• Journal of Yeungnam Medical Science
• /
• 제8권1호
• /
• pp.166-177
• /
• 1991

1986년 4월부터 1991년 3월까지 영남대학교 의과대학 부속병원에서 자궁 경부암으로 확진되어 수술후 방사선치료를 시행한 22명의 환자에서 방사선 선량 분포에 따른 치료성적은 다음과 같다. 1. 22명중 3명(13.6%)에서 골반이나 복부에 재발이 생겼으며 임상적 병기가 진행될수록, 외부조사선량이 적을수록 재발이 많았다. 2. 골반내 임파선 전이와 임파혈관 침범인 경우에 재발이 되었다. 3. 강내조사 선량이나 수술방법은 재발과 무관하였다. 4. 중대한 합병중은 임상적 병기가 앞설수록 외부조사 선량이나, 총조사 선량이 증가할수록 많이 발생하였다. 이상의 결과를 보면 본원 치료방사선과의 자궁 경부암의 수술후 방사선 치료원칙은 적절하며 재발방지와 합병증의 예방을 위한 세심한 주의와 항암제를 위시한 전신요법의 추가를 고려하여야 하겠다.

• Journal of Periodontal and Implant Science
• /
• 제30권1호
• /
• pp.203-212
• /
• 2000

Putrefactive activity within the oral cavity is the principal cause of halitosis. The most common intraoral sites of oral malodor production are tongue, interdental and subgingival areas. The other foci may include faulty restorations, sites of food impaction and abscesses. Periodontal disease frequently involves pathological oral malodor, which is caused mainly by volatile sulfur compounds(VSC), such as hydrogen sulfide, methyl mercaptan, and dimethyl sulfide. The purpose of this study is to evaluate the association between oral malodor and periodontal status. Volatile sulfur compounds in mouth air were estimated by portable sulfide monitor($Halimeter^{TM}$). The results were as follows : 1. The levels of volatile sulfur compounds were significantly greater in a periodontitis group than in a control group(P<0.01). The amounts of VSC in mouth air from patients with periodontal involvement were four times greater than those of the control group. 2. The significant positive correlation was found between VSC concentrations and the number of pocket depth above 4mm(P<0.01), but correlation between VSC concentrations and plaque score was not statistically significant(P>0.05). 3. In the periodontitis group, VSC concentrations of pre-treatment significantly decreased after scaling and root planing(P<0.01). 4. No statistically significant correlation was found between VSC concentrations and sex / age in the periodontitis group. The above results indicate that periodontal disease may play a role as an important factor of oral malodor and deep periodontal pockets are a source of volatile sulfur compounds.

• 한국환경성돌연변이발암원학회지
• /
• 제25권1호
• /
• pp.19-24
• /
• 2005

The Swedish double mutation (KM670/671NL) of amyloid precursor protein (Swe-APP) is associated with early-onset familial Alzheimer's disease (FAD) and increases amyloid beta peptide production. Although APP/A/3 mediated neurotoxicity is observed both in vitro and in vivo, the relationship between mutant APP expression, A/3 production, and neuronal death observed in the brains of FAD patients remains to be elucidated. In this study, we investigated the mechanisms of Swe-APP-induced cell death in HEK293 and NGF-differentiated PC 12 cells. We found that the expression of Swe-APP induced cytochrome C relase, activation of caspase 3 in HEK 293 and NGF-differentiated PC 12 cells. We also show that the reactive oxygen species (ROS) was detected in Swe-APP expressing HEK 293 cells and NGF-differentiated PC 12 cells and that pretreatment with vitamine E attenuated the cellular death, cytochrome C release induced by Swe-APP expression, indicating the involvement of free radical in these processes. These results suggest one of possible apoptotic mechanisms of Swe-APP which could occur through cytochrome C release from mitochondria and this apoptosis inducing effects could be at least in part, due to ROS generation by Swe-APP expression.

• 대한두개안면성형외과학회지
• /
• 제19권3호
• /
• pp.190-193
• /
• 2018

Background: This study was conducted to determine the effect of the distributional relationship between dental roots and the mandibular bone on single mandibular bone fractures, which are common craniofacial fractures. Methods: This was a retrospective, single-center study in Seoul, Korea. Patients with single mandibular fractures in the symphysis, parasymphysis, body, and angle area, with tooth structure involvement were included. The control group included patients with simple, bone-level lacerations without fractures. In total, 94 patients (72 males and 22 females) were included in the treatment group, and 125 (71 males and 54 females) were included in the control group. The height of the mandibular bone and the dental root were measured with panoramic radiography. The central incisor represented the symphysis area, the canine represented the parasymphysis area, the first molar represented the body area, and the second molar represented the angle area. Results: In the treatment group, symphysis fractures occurred in 16 patients (17%), parasymphysis fractures in 36 patients (38%), body fractures in 17 patients (18%), and angle fractures in 25 patients (27%). The ratios of the dental roots to the total height of the mandibular bone in the treatment group were 30.35%, 39.75%, 39.53%, and 36.27% for symphysis, parasymphysis, body, and angle areas, respectively, whereas in the control group, they were 27.73%, 39.70%, 36.76%, and 35.48%. The ratios of the treatment group were significantly higher than those of the control group. Conclusion: The results show that the higher ratio of the dental root to the height of the mandibular bone increases the fracture risk.

• 한국미생물·생명공학회지
• /
• 제22권3호
• /
• pp.240-245
• /
• 1994

Relation the phage defense mechanism of phage resistant Lactococcus lactis subsp. cremoris ATCC 11602-A1 to its cell wall components was investigated. To determine whether teichoic acid which is known to be one of the phage receptor site present on the cell wall, phage adsorption was examined after treatment 5% TCA(60%$\CIRC $C) and concanavalin A to the cell wall of A1 and parent strain. However, the adsorption rate of two strains did not change. Total amount of phosphate after TCA treatment did not change in both strains, but a difference between the two strains was observed. Ribitol and glycerol, components of teichoic acid, could not be detected in the cell walls of two strains by GC analysis. These results suggest that although teichoic acid was not present in the cell walls of both strains, the composition of cell wall of two strains was not identical. Measurement of amount of protein and SDS-polyacryamide gel electrophoresis were carried out to examine the involvement of cell wall protein in phage resistance, showing that protein is nothing to do with phage adsorption of parent strain, but phage resistance of A1 is related to protein. Cell wall carbohydrates of A1 contained rhamnose, glucose, and galactose. Total amount of carbohydrate of 1% SDS-treated A1 cell wall was reduced to the level of parent strain. The results suggest that phage resistance of A1 was due to the presence of a higher level of carbohydrates then parent strain, and to interaction of carbohydrate and protein.

• 대한약리학회지
• /
• 제22권2호
• /
• pp.128-134
• /
• 1986

hydrochlorothiazide의 이뇨작용과 cyclic nucleotides와의 관계를 알아보기 위해 신조직내cyclic nucleotides 함량과 adenylate cyclase 및 guanylate cyclase 활성에 대한 hydrochlorothiazide의 영향을 관찰하였다. hydrochlorothiazide를 정맥내 투여시 약물투여 후 10분과 20분 사이에서 이뇨작용이 가장 강하게 나타났으며 60분 경과시는 이뇨작용이 소실되었다. 신조직 내 CAMP 함량은 약물투여 후 5분과 15분에 유의하게 감소되었으며 60분 경과시는 대조군과 차이가 없었다. 신조직내 cGMP 함량은 hydrochlorothiazide에 의해 영향받지 않았다. 신조직의 adenylate cyclase는 hydrochlorothiazide에 의해 활성이 억제되었으며 guanylate cyclase는 영향받지 않았다. 이상의 결과는 hydrochlorothiazide의 이뇨작용에 cAMP가 어떤 관련성을 가질 것을 시사하며 cGMP는 관련성이 없는 것으로 사료된다.

• 임상간호연구
• /
• 제24권2호
• /
• pp.137-146
• /
• 2018

Purpose: The purpose of this study was to identify the influence of nursing organization culture on resilience of new nurses. Methods: Participants were 1,033 new nurses with careers of less than 12 months and who were from 43 general hospitals located in Seoul, Incheon, other metropolitan cities and provinces in Korea. The data were analyzed using t-test, ANOVA, Pearson correlation coefficient and multiple regression with SPSS/WIN 24.0 program. Results: Relation-oriented culture was scored highest for perception of organizational culture by new nurses (3.35), followed by hierarchy-oriented culture (3.19), innovation-oriented culture (3.12), and task-oriented culture (2.73). The score for resilience of the new nurses was 3.49, and the first subcategories were interpersonal relationship ability 3.66, self-positivity 3.45, and self-control ability 3.36. Relation-oriented culture (${\beta}=.30$, p<.001) was the most significant factor influencing resilience of new nurses, followed by innovation-oriented culture (${\beta}=.14$, p=.001), hierarchy-oriented culture (${\beta}=.12$, p<.001), task-oriented culture (${\beta}=-.10$, p=.003) in that order ($R^2(adj. R^2)=.16$, F=47.04, p<.001). Conclusion: Findings show that for improved resilience in new nurses it is necessary to develop relation-oriented culture to provide a cooperative work environment(friendly interpersonal relation and dialogue) for new nurses and to encourage involvement of these members in the hospital culture.

• 한국가족복지학
• /
• 제61호
• /
• pp.35-57
• /
• 2018

본 연구는 한국사회 결혼이주여성의 사회적 자본의 네트워크 요인과 인지적 요인간의 종단적관계를 살펴보고, 궁극적으로 이들의 문화변용에 영향을 미치는지를 분석하고자 한다. 이를 위해 본 연구는 자녀가 있는 결혼이주여성의 종단패널자료 중 2개년도의 자료를 활용하여 매개경로모형을 설정하여 분석하였다. 분석결과 결혼이주여성의 사회적 자본 중 네트워트적 요인인공식적 지원이 신뢰감, 소속감 및 지역사회와의 관계 등과 같은 인지적 요인의 형성에 기여하고 있음을 보여준다. 또한 이들의 공식적 지원과 인지적 측면의 사회적 자본은 문화변용에 모두 긍정적으로 영향을 미치는데, 이는 가족의 범위를 넘어서 지역사회 내에서의 활동참여나공식적이고 체계적인 지원의 중요성을 보여준다. 본 연구는 결혼이주여성의 사회적 자본의 형성과정 및 사회적 자본과 문화변용간의 관계에 대한 이해의 기반을 제공하며, 실천적으로 가족과 친구 등에 의한 비공식적 지원이 아닌 공식적 지원체계의 수립의 필요성을 제시한다는점에서 의의를 지닌다.

• 한국아동복지학
• /
• 제55호
• /
• pp.1-29
• /
• 2016

본 연구는 서울아동패널 3차년도 데이터를 활용하여 가구소득이 아동의 학업성취에 미치는 영향을 확인하고, 그 과정에서 부모의 시간적 물질적 투자가 매개효과를 지니는지를 살펴보았다. 그 결과, 가구의 소득은 아동의 학업성취에 통계적으로 유의한 정적인 영향을 미치는 것으로 나타났다. 특히 가구소득과 아동 학업성취의 관계를 설명하는 구체적인 매개 경로를 파악하기 위해 부모의 시간적 투자와 물질적 투자가 아동의 학업성취에 미치는 영향을 분석하였다. 그 결과, 부모의 물질적 투자를 나타내는 변수들(인지적 자극물 제공, 교과 외 활동 투자)을 통해 가구소득이 아동의 학업성취에 미치는 영향이 매개되는 것을 확인할 수 있었다. 그러나 부모의 시간적 투자를 나타내는 변수들(부모와의 외부활동, 부모의 학교생활 관여)에서는 통계적으로 유의한 매개효과가 확인되지 않았다. 이러한 결과를 바탕으로 교육불평등에 대한 사회복지 영역에서의 정책적 실천적 개입 방안을 제언하였다.

• 생물치료정신의학
• /
• 제24권3호
• /
• pp.163-172
• /
• 2018

Objectives : The aim of this study was to examine associations between quality of life in patients with schizophrenia and their family relationships. Methods : A total of 68 patients with schizophrenia participated in the study. Socio-demographic and clinical data were collected, as well as results from the Subjective Well-being under Neuroleptic Treatment Scale-Short Form(SWN-K), Family Emotional Involvement and Criticism Scale(FEICS), a visual analogue scale for evaluating the degree of perceived criticism(VAS), the Family Adaptability and Cohesion Evaluation Scale(FACES), Beck Cognitive Insight Scale(BCIS), and Rosenberg Self Esteem Scale(R-SES). Psychiatrists administered the Positive and Negative Syndrome Scale and the Calgary Depression Scale for Schizophrenia(CDSS), and collected a history of previous suicide attempts. Results : The SWN-K total scores showed significant negative correlations with scores on the FEICS perceived criticism, CDSS, and VAS measures and significant positive correlations with scores on the R-SES, FACES, and BCIS. Multiple regression analysis revealed that FEICS perceived criticism, FACES, and BCIS scores were significantly associated with SWN-K scores. The FACES total score was significantly lower in patients with a history of previous suicide attempt. Conclusion : The quality of life of patients with schizophrenia was negatively associated with greater perceived familial criticism and positively associated with better family cohesion and higher patient insight. In patients with a history of suicide attempts, family adaptability and cohesion were significantly low.