• 한국임상약학회지
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• 제21권2호
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• pp.145-155
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• 2011

The objective of this study was to determine whether any pretreatment parameters were associated with pharmacological effect or toxicity parameters after vincristine administration and to describe a mathematical model, which explains the interpatient pharmacodynamic variability. The relationship between patient characteristics and vincristine dose and hematological toxicity were evaluated. 68 pediatric and adolescence patients and 107 adults with acute lymphoblastic leukemia were treated with vincristine $1.5mg/m^2/day$ IV and other anticancer drugs as scheduled. Complete blood counts and other blood test results were obtained. The input variables were age, gender, weight, lean body weight (LBW), height, body surface area, vincristine dose and total vincristine dose. The outcome measures were nadir values (white blood cells, absolute neutrophil counts, hemoglobin, and platelets); the absolute decrease, relative decrease, and survival fraction of blood cells. Polynomial regression analysis was carried out to determine the other significant covariates. The variability of $WBC_{nadir}$ was modeled with good precision and accuracy with a two-covariate model. This model should be validated and improved on with further clinical data. We believe that such pharmacodynamic modeling should be explored further to determine its performance and clinical relevance compared with modeling using pharmacokinetic parameter.

• Journal of Microbiology and Biotechnology
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• 제26권10호
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• pp.1746-1754
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• 2016

Recently, spherical beads entrapping quorum quenching (QQ) bacteria have been reported as effective moving QQ-media for biofouling control in MBRs for wastewater treatment owing to their combined effects of biological (i.e., quorum quenching) and physical washing. Taking into account both the mass transfer of signal molecules through the QQ-medium and collision efficiencies of the QQ-medium against the filtration membranes in a bioreactor, a cylindrical medium (QQ-cylinder) was developed as a new shape of moving QQ-medium. The QQ-cylinders were compared with previous QQ-beads in terms of the QQ activity and the physical washing effect under identical loading volumes of each medium in batch tests. It was found that the QQ activity of a QQ-medium was highly dependent on its specific surface area, regardless of the shape of the medium. In contrast, the physical washing effect of a QQ-medium was greatly affected by its geometric structure. The enhanced anti-biofouling property of the QQ-cylinders relative to QQ-beads was confirmed in a continuous laboratory-scale MBR with a flat-sheet membrane module.

• 한국수산과학회지
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• 제22권4호
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• pp.189-195
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• 1989

본 연구는 1982년 8월부터 1986년 2월 까지 5년에 걸쳐 계절별로 한반도에 인접한 황해의 저서다모류를 대상으로 정량 채집하여 다모류의 중요성과 종조성을 파악하였다. 다모류의 비중은 전 저서동물군 중에서 가장 높은 $35.1\~46.4\%$의 조성률을 나타내었고, 생체양에 있어서는 극피동물이나 연체동물군이 우점군으로 나타났으나 그들의 계절적 변화 폭이 일정하지 않고 매우 다양했다. 채집도구에 따른 다모류의 비중은 드레지(dre-dge)를 사용할 경우 채이기(grab)의 경우보다 약간 낮은 조성률을 나타내었다. 이는 드레지의 경우가 훨씬 더 퇴적물의 표층부분만을 예인하기 때문이었으며 다모류의 조성률도 다소 낮은 경향을 보였다. 본 연구기간 중 출현한 다모류는 모두 141종으로 나타났으며 이 해역에서의 대표종은Spiophanes bormbyx, Ampharete arctica, Geniada maulata, Nephtys caeca, Nothria iridescens이었다.

• Asian Journal of Atmospheric Environment
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• 제7권3호
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• pp.129-138
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• 2013

The water uptake by fine aerosol in the atmosphere has been investigated at Gosan, Korea during ABC-EAREX 2005. The concentration of inorganic ion and carbon components, size distribution, and light scattering coefficients in normal and dry conditions were simultaneously measured for $PM_{2.5}$ by using a parallel integrated monitoring system. The result of this study shows that ambient fine particles collected at Gosan were dominated by water-soluble ionic species (35%) and carbonaceous materials (18%). In addition, it shows the large growth of aerosol in the droplet mode when RH is higher than 70%. Size distribution of the particulate surface area in a wider size range ($0.07-17{\mu}m$) shows that the elevation of RH make ambient aerosol grow to be the droplet mode one around $0.6{\mu}m$ or the coarse mode one, larger than $2.5{\mu}m$. Hygroscopic factor data calculated from the ratio of aerosol scattering coefficients at a given ambient RH and a reference RH (25%) show that water uptake began at the intermediate RH range, from 40% to 60%, with the average hygroscopic factor of 1.10 for 40% RH, 1.11 for 50% RH, and 1.17 for 60% RH, respectively. Finally, average chemical composition and the corresponding growth curves were analyzed in order to investigate the relationship between carbonaceous material fraction and hygroscopicity. As a result, the aerosol growth curve shows that inorganic salts such as sulphate and nitrate as well as carbonaceous materials including OC largely contribute to the aerosol water uptake.

• Carbon letters
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• 제13권2호
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• pp.109-114
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• 2012

A nuclear, biological, chemical (NBC) canister was indigenously developed using active carbon impregnated with ammoniacal salts of copper (II), chromium (VI) and silver (I), and high efficiency particulate aerosol filter media. The NBC canister was evaluated against carbon tetra chloride ($CCl_4$) vapours, which were used as a simulant for persistent chemical warfare agents under dynamic conditions for testing breakthrough times of canisters of gas masks in the National Approval Test of Respirators. The effects of $CCl_4$ concentration, test flow rate, temperature, and relative humidity (RH) on the breakthrough time of the NBC canister against $CCl_4$ vapour were also studied. The impregnated carbon that filled the NBC canister was characterized for surface area and pore volume by $N_2$ adsorption-desorption isotherm at liquid nitrogen temperature. The study clearly indicated that the NBC canister provides adequate protection against $CCl_4$ vapours. The breakthrough time decreased with the increase of the $CCl_4$ concentration and flow rate. The variation in temperature and RH did not significantly affect the breakthrough behaviour of the NBC canister at high vapour concentration of $CCl_4$, whereas the breakthrough time of the NBC canister was reduced by an increase of RH at low $CCl_4$ vapour concentration.

• 환경영향평가
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• 제16권5호
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• pp.351-361
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• 2007

To evaluate dominant synoptic classes which affect on $PM_{10}$ concentration in Seoul, 64 synoptic classes are classified from four seasons, 850hPa geopotential wind and lower level stability Index. In this study, we used air monitoring and meteorological data in Seoul for five years from 2001 to 2005. The results indicate that the highest occurrence frequency of synoptic class is under a strong westerly geopotential wind and stable lower atmosphere in spring. The highest $PM_{10}$ concentration of synoptic class is associated with a weak geopotential wind speed and high lower level stability. In that class, not only $PM_{10}$ but $SO_2$, $NO_2$ and CO concentrations are also higher than other classes. The analysis of spacial distribution of $PM_{10}$ concentration in each class are indicate that the influence of synoptic class are similar in the Metropolitan area in Korea. But $PM_{10}$ concentration in some areas in Kyoung-Gi are more higher than in Seoul. The relationship between $PM_{10}$ concentration and Meteorological indicator (relative humidity, temperature, surface wind speed) under same synoptic class is more correlative in Winter than other season.

• Carbon letters
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• 제8권4호
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• pp.280-284
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• 2007

Samples of active carbon of $1150\;m^2/g$ surface area were impregnated with ammoniacal salts of copper, chromium and silver, with and without triethylenediamine. The samples of impregnated carbon were aged at $50^{\circ}C$, with and without 90% RH (relative humidity), for a little more than one year and chemically evaluated periodically. Initially copper (II) and chromium (VI) reduced very fast in the samples in humid atmosphere to the extent of 30% and 60% respectively in four months. These values were found to be unaffected by the presence of triethylenediamine (TEDA) indicating that the chemical did not retard the reduction process of chromium (VI) and copper (II). However, in the absence of humidity the reduction of the impregnants was significantly less (10-12%, w/w) in four months. It was quite evident; therefore, that the moisture was mainly responsible for the reduction of chromium (VI) and copper (II) species in impregnated carbons. The prolonged ageing of the samples with and without triethylenediamme after four months with and without humid atmosphere showed that the extent of reduction of chromium (VI) was very low, i.e. 5-10% and of copper (II) was 2-25%. Silver is not reduced due to carbon, as it remained unchanged in concentration on storage. The impregnated carbon samples (100 g) without triethylenediamine, which were aged at room temperature for 5 years in absence of humidity and unaged when evaluated against cyanogen chloride (CNCl) at a concentration of 4 mg/L and airflow rate of 30 lpm showed a high degree of protection (80- 110 minutes).

• Asian-Australasian Journal of Animal Sciences
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• 제31권10호
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• pp.1611-1618
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• 2018

Objective: The objective of this experiment was to examine the effects of different amylose/amylopectin ratios on rumen fermentation and development of fattening lambs. Methods: Forty-eight 7-day-old male Small-tailed Han sheep${\times}$Northeast fine wool sheep were randomly assigned to four treatments of dietary amylose/amylopectin ratios (0.12, 0.23, 0.24, and 0.48 in tapioca starch, corn starch, wheat starch and pea starch diets, respectively). Three lambs from each treatment were slaughtered at 21, 35, 56, and 77 days of age to determine the rumen fermentation and development. Results: Compared with tapioca starch diet, the pea starch diet significantly increased the concentration of ammonia nitrogen in the ruminal fluid of lambs but significantly decreased the bacterial protein content. At 56 and 77 d, the rumen propionate concentration tended to be greatest in the tapioca starch group than in other groups. The rumen butyrate concentration was the greatest in lambs fed on pea starch compared with those fed on other starch diets. Furthermore, the pea starch diet significantly stimulated rumen development by increasing the papillae height, width and surface area in the rumen ventral or dorsal locations in lambs. However, different amylose/amylopectin ratios diets did not significantly affect the feed intake, body weight, average daily gain, the relative weight and capacity of the rumen in lambs with increasing length of trial periods. Conclusion: Lambs early supplemented with a high amylose/amylopectin ratio diet had favourable morphological development of rumen epithelium, which was not conducive to bacterial protein synthesis.

• 멤브레인
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• 제22권6호
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• pp.395-403
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• 2012

분리막에 대한 지속적인 성장과 더불어 나노섬유 분리막은 현재 기체, 수처리, 에너지 등 다양한 분야에서 활발히 연구가 진행되고 있다. 나노섬유를 제조하는 방법에는 연신(drawing), 템플레이트 합성(template synthesis), 상분리(phase separation), 자가조립(self-assembly), 전기방사(electrospinning)법이 있으며, 특히, 전기방사법은 다른 제법들에 비해 높은 생산성과 생산비용이 낮은 장점이 있다. 또한, 재료의 선택성이 용이하며, 높은 비표면적과 기능기 추가가 용이하다. 분리막에 있어서 나노섬유의 적용은, 이차전지분야에서 기존의 PP, PE 혹은 PE/PP 격리막 위에 나노섬유를 도포함으로써 고온에서 안정성과 고출력을 가진 분리막을 개발할 수 있으며, 수처리 분야에서는 나노섬유 사이에 항균성 물질 등 다양한 첨가제를 추가하여 고기능성 분리막을 개발할 수 있다. 따라서 나노섬유 분리막은 에너지 분야에서 수처리 분야에 이르기까지 다양한 용도에 활용가능하며, 다양한 기능성의 발현으로 고부가 가치가 기대된다.

• 센서학회지
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• 제8권4호
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• pp.327-332
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• 1999

비표면적이 약 $200\;m^2/g$인 ${\gamma}-Al_2O_3$를 합성하여 얻은 ${\gamma}-Al_2O_3$ 담체에 Pd, Pt와 같은 귀금속 촉매를 첨가하여 접촉연소식 가스감지소자를 제작하였다. 제작된 센서는 최적동작을 위한 인가전압 1.75 V에서 소모전력은 약 500 mV였고, 부탄, 메탄 및 프로판 각각 100 %LEL에 대해서 약 120 mV의 높은 감도 특성을 보였다. 제작된 센서는 탄화수소 가스 농도에 대한 선형성, 재현성, 그리고 상대 습도변화에 대해서 안정된 감도 특성을 보여 주었다. 그리고 약 100일 동안 부탄 가스에 대해서 안정된 센서 감도 특성을 보여 주었다.