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• pp.157-163
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• 2005

The pellets with multiple drug release system (MDRS) of Diltiazem. HCl which consist of immediate drug release layer, drug reservoir layer and controlled release rate membrane, were prepared by using CF-Coater. As main factors for more effective MDRS of Diltiazem. HCl, ethylcellulose was used for the controlling drug release rate, and diethylphthalate was used for plasticizer, respectively. In vitro evaluation study was performed by comparative dissolution test between our test MDRS and reference Diltiazem. HCl preparation. The physical tests were performed using FT-IR and SEM. In vivo evaluation was also performed by observing the behavior of a plasma drug concentration after oral administration. The bioavailability was determined by analyzing the blood sample after oral administration to healthy, male volunteers once a day. As a result, there were no significant differences in bioequivalence parameters $(AUC_{\infty},\;C_{max},\;t_{1/2})$ between two systems. It might be concluded that our MDRS of Diltiazem. HCl could be an alternative delivery system to reference drug preparation.

• Korean Journal of Veterinary Research
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• v.51 no.1
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• pp.1-6
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• 2011

Sixteen steers were used to investigate the efficacy of the sustained-release implant of bovine somatotropin (bST) in improving growth and feed:gain ratio during 12 weeks. Administration of the 400 mg bST implant resulted in a 16.1% increase in growth rate, and this increase was significant (p<.05). The use of the sustained-release implant did not alter (p>.05) feed intake and feed:gain ratio. Thirty-four cows were used to investigate the efficacy of the sustained-release implant of bST in milk production during 4 weeks. Administration of the 200 mg bST implant resulted in an 8.7% increase in milk production, and this increase was significant (p<.05). Twenty-four barrows were used to investigate the efficacy of the sustained-release implant of porcine somatotropin (pST) in improving growth, feed:gain ratio and backfat thickness during 6 weeks. Administration of the 120 mg pST implant resulted in a 11.4% increase in feed:gain ratio and a 60% decrease in backfat thickness, and these results were significant (p<.05). But the use of the sustained-release implant did not alter (p>.05) growth rate and feed intake.

• The Journal of Fisheries Business Administration
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• v.36 no.1 s.67
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• pp.121-138
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• 2005

This study was conducted to investigate the economic effect of the release of seed flounder to the central area of the West Sea, which was analyzed into both direct and indirect effects. The results showed that based on the data collected from partial area, the economic effect of flounder seed release reached 6.97 times, average catch proportion was 32.27$\%$, and recapture rate was 11.26$\%$, suggesting that economic effect was very high. In addition, it was observed that the recapture rate was greatly higher than 2.05$\%$, that of Break-Even-Point. It was noted that the increased catch by the release of seed flounder resulted in the increase in commission of sales and the increase in sports fishing. Another economic effect observed were diverse including the increase in income of fishing village, elevated spirit to proper management of fisheries resources, maintaining of willingness to live in fishing village through activation of local fishing village, prevention of illegal fishing including capture of juvenile fish, and the increase in the supply of sea food of high quality. It is emphasized that although the investigation was conducted in the same area, the results will vary by size at release, time at release and other factors. Finally, there is a need to expand species and area of study for more active economic analysis incorporating natural sciences.

• Journal of Mechanical Science and Technology
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• v.16 no.6
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• pp.829-838
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• 2002

A constant volume combustion chamber is used to investigate the flame kernel development of gasoline air mixtures under various ignition systems, ignition energies and spark plugs. Three kinds of ignition systems are designed and assembled, and the ignition energy is controlled by the variation of the dwell time. Several kinds of spark plugs are also tested. The velocity of flame propagation is measured by a laser deflection method, and the combustion pressure is analyzed by the heat release rate and the mass fraction burnt. The results represent that as the ignition energy is increased by enlarging either dwell time or spark plug gap, the heat release rate and the mass fraction burnt are increased. The electrodes materials and shapes influence the flame kernel development by changing he transfer efficiency of electrical energy to chemical energy. The diameter of electrodes also influences the heat release rate and the burnt mass fraction.

• 연구논문집
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• s.29
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• pp.49-55
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• 1999

Heat release rate used to characterize the fire is an important factor for determining the fire size, the fire growth and the time for suppression and evacuation. The purpose of present work is to review theoretical backgrounds and to introduce equations for estimation of heat release rate with oxygen consumption method in fires. Our work also shows the experimental results of applications for liquid fuels. The oxygen concentration is measured by the analyzer of paramagnetic type. The analyzers of Infra-Red type are used to measure the concentrations of $CO_2$ and CO gas. Time delays of analyzers are ignored.

• Transactions of the Korean Society of Mechanical Engineers
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• v.19 no.2
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• pp.330-337
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• 1995

For a rotating body with cracks, the new energy release rate equation is presented. The derived equation is different from the other researcher's results. It is a path-independent integral which excluded the derivatives of displacements near the crack tip, thereby improving the numerical accuracy of the energy release rate computation. Moreover, as the equation was derived on basis of the energy principle and non-linear elasticity without assumptions, it can applied to the cracked body with arbitrary shape under elastic-plastic deformation. Several examples are treated to demonstrate the efficiency and accuracy of the proposed method compared to existing methods.