• 한국연소학회:학술대회논문집
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• 2004.06a
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• pp.248-255
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• 2004

For the compactness of regenerative combustion, self regenerative combustion and embedding regenerator inside furnace are proposed. The Self Regenerative burner system was developed to enhance thermal efficiency and Low Nox emission. In the twin regenerative system, two burner heads are generally used for preheating and exhausting combustion mode. But self regenerative burner system use only single nozzle body for regenerative combustion. Also two kind of regenerator, internal and external type, were designed to operate conveniently in both large and small furnace. According to test result, the self regenerative combustion system gives strong internal exhaust gas recirculation that reduce NOx emission significantly. NOx was measured as 50ppm(5% O2, 1290C furnace temperature). Also it is found that the fuel saving rate due to the self regenerative burner system reach to 30-40%. Thus it can be concluded that self regenerative mild combustion system appears to provide a reasonable regenerative burner for compactness and high performance as compared with conventional twin regenerative burner system. Also in the RT Application , compact twin regenerative burner was developed with the help of embedding regenerator inside furnace.

• Clinical and Experimental Otorhinolaryngology
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• v.11 no.4
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• pp.224-232
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• 2018

Objectives. Spiral ganglion neurons (SGNs) include potential endogenous progenitor populations for the regeneration of the peripheral auditory system. However, whether these populations are present in adult mice is largely unknown. We examined the presence and characteristics of SGN-neural stem cells (NSCs) in mice as a function of age. Methods. The expression of Nestin and Ki67 was examined in sequentially dissected cochlear modiolar tissues from mice of different ages (from postnatal day to 24 weeks) and the sphere-forming populations from the SGNs were isolated and differentiated into different cell types. Results. There were significant decreases in Nestin and Ki67 double-positive mitotic progenitor cells in vivo with increasing mouse age. The SGNs formed spheres exhibiting self-renewing activity and multipotent capacity, which were seen in NSCs and were capable of differentiating into neuron and glial cell types. The SGN spheres derived from mice at an early age (postnatal day or 2 weeks) contained more mitotic stem cells than those from mice at a late age. Conclusion. Our findings showed the presence of self-renewing and proliferative subtypes of SGN-NSCs which might serve as a promising source for the regeneration of auditory neurons even in adult mice.

• Journal of Mechanical Science and Technology
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• v.15 no.11
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• pp.1490-1498
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• 2001

In this paper, a regenerative braking algorithm is presented and performance of a hybrid electric vehicle (HEV) is investigated. The regenerative braking algorithm calculates the available regenera tive braking torque by considering the motor characteristics, the battery SOC and the CVT speed ratio. When the regenerative braking and the friction braking are applied simultaneously, the friction braking torque corresponding to the regenerative braking should be reduced by decreasing the hydraulic pressure at the front wheel. To implement the regenerative braking algorithm, a hydraulic braking module is designed. In addition, the HEV powertrain models including the internal combustion engine, electric motor, battery, CVT and the regenerative braking system are obtained using AMESim, and the regenerative braking performance is investigated by the simulation. Simulation results show that the proposed regenerative braking algorithm contributes to increasing the battery SOC which results in the improved fuel economy. To verify the regenerative braking algorithm, an experimental study is performed. It is found from the experimental results that the regenerative braking hydraulic module developed in this study generates the desired front wheel hydraulic pressure specified by the regenerative braking control algorithm.

• Animal Bioscience
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• v.37 no.6
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• pp.1021-1030
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• 2024

Objective: R-loops are DNA:RNA triplex hybrids, and their metabolism is tightly regulated by transcriptional regulation, DNA damage response, and chromatin structure dynamics. R-loop homeostasis is dynamically regulated and closely associated with gene transcription in mouse zygotes. However, the factors responsible for regulating these dynamic changes in the R-loops of fertilized mouse eggs have not yet been investigated. This study examined the functions of candidate factors that interact with R-loops during zygotic gene activation. Methods: In this study, we used publicly available next-generation sequencing datasets, including low-input ribosome profiling analysis and polymerase II chromatin immunoprecipitation-sequencing (ChIP-seq), to identify potential regulators of R-loop dynamics in zygotes. These datasets were downloaded, reanalyzed, and compared with mass spectrometry data to identify candidate factors involved in regulating R-loop dynamics. To validate the functions of these candidate factors, we treated mouse zygotes with chemical inhibitors using in vitro fertilization. Immunofluorescence with an anti-R-loop antibody was then performed to quantify changes in R-loop metabolism. Results: We identified DEAD-box-5 (DDX5) and histone deacetylase-2 (HDAC2) as candidates that potentially regulate R-loop metabolism in oocytes, zygotes and two-cell embryos based on change of their gene translation. Our analysis revealed that the DDX5 inhibition of activity led to decreased R-loop accumulation in pronuclei, indicating its involvement in regulating R-loop dynamics. However, the inhibition of histone deacetylase-2 activity did not significantly affect R-loop levels in pronuclei. Conclusion: These findings suggest that dynamic changes in R-loops during mouse zygote development are likely regulated by RNA helicases, particularly DDX5, in conjunction with transcriptional processes. Our study provides compelling evidence for the involvement of these factors in regulating R-loop dynamics during early embryonic development.

• Proceedings of the KSR Conference
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• 2007.05a
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• pp.836-845
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• 2007

In DC 1500V electric traction substations, diode rectifiers are commonly used to supply stable DC power with electric train sets. However, it operates in the first quadrant of the voltage-current plane and thus needs regenerative inverters which transfer the surplus regenerative power caused by regenerative braking of electric train sets into the grid. In order to select the proper capacity and installation position of regenerative inverter, it needs to investigate the consumed and regenerative energy of the electric traction substations in advance. This paper presents an analysis of regenerative energy in two substations operating in Seoul line 2 and Kwangju line 1. DC line voltage and feeder currents are measured for a day to calculate consumed and regenerative power for four feeders. We calculated an amount of regenerative energy consumed in other feeders and estimated the cost reduction in energy consumption due to the reuse of regenerative energy.

• Proceedings of the KSR Conference
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• 2005.11a
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• pp.705-711
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• 2005

In DC traction substation with 12-pulse diode rectifiers, the DC line voltage tends to rise above noload voltage because it can't absorb the regenerative power caused by electric brakes of train. To solve this problem, an IGBT regenerative inverter should be installed and recycles the surplus regenerative power by delivering it. to the supply grid. In this paper, the DC traction substation equipped with a IGBT regenerative inverter is studied using computer simulation. Matlab/simulink is used to simulate the operation of regenerative inverter which injects the regenerative power into the supply grid and stabilizes the DC line voltage. It is confirmed that the high quality regenerative power is delivered to the supply grid thorough computer simulation.

• Transactions of the Korean Society of Automotive Engineers
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• v.13 no.6
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• pp.38-47
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• 2005

In this paper, a regenerative braking algorithm is proposed to make the maximum use of the regenerative braking energy for an independent front and rear motor drive parallel HEV. In the regenerative braking algorithm, the regenerative torque is determined by considering the motor capacity, motor efficiency, battery SOC, gear ratio, clutch state, engine speed and vehicle velocity. To implement the regenerative braking algorithm, HEV powertrain models including the internal combustion engine, electric motor, battery, manual transmission and the regenerative braking system are developed using MATLAB, and the regenerative braking performance is investigated by the simulator. Simulation results show that the proposed regenerative braking algorithm contributes to increasing the battery SOC, which recuperates 60 percent of the total braking energy while satisfying the design specification of the control logic. In addition, a control algorithm which limits the regenerative braking is suggested by considering the battery power capacity and dynamic response characteristics of the hydraulic control module.

• International Journal of Stem Cells
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• v.16 no.2
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• pp.215-233
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• 2023

Background and Objectives: MYC, also known as an oncogenic reprogramming factor, is a multifunctional transcription factor that maintains induced pluripotent stem cells (iPSCs). Although MYC is frequently upregulated in various cancers and is correlated with a poor prognosis, MYC is downregulated and correlated with a good prognosis in lung adenocarcinoma. MYC and two other MYC family genes, MYCN and MYCL, have similar structures and could contribute to tumorigenic conversion both in vitro and in vivo. Methods and Results: We systematically investigated whether MYC family genes act as prognostic factors in various human cancers. We first evaluated alterations in the expression of MYC family genes in various cancers using the Oncomine and The Cancer Genome Atlas (TCGA) database and their mutation and copy number alterations using the TCGA database with cBioPortal. Then, we investigated the association between the expression of MYC family genes and the prognosis of cancer patients using various prognosis databases. Multivariate analysis also confirmed that co-expression of MYC/MYCL/MYCN was significantly associated with the prognosis of lung, gastric, liver, and breast cancers. Conclusions: Taken together, our results demonstrate that the MYC family can function not only as an oncogene but also as a tumor suppressor gene in various cancers, which could be used to develop a novel approach to cancer treatment.

• Journal of the Korean Society for Railway
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• v.10 no.6
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• pp.717-722
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• 2007

Most of DC 1500V electric railway substations have adopted diode rectifiers to supply stable DC power. However, the diode rectifiers operate in the first quadrant of the voltage-current plane and thus need regenerative inverters which transfer the surplus regenerative power caused by regenerative braking of electric train sets into the grid. In order to select the proper capacity and installation position of regenerative inverter, it needs to investigate the consumed and regenerative energy of the electric traction substations in advance. This paper presents an analysis of regenerative energy in two substations operating in Seoul Seolleung and Kwangju Yangdong substations. DC line voltage and feeder currents are measured for a day to calculate consumed and regenerative power far four feeders. We calculated an amount of regenerative energy consumed in other feeders and estimated the cost reduction in energy consumption due to the reuse of regenerative energy

• Journal of Power System Engineering
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• v.21 no.4
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• pp.5-17
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• 2017

This study focuses on the application of the PEM Fuel Cell(PEMFC) hybrid system, which includes a regenerative braking system with supercapacitor(SC) and battery. The purpose of this study is to evaluate the characteristics of regenerative energy and to propose solutions to increase regenerative energy via vehicle simulation. To achieve this target, we set the rated motor speed to 3,000/2,500/2,000 rpm. Because the flywheel is directly connected to the motor, the generator activates regenerative braking by using the rotational momentum of the flywheel when the flywheel reaches the set speed after the motor stops. We could then measure the characteristics of regenerative braking of voltage, current, power, energy change, etc. Meanwhile, we calculate the storage efficiency of the SC or the battery. Our results show that the SC stores 18% of the regenerative energy, while battery stores 15% of the energy. Since the regenerative energy decreases with the decrease of the motor rotating speed that 5,027 J and 2,915 J are restored at 3,000 and 2,500 rpm, respectively. The experimental results also prove that regenerative braking energy is able to be obtained if and only if the speed of flywheel is over 2,500 PRM, and the efficiency of the system can be further improved.