• The Journal of Korean Physical Therapy
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• 제11권3호
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• pp.133-140
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• 1999

Why does the CNS not regenerate after injury? The failure of axonal regeneration in the CNS after injury is not due to an inherent inability of these neurons to regrowth axon. Recently, an inhibitory substrate effect of CNS has been discovered which could be directly invoked in the lack of regeneration. The failure of axon regrowth in the CNS is crucially influenced by the presence of neurtie growth inhibitor NI35/250 and possibly also by molecules such as myelin associated glycoprotein(MAG) and chondroitin sulphate proteoglycans(CSPGs). The application of the monoclonal antibody IN-1, which efficinetly neutralizes the N135/250 inhibitory molecules. This new finding has a strong impact on the development of, a new neuroscienctific research directed to stimulate axonal regeneration. In this review summarize the current knowledge on the factors and molecules involved in the regeneration failure.

• Journal of Periodontal and Implant Science
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• 제39권sup2호
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• pp.205-212
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• 2009

Purpose: The aim of this retrospective study was to compare the survival rate of oxidized titanium implants and sandblasted large-grit acid etched implants in soft bone. Methods: 201 oxidized titanium implants were inserted in 84 patients between May 1999 and May 2004. 120 sandblasted large-grit acid etched implants were inserted in 74 patients between December 2000 and May 2004. The patients were followed-up 0${\sim}$5 years in ITI group or 0${\sim}$6 years in BRA group, respectively. The following information was collected from the patient records: age, gender, systemic disease, implant type, number, length and diameter of the implants, their location in the jaws, bone quantity, the number of failed implants, the causes of failure, and advanced surgery for bone augmentation. Results: In the oxidized titanium implants, 8 implants showed early failure, and 1 implant showed late failure, respectively. The cumulative survival rate was 95.48%. In the sandblasted large-grit acid etched implants, 1 implant showed late failure and cumulative survival rate was 99.10%. The cumulative survival rate and the survival rates in the case of the advanced procedure during the implant placement were not significantly different in both groups. Conclusions: Oxidized titanium implants and sandblasted large-grit acid etched implants can be used successfully in soft bone regardless of the surgical methods used during the implant placement. (J Korean Acad Periodontol 2009;39:205-212)

• Journal of Periodontal and Implant Science
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• 제27권1호
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• pp.117-128
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• 1997

Using barrier membrane, guided bone regeneration(GBR) and guided tissue regeneration(GTR) of periodontal tissue are now widely studied and good results were reported. In bone regeneration, not all cases gained good results and in some cases using GTR, bone were less regenerated than that of control. The purpose of this study is to search for the method to improve the success rate of GBR and GTR by examination of the cause of the failure. For these study, rats and beagle dogs were used. In rat study, 5mm diameter round hole was made on parietal bone of the rat and 10mm diameter of bioresorbable membrane was placed on the bone defects and sutured. In 1 ,2, 4 weeks later, the rats were sacrificed and Masson-Trichrome staining was done and inspected under light microscope for guided bone regeneration. In dog study, $3{\times}4mm^2$ Grade III furcation defect was made at the 3rd and 1th premolar on mandible of 6 beagle dogs. The defects were covered by bioresorbable membrane extending 2-3mm from the defect margin. The membrane was sutured and buccal flap was covered the defect perfectly. In 2, 4. 8 weeks later. the animals were sacrificed and undecalcified specimens were made and stained by multiple staining method. In rats. there was much amount of new bone formation at 2 weeks. and in 4 weeks specimen, bony defect was perfectly dosed and plenty amount of new bone marrow was developed. In some cases, there were failures of guided bone regeneration. In beagle dogs, guided tissue regeneration was incomplete when the defect was collapsed by the membrane itself and when the rate of resorption was so rapid than expected. The cause of the failure in GBR and GTR procedure is that 1) the membrane was not tightly seal the bony defects. If the sealing was not perfect, fibrous connective tissue infiltrate into the defect and inhibit the new bone formation and regeneration. 2) the membrane was too tightly attached to the tissue and then there was no space to be regenerated. In conclusion, the requirements of the membrane for periodontal tissue and bone regeneration are the biocompatibility, degree of sealingness, malleability. space making and manipulation. In this animal study. space making for new bone and periodontal ligament, and sealing the space might be the most important point for successful accomplishment of GBR and GTR.

• 한국자동차공학회논문집
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• 제3권6호
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• pp.41-54
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• 1995

A mathematical model for wall-flow monolith ceramic diesel particulate filter was developed in order to describe the processes which take place in the filter during regeneration. The major output of the model comprises ceramic wall temperature and regeneration time(soot reduction). Various numerical tests were performed to demonstrate how the gas oxygen concentration, flow rate and the initial particulate trap loading affect the regeneration time and peak trap temperature. The model is shown to b in reasonable agreement with the published experimental results. This model can be applied to predict the thermal shock failure due to high temperature during combustion regeneration process.

• 한국산림과학회지
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• 제84권3호
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• pp.394-405
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• 1995

온대 삼림지대에서 산화 적지나 개벌 적지에 왕성하게 번성하는 것이 ericaceous속이다. ericaceous속의 식물들은 성장이 빨라서 다른 종과의 경쟁에서 유리하고 또한 allelopathy 효과 때문에 침엽수 갱신에 영향을 미친다. Kalmia가 번성하는 지역에서는 삼림 갱신이 잘 되지 않거나 조림한 침엽수의 생장이 저조하였다. 이러한 생상 저해 현상은 서유럽의 Calluna - Sitca spruce - Scots pine 생태계와 미국의 북서 태평양 지역의 Gaultheria - cedar/hemlock 생태계에서도 나타나고 있다. 삼림이 파괴된 다음에 Kalmia - black spruce 생태계의 다양한 변화는 침엽수 생장을 저해하거나 갱신을 방해하는 원인으로 생각되어지고 있다. 양분경쟁에 대한 논쟁의 여지는 있으나 Kalmia는 black spruce 생장을 억제하는 주원인으로 작용한다. 여러 곳의 야외, 실내 및 온실에서 한 실험 결과는 이러한 결론을 뒷받침해 주고 있다. 본 논문에서는 Kalmia 잎으로부터 8가지의 폐놀물질을 분리동정해 냈으며 이들 중 4가지는 black spruce에 고도의 독성을 나타냈다. Kalmia 우점지역에서 allelopathic 영향을 적게 하므로써 black spruce의 갱신을 증진시키기 위한 여러 가지 방법에 대한 고찰을 하였다.

• 한국CDE학회논문집
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• 제14권3호
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• pp.197-206
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• 2009

In a finite element analysis of the metal forming processes having large plastic deformation, largely distorted elements are unstable and hence they influence upon the result toward negative way so that adaptive remeshing is required to avoid a failure in the numerical computation. Therefore automatic mesh generation and regeneration is very important to avoid a numerical failure in a finite element analysis. In case of generating quadrilateral mesh, the automation is more difficult than that of triangular mesh because of its geometric complexity. However its demand is very high due to the precision of analysis. Thus, in this study, an automatic quadrilateral mesh generation and regeneration method using grid-based approach is developed. The developed method contains decision of grid size to generate initial mesh inside a two dimensional domain, classification of boundary angles and inner boundary nodes to improve element qualities in case of concave domains, and boundary projection to construct the final mesh.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제46권5호
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• pp.361-366
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• 2020

Guided bone regeneration (GBR) is a surgical procedure that utilizes bone grafts with barrier membranes to reconstruct small defects around dental implants. This procedure is commonly deployed on dehiscence or fenestration defects ≥2 mm, and mixing with autogenous bone is recommended on larger defects. Tension-free primary closure is a critical factor to prevent wound dehiscence, which is critical cause of GBR failure. A barrier membrane should be rigidly fixed without mobility. If the barrier is exposed, closed monitoring should be utilized to prevent secondary infection.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제33권4호
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• pp.359-362
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• 2011

Purpose: This study evaluated the clinical applications of implant placement and guided bone regeneration using a mineralized bone allograft and a barrier membrane derived from ox pericardium Methods: From January 2007 to June 2009, among the patients who received an implant at Chosun University Dental Hospital, patients were selected if they were treated with guided bone regeneration (GBR) with simultaneous implant placement or GBR prior to implant placement. The selected patients were sorted according to the materials and membranes used in GBR, and the implant survival rate was recorded by clinical examination and reviewing the medical records and the radiographs. Each study list was analyzed by SPSS (version 12.0, SPSS Inc., USA) software and the survival rate was verified by Chi-square tests. $P$ values less than 0.05% were deemed significant. Results: 278 implants were placed on a total of 101 patients and 8 implants resulted in failure. Three implants failed among 15 implants with only a mineralized bone allograft. No failure was shown among the 74 implants placed with mineralized bone allograft and a barrier membrane derived from ox pericardium. One group of 4 implant placements showed failure among the 102 implants placed with a mineralized bone allograft and another bone graft material. The group that had a barrier membrane derived from ox pericardium with a mineralized bone allograft or other bone materials showed no implant failure. Three failures were shown among the 21 implants placed with only bone graft and not using a membrane. The group with membranes other than a barrier membrane derived from ox pericardium showed 5 failures among 170 implants. Conclusion: The implant survival rate of the group with GBR using a mineralized bone allograft was 96.3%, which meant there was little difference compared to the groups of another bone graft materials (98.9%). The implant survival rate of the group without a membrane-was 85.7% and it showed a significant difference compared to the group using a barrier membrane derived from ox pericardium (100%) and the group using another membrane (97.1%).

• Journal of Periodontal and Implant Science
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• 제44권1호
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• pp.13-19
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• 2014

Purpose: The purpose of this study was to retrospectively evaluate the survival of periodontally hopeless teeth that were intentionally extracted and replanted after a delay and to compare the radiographic characteristics of the survival group with those of the failure group. Methods: The clinical and radiographic data from patients who underwent delayed intentional replantation between March 2000 and July 2010 were reviewed. Twenty-seven periodontally hopeless teeth were extracted and preserved in medium supplemented with antibiotics for 10-14 days. The teeth were then repositioned in the partially healed extraction socket and followed for 3 to 21 months. The radiographic parameters were analyzed using a paired t test and the cumulative survival rate was analyzed using Kaplan-Meier analysis. Results: Seven replanted teeth failed and the overall cumulative survival rate was 66.4%. In the survival group, the amount of bone loss was reduced from 68.45% to 34.66% three months after replantation. There was radiologic and clinical evidence of ankylosis with 5 teeth. However, no root resorption was found throughout the follow-up period. In the failure group, bone formation occurred from the bottom of the socket. However, a remarkable radiolucent line along the root of a replanted tooth existed. The line lengthened and thickened as time passed. Finally, in each case of failure, the tooth was extracted due to signs of inflammation and increased mobility. Conclusions: Delayed intentional replantation has many advantages compared to immediate intentional replantation and could serve as an alternative treatment for periodontally involved hopeless teeth. However, techniques for maintaining the vitality of periodontal structures on the tooth surface should be developed for improved and predictable results.

• Korean Chemical Engineering Research
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• 제43권5호
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• pp.571-578
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• 2005

불연속 화학공정은 소비자 수요에 탄력성 있게 대처할 수 있는 장점이 있는 반면에 그 특유의 동특성 때문에 복잡하고, 계획된 조업 시간과 실제 조업 시간 사이에서 외란(disruption) 또는 불확실 변수(uncertainty)에 의한 차이가 자주 발생하는 단점이 있다. 이에, 본 논문에서는 예측 생산계획(predictive scheduling)에 의해 결정된 생산계획에서 미래에 발생하는 공정 변수 값의 변화를 실시간으로 예측 생산계획을 수정, 제시하여 주는 생산 계획 시스템인 동적 생산계획(reactive scheduling) 기법을 개발하였다. 불확실 인자를 고려한 동적 생산계획에서, 본 논문에서는 장치 이상(equipment failure)이 발생하였을 때 공정 운전조건의 변화를 실시간으로 반영하여, 예측 생산계획(predictive scheduling) 모델에 의하여 제시된 전체 생산 계획을 최대한 유지하고 공정 변수의 변화를 실시간으로 반영하기 위하여 right shift rescheduling과 total regeneration 기법을 사용하였다. 또한, 불확실 인자의 발생 전후의 predictive scheduling과 reactive scheduling 간의 변화 정도를 측정하는 수단인 schedule stability 위하여, 본 논문에서는 수정된 sequence deviation과 percentage change in makespan을 사용하여 제안된 동적 생산계획의 안정성을 측정하였다. 본 논문에서 제안한 동적 생산계획 시스템은 기존에 제시되었던 경험 법칙에 의한 결과값에 비해 좋은 결과를 보여주었다.