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http://dx.doi.org/10.4333/KPS.2007.37.2.095

In vitro Release Characteristics of Nitroglycerin from Microemulsion-Based Hydrogel System for Anal Fissure Treatment  

Lee, Sang-Kil (Department of Pharmaceutical Engineering, Inje University)
Shin, Hyun-Woo (College of Pharmacy, Chung-Ang University)
Kang, Myung-Joo (College of Pharmacy, Chung-Ang University)
Cho, Seong-Wan (Department of Pharmaceutical Engineering, Konyang University)
Cho, Jae-Youl (School of Bioscience and Biotechnology, Kangwon National University)
Lee, Jae-Hwi (College of Pharmacy, Chung-Ang University)
Choi, Young-Wook (College of Pharmacy, Chung-Ang University)
Publication Information
Journal of Pharmaceutical Investigation / v.37, no.2, 2007 , pp. 95-99 More about this Journal
Abstract
To develop topical nitroglycerin (NTG) preparation far chronic anal fissure treatment, the release rate of NTG should be controlled carefully. For this, microemulsion was prepared from the phase diagram construction with Cremophor ELP, ethanol and Labrafil $M1944CS^{(R)}$ and the topical gel was prepared by dispersing NTG containing microemulsion into hydrophilic polymers. in viかo release characteristics were evaluated with Franz diffusion cell using cellulose membrane and compared with control hydrogels. The release rate of NTG was followed $1^{st}$ order kinetics and, when comparing the NTG release from control hydrogel with that from the microemulsion-based hydrogel, the NTG release rate was controlled by the content of polymers within continuous phase and the concentration of dispersed phase.
Keywords
Nitroglycerin; Mictroemulsion; Hydrogel; Controlled release; Anal fissure;
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1 U. Elkayam, F. Bitar, M. W. Akhter, S. Khan, S. Patrus and M. Derakhshani, Intravenous nitroglycerin in the treatment of decompensated heart failure: potential benefits and limitations, Cardiovasc. Pharmacal. Ther., 9, 227-241. (2004)   DOI
2 S. A. Imtiaz, J. B. Karen and M. Andrew, Impact of preoperative intravenous nitroglycerin on in-hospital outcomes after coronary artery bypass grafting for unstable angina, Am. Heart J., 148, 727-732 (2004)   DOI   ScienceOn
3 U. Stenestrand, J. Lindback and L Wallentin, Hospital therapy traditions influence long-term survival in patients with acute myocardial infarction, Am. Heart J., 149, 82-90 (2005)   DOI   ScienceOn
4 Merck index 11th Ed., Merck&Co. Inc., Rahway, N.J. U.S.A pp. 1045 (1989)
5 http://en.wikipedia.org/wiki/Nitroglycerin
6 M. R. Nabih and M. B. Thomas, New and future migraine therapy, Pharmacal. Ther., 112, 199-212 (2006)   DOI   ScienceOn
7 R. A. Kloner, Pharmacology and Drug Interaction Effects of the Phosphodiesterase 5 Inhibitors: Focus on ${\alpha}$-Blocker Interactions, The Am. J. Cardiol., 96, Supplement 2, 42-46 (2005)
8 A. MacLean, Chemical Sphincterotomy in the treatment of anal fissure, J. Gastro. Surg., 10, 629-630 (2006)   DOI   ScienceOn
9 R. S. McLeod and J. Evans, Symptomatic care and nitroglycerin in the management of anal fissure, J. Gastrointest. Surg., 6, 278-280 (2002)   DOI   ScienceOn
10 M. J. Utzig, A. J. Kroesen and H. J. Buhr, Concepts in pathogenesis and treatment of chronic anal fissure-A review of the literature, Am. J. Gastroenterol., 98, 968-974 (2003)
11 I. Lindsey, O. M. Jones, C. Cunningham and N. J. M. Mortensen, Chronic anal fissure, Br. J. Surg., 91, 270-279 (2004)   DOI   ScienceOn
12 USP NF 23rd Ed., The United States Pharmacopeial Convention Inc., U.S.A. pp. 1090 (1994)
13 U. Thadani and T. Rodgers, Side effects of using nitrates to treat angina., Expert. Opin. Drug Saf Expert., 5, 667-674 (2006)   DOI   ScienceOn
14 A. C. Sintov and L. Shapiro, New microemulsion vehicle facilitates percutaneous penetration in vitro and cutaneous drug bioavailability in vivo, J. Controlled Rel., 95, 173-183 (2004)   DOI   ScienceOn
15 M. R. Gasco, M. Gallarate, M. Trotta, L. Bauchiero, E. Gremmo and O. Chiappero, Microemulsions as topical delivery vehicles: ocular administration of timolol, J. Pharm. Biomed. Anal., 7, 433-439 (1989)   DOI   ScienceOn
16 M. Trotta, M. R. Gasco and S. Morel, Release of drugs from oil-water microemulsions, J. Controlled Rel., 10, 237-243 (1989)   DOI   ScienceOn
17 P. P. Constantinides, Lipid microemulsion for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects, Pharm. Res., 12, 1561-1570 (1995)   DOI
18 P. Spiclin, M. Homar, A. Zupani- Valant and M. Gasperlin, Sodium ascorbyl phosphate in topical microemulsions, Int. J. Pharm., 256, 65-73 (2003)   DOI   ScienceOn
19 E. A. Mueler, F. M. Kovarik, J. B. van Bree, W. Tetzloff, J. Grevel and K. Kutz, Improved dose linearity of cyclosporine pharmacokinetics from a microemulsion formulation, Pharm Res., 11, 301-304 (1994)   DOI
20 A. C. Sintov and S. Botner, Transdermal drug delivery using microemulsion and aqueous systems: Influence of skin storage conditions on the in vitro permeability of diclofenac from aqueous vehicle systems, Int. J. Pharm., 311, 55-62 (2006)   DOI   ScienceOn
21 M. Trotta, Influence of phase transformation on indomethacin release from microemulsions, J. Controlled Rel., 60, 399-405 (1999)   DOI   ScienceOn