• Journal of Microbiology and Biotechnology
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• 제21권7호
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• pp.757-765
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• 2011

Many studies have suggested that the behavioral and reinforcing effects of morphine are induced by hyperactivation of the mesolimbic dopaminergic system, which results in increases in locomotor activity, c-Fos expression in the nucleus accumbens (NAc), and tyrosine hydroxylase (TH) in the ventral tegmental area (VTA). In order to investigate the effect of wild ginseng (WG) on treating morphine addiction, we examined the behavioral sensitization of locomotor activity and c-Fos and TH expression in the rat brain using immunohistochemistry. Intraperitioneal injection of WG (100 and 200 mg/kg), 30 min before administration of a daily injection of morphine (40 mg/kg, s.c.), significantly inhibited morphine-induced increases in c-Fos expression in NAc and TH expression in VTA as well as in locomotor activity, as compared with Panax ginseng. It was demonstrated that the inhibitory effect of WG on the behavioral sensitization after repeated exposure to morphine was closely associated with the reduction of dopamine biosynthesis and postsynaptic neuronal activity. It suggests that WG extract may be effective for inhibiting the behavioral effects of morphine by possibly modulating the central dopaminergic system and that WG might be a useful resource to develop an agent for preventing and treating morphine addiction.

• Steel and Composite Structures
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• 제10권2호
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• pp.187-205
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• 2010

The existing CFT columns present the deterioration in confining effect after the yield of steel tube, local buckling and the deterioration in load capacity. If lateral load such as earthquake load is applied to CFT columns, strong shearing force and moment are generated at the lower part of the columns and local buckling appears at the column. In this study, axial compression test and beam-column test were conducted for existing CFT square column specimens and those reinforced with carbon fiber sheets (CFS). The variables for axial compression test were width-thickness ratio and the number of CFS layers and those for beamcolumn test were concrete strength and the number of CFS layers. The results of the compression test showed that local buckling was delayed and maximum load capacity improved slightly as the number of layers increased. The specimens' ductility capacity improved due to the additional confinement by carbon fiber sheets which delayed local buckling. In the beam-column test, maximum load capacity improved slightly as the number of CFS layers increased. However, ductility capacity improved greatly as the increased number of CFS layers delayed the local buckling at the lower part of the columns. It was observed that the CFT structure reinforced with carbon fiber sheets controlled the local buckling at columns and thus improved seismic performance. Consequently, it was deduced that the confinement of CFT columns by carbon fiber sheets suggested in this study would be widely used for reinforcing CFT columns.

• 대한조선학회지
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• 제6권1호
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• pp.43-67
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• 1969

The effect of a circular hole reinforced by a ring of different material in a plate under biaxial loadings is considered. In this problem, an infinitely large flat is assumed. The reinforcing ring is of uniform rectangular cross-section of same thickness as the plate. The outer boundary of the ring is cemented to the inner boundary of the hole in the plate. The plate is subjected to hydrostatic tension and pure shear loadings. The stress distribution around the hole is obtained by means of the two dimensional theory of elasticity. To conform the validities of above solutions, a series of photo-elastic stress analysis for a composite model was carried out. Fair agreements were observed between two sets of values. The conclusions arrived at are as follows: 1) The theoretical solutions are exact ones for the case of infinitely large flat plate. 2) The solutions can be used for most case of engineering problem if the bonding between the plate and ring is perfect. 3) If the ratio of Young's moduli of the ring and the plate is increased, the stresses in the plate decrease whereas those in the ring increase. 4) The stress concentration near the hole has localized effect. 5) Under hydrostatic tension, maximum principal stress and maximum shear stress increase as the ratio of inner and outer diameters of the ring increases. 6) Under pure shear, the stresses depend upon angular orientations of the points and maximum principal stress and maximum shear stress appear at 45 degree. They increase as the ratio of inner and outer diameters of the ring increases.

• 지역사회간호학회지
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• 제32권2호
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• pp.220-231
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• 2021

Purpose: This study is a pseudo-experimental study of design before and after the non-equivalent control group, which was attempted to verify that the application of the ukulele to the elderly has the effects of reducing depression, improving self-efficacy, strengthening social bonding, and improving cognitive function. Methods: 46 (23 in the experimental group and 23 in the control group) participants were selected. The experimental group was provided with three sessions of a music program using eight Ukuleles for the elderly, while the control group was provided with three sessions for the elderly. IBM SPSS 25.0 was used for data analysis, and the independent t-test, 𝑥²-test, and Fisher's exact probability test were performed to verify the homogeneity of the subject's general characteristics. The effect verification after the experimental treatment was analyzed by Fisher's exact probability test, Friedman test, and Mann-Whitney U test. Results: Depression showed a statistically significant difference between the two groups (F=39.88, p<.001), self-efficacy showed a statistically significant difference between the two groups (z=-4.96, p<.001), social bonding showed a statistically significant difference between the two groups (z=-5.19, p<.001), and cognitive function showed a statistically significant difference between the two groups (z=-3.98, p<.001). Conclusion: It was found that the 'Music Program using the Ukulele' was effective in reducing depression of the elderly, improving self-efficacy, reinforcing social bonding, and improving cognitive function. We hope that the Music Program using the Ukulele can be used in the elderly nursing curriculum in the future, and we suggest it should be applied as a nursing intervention to those who are experiencing cognitive decline.

• 한국염색가공학회지
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• 제34권3호
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• pp.185-196
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• 2022

In this study, carbon fiber and coated glass fiber are applied to warp and weft fiber in order to reduce the amount of carbon fiber used in carbon fiber fabrics, which are often used for reinforcement of building structures. A low-cost thermoplastic resin was coated on glass fibers to prepare a shape-stabilizing glass fiber. A unidirectional carbon fiber sheet was manufactured using the prepared coated glass fiber and carbon fiber. In order to identify whether it can be used for reinforcing architectural and civil structures, it was attached to a concrete specimen and its mechanical properties were analyzed. The optimum manufacturing conditions for the coated glass fiber were 0.3 mm in diameter of the coating nozzle, the coating temperature was 190 ℃, and the coating speed was 0.3 m/s. 14 mm was optimal for the weft spacing of the coated glass fiber. The flexural strength of the concrete reinforced with the manufactured unidirectional carbon fiber sheet was slightly lower than that of the concrete reinforced with carbon fiber fabric, but it was confirmed that the reinforcement effect was better when the amount of carbon fiber was considered.

• Journal of Ginseng Research
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• 제46권1호
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• pp.147-155
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• 2022

Background: Methamphetamine (METH) is the most widely used psychostimulant and has been known to exhibit reinforcing effects even after long abstinence. We showed the inhibitory effect of Korean Red Ginseng extract (RGE) on METH-induced addictive behaviors in animal models mimicking the human drug-use pattern. Methods: We first investigated the effect of RGE on the acquisition of METH-induced dependence using self-administration and conditioned place preference (CPP) tests. Additionally, further experiments such as METH-induced motivational behavior and seeking behavior were conducted. To study the underlying mechanism, dopamine receptor, dopamine transporter, and N-methyl-D-aspartate receptor were assessed through Western blot analysis. Results: Treatment with RGE significantly reduced METH-induced self-administration on a fixed-ratio 1 schedule of reinforcement. It could be also decreased a progressive ratio schedule, and inhibited METH-primed reinstatement. In CPP, RGE significantly prevented the development of METH-induced CPP. Moreover, RGE not only shortened the withdrawal period clearly, but also prevented the reinstatement of CPP. RGE treatment also reversed METH-induced overexpression of dopamine transporter, dopamine receptor D1, and NMDA receptor in the nucleus accumbens. Conclusion: Our findings reflect that RGE has therapeutic potential to suppress METH-induced addictive behaviors by regulating dopaminergic and NMDAergic system.

• 한국구조물진단유지관리공학회 논문집
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• 제27권1호
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• pp.54-63
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• 2023

본 논문에서는 부식된 철근과 콘크리트 계면의 부착강도-슬립거동에 있어 부식수준 및 균열폭의 영향에 대한 연구를 수행하였다. 기존의 연구는 주로 부식수준에 따른 부착강도 저하에 초점을 맞추고 있으나 부식에 의한 콘크리트 표면 균열폭에 따른 부착강도 저하에 관한 연구는 매우 적다. 따라서 본 연구에서는 부식된 철근과 콘크리트 접합부의 부착강도, 슬립 거동 및 철근의 질량손실 등을 평가하고 균열폭 대비 접합성능을 확인하기 인발시험을 실시하였다. 그 결과로 표면 균열폭에 따른 접착강도 저하의 경향성이 부식수준에 따른 경향성보다 균등하게 나타났다. 따라서 부식수준에 비해 콘크리트 표면 균열 발생 여부가 부착강도-슬립거동 관계의 성능저하를 판단하기에 적합한 것으로 판단된다.

• 한국지반환경공학회 논문집
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• 제24권4호
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• pp.13-22
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• 2023

본 논문에서는 시험적 연구를 통해 록볼트가 지보효과를 발휘하는 시기를 그라우트 강도로 제시하고, 수치해석적 연구를 통해 지반조건과 경계면 강도감소계수에 따른 록볼트 인발 거동을 분석한 연구를 다루었다. 그 결과 록볼트는 그라우트 강도 5 MPa(재령 18시간)에서 지보효과를 발휘하였으며, 경계면 강도감소계수의 영향은 록볼트 변위의 경우 연약한 지반일수록, 그라우트- 지반의 전단응력의 경우 지반의 탄성계수가 높을수록, 그라우트 응력의 경우 모든 지반조건에서 영향이 큰 것으로 분석되었다. 이러한 연구결과는 록볼트 인발시험의 구체적인 기준 재정립과 록볼트 수치해석에 도움이 될 것으로 판단된다.

• 한국지반공학회논문집
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• 제24권12호
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• pp.93-101
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• 2008

본 논문에서는 연약지반 성토시 지반보강 공법으로 적용되는 지오그리드 감쌈 스톤컬럼공법의 하중지지 메카니즘에 대한 내용을 다루었다. 이를 위해 연약지반 성토 시공과정과 지오그리드 감쌈 스톤컬럼의 배수 및 보강 효과를 현실적으로 모사할 수 있는 3차원 응력-간극수압 수치해석 모델을 이용하여 다양한 시공조건에 대한 해석을 수행하고 그 결과를 분석하였다. 그 결과, 임의 시공조건에 있어 지오그리드 감쌈으로 발현되는 구속효과로 인해 스톤컬럼의 강성이 증가되어 상부 성토하중의 주변 연약지반으로의 하중분담율을 감소시키고 따라서 과잉간극수압 및 이에 따른 침하량이 감소되는 것으로 나타났다. 이러한 효과는 지오그리드 감쌈길이 및 강성 등 보강조건에 좌우되는 것으로 나타났으며 임의 시공조건에 있어 보강효과를 최대로 확보할 수 있는 임계감쌈길이와 임계강성이 존재하는 것으로 분석되었다.

• 한국농공학회지
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• 제20권2호
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• pp.4645-4687
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• 1978

This study was attempted to investigate the mechanical properties of concrete and crack control effects of reinforced concrete with steel and glass fiber. The experimental program includes tests on the properties of fresh concrete containing fibers, compressive strength, tensile strength, flexural strength, Young's modulus, Shrinkage and deformation of steel or glass fiber reinforced concrete. Also this study was carried out to investigate the effect of steel or glass fiber to retard the development in reinforced concrete subject to uniaxial tension and thus facilitate the use of steels of higher strength. The major conclusions that can be drawn from the studies are as follows: 1. The effect of the fibers in various mixes on fresh concrete confirmed that fibers do have a significant effect on the properties of fresh concrete, bringing much more stable and exhibiting a signiflcant reduction in surface bleeding, and that the cohesion is greatly improved and the internal resistance increases with fiber concentration. But the addition of an excess contents and length of fibers brings about the reduction of workability. 2. With the addition of steel fibers(1.5% Vol.) to concrete, the compressive strength as compared with plain concrete showed a very slight increase, but excess addition, over 1.5% Vol. of steel and glass fiber reduced its strength. 3. Splitting tensile strength of fiber reinforced concrete showed a significant increase tendency, as compared with plain concrete. In case of containing steel fiber (2.5%, 30mm), it showed that the maximum increase rate of 1.48 times as much rate, and in case of containing glass fiber (2.5%, 30mm), the increase rate of strength was 1.25 times as much rate. 4. Flexural strength of fiber reinforced concrete showed a significant tendency, as compared with plain concrete. Containing steel fiber (2.5%, 30mm) showed the maximum increase rate of 1.64 times as much rate and containing glass fiber (2.5%, 30mm) showed the increase rate of strength of 1.32 times as much rate, and in general, the 30mm length brougth the best results. 5. The strength ratio ($\sigma$b/$\sigma$c and $\sigma$t/$\sigma$c) increased, when steel fiber's average spacing was up to 3.05mm, but decreased when beyond 3.05mm, and it was confirmed that tensile or flexural strengths of steel fiber reinforced concrete are apparently governed by fiber's average spacing. 6. The compressive strain of fiber reinforced concrete showed a significant increasing tendency as the fiber was added, but Young's modulus. with the addition of steel and glass fibers, showed a slight decrease tendency. And according to the increase of flexural strength, a considerable increase was seen in toughness. 7. With the addition of fiber's the shrinkage of concrete was significantly decreased, in both case of adding steel fibers 12.5%, 30mm, and showed a significant decrease ratio, in average 30.4% and 36.7%, as compared with plain concrete. 8. With the increase of fiber volume fraction and length, the gained stress in reinforcing bar in concrete specimens increased in all crack widths, but at different rates, with the decrease of fiber diameter, the stress showed a considerable increasing tendency. And the duoform steel fibers showed the greatest improvement, as compared with the other types tested. 9. The influence of fiber dimensions in order of significanse on the machanical properties of concrete and the crack control of reinforced concrete was explained as follows: content, length, aspect ratio and dimeter.