• The Korean Journal of Physiology
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• 제20권1호
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• pp.43-52
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• 1986

The influences of extracellular $Ca^{2+}\;and\;K^+$ upon the spike action potentials were studied in isolated uterine strips of rat. Regular, rhythmic uterine contractions were induced by the administration of oxytocin$(0.2{\sim}0.5\;I.U.)$, and recorded with force transducer. Spike action potentials were extracellularly measured by use of suction electrode, and compared with those recorded intracellularly by glass microelectrode. The results obtained were as follows : 1) The frequency and duration of spike bursts, and the number of spikes in a burst could be analyzed by use of both methods. But the absolute values of membrane potential were not measurable with the suction electrode. 2) The duration of contraction$(CD_{90};\;the\;duration\;of\;90%\;relaxation)$ was lengthened from the control 17.0 sec to 20.6 sec, in parallel with the increase of spike number from the control 21 to 26, as the increase in $Ca^{2+}$ concentration from 2 to 4 mM. 3) The amplitude and frequency of contractions were gradually decreased, simultaneously with the decrease in the number of spikes in a burst, when the $Ca^{2+}-antagonist$, verapamil was administered cumulatively. 4) The number of spikes was changed from the control 15 to 7, in cabs of the administration of ver)'low dose of verapamil$(10^{-6}\;g/l)$. 5) Increase in the numbers of spike bursts was well matched to the increase in frequency of contractions when extracellular $K^+$ was increased.

• 한국농공학회논문집
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• 제61권3호
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• pp.101-112
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• 2019

This study developed selection criteria of small-scales reservoirs, having under $300,000m^3$ storage capacity, for the Emergency Action Plan(EAP) establishment in order to reduce the disaster risks of the reservoir's failures. Those reservoirs are out of ranges of Korean EAP establishment standard, but have potential risk of disasters as they have often failed by the recent extreme rainfall events and earthquakes, causing economical and life losses. The problem of reservoir aging is also one of the reasons of them. In this study, the developed selection criteria of small reservoirs for EAP establishment are storage capacity, embankment height, reservoir age, heavy rain factor and earthquake factor. These criteria were selected based on the review of the existing EAP establishment guidelines, analysis of the past dam failure cases, and the previous related studies. The quantification of these criteria were conducted for the practical applications in the fields, and applied to 67 previous failures in order to investigate the relation of each criteria with these failures. The earthquake factor found to be the highest relations followed by heavy rain factors, combination of earthquake and heavy rain factors, and reservoir age. The classification was made as observation and review groups for EAP establishments based on overlapping numbers of each criteria. This classifications applied to 354 reservoirs designated as having the potential disaster risk by MOIS, and showed 38.4% of observation and 11.9% of review groups. Anticipatory monitoring and regular inspection should be made by professional facility managers for the observation group, and necessity of EAP establishment should be assessed for the review group based on the downstream status and financial budget.

• 한국가축번식학회지
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• 제19권2호
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• pp.141-145
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• 1995

The effect of splenectomy on the concentration of progesterone in pregnant wistar rats showing 4-day regular estrous cycles more than two cycles were investigated. The day after mating with the same male animal was designated day 0 of pregnancy. Splenectomy was conducted on day 0 (early-S), 6 (middle-S) and 13 (late-S) of pregnant rat, respectively. Blood sample were collected at day 1, 7, 14 and 21 of pregnancy. Concentraton of serum progesterone was determined by emzyme-linked immunosorbent assay (ELISA) using specific antibodies and emzyme conjugate(progesterone peroxidase labeled). In normal pregnant rats, serum progesterone concentrations were increased significantly (P<0.05) on day 7 and 14 of pregnancy compared with on day 1 of pregnancy and then dramatically decreased on day 21. However in early and middle splenectomized rats, progesterone concentrations were significantly (P<0.05) decreased on day 7 and 14 of pregnancy compared with same day of normal rats. These observations indicate that luteotropic action and steroidogenesis by corpus luteum of ovary may be regulated by splenocytes in rat.

• Journal of Chest Surgery
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• 제22권4호
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• pp.580-588
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• 1989

The potential for enhancing myocardial protection by adding high-energy phosphate to cardioplegic solutions [St. Thomas Hospital solution] was investigated in a rat heart model of cardiopulmonary bypass and ischemic arrest. Creatine phosphate was evaluated as an additive to the St. Thomas Hospital cardioplegic solution. Creatine phosphate 10.0 mmol/L as the optimal concentration which improved recovery of aortic flow and cardiac output after a 30 minute period of normothermic [37oC] ischemic arrest. In comparing mechanical function in both groups the mean postischemic recoveries of aortic flow, cardiac output, stroke volume and stroke work [expressed as a percentage of its preischemic control] were significantly greater in STH-CP group than in CP- free control group. In addition to improving function and decreasing CK release, CP reduced reperfusion arrhythmias significantly decreasing the time between cross-clamp removal and return to regular rhythm from 81.8 * 13.9 [sec] in CP-free group to 35.9 * 6.8 [sec] in CP group [P< 0.05] so, exogenous CP exerts potent protective and antiarrhythmic effects when added to the St. Thomas Hospital cardioplegic solution. However, the mechanism of action remains to be elucidated.

• International Journal of Concrete Structures and Materials
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• 제10권1호
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• pp.1-13
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• 2016

The progressive collapse analysis of reinforced concrete (RC) moment-frame buildings under extreme loads is discussed from the perspective of modeling issues. A threat-independent approach or the alternate path method forms the basis of the simulations wherein the extreme event is modeled via column removal scenarios. Using a prototype RC frame building, issues and considerations in constitutive modeling of materials, options in modeling the structural elements and specification of gravity loads are discussed with the goal of achieving consistent models that can be used in collapse scenarios involving successive loss of load-bearing columns at the lowest level of the building. The role of the floor slabs in mobilizing catenary action and influencing the progressive collapse response is also highlighted. Finally, an energy-based approach for identifying the proximity to collapse of regular multi-story buildings is proposed.

• 한국건강관리협회지
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• 제3권1호
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• pp.55-61
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• 2005

Functional constipation is regarded as a long-standing symptomatic manifestation of abnormal defecation expressed by either a reduced frequency of bowel movements and /or an altered act of evacuation. Patients with constipation can be treated with laxatives, diets and regular habits. Thorough evaluation of functional constipation is considered in those in whom conservative treatment with dietary advice and use of laxatives fails. Patients with normal colonic transit and normal anorectal function may only need reassurance, education and dietary advice with fiber supplementation. For constipated patients in whom such treatment modalities fail, laxatives including bulk-forming and osmotic agents may be used Although most laxatives, if used intermittently, are relatively safe, they must be chosen bearing in mind possible side effects, patient compliance and their action mechanisms. A subgroup of patients with slow transit through the colon ay be unresponsive to conventional laxatives, and, in these subjects, a trial with enteroprokinetics and sometimes stimulant laxatives should be attempted. This article presents our view of the assessment and pharmacologic treatment of functional constipation.

• 한국항해학회지
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• 제5권1호
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• pp.25-35
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• 1981

Since 1960 tankers and bulk carriers have rapidly increased in size up to 500, 000 dwt. in operating as main system of transportation for the international trade at sea, and studies are doing carried out by various groups with a view to increasing the size still further. However, the service speed of these ships has remained almost constant, and steering devices of them have nearly not changed, comparing with regular size of a dry cargo ship. This creats the dituation where stopping distance and advance are proportionally longer for larger ships. In case of collision at sea, these vessels have been arised some serious casualties, such as sinking, fire and oil pollution. This paper analyzers a study for the handling of super huge vessels to avoid collision at sea, basing on the results of the crash astern test and turning test of them.

• 한국항만학회지
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• 제7권1호
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• pp.79-88
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• 1993

This study deals with the case of a fixed floating structure(FFS) at the mouth of a rectangular harbor under the action of waves represented by the linear wave theory. Modified forms of the mild-slope equation is applied to the propagation of regular wave over constant water depth. The model is extended to include bottom friction and boundary absorption. A hybrid element approximation is used for calculation of linear wave oscillation in and near coastal harbor. Modification of the model was necessary for the FFS. For the conditions tested, the results of laboratory experiments by Ippen and Goda(1963), and Lee (1969) are compared with the calculated one from this model. The cases of flat cylinderical structures, both fixed and floating, were taken to be in an intermediate water depth.

• International Journal of Naval Architecture and Ocean Engineering
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• 제13권1호
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• pp.526-544
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• 2021

Based on the potential flow theory, a fully nonlinear numerical procedure is developed with boundary element method to analyze the interaction between a fixed semi-submersible platform and incident waves in open water. The incident wave is separated from the scattered wave under fully nonlinear boundary conditions. The mixed Euler-Lagrangian method is used to capture the position of the disturbed wave surface in local coordinate systems. The wave forces exerted on an inverted conical frustum are used to ensure the accuracy of the present method and good agreements with published results are obtained. The hydrodynamic characteristics of the semi-submersible platform interacting with regular waves are analyzed. Pressure distribution with time and space, tension and compression of the platform under wave action are investigated. 3D behaviors of wave run-ups are predicted. Strong nonlinear phenomena such as wave upwelling and wave interference are observed and analyzed.

• 한국해안·해양공학회논문집
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• 제29권1호
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• pp.20-35
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• 2017

잠제와 같은 중력식구조물 하부 해저지반에 고파랑이 장시간 작용하는 경우 토립자내 간극의 체적변화를 일으키는 과정에서 과잉간극수압이 크게 발생될 수 있고, 이에 따른 유효응력의 감소에 의하여 구조물 근방 및 하부의 해저지반에 액상화가 발생될 수 있으며, 종국에는 구조물이 침하파괴될 가능성이 있다. 또한, 액생화를 방지하기 위한 대책공법으로 규칙파의 경우 콘크리트매트를 해저지반상에 포설하여 구조물의 동적변위 및 지반내 간극 수압 및 간극수압비가 감소하는 것을 규명하였다. 본 연구에서는 실해역을 모사한 불규칙파랑을 대상으로 규칙파 해석에서 적용된 동일한 수치해석법을 적용하여 잠제의 동적변위 및 해저지반내 간극수압, 간극수압비 등과 같은 지반거동의 시 공간변화를 규칙파의 경우와 대비하면서 액상화 가능성을 검토하였다. 이로부터 불규칙파동장하에서도 콘크리트매트하의 해저지반내에서 액상화 가능성을 크게 줄일 수 있고, 한정된 본 결과이지만 콘크리트매트가 포설된 경우에도 액상화 평가시 불규칙파의 유의파에 해당하는 파랑조건을 적용한 규칙파 해석이 더욱 안정적인 설계로 된다는 것을 확인할 수 있었다.