• Biomedical Science Letters
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• v.18 no.3
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• pp.227-236
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• 2012

Previous study showed that swimming improved obesity but was not through $PPAR{\alpha}$ activation in liver and skeletal muscle in high fat diet-fed female mice with functioning ovaries as an animal model of obese premenopausal women. Thus, this study was aimed at investigation of the effects of swimming on the promotion of health and its molecular mechanism in adipose tissue of high fat diet-fed female mice. Eight-week-old female C57BL/6J mice were randomly divided into two groups (a non-swim control group and a swim group, n=8/group). Mice in the swim group swam for 2 h daily for 6 weeks in water bath with temperature of $35{\pm}1^{\circ}C$. All the animals received high fat diet (45% kcal fat) for 6 weeks. Reverse transcription-polymerase chain reaction was used to elucidate the molecular mechanism. Female mice subjected to swimming had significantly decreased body weight gain and white adipose tissue mass compared with the female control mice. Histological studies illustrated that swimming decreases the hepatic lipid accumulation. As expected, swimming did not affect the expression of mRNA levels of peroxisome proliferator-activated receptor (PPAR) ${\alpha}$ and $PPAR{\alpha}$ target genes responsible for mitochondrial fatty acid ${\beta}$-oxidation, such as carnitine palmitoyltransgerase-1 and medium chain acyl-CoA dehydrogenase in the white adipose tissue. However, mice that underwent 6-weeks of swimming exercise had decreased the mRNA expression of lipogenic genes, such as sterol regulatory element-binding proteins-1C and fatty acid synthase in comparison to sedentary control mice, with decreased $PPAR{\gamma}$ target genes involved in adipocyte-specific marker genes, such as adipocyte fatty acid binding protein and leptin in the white adipose tissue. These results suggest that swimming can effectively prevent obesity induced by high fat diet-fed, in part through down-regulation of adipogenesis and lipogenesis in white adipose tissue of female obese mice. Moreover, these results suggest that swimming maybe contributing the promotion of health through regulation of adipogenesis and lipogenesis in overweight premenopausal women.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2003.04a
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• pp.115-119
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• 2003

Pollutants from industry, mining, agriculture, and other sources have contaminated sediments in many surface water bodies. Sediment contamination poses a severe threat to human health and environment because many toxic contaminants that are barely detectable in the water body can accumulate in sediment at much higher levels, the purpose of this study was to make convenient sampling method and optimal treatment of sediment for water quality improvement in reservoir or stream based on an evaluation of degree of contamination. Results for analysis of S-reservoir sediments were observed that copper concentration of almost areas were higher than the regulation of soil pollution (50 mg/1) for the riverbed. S-stream sediments were observed that copper, arsenic and TPH concentration of almost areas were exceeded soil pollution concerning levels for factorial areas. We used Remscreen(version. 1.0) program which is contaminated soil recovery program to select optimal treatment method of contaminant sediments. The result was shown in the order of Thermal Calcination > Excavation, Retrieval and Off-site Disposal(comparative less then contaminant) > Low Temperature Thermal Desorption + Solidification/Stabilization.

• Korean Journal of Human Ecology
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• v.13 no.5
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• pp.777-785
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• 2004

We intend to analyze reasons for low acceptability of protective clothing in pesticide-spraying farmers in Korea, and to use the information for designing new clothing with better acceptability. To understand the attitude of farmers toward wearing protective clothing during spray, a survey was performed on 256 farmers. It is evident that the stress, which is caused by inadequate body temperature regulation, and its accompanying physiological responses are two of the leading factors for the low acceptability of protective clothing. Although the cost of clothing is not an important factor currently, low cost clothing is desirable in the future. Fancy of design is unimportant for new clothing. The results are discussed in conjunction with a desirable research focus for new types of protective clothing. Efforts should be made to ameliorate thermal stress through protective material development and garment design.

• Journal of Mushroom
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• v.13 no.4
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• pp.288-293
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• 2015

In the structural investigation of cultivation facilities, the proportion of farmers to grown with double or triple structure were investigated 96%. It has been shown to grow with a stable cultivation facilities structure against environmental changes. The results of the analysis of the changes in the cultivation environment of Yeoju area in July-august, temperature and humidity of the external instrument shelter was $20.2{\sim}29.9^{\circ}C$ and 66.2~99.9% respectively. In the greenhouse 2 model capable of temperature environment regulation in the cultivation facility, temperature and humidity were investigated $19.3{\sim}25.7^{\circ}C$ and 81.6~99.9% respectively. Result of the survey of fruiting body characteristics and yields in the greenhous 2, pileus diameter and stipe length were investigated 66.2 and 54.1 mm, yield of mushroom and individual weight were 312 g and 26.6 g. High-temperature environment regulation shows the improvement of the quality and productivity of the mushroom. Power consumption of the air conditioning has been investigated using 56kwh/day, electricity costs were calculated 2195 won/day.

• The Korean Journal of Community Living Science
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• v.18 no.4
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• pp.599-607
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• 2007

We analyzed the effects of regular Jjimjilbang (Korean sauna) exposure on the cold tolerance in young and elderly females. Subjects were young (n=7) and elderly (n=7) females who had never had Jjimjilbang exposure experience. The Jjimjil training group was exposured in the Jjimjilbang 19 times per week. Jjimjibang exposure was limited to three times per day. Jjimjil activity was taken freely. To prove the effects of the cold tolerance, subjects were exposed to cold air ($12{\pm}1^{\circ}C,\;60{\pm}10%$RH). In these conditions, subjects were exposed for 30 minutes at which time rectal temperature, skin temperatures, clothing microclimate, energy expenditure, blood pressure and subjective sensation were measured. To prove the effects of the local cold tolerance, vascular hunting reaction was observed measuring the finger skin temperature while the left middle finger tip was immersed in cold water of $0^{\circ}C$ for 30 minutes. The results are as follows. According to repeated Jjimjil exposure, rectal temperature changes, peripheral temperature and energy expenditure were increased gradually in the cold climate chamber. Blood pressure, subjective sensation and vascular hunting reactions did not show any significant difference. In conclusion, regular Jjimjilbang exposure has negative effects on the ability of the body to improve its regulation of temperature especially in cold tolerance.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2017.05a
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• pp.152-152
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• 2017

Titanium and its alloys have been widely used for biomedical applications. However, the use of the Ti-6Al-4V alloy in biomaterial is then a subject of controversy because aluminum ions and vanadium oxide have potential detrimental influence on the human body due to vanadium and aluminum. Hence, recent works showed that the synthesis of new Ti-based alloys for implant application involves more biocompatible metallic alloying element,such as, Nb, Hf, Zr and Mo. In particular, Nb and Hf are one of the most effective Ti ${\beta}$-stabilizer and reducing the elastic modulus. Plasma electrolyte oxidation (PEO) is known as excellent method in the biocompatibility of biomaterial due to quickly coating time and controlled coating condition. The anodized oxide layer and diameter modulation of Ti alloys can be obtained function of improvement of cell adhesion. Silicon (Si) and magnesium (Mg) has a beneficial effect on bone. Si in particular has been found to be essential for normal bone and cartilage growth and development. In vitro studies have shown that Mg plays very important roles in essential for normal growth and metabolism of skeletal tissue in vertebrates and can be detected as minor constituents in teeth and bone. Therefore, in this study, Si and Mg coatings on the hydroxyapatite film formed Ti-29Nb-xHf alloys by plasma electrolyte oxidation has been investigated using several experimental techniques. Ti-29Nb-xHf (x= 0, 3, 7 and 15wt%, mass fraction) alloys were prepared Ti-29Nb-xHf alloys of containing Hf up from 0 wt% to 15 wt% were melted by using a vacuum furnace. Ti-29Nb-xHf alloys were homogenized for 2 hr at $1050^{\circ}C$. The electrolyte was Si and Mg ions containing calcium acetate monohydrate + calcium glycerophosphate at room temperature. The microstructure, phase and composition of Si and Mg coated oxide surface of Ti-29Nb-xHf alloys were examined by FE-SEM, EDS, and XRD.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2017.05a
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• pp.153-153
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• 2017

The application of the coating supports the mechanical characteristics of the implant, and various materials and coatings are currently being used in the implant in a way to accelerate adhesion. Especially, plasma electrolytic oxidation (PEO) coating has been proposed continually with good surface treatment of titanium alloys. Also, the PEO process can incorporate Ca and P ions on the titanium surface through variables varied factor. PEO process for bioactive surface has carried out in electrolytes containing Ca and P ions. Natural bone is composed of mineral elements such as Mg, Si, Zn, Sr, and Mn, etc. Especially, Mg and Si of these elements play role in bone formation and growth after clinical implantation of bio-implants. In this study, corrosion charateristics of PEO-treated Ti-6Al-4V alloy in solution containing Si and Mg ions has been investigated using several experimental techniques. The PEO-treated surfaces were identified by X-ray diffraction, using a diffractometer (XRD, Philips X' pert PRO, Netherlands) with Cu $K{\alpha}$ radiation. The morphology was observed by field-emission scanning electron microscopy (FE-SEM, Hitachi 4800, Japan) and energy-dispersive X-ray spectroscopy (EDX, Oxford ISIS 310, England). The potentiodynamic polarization and AC impedance tests for electrochemical degradations were carried out in 0.9% NaCl solution at similar body temperature using a potentiostat with a scan rate of 1.67mV/s and potential range from -1500mV to + 2000mV.

• Journal of the Society of Naval Architects of Korea
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• v.51 no.3
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• pp.212-219
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• 2014

As subsea production has been revived up, the demand of subsea equipment has also been increased. Among the equipment, subsea tree plays a major role in safety. The tubing hanger is one of the most important components in subsea tree. In this study structural reliability analysis on dual bore tubing hanger of subsea tree is performed. The target reliability which is introduced in ISO regulation is used for judging whether tubing hanger is safe or not. The considered loads are working pressure, working temperature and suspended tubing weight. Thermal-stress analysis on tubing hanger is performed and kriging model is created based on the results of FEM analysis. According to von Mises criterion, limit state equation can be estimated. Reliability analysis is performed by using level 2 method and the result is verified by that of Monte Carlo Simulation. For finding most probable failure point, enhanced HL-RF method is adopted. Because the reliability of model doesn't reach target reliability, an improvement measure should be considered. Thus, it is suggested to change the material of tubing hanger main body to AISI 4140.

• The Korean Journal of Physiology and Pharmacology
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• v.5 no.1
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• pp.93-98
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• 2001

The precise mechanism of set-point regulation in hypothalamus was not elucidated. Nitric oxide synthases(NOS) were detected in hypothalamus, however, the roles of NO in hypothalamus was not fully studied. So, we tested the effects of NO on body temperature because preoptic-anterior hypothalamus was known as the presumptive primary fever-producing site. NO donor sodium nitroprusside (SNP, 4 nmol, i.c.v.) elicited marked febrile response, and this febrile response was completely blocked by indomethacin (a cyclooxygenase inhibitor). But, ODQ (selective guanylate cyclase inhibitor, $50\;{\mu}g,$ i.c.v.) did not inhibit fever induced by SNP. The cyclic GMP analogue dibutyryl-cGMP $(100\;{\mu}g,\;i.c.v.)$ induced significant pyreses, which is blocked by indomethacin. $N^G-nitro-L-arginine$ methyl ester (L-NAME, non selective NOS inhibitor) inhibited fever induced by $interleukin-1{\beta}\;(IL-1{\bata},\;10\;ng,\;i.c.v.),$ one of endogenous pyrogens. These results indicate that NO may have an important role, not related to stimulation of soluble guanylate cyclase, in the signal pathway of thermoregulation in hypothalamus.

• Proceedings of the Korean Institute of Surface Engineering Conference
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• 2017.05a
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• pp.160-160
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• 2017

Commercially pure titanium (Cp-Ti) and Ti alloys (typically Ti-6Al-4V) display excellent corrosion resistance and biocompatibility. Although the chemical composition and topography are considered important, the mechanical properties of the material and the loading conditions in the host have, conventionally. Ti and its alloys are not bioactive. Therefore, they do not chemically bond to the bone, whereas they physically bond with bone tissue. The electrochemical deposition process provides an effective surface for biocompatibility because large surface area can be served to cell proliferation. Plasma electrolyte oxidation (PEO) enables control in the chemical composition, porous structure, and thickness of the TiO2 layer on Ti surface. Silicon (Si) in particular has been found to be essential for normal bone and cartilage growth and development. Zinc (Zn) plays very important roles in bone formation and immune system regulation, and is also the most abundant trace element in bone. The objective of this work was to study on electrochemical behaviors of PEO-treated Ti-6Al-4V Alloy in solution containing Zn and Si ions. The morphology, the chemical composition, and the microstructure analysis of the sample were examined using FE-SEM, EDS, and XRD. The potentiodynamic polarization and AC impedance tests for corrosion behaviors were carried out in 0.9% NaCl solution at similar body temperature using a potentiostat. The promising results successfully demonstrated the immense potential of Si/Zn-TiO2 coatings in dental and biomaterials applications.